Compile Data Set for Download or QSAR

Found 18 hits of ic50 for monomerid = 397151   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytoplasmic tyrosine-protein kinase BMX (Homo sapiens (Human))	BDBM397151 (US10596172, Compound I-39 | US10828300, Compound I...) Show SMILES Cc1cnc(Nc2ccccc2)nc1Nc1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C20H19N5O/c1-3-18(26)22-16-9-11-17(12-10-16)23-19-14(2)13-21-20(25-19)24-15-7-5-4-6-8-15/h3-13H,1H2,2H3,(H,22,26)(H2,21,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Celgene CAR LLC US Patent					Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...				US Patent US10596172 (2020) BindingDB Entry DOI: 10.7270/Q2VM4G9X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM397151 (US10596172, Compound I-39 | US10828300, Compound I...) Show SMILES Cc1cnc(Nc2ccccc2)nc1Nc1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C20H19N5O/c1-3-18(26)22-16-9-11-17(12-10-16)23-19-14(2)13-21-20(25-19)24-15-7-5-4-6-8-15/h3-13H,1H2,2H3,(H,22,26)(H2,21,23,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Celgene CAR LLC US Patent					Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...				US Patent US10596172 (2020) BindingDB Entry DOI: 10.7270/Q2VM4G9X
					More data for this Ligand-Target Pair
Cytoplasmic tyrosine-protein kinase BMX (Homo sapiens (Human))	BDBM397151 (US10596172, Compound I-39 | US10828300, Compound I...) Show SMILES Cc1cnc(Nc2ccccc2)nc1Nc1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C20H19N5O/c1-3-18(26)22-16-9-11-17(12-10-16)23-19-14(2)13-21-20(25-19)24-15-7-5-4-6-8-15/h3-13H,1H2,2H3,(H,22,26)(H2,21,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description BMX: The activity of selected compounds of this invention in the BMX inhibition assay				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2NV9MM2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM397151 (US10596172, Compound I-39 | US10828300, Compound I...) Show SMILES Cc1cnc(Nc2ccccc2)nc1Nc1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C20H19N5O/c1-3-18(26)22-16-9-11-17(12-10-16)23-19-14(2)13-21-20(25-19)24-15-7-5-4-6-8-15/h3-13H,1H2,2H3,(H,22,26)(H2,21,23,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description JAK3: The Omnia Assay Protocol for potency assessment against JAK3 was performed in a substantially similar manner as that described in Example 251 a...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2NV9MM2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM397151 (US10596172, Compound I-39 | US10828300, Compound I...) Show SMILES Cc1cnc(Nc2ccccc2)nc1Nc1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C20H19N5O/c1-3-18(26)22-16-9-11-17(12-10-16)23-19-14(2)13-21-20(25-19)24-15-7-5-4-6-8-15/h3-13H,1H2,2H3,(H,22,26)(H2,21,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Celgene CAR LLC US Patent					Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...				US Patent US10828300 (2020) BindingDB Entry DOI: 10.7270/Q2JS9THK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM397151 (US10596172, Compound I-39 | US10828300, Compound I...) Show SMILES Cc1cnc(Nc2ccccc2)nc1Nc1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C20H19N5O/c1-3-18(26)22-16-9-11-17(12-10-16)23-19-14(2)13-21-20(25-19)24-15-7-5-4-6-8-15/h3-13H,1H2,2H3,(H,22,26)(H2,21,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Celgene CAR LLC US Patent					Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...				US Patent US10596172 (2020) BindingDB Entry DOI: 10.7270/Q2VM4G9X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM397151 (US10596172, Compound I-39 | US10828300, Compound I...) Show SMILES Cc1cnc(Nc2ccccc2)nc1Nc1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C20H19N5O/c1-3-18(26)22-16-9-11-17(12-10-16)23-19-14(2)13-21-20(25-19)24-15-7-5-4-6-8-15/h3-13H,1H2,2H3,(H,22,26)(H2,21,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X92FHZ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM397151 (US10596172, Compound I-39 | US10828300, Compound I...) Show SMILES Cc1cnc(Nc2ccccc2)nc1Nc1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C20H19N5O/c1-3-18(26)22-16-9-11-17(12-10-16)23-19-14(2)13-21-20(25-19)24-15-7-5-4-6-8-15/h3-13H,1H2,2H3,(H,22,26)(H2,21,23,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X92FHZ
					More data for this Ligand-Target Pair
Cytoplasmic tyrosine-protein kinase BMX (Homo sapiens (Human))	BDBM397151 (US10596172, Compound I-39 | US10828300, Compound I...) Show SMILES Cc1cnc(Nc2ccccc2)nc1Nc1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C20H19N5O/c1-3-18(26)22-16-9-11-17(12-10-16)23-19-14(2)13-21-20(25-19)24-15-7-5-4-6-8-15/h3-13H,1H2,2H3,(H,22,26)(H2,21,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X92FHZ
