Found 2 hits of ic50 for monomerid = 50398586 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50398586
![PNG](/data/jpeg/tenK5039/BindingDB_50398586.png) (CHEMBL2177105 | US8530504, 5)Show SMILES COCc1cc(OC)c(-c2c(C)sc3c(N(CC4CC4)CC4CCOCC4)c(C)nn23)c(OC)c1 |(51.97,-36.57,;51.23,-35.23,;49.69,-35.2,;48.94,-33.85,;47.4,-33.83,;46.66,-32.48,;45.12,-32.46,;44.32,-33.78,;47.44,-31.16,;46.7,-29.82,;47.57,-28.56,;49.11,-28.52,;46.65,-27.33,;45.19,-27.84,;43.72,-27.39,;43.17,-25.95,;41.65,-25.7,;40.68,-26.89,;39.24,-27.44,;40.44,-28.41,;43.93,-24.61,;43.14,-23.29,;43.89,-21.95,;43.1,-20.62,;41.56,-20.64,;40.81,-21.99,;41.6,-23.31,;42.84,-28.66,;41.3,-28.69,;43.77,-29.88,;45.23,-29.37,;48.98,-31.19,;49.78,-29.87,;51.31,-29.89,;49.73,-32.54,)| Show InChI InChI=1S/C27H37N3O4S/c1-17-25(29(14-19-6-7-19)15-20-8-10-34-11-9-20)27-30(28-17)26(18(2)35-27)24-22(32-4)12-21(16-31-3)13-23(24)33-5/h12-13,19-20H,6-11,14-16H2,1-5H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay |
J Med Chem 55: 8450-63 (2012)
Article DOI: 10.1021/jm300864p BindingDB Entry DOI: 10.7270/Q2KD202P |
More data for this Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50398586
![PNG](/data/jpeg/tenK5039/BindingDB_50398586.png) (CHEMBL2177105 | US8530504, 5)Show SMILES COCc1cc(OC)c(-c2c(C)sc3c(N(CC4CC4)CC4CCOCC4)c(C)nn23)c(OC)c1 |(51.97,-36.57,;51.23,-35.23,;49.69,-35.2,;48.94,-33.85,;47.4,-33.83,;46.66,-32.48,;45.12,-32.46,;44.32,-33.78,;47.44,-31.16,;46.7,-29.82,;47.57,-28.56,;49.11,-28.52,;46.65,-27.33,;45.19,-27.84,;43.72,-27.39,;43.17,-25.95,;41.65,-25.7,;40.68,-26.89,;39.24,-27.44,;40.44,-28.41,;43.93,-24.61,;43.14,-23.29,;43.89,-21.95,;43.1,-20.62,;41.56,-20.64,;40.81,-21.99,;41.6,-23.31,;42.84,-28.66,;41.3,-28.69,;43.77,-29.88,;45.23,-29.37,;48.98,-31.19,;49.78,-29.87,;51.31,-29.89,;49.73,-32.54,)| Show InChI InChI=1S/C27H37N3O4S/c1-17-25(29(14-19-6-7-19)15-20-8-10-34-11-9-20)27-30(28-17)26(18(2)35-27)24-22(32-4)12-21(16-31-3)13-23(24)33-5/h12-13,19-20H,6-11,14-16H2,1-5H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description A binding competition experiment with CRF was conducted by the SPA (GE Healthcare) method