Found 4 hits of ic50 for monomerid = 245488 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Serine-protein kinase ATM
(Homo sapiens (Human)) | BDBM245488
(US9428503, 15)Show SMILES Cn1c2cnc3ccc(cc3c2n([C@@H]2C[C@H](O)C2)c1=O)-c1ccc(OCCCN2CCCC2)nc1 |r,wD:13.14,15.17,(10.5,-1.21,;9.02,-.81,;7.87,-1.84,;7.87,-3.38,;6.54,-4.15,;5.2,-3.38,;3.87,-4.15,;2.54,-3.38,;2.54,-1.84,;3.87,-1.07,;5.2,-1.84,;6.54,-1.07,;6.86,.43,;5.77,1.52,;4.23,1.52,;4.23,3.06,;3.14,4.15,;5.77,3.06,;8.39,.6,;9.16,1.93,;1.2,-1.07,;1.2,.47,;-.13,1.24,;-1.46,.47,;-2.8,1.24,;-4.13,.47,;-5.47,1.24,;-6.8,.47,;-8.13,1.24,;-8.13,2.78,;-9.6,3.25,;-10.5,2.01,;-9.6,.76,;-1.46,-1.07,;-.13,-1.84,)| Show InChI InChI=1S/C27H31N5O3/c1-30-24-17-28-23-7-5-18(13-22(23)26(24)32(27(30)34)20-14-21(33)15-20)19-6-8-25(29-16-19)35-12-4-11-31-9-2-3-10-31/h5-8,13,16-17,20-21,33H,2-4,9-12,14-15H2,1H3/t20-,21+ | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.447 | n/a | n/a | n/a | n/a | n/a | 37 |
AstraZeneca AB
US Patent
| Assay Description Assay a) HT29 cells (ECACC #85061109) were seeded into 384 well assay plates (Costar #3712) at a density of 3500 cells/well in 40 μl EMEM medium c... |
US Patent US9428503 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GVJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM245488
(US9428503, 15)Show SMILES Cn1c2cnc3ccc(cc3c2n([C@@H]2C[C@H](O)C2)c1=O)-c1ccc(OCCCN2CCCC2)nc1 |r,wD:13.14,15.17,(10.5,-1.21,;9.02,-.81,;7.87,-1.84,;7.87,-3.38,;6.54,-4.15,;5.2,-3.38,;3.87,-4.15,;2.54,-3.38,;2.54,-1.84,;3.87,-1.07,;5.2,-1.84,;6.54,-1.07,;6.86,.43,;5.77,1.52,;4.23,1.52,;4.23,3.06,;3.14,4.15,;5.77,3.06,;8.39,.6,;9.16,1.93,;1.2,-1.07,;1.2,.47,;-.13,1.24,;-1.46,.47,;-2.8,1.24,;-4.13,.47,;-5.47,1.24,;-6.8,.47,;-8.13,1.24,;-8.13,2.78,;-9.6,3.25,;-10.5,2.01,;-9.6,.76,;-1.46,-1.07,;-.13,-1.84,)| Show InChI InChI=1S/C27H31N5O3/c1-30-24-17-28-23-7-5-18(13-22(23)26(24)32(27(30)34)20-14-21(33)15-20)19-6-8-25(29-16-19)35-12-4-11-31-9-2-3-10-31/h5-8,13,16-17,20-21,33H,2-4,9-12,14-15H2,1H3/t20-,21+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.39E+3 | n/a | n/a | n/a | n/a | n/a | 37 |
AstraZeneca AB
US Patent
| Assay Description Assay c) BT474 cells (human breast ductal carcinoma, ATCC HTB-20) were seeded into black 384 well plates (Costar, #3712) at a density of 5600 cells/w... |
US Patent US9428503 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GVJ |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM245488
(US9428503, 15)Show SMILES Cn1c2cnc3ccc(cc3c2n([C@@H]2C[C@H](O)C2)c1=O)-c1ccc(OCCCN2CCCC2)nc1 |r,wD:13.14,15.17,(10.5,-1.21,;9.02,-.81,;7.87,-1.84,;7.87,-3.38,;6.54,-4.15,;5.2,-3.38,;3.87,-4.15,;2.54,-3.38,;2.54,-1.84,;3.87,-1.07,;5.2,-1.84,;6.54,-1.07,;6.86,.43,;5.77,1.52,;4.23,1.52,;4.23,3.06,;3.14,4.15,;5.77,3.06,;8.39,.6,;9.16,1.93,;1.2,-1.07,;1.2,.47,;-.13,1.24,;-1.46,.47,;-2.8,1.24,;-4.13,.47,;-5.47,1.24,;-6.8,.47,;-8.13,1.24,;-8.13,2.78,;-9.6,3.25,;-10.5,2.01,;-9.6,.76,;-1.46,-1.07,;-.13,-1.84,)| Show InChI InChI=1S/C27H31N5O3/c1-30-24-17-28-23-7-5-18(13-22(23)26(24)32(27(30)34)20-14-21(33)15-20)19-6-8-25(29-16-19)35-12-4-11-31-9-2-3-10-31/h5-8,13,16-17,20-21,33H,2-4,9-12,14-15H2,1H3/t20-,21+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.58E+3 | n/a | n/a | n/a | n/a | n/a | 37 |
AstraZeneca AB
US Patent
| Assay Description Assay d) MDA-MB-468 cells (human breast adenocarcinoma ##ATCC HTB 132) were seeded at 1500 cells/well in 40 μl of DMEM containing 10% FBS and 1% g... |
US Patent US9428503 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GVJ |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase ATR
(Homo sapiens (Human)) | BDBM245488
(US9428503, 15)Show SMILES Cn1c2cnc3ccc(cc3c2n([C@@H]2C[C@H](O)C2)c1=O)-c1ccc(OCCCN2CCCC2)nc1 |r,wD:13.14,15.17,(10.5,-1.21,;9.02,-.81,;7.87,-1.84,;7.87,-3.38,;6.54,-4.15,;5.2,-3.38,;3.87,-4.15,;2.54,-3.38,;2.54,-1.84,;3.87,-1.07,;5.2,-1.84,;6.54,-1.07,;6.86,.43,;5.77,1.52,;4.23,1.52,;4.23,3.06,;3.14,4.15,;5.77,3.06,;8.39,.6,;9.16,1.93,;1.2,-1.07,;1.2,.47,;-.13,1.24,;-1.46,.47,;-2.8,1.24,;-4.13,.47,;-5.47,1.24,;-6.8,.47,;-8.13,1.24,;-8.13,2.78,;-9.6,3.25,;-10.5,2.01,;-9.6,.76,;-1.46,-1.07,;-.13,-1.84,)| Show InChI InChI=1S/C27H31N5O3/c1-30-24-17-28-23-7-5-18(13-22(23)26(24)32(27(30)34)20-14-21(33)15-20)19-6-8-25(29-16-19)35-12-4-11-31-9-2-3-10-31/h5-8,13,16-17,20-21,33H,2-4,9-12,14-15H2,1H3/t20-,21+ | PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
AstraZeneca AB
US Patent
| Assay Description Assay b) HT29 cells (ECACC #85061109) were seeded into 384 well assay plates (Costar #3712) at a density of 6000 cells/well in 40 μl EMEM medium c... |
US Patent US9428503 (2016)
BindingDB Entry DOI: 10.7270/Q2GH9GVJ |
More data for this Ligand-Target Pair | |