Found 2 hits of ic50 for monomerid = 50334679 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50334679
![PNG](/data/jpeg/tenK5033/BindingDB_50334679.png) (CHEMBL1642599 | N-((4S)-4-(3-amino-3-oxopropyl)-4-...)Show SMILES C[C@](O)(c1ccc(cc1)C(=O)N(C1CC1)[C@H]1CC[C@@](CCC(N)=O)(CC1)c1ccccn1)C(F)(F)F |r,wU:1.0,15.16,wD:1.1,18.28,(-9.42,-25.72,;-8.09,-24.94,;-9.58,-24.55,;-6.75,-25.71,;-5.42,-24.93,;-4.09,-25.7,;-4.09,-27.24,;-5.41,-28.01,;-6.74,-27.25,;-2.75,-28,;-2.75,-29.54,;-1.42,-27.23,;-1.43,-25.69,;-.66,-24.36,;-2.2,-24.36,;-.09,-27.99,;1.24,-27.22,;2.57,-27.99,;2.57,-29.54,;3.99,-28.94,;5.21,-29.88,;6.64,-29.29,;7.86,-30.22,;6.83,-27.76,;1.24,-30.3,;-.09,-29.53,;3.33,-30.86,;4.85,-30.87,;5.61,-32.19,;4.84,-33.52,;3.31,-33.51,;2.55,-32.18,;-8.1,-23.4,;-6.77,-22.63,;-9.43,-22.64,;-8.5,-21.92,)| Show InChI InChI=1S/C27H32F3N3O3/c1-25(36,27(28,29)30)19-7-5-18(6-8-19)24(35)33(20-9-10-20)21-11-14-26(15-12-21,16-13-23(31)34)22-4-2-3-17-32-22/h2-8,17,20-21,36H,9-16H2,1H3,(H2,31,34)/t21-,25-,26-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description Inhibition of human full length 11beta-HSD1 assessed as inhibition of conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay |
Bioorg Med Chem Lett 21: 405-10 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.129 BindingDB Entry DOI: 10.7270/Q2K937SB |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50334679
![PNG](/data/jpeg/tenK5033/BindingDB_50334679.png) (CHEMBL1642599 | N-((4S)-4-(3-amino-3-oxopropyl)-4-...)Show SMILES C[C@](O)(c1ccc(cc1)C(=O)N(C1CC1)[C@H]1CC[C@@](CCC(N)=O)(CC1)c1ccccn1)C(F)(F)F |r,wU:1.0,15.16,wD:1.1,18.28,(-9.42,-25.72,;-8.09,-24.94,;-9.58,-24.55,;-6.75,-25.71,;-5.42,-24.93,;-4.09,-25.7,;-4.09,-27.24,;-5.41,-28.01,;-6.74,-27.25,;-2.75,-28,;-2.75,-29.54,;-1.42,-27.23,;-1.43,-25.69,;-.66,-24.36,;-2.2,-24.36,;-.09,-27.99,;1.24,-27.22,;2.57,-27.99,;2.57,-29.54,;3.99,-28.94,;5.21,-29.88,;6.64,-29.29,;7.86,-30.22,;6.83,-27.76,;1.24,-30.3,;-.09,-29.53,;3.33,-30.86,;4.85,-30.87,;5.61,-32.19,;4.84,-33.52,;3.31,-33.51,;2.55,-32.18,;-8.1,-23.4,;-6.77,-22.63,;-9.43,-22.64,;-8.5,-21.92,)| Show InChI InChI=1S/C27H32F3N3O3/c1-25(36,27(28,29)30)19-7-5-18(6-8-19)24(35)33(20-9-10-20)21-11-14-26(15-12-21,16-13-23(31)34)22-4-2-3-17-32-22/h2-8,17,20-21,36H,9-16H2,1H3,(H2,31,34)/t21-,25-,26-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full length 11beta-HSD1 expressed in human adipocytes assessed as inhibition of conversion of [3H]cortisone to [3H]co... |
Bioorg Med Chem Lett 21: 405-10 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.129 BindingDB Entry DOI: 10.7270/Q2K937SB |
More data for this Ligand-Target Pair | |