Found 3 hits of ic50 for monomerid = 50178524 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50178524
(5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazo...)Show SMILES Cn1cnc(NCc2ccncc2)c1-c1nnc(Nc2ccc(OC(F)(F)F)cc2)o1 Show InChI InChI=1S/C19H16F3N7O2/c1-29-11-25-16(24-10-12-6-8-23-9-7-12)15(29)17-27-28-18(30-17)26-13-2-4-14(5-3-13)31-19(20,21)22/h2-9,11,24H,10H2,1H3,(H,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
Chemical Diversity, Inc.
Curated by ChEMBL
| Assay Description Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assay |
Bioorg Med Chem Lett 16: 1440-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.033 BindingDB Entry DOI: 10.7270/Q2NP240T |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50178524
(5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazo...)Show SMILES Cn1cnc(NCc2ccncc2)c1-c1nnc(Nc2ccc(OC(F)(F)F)cc2)o1 Show InChI InChI=1S/C19H16F3N7O2/c1-29-11-25-16(24-10-12-6-8-23-9-7-12)15(29)17-27-28-18(30-17)26-13-2-4-14(5-3-13)31-19(20,21)22/h2-9,11,24H,10H2,1H3,(H,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Chemical Diversity, Inc.
Curated by ChEMBL
| Assay Description Inhibition of VEGFR2 by enzymatic assay |
Bioorg Med Chem Lett 16: 1440-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.033 BindingDB Entry DOI: 10.7270/Q2NP240T |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50178524
(5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazo...)Show SMILES Cn1cnc(NCc2ccncc2)c1-c1nnc(Nc2ccc(OC(F)(F)F)cc2)o1 Show InChI InChI=1S/C19H16F3N7O2/c1-29-11-25-16(24-10-12-6-8-23-9-7-12)15(29)17-27-28-18(30-17)26-13-2-4-14(5-3-13)31-19(20,21)22/h2-9,11,24H,10H2,1H3,(H,26,28) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Chemical Diversity, Inc.
Curated by ChEMBL
| Assay Description Inhibition of VEGFR1 by enzymatic assay |
Bioorg Med Chem Lett 16: 1440-4 (2006)
Article DOI: 10.1016/j.bmcl.2005.11.033 BindingDB Entry DOI: 10.7270/Q2NP240T |
More data for this Ligand-Target Pair | |