Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-secretase 1 (Homo sapiens (Human)) | BDBM477886![]() ((4S,6S)-methyl 2-amino-4-(5-((Z)-2-(5-chloropyridi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. US Patent | Assay Description The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ... | US Patent US10889579 (2021) BindingDB Entry DOI: 10.7270/Q241715H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 2 (Homo sapiens (Human)) | BDBM477886![]() ((4S,6S)-methyl 2-amino-4-(5-((Z)-2-(5-chloropyridi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. US Patent | Assay Description The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ... | US Patent US10889579 (2021) BindingDB Entry DOI: 10.7270/Q241715H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin D (Homo sapiens (Human)) | BDBM477886![]() ((4S,6S)-methyl 2-amino-4-(5-((Z)-2-(5-chloropyridi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 9.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. US Patent | Assay Description Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ... | US Patent US10889579 (2021) BindingDB Entry DOI: 10.7270/Q241715H | |||||||||||
More data for this Ligand-Target Pair |