BindingDB PrimarySearch

Found 11 hits of ic50 for monomerid = 14454
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM14454 (1-(4-pyridylacetyl)-4-(8-chloro-5,6-dihydro-11H-be...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	7.5	22
Schering-Plough Research Institute					Assay Description FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...				J Med Chem 41: 4890-902 (1998) Article DOI: 10.1021/jm980462b BindingDB Entry DOI: 10.7270/Q2ZS2TRS
Schering-Plough Research Institute					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Rattus norvegicus-Rattus norvegicus (rat))	BDBM14454 (1-(4-pyridylacetyl)-4-(8-chloro-5,6-dihydro-11H-be...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Activity against rat brain Farnesyltransferase				J Med Chem 40: 2971-90 (1997) Article DOI: 10.1021/jm970226l BindingDB Entry DOI: 10.7270/Q26M37HF
Warner-Lambert Company Curated by ChEMBL					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM14454 (1-(4-pyridylacetyl)-4-(8-chloro-5,6-dihydro-11H-be...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Compound was tested for the inhibition of Farnesyltransferase				J Med Chem 40: 4290-301 (1998) Article DOI: 10.1021/jm970464g BindingDB Entry DOI: 10.7270/Q2NC60B2
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM14454 (1-(4-pyridylacetyl)-4-(8-chloro-5,6-dihydro-11H-be...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human farnesyltransferase				J Med Chem 40: 4103-12 (1998) Article DOI: 10.1021/jm970291v BindingDB Entry DOI: 10.7270/Q2T152R0
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM14454 (1-(4-pyridylacetyl)-4-(8-chloro-5,6-dihydro-11H-be...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-Ras-CLVS.				Bioorg Med Chem Lett 8: 2521-6 (1999) BindingDB Entry DOI: 10.7270/Q24M93PP
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM14454 (1-(4-pyridylacetyl)-4-(8-chloro-5,6-dihydro-11H-be...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against farnesyltransferase was determined				J Med Chem 47: 1869-78 (2004) Article DOI: 10.1021/jm0305467 BindingDB Entry DOI: 10.7270/Q2RX9CVX
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM14454 (1-(4-pyridylacetyl)-4-(8-chloro-5,6-dihydro-11H-be...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of Farnesyltransferase				J Med Chem 42: 2125-35 (1999) Article DOI: 10.1021/jm990030g BindingDB Entry DOI: 10.7270/Q2ZS2VP9
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM14454 (1-(4-pyridylacetyl)-4-(8-chloro-5,6-dihydro-11H-be...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description In vitro inhibition of Ras processing in COS cells				Bioorg Med Chem Lett 8: 2521-6 (1999) BindingDB Entry DOI: 10.7270/Q24M93PP
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM14454 (1-(4-pyridylacetyl)-4-(8-chloro-5,6-dihydro-11H-be...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibition of [3H]-farnesyl pyrophosphate binding to human farnesyltransferase				Bioorg Med Chem Lett 13: 1523-6 (2003) BindingDB Entry DOI: 10.7270/Q2QZ29BR
Kumamoto University Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM14454 (1-(4-pyridylacetyl)-4-(8-chloro-5,6-dihydro-11H-be...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.14E+5	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Compound was tested for the inhibition of Geranylgeranyl transferase type I				J Med Chem 40: 4290-301 (1998) Article DOI: 10.1021/jm970464g BindingDB Entry DOI: 10.7270/Q2NC60B2
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM14454 (1-(4-pyridylacetyl)-4-(8-chloro-5,6-dihydro-11H-be...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.14E+5	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Activity against Geranylgeranyl transferase type I				J Med Chem 40: 2971-90 (1997) Article DOI: 10.1021/jm970226l BindingDB Entry DOI: 10.7270/Q26M37HF
Warner-Lambert Company Curated by ChEMBL					More data for this Ligand-Target Pair