Found 4 hits of ic50 for monomerid = 287001 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM287001
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC(C)(C)O)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(2.67,8.47,;4,7.7,;4,6.16,;5.33,5.39,;5.33,3.85,;6.67,3.08,;8,3.85,;4,3.08,;4,1.54,;2.67,3.85,;2.67,5.39,;1.33,6.16,;1.33,3.08,;,3.85,;-1.33,3.08,;-2.67,3.85,;-4,3.08,;-4,1.54,;-5.33,.77,;-5.33,-.77,;-6.67,-1.54,;-8,-.77,;-8,-2.31,;-6.67,-3.08,;-2.67,.77,;-1.33,1.54,;,.77,;,-.77,;1.33,-1.54,;1.33,-3.08,;2.67,-3.85,;2.67,-5.39,;4,-6.16,;5.33,-5.39,;5.33,-3.85,;4,-3.08,;6.67,-6.16,;8,-5.39,;6.67,-7.7,;8,-8.47,;1.33,1.54,;2.67,.77,)| Show InChI InChI=1S/C29H36Cl2N6O5/c1-6-22(38)36-12-10-35(11-13-36)8-7-9-37-26-18(16-32-28(34-26)33-17-29(2,3)40)14-19(27(37)39)23-24(30)20(41-4)15-21(42-5)25(23)31/h6,14-16,40H,1,7-13,17H2,2-5H3,(H,32,33,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | 25 |
Principia Biopharma, Inc.
US Patent
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
US Patent US9567334 (2017)
BindingDB Entry DOI: 10.7270/Q2XK8HKQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM287001
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC(C)(C)O)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(2.67,8.47,;4,7.7,;4,6.16,;5.33,5.39,;5.33,3.85,;6.67,3.08,;8,3.85,;4,3.08,;4,1.54,;2.67,3.85,;2.67,5.39,;1.33,6.16,;1.33,3.08,;,3.85,;-1.33,3.08,;-2.67,3.85,;-4,3.08,;-4,1.54,;-5.33,.77,;-5.33,-.77,;-6.67,-1.54,;-8,-.77,;-8,-2.31,;-6.67,-3.08,;-2.67,.77,;-1.33,1.54,;,.77,;,-.77,;1.33,-1.54,;1.33,-3.08,;2.67,-3.85,;2.67,-5.39,;4,-6.16,;5.33,-5.39,;5.33,-3.85,;4,-3.08,;6.67,-6.16,;8,-5.39,;6.67,-7.7,;8,-8.47,;1.33,1.54,;2.67,.77,)| Show InChI InChI=1S/C29H36Cl2N6O5/c1-6-22(38)36-12-10-35(11-13-36)8-7-9-37-26-18(16-32-28(34-26)33-17-29(2,3)40)14-19(27(37)39)23-24(30)20(41-4)15-21(42-5)25(23)31/h6,14-16,40H,1,7-13,17H2,2-5H3,(H,32,33,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
Bioorg Med Chem Lett 19: 773-7 (2009)
BindingDB Entry DOI: 10.7270/Q2GX4DVZ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM287001
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC(C)(C)O)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(2.67,8.47,;4,7.7,;4,6.16,;5.33,5.39,;5.33,3.85,;6.67,3.08,;8,3.85,;4,3.08,;4,1.54,;2.67,3.85,;2.67,5.39,;1.33,6.16,;1.33,3.08,;,3.85,;-1.33,3.08,;-2.67,3.85,;-4,3.08,;-4,1.54,;-5.33,.77,;-5.33,-.77,;-6.67,-1.54,;-8,-.77,;-8,-2.31,;-6.67,-3.08,;-2.67,.77,;-1.33,1.54,;,.77,;,-.77,;1.33,-1.54,;1.33,-3.08,;2.67,-3.85,;2.67,-5.39,;4,-6.16,;5.33,-5.39,;5.33,-3.85,;4,-3.08,;6.67,-6.16,;8,-5.39,;6.67,-7.7,;8,-8.47,;1.33,1.54,;2.67,.77,)| Show InChI InChI=1S/C29H36Cl2N6O5/c1-6-22(38)36-12-10-35(11-13-36)8-7-9-37-26-18(16-32-28(34-26)33-17-29(2,3)40)14-19(27(37)39)23-24(30)20(41-4)15-21(42-5)25(23)31/h6,14-16,40H,1,7-13,17H2,2-5H3,(H,32,33,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
| Assay Description The cell-based effects of FGFR inhibitors were determined by measuring inhibition of FGFR-dependent cell line growth. The cell lines SNU-16 was used ... |
Bioorg Med Chem Lett 19: 773-7 (2009)
BindingDB Entry DOI: 10.7270/Q2GX4DVZ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM287001
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC(C)(C)O)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(2.67,8.47,;4,7.7,;4,6.16,;5.33,5.39,;5.33,3.85,;6.67,3.08,;8,3.85,;4,3.08,;4,1.54,;2.67,3.85,;2.67,5.39,;1.33,6.16,;1.33,3.08,;,3.85,;-1.33,3.08,;-2.67,3.85,;-4,3.08,;-4,1.54,;-5.33,.77,;-5.33,-.77,;-6.67,-1.54,;-8,-.77,;-8,-2.31,;-6.67,-3.08,;-2.67,.77,;-1.33,1.54,;,.77,;,-.77,;1.33,-1.54,;1.33,-3.08,;2.67,-3.85,;2.67,-5.39,;4,-6.16,;5.33,-5.39,;5.33,-3.85,;4,-3.08,;6.67,-6.16,;8,-5.39,;6.67,-7.7,;8,-8.47,;1.33,1.54,;2.67,.77,)| Show InChI InChI=1S/C29H36Cl2N6O5/c1-6-22(38)36-12-10-35(11-13-36)8-7-9-37-26-18(16-32-28(34-26)33-17-29(2,3)40)14-19(27(37)39)23-24(30)20(41-4)15-21(42-5)25(23)31/h6,14-16,40H,1,7-13,17H2,2-5H3,(H,32,33,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
PRINCIPIA BIOPHARMA, INC.
US Patent
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
US Patent US9815834 (2017)
BindingDB Entry DOI: 10.7270/Q2B85B83 |
More data for this Ligand-Target Pair | |