Compile Data Set for Download or QSAR

Found 4 hits of ic50 for monomerid = 345844   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM345844 (US10202365, Compound 21 | US10774070, Compound 21) Show SMILES Cc1cc(Nc2cc(C)nc(n2)-c2ccc(nc2)C(=O)NCc2cnc(cn2)-n2cc(F)cn2)n[nH]1 Show InChI InChI=1S/C23H20FN11O/c1-13-5-19(31-20-6-14(2)33-34-20)32-22(30-13)15-3-4-18(26-7-15)23(36)28-10-17-9-27-21(11-25-17)35-12-16(24)8-29-35/h3-9,11-12H,10H2,1-2H3,(H,28,36)(H2,30,31,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) is incubated in a total of 12.5 μL of buffer (100 mM HEP...				US Patent US10202365 (2019) BindingDB Entry DOI: 10.7270/Q2736T1G
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM345844 (US10202365, Compound 21 | US10774070, Compound 21) Show SMILES Cc1cc(Nc2cc(C)nc(n2)-c2ccc(nc2)C(=O)NCc2cnc(cn2)-n2cc(F)cn2)n[nH]1 Show InChI InChI=1S/C23H20FN11O/c1-13-5-19(31-20-6-14(2)33-34-20)32-22(30-13)15-3-4-18(26-7-15)23(36)28-10-17-9-27-21(11-25-17)35-12-16(24)8-29-35/h3-9,11-12H,10H2,1-2H3,(H,28,36)(H2,30,31,32,33,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) is incubated in a total of 12.5 μL of buffer (100 mM HEPES ...				US Patent US10774070 (2020) BindingDB Entry DOI: 10.7270/Q2HM5CHN
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM345844 (US10202365, Compound 21 | US10774070, Compound 21) Show SMILES Cc1cc(Nc2cc(C)nc(n2)-c2ccc(nc2)C(=O)NCc2cnc(cn2)-n2cc(F)cn2)n[nH]1 Show InChI InChI=1S/C23H20FN11O/c1-13-5-19(31-20-6-14(2)33-34-20)32-22(30-13)15-3-4-18(26-7-15)23(36)28-10-17-9-27-21(11-25-17)35-12-16(24)8-29-35/h3-9,11-12H,10H2,1-2H3,(H,28,36)(H2,30,31,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) is incubated in a total of 12.5 μL of buffer (100 mM HEP...				US Patent US10774070 (2020) BindingDB Entry DOI: 10.7270/Q2HM5CHN
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM345844 (US10202365, Compound 21 | US10774070, Compound 21) Show SMILES Cc1cc(Nc2cc(C)nc(n2)-c2ccc(nc2)C(=O)NCc2cnc(cn2)-n2cc(F)cn2)n[nH]1 Show InChI InChI=1S/C23H20FN11O/c1-13-5-19(31-20-6-14(2)33-34-20)32-22(30-13)15-3-4-18(26-7-15)23(36)28-10-17-9-27-21(11-25-17)35-12-16(24)8-29-35/h3-9,11-12H,10H2,1-2H3,(H,28,36)(H2,30,31,32,33,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) is incubated in a total of 12.5 μL of buffer (100 mM HEPES ...				US Patent US10202365 (2019) BindingDB Entry DOI: 10.7270/Q2736T1G
					More data for this Ligand-Target Pair