Found 2 hits of ic50 for monomerid = 50261170 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human)) | BDBM50261170
(CHEMBL4092920)Show SMILES CC(=O)N[C@H]1CC[C@H](CC1)Nc1ncnc2n(cnc12)[C@@H]1C[C@@H](C1)NC(=O)c1cccc(C)n1 |r,wU:4.3,7.10,20.22,22.27,(16.83,-30.61,;16.84,-32.15,;15.51,-32.93,;18.17,-32.92,;19.5,-32.14,;19.5,-30.6,;20.83,-29.83,;22.16,-30.59,;22.17,-32.13,;20.84,-32.91,;23.5,-29.82,;24.83,-30.58,;24.84,-32.12,;26.18,-32.88,;27.5,-32.11,;27.5,-30.57,;28.64,-29.53,;28.01,-28.13,;26.48,-28.3,;26.16,-29.8,;30.14,-29.85,;30.99,-31.14,;32.28,-30.29,;31.43,-29,;33.79,-30.6,;34.81,-29.46,;36.32,-29.77,;34.4,-27.97,;32.91,-27.58,;32.52,-26.09,;33.6,-25,;35.09,-25.39,;36.17,-24.3,;35.49,-26.87,)| Show InChI InChI=1S/C24H30N8O2/c1-14-4-3-5-20(28-14)24(34)31-18-10-19(11-18)32-13-27-21-22(25-12-26-23(21)32)30-17-8-6-16(7-9-17)29-15(2)33/h3-5,12-13,16-19H,6-11H2,1-2H3,(H,29,33)(H,31,34)(H,25,26,30)/t16-,17+,18-,19+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Research Institute of Chemical Technology
Curated by ChEMBL
| Assay Description Inhibition of CDK5/p35 (unknown origin) using ULingt-4E-BP as substrate after 1 hr in presence of ATP by fluorescence assay |
Bioorg Med Chem Lett 27: 4399-4404 (2017)
Article DOI: 10.1016/j.bmcl.2017.08.018 BindingDB Entry DOI: 10.7270/Q2W66P60 |
More data for this Ligand-Target Pair | |
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50261170
(CHEMBL4092920)Show SMILES CC(=O)N[C@H]1CC[C@H](CC1)Nc1ncnc2n(cnc12)[C@@H]1C[C@@H](C1)NC(=O)c1cccc(C)n1 |r,wU:4.3,7.10,20.22,22.27,(16.83,-30.61,;16.84,-32.15,;15.51,-32.93,;18.17,-32.92,;19.5,-32.14,;19.5,-30.6,;20.83,-29.83,;22.16,-30.59,;22.17,-32.13,;20.84,-32.91,;23.5,-29.82,;24.83,-30.58,;24.84,-32.12,;26.18,-32.88,;27.5,-32.11,;27.5,-30.57,;28.64,-29.53,;28.01,-28.13,;26.48,-28.3,;26.16,-29.8,;30.14,-29.85,;30.99,-31.14,;32.28,-30.29,;31.43,-29,;33.79,-30.6,;34.81,-29.46,;36.32,-29.77,;34.4,-27.97,;32.91,-27.58,;32.52,-26.09,;33.6,-25,;35.09,-25.39,;36.17,-24.3,;35.49,-26.87,)| Show InChI InChI=1S/C24H30N8O2/c1-14-4-3-5-20(28-14)24(34)31-18-10-19(11-18)32-13-27-21-22(25-12-26-23(21)32)30-17-8-6-16(7-9-17)29-15(2)33/h3-5,12-13,16-19H,6-11H2,1-2H3,(H,29,33)(H,31,34)(H,25,26,30)/t16-,17+,18-,19+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 112 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Research Institute of Chemical Technology
Curated by ChEMBL
| Assay Description Inhibition of CDK2/CyclinA (unknown origin) using ULingt-4E-BP as substrate after 1 hr in presence of ATP by fluorescence assay |
Bioorg Med Chem Lett 27: 4399-4404 (2017)
Article DOI: 10.1016/j.bmcl.2017.08.018 BindingDB Entry DOI: 10.7270/Q2W66P60 |
More data for this Ligand-Target Pair | |