Found 3 hits of ic50 for monomerid = 274323 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Bromodomain-containing protein 4 [44-477]
(Homo sapiens (Human)) | BDBM274323
![PNG](/data/jpeg/tenK27/BindingDB_274323.png) (Ethyl 6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]tr...)Show SMILES CCOC(=O)n1c2C(N(C(=O)c2c(C)c1-c1cccnc1OC)c1cc(C)c2nnc(C)n2c1)c1ccc(Cl)cc1 |(.92,-4.8,;2.01,-3.71,;1.61,-2.22,;2.7,-1.14,;4.18,-1.53,;2.3,.35,;.83,.83,;-.63,.35,;-1.54,1.6,;-.63,2.84,;-1.4,4.18,;.83,2.37,;2.3,2.84,;3.07,4.18,;3.2,1.6,;4.74,1.6,;5.51,.26,;7.05,.26,;7.82,1.6,;7.05,2.93,;5.51,2.93,;4.74,4.26,;5.51,5.6,;-3.08,1.6,;-3.85,2.93,;-5.39,2.93,;-6.16,4.26,;-6.16,1.6,;-7.66,1.28,;-7.82,-.25,;-6.42,-.88,;-6.02,-2.37,;-5.39,.26,;-3.85,.26,;-1.03,-1.14,;.06,-2.22,;-.34,-3.71,;-1.83,-4.11,;-2.23,-5.6,;-2.92,-3.02,;-2.52,-1.53,)| Show InChI InChI=1S/C30H27ClN6O4/c1-6-41-30(39)37-24(22-8-7-13-32-28(22)40-5)17(3)23-26(37)25(19-9-11-20(31)12-10-19)36(29(23)38)21-14-16(2)27-34-33-18(4)35(27)15-21/h7-15,25H,6H2,1-5H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | 7.5 | n/a |
NOVARTIS AG
US Patent
| Assay Description All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... |
US Patent US9550796 (2017)
BindingDB Entry DOI: 10.7270/Q2QN68SK |
More data for this Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM274323
![PNG](/data/jpeg/tenK27/BindingDB_274323.png) (Ethyl 6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]tr...)Show SMILES CCOC(=O)n1c2C(N(C(=O)c2c(C)c1-c1cccnc1OC)c1cc(C)c2nnc(C)n2c1)c1ccc(Cl)cc1 |(.92,-4.8,;2.01,-3.71,;1.61,-2.22,;2.7,-1.14,;4.18,-1.53,;2.3,.35,;.83,.83,;-.63,.35,;-1.54,1.6,;-.63,2.84,;-1.4,4.18,;.83,2.37,;2.3,2.84,;3.07,4.18,;3.2,1.6,;4.74,1.6,;5.51,.26,;7.05,.26,;7.82,1.6,;7.05,2.93,;5.51,2.93,;4.74,4.26,;5.51,5.6,;-3.08,1.6,;-3.85,2.93,;-5.39,2.93,;-6.16,4.26,;-6.16,1.6,;-7.66,1.28,;-7.82,-.25,;-6.42,-.88,;-6.02,-2.37,;-5.39,.26,;-3.85,.26,;-1.03,-1.14,;.06,-2.22,;-.34,-3.71,;-1.83,-4.11,;-2.23,-5.6,;-2.92,-3.02,;-2.52,-1.53,)| Show InChI InChI=1S/C30H27ClN6O4/c1-6-41-30(39)37-24(22-8-7-13-32-28(22)40-5)17(3)23-26(37)25(19-9-11-20(31)12-10-19)36(29(23)38)21-14-16(2)27-34-33-18(4)35(27)15-21/h7-15,25H,6H2,1-5H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | 7.5 | n/a |
NOVARTIS AG
US Patent
| Assay Description All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... |
US Patent US9550796 (2017)
BindingDB Entry DOI: 10.7270/Q2QN68SK |
More data for this Ligand-Target Pair | |
CREB-binding protein
(Homo sapiens (Human)) | BDBM274323
![PNG](/data/jpeg/tenK27/BindingDB_274323.png) (Ethyl 6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]tr...)Show SMILES CCOC(=O)n1c2C(N(C(=O)c2c(C)c1-c1cccnc1OC)c1cc(C)c2nnc(C)n2c1)c1ccc(Cl)cc1 |(.92,-4.8,;2.01,-3.71,;1.61,-2.22,;2.7,-1.14,;4.18,-1.53,;2.3,.35,;.83,.83,;-.63,.35,;-1.54,1.6,;-.63,2.84,;-1.4,4.18,;.83,2.37,;2.3,2.84,;3.07,4.18,;3.2,1.6,;4.74,1.6,;5.51,.26,;7.05,.26,;7.82,1.6,;7.05,2.93,;5.51,2.93,;4.74,4.26,;5.51,5.6,;-3.08,1.6,;-3.85,2.93,;-5.39,2.93,;-6.16,4.26,;-6.16,1.6,;-7.66,1.28,;-7.82,-.25,;-6.42,-.88,;-6.02,-2.37,;-5.39,.26,;-3.85,.26,;-1.03,-1.14,;.06,-2.22,;-.34,-3.71,;-1.83,-4.11,;-2.23,-5.6,;-2.92,-3.02,;-2.52,-1.53,)| Show InChI InChI=1S/C30H27ClN6O4/c1-6-41-30(39)37-24(22-8-7-13-32-28(22)40-5)17(3)23-26(37)25(19-9-11-20(31)12-10-19)36(29(23)38)21-14-16(2)27-34-33-18(4)35(27)15-21/h7-15,25H,6H2,1-5H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
NOVARTIS AG
US Patent
| Assay Description All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... |
US Patent US9550796 (2017)
BindingDB Entry DOI: 10.7270/Q2QN68SK |
More data for this Ligand-Target Pair | |