Found 2 hits of ic50 for monomerid = 303808 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM303808
(4-{[2-(11′-Chloro-2′,5′-dioxo-2&...)Show SMILES CO[C@H]1CC[C@H](CC(C(=O)Nc2ccc(C(N)=O)c(F)c2)n2cc3c(cc2=O)-c2cc(Cl)ccc2CC2(CC2)NC3=O)CC1 |r,wU:2.1,wD:5.5,$;;;;;;;;;;HN;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;$,(6.38,5.01,;5.05,5.78,;3.71,5,;3.71,3.46,;2.38,2.7,;1.05,3.46,;-.29,2.69,;-.29,1.15,;1.05,.38,;1.05,-1.16,;2.38,1.15,;3.71,.38,;3.71,-1.16,;5.05,-1.93,;6.38,-1.16,;7.71,-1.92,;9.05,-1.15,;7.71,-3.46,;6.38,.38,;7.71,1.15,;5.05,1.15,;-1.62,.38,;-2.95,1.15,;-4.29,.38,;-4.29,-1.16,;-2.95,-1.93,;-1.62,-1.16,;-.29,-1.93,;-5.62,-1.93,;-5.62,-3.47,;-6.96,-4.24,;-6.96,-5.78,;-8.29,-3.47,;-8.29,-1.93,;-6.96,-1.16,;-7.91,.01,;-7.51,1.5,;-9.05,1.5,;-8.28,2.83,;-6.17,2.27,;-4.69,1.87,;-3.6,2.96,;1.05,5,;2.38,5.77,)| Show InChI InChI=1S/C33H34ClFN4O5/c1-44-22-7-2-18(3-8-22)12-28(32(43)37-21-6-9-23(30(36)41)27(35)14-21)39-17-26-25(15-29(39)40)24-13-20(34)5-4-19(24)16-33(10-11-33)38-31(26)42/h4-6,9,13-15,17-18,22,28H,2-3,7-8,10-12,16H2,1H3,(H2,36,41)(H,37,43)(H,38,42)/t18-,22-,28? | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT
US Patent
| Assay Description The factor XIa inhibition of the substances according to the invention is determined using a biochemical test system which utilizes the reaction of a... |
US Patent US10138236 (2018)
BindingDB Entry DOI: 10.7270/Q2445PH4 |
More data for this Ligand-Target Pair | |
Plasma kallikrein
(Homo sapiens (Human)) | BDBM303808
(4-{[2-(11′-Chloro-2′,5′-dioxo-2&...)Show SMILES CO[C@H]1CC[C@H](CC(C(=O)Nc2ccc(C(N)=O)c(F)c2)n2cc3c(cc2=O)-c2cc(Cl)ccc2CC2(CC2)NC3=O)CC1 |r,wU:2.1,wD:5.5,$;;;;;;;;;;HN;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;$,(6.38,5.01,;5.05,5.78,;3.71,5,;3.71,3.46,;2.38,2.7,;1.05,3.46,;-.29,2.69,;-.29,1.15,;1.05,.38,;1.05,-1.16,;2.38,1.15,;3.71,.38,;3.71,-1.16,;5.05,-1.93,;6.38,-1.16,;7.71,-1.92,;9.05,-1.15,;7.71,-3.46,;6.38,.38,;7.71,1.15,;5.05,1.15,;-1.62,.38,;-2.95,1.15,;-4.29,.38,;-4.29,-1.16,;-2.95,-1.93,;-1.62,-1.16,;-.29,-1.93,;-5.62,-1.93,;-5.62,-3.47,;-6.96,-4.24,;-6.96,-5.78,;-8.29,-3.47,;-8.29,-1.93,;-6.96,-1.16,;-7.91,.01,;-7.51,1.5,;-9.05,1.5,;-8.28,2.83,;-6.17,2.27,;-4.69,1.87,;-3.6,2.96,;1.05,5,;2.38,5.77,)| Show InChI InChI=1S/C33H34ClFN4O5/c1-44-22-7-2-18(3-8-22)12-28(32(43)37-21-6-9-23(30(36)41)27(35)14-21)39-17-26-25(15-29(39)40)24-13-20(34)5-4-19(24)16-33(10-11-33)38-31(26)42/h4-6,9,13-15,17-18,22,28H,2-3,7-8,10-12,16H2,1H3,(H2,36,41)(H,37,43)(H,38,42)/t18-,22-,28? | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 740 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT
US Patent
| Assay Description o determine the plasma kallikrein inhibition of the substances according to the invention, a biochemical test system is used which utilizes the react... |
US Patent US10138236 (2018)
BindingDB Entry DOI: 10.7270/Q2445PH4 |
More data for this Ligand-Target Pair | |