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human))	BDBM397151 (US10596172, Compound I-39 | US10828300, Compound I...) Show SMILES Cc1cnc(Nc2ccccc2)nc1Nc1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C20H19N5O/c1-3-18(26)22-16-9-11-17(12-10-16)23-19-14(2)13-21-20(25-19)24-15-7-5-4-6-8-15/h3-13H,1H2,2H3,(H,22,26)(H2,21,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene CAR LLC US Patent					Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...				US Patent US10596172 (2020) BindingDB Entry DOI: 10.7270/Q2VM4G9X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK (Homo sapiens (Human))	BDBM397151 (US10596172, Compound I-39 | US10828300, Compound I...) Show SMILES Cc1cnc(Nc2ccccc2)nc1Nc1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C20H19N5O/c1-3-18(26)22-16-9-11-17(12-10-16)23-19-14(2)13-21-20(25-19)24-15-7-5-4-6-8-15/h3-13H,1H2,2H3,(H,22,26)(H2,21,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description ITK: This example describes continuous-read kinase assays to measure inherent potency of compound against active forms of ITK enzymes as described in...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2NV9MM2
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human))	BDBM397151 (US10596172, Compound I-39 | US10828300, Compound I...) Show SMILES Cc1cnc(Nc2ccccc2)nc1Nc1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C20H19N5O/c1-3-18(26)22-16-9-11-17(12-10-16)23-19-14(2)13-21-20(25-19)24-15-7-5-4-6-8-15/h3-13H,1H2,2H3,(H,22,26)(H2,21,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description EGFR (WT) and EGFR (T790M/L858R): The Omnia Assay Protocol for potency assessment against EGFR is performed as described in Example 251 above except ...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2NV9MM2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK (Homo sapiens (Human))	BDBM397151 (US10596172, Compound I-39 | US10828300, Compound I...) Show SMILES Cc1cnc(Nc2ccccc2)nc1Nc1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C20H19N5O/c1-3-18(26)22-16-9-11-17(12-10-16)23-19-14(2)13-21-20(25-19)24-15-7-5-4-6-8-15/h3-13H,1H2,2H3,(H,22,26)(H2,21,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene CAR LLC US Patent					Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...				US Patent US10596172 (2020) BindingDB Entry DOI: 10.7270/Q2VM4G9X
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK (Homo sapiens (Human))	BDBM397151 (US10596172, Compound I-39 | US10828300, Compound I...) Show SMILES Cc1cnc(Nc2ccccc2)nc1Nc1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C20H19N5O/c1-3-18(26)22-16-9-11-17(12-10-16)23-19-14(2)13-21-20(25-19)24-15-7-5-4-6-8-15/h3-13H,1H2,2H3,(H,22,26)(H2,21,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X92FHZ
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM397151 (US10596172, Compound I-39 | US10828300, Compound I...) Show SMILES Cc1cnc(Nc2ccccc2)nc1Nc1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C20H19N5O/c1-3-18(26)22-16-9-11-17(12-10-16)23-19-14(2)13-21-20(25-19)24-15-7-5-4-6-8-15/h3-13H,1H2,2H3,(H,22,26)(H2,21,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene CAR LLC US Patent					Assay Description Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...				US Patent US10596172 (2020) BindingDB Entry DOI: 10.7270/Q2VM4G9X
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human))	BDBM397151 (US10596172, Compound I-39 | US10828300, Compound I...) Show SMILES Cc1cnc(Nc2ccccc2)nc1Nc1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C20H19N5O/c1-3-18(26)22-16-9-11-17(12-10-16)23-19-14(2)13-21-20(25-19)24-15-7-5-4-6-8-15/h3-13H,1H2,2H3,(H,22,26)(H2,21,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X92FHZ
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM397151 (US10596172, Compound I-39 | US10828300, Compound I...) Show SMILES Cc1cnc(Nc2ccccc2)nc1Nc1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C20H19N5O/c1-3-18(26)22-16-9-11-17(12-10-16)23-19-14(2)13-21-20(25-19)24-15-7-5-4-6-8-15/h3-13H,1H2,2H3,(H,22,26)(H2,21,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X92FHZ
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM397151 (US10596172, Compound I-39 | US10828300, Compound I...) Show SMILES Cc1cnc(Nc2ccccc2)nc1Nc1ccc(NC(=O)C=C)cc1 Show InChI InChI=1S/C20H19N5O/c1-3-18(26)22-16-9-11-17(12-10-16)23-19-14(2)13-21-20(25-19)24-15-7-5-4-6-8-15/h3-13H,1H2,2H3,(H,22,26)(H2,21,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description EGFR (WT) and EGFR (T790M/L858R): The Omnia Assay Protocol for potency assessment against EGFR is performed as described in Example 251 above except ...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2NV9MM2
					More data for this Ligand-Target Pair