Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM401307![]() (US10005756, Compound A78) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare Curated by ChEMBL | Assay Description Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay | J Med Chem 62: 11119-11134 (2019) Article DOI: 10.1021/acs.jmedchem.9b01070 BindingDB Entry DOI: 10.7270/Q26H4MXQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM401307![]() (US10005756, Compound A78) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare Curated by ChEMBL | Assay Description Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay | J Med Chem 62: 11119-11134 (2019) Article DOI: 10.1021/acs.jmedchem.9b01070 BindingDB Entry DOI: 10.7270/Q26H4MXQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM401307![]() (US10005756, Compound A78) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and MnCl2 as co-facor preincubated fo... | J Med Chem 62: 11119-11134 (2019) Article DOI: 10.1021/acs.jmedchem.9b01070 BindingDB Entry DOI: 10.7270/Q26H4MXQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM401307![]() (US10005756, Compound A78) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and MnCl2 as co-facor preincubated fo... | J Med Chem 62: 11119-11134 (2019) Article DOI: 10.1021/acs.jmedchem.9b01070 BindingDB Entry DOI: 10.7270/Q26H4MXQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM401307![]() (US10005756, Compound A78) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description The MetAP-2 activity is determined by coupling enzymatic reactions. The tripeptide Met-Arg-Ser (MAS) is employed as substrate. The methionine liberat... | Bioorg Med Chem 17: 7933-48 (2009) BindingDB Entry DOI: 10.7270/Q2T72KSK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 1 (Homo sapiens (Human)) | BDBM401307![]() (US10005756, Compound A78) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare Curated by ChEMBL | Assay Description Inhibition of N-terminal MetAP1 (unknown origin) | J Med Chem 62: 11119-11134 (2019) Article DOI: 10.1021/acs.jmedchem.9b01070 BindingDB Entry DOI: 10.7270/Q26H4MXQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 1 (Homo sapiens (Human)) | BDBM401307![]() (US10005756, Compound A78) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare Curated by ChEMBL | Assay Description Inhibition of N-terminal MetAP1 (unknown origin) | J Med Chem 62: 11119-11134 (2019) Article DOI: 10.1021/acs.jmedchem.9b01070 BindingDB Entry DOI: 10.7270/Q26H4MXQ | |||||||||||
More data for this Ligand-Target Pair |