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Compile Data Set for Download or QSAR

Found 2 hits of ic50 for monomerid = 387270   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-2


(Homo sapiens (Human))		BDBM387270
PNG
(2,6- Difluoro-N-(5-(2- methyl-5-(4- methyl-5-oxo-4...)
Show SMILES Cc1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1)-c1nn(C)c(=O)o1
Show InChI InChI=1S/C21H15F2N5O3/c1-11-6-7-12(20-27-28(2)21(30)31-20)8-13(11)16-9-25-17(10-24-16)26-19(29)18-14(22)4-3-5-15(18)23/h3-10H,1-2H3,(H,25,26,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 64n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01403
BindingDB Entry DOI: 10.7270/Q2C82F4Q
More data for this
Ligand-Target Pair
Interleukin-2


(Homo sapiens (Human))		BDBM387270
PNG
(2,6- Difluoro-N-(5-(2- methyl-5-(4- methyl-5-oxo-4...)
Show SMILES Cc1ccc(cc1-c1cnc(NC(=O)c2c(F)cccc2F)cn1)-c1nn(C)c(=O)o1
Show InChI InChI=1S/C21H15F2N5O3/c1-11-6-7-12(20-27-28(2)21(30)31-20)8-13(11)16-9-25-17(10-24-16)26-19(29)18-14(22)4-3-5-15(18)23/h3-10H,1-2H3,(H,25,26,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...

Bioorg Med Chem Lett 18: 1958-62 (2008)


BindingDB Entry DOI: 10.7270/Q2D50Q8B
More data for this
Ligand-Target Pair