Found 3 hits of ic50 for monomerid = 217977 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM217977
![PNG](/data/jpeg/tenK21/BindingDB_217977.png) (US10729684, Example 9 | US9212182, 645)Show SMILES COc1cc(C#CC2CCCC2)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1cccnn1 |(6.67,-5.39,;5.33,-4.62,;4,-5.39,;4,-6.93,;2.67,-7.7,;2.67,-9.24,;2.67,-10.78,;2.67,-12.32,;3.91,-13.23,;3.44,-14.69,;1.9,-14.69,;1.42,-13.23,;1.33,-6.93,;,-7.7,;1.33,-5.39,;2.67,-4.62,;2.67,-3.08,;1.33,-2.31,;,-3.08,;-1.33,-2.31,;-1.33,-.77,;;1.33,-.77,;2.67,,;4,-.77,;4,-2.31,;5.33,-3.08,;-2.67,,;-3.44,-1.33,;-1.9,1.33,;-4,.77,;-4,2.31,;-5.33,3.08,;-5.33,4.62,;-4,5.39,;-2.67,4.62,;-2.67,3.08,)| Show InChI InChI=1S/C27H23FN4O4S/c1-36-25-16-19(9-8-18-5-2-3-6-18)22(28)17-24(25)32-23-12-11-21(15-20(23)10-13-27(32)33)37(34,35)31-26-7-4-14-29-30-26/h4,7,10-18H,2-3,5-6H2,1H3,(H,30,31) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
US Patent
| Assay Description HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy... |
US Patent US9212182 (2015)
BindingDB Entry DOI: 10.7270/Q2TT4PTW |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM217977
![PNG](/data/jpeg/tenK21/BindingDB_217977.png) (US10729684, Example 9 | US9212182, 645)Show SMILES COc1cc(C#CC2CCCC2)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1cccnn1 |(6.67,-5.39,;5.33,-4.62,;4,-5.39,;4,-6.93,;2.67,-7.7,;2.67,-9.24,;2.67,-10.78,;2.67,-12.32,;3.91,-13.23,;3.44,-14.69,;1.9,-14.69,;1.42,-13.23,;1.33,-6.93,;,-7.7,;1.33,-5.39,;2.67,-4.62,;2.67,-3.08,;1.33,-2.31,;,-3.08,;-1.33,-2.31,;-1.33,-.77,;;1.33,-.77,;2.67,,;4,-.77,;4,-2.31,;5.33,-3.08,;-2.67,,;-3.44,-1.33,;-1.9,1.33,;-4,.77,;-4,2.31,;-5.33,3.08,;-5.33,4.62,;-4,5.39,;-2.67,4.62,;-2.67,3.08,)| Show InChI InChI=1S/C27H23FN4O4S/c1-36-25-16-19(9-8-18-5-2-3-6-18)22(28)17-24(25)32-23-12-11-21(15-20(23)10-13-27(32)33)37(34,35)31-26-7-4-14-29-30-26/h4,7,10-18H,2-3,5-6H2,1H3,(H,30,31) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 8.95 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM217977
![PNG](/data/jpeg/tenK21/BindingDB_217977.png) (US10729684, Example 9 | US9212182, 645)Show SMILES COc1cc(C#CC2CCCC2)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1cccnn1 |(6.67,-5.39,;5.33,-4.62,;4,-5.39,;4,-6.93,;2.67,-7.7,;2.67,-9.24,;2.67,-10.78,;2.67,-12.32,;3.91,-13.23,;3.44,-14.69,;1.9,-14.69,;1.42,-13.23,;1.33,-6.93,;,-7.7,;1.33,-5.39,;2.67,-4.62,;2.67,-3.08,;1.33,-2.31,;,-3.08,;-1.33,-2.31,;-1.33,-.77,;;1.33,-.77,;2.67,,;4,-.77,;4,-2.31,;5.33,-3.08,;-2.67,,;-3.44,-1.33,;-1.9,1.33,;-4,.77,;-4,2.31,;-5.33,3.08,;-5.33,4.62,;-4,5.39,;-2.67,4.62,;-2.67,3.08,)| Show InChI InChI=1S/C27H23FN4O4S/c1-36-25-16-19(9-8-18-5-2-3-6-18)22(28)17-24(25)32-23-12-11-21(15-20(23)10-13-27(32)33)37(34,35)31-26-7-4-14-29-30-26/h4,7,10-18H,2-3,5-6H2,1H3,(H,30,31) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 19.3 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this Ligand-Target Pair | |