Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Homo sapiens (Human)) | BDBM20182![]() ((1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-me...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Upjohn Laboratories Curated by ChEMBL | Assay Description Tested for its inhibitory activity against HMG-CoA reductase transcription in HepG2 cells | J Med Chem 37: 2343-51 (1994) BindingDB Entry DOI: 10.7270/Q2JH3K72 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol regulatory element-binding protein 2 (Homo sapiens (Human)) | BDBM20182![]() ((1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-me...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Curated by ChEMBL | Assay Description Inhibition of SREBP2 activation expressed in CHO-K1 cells cotransfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 2... | J Med Chem 54: 4923-7 (2011) Article DOI: 10.1021/jm200304y BindingDB Entry DOI: 10.7270/Q2NG4R0Z | |||||||||||
More data for this Ligand-Target Pair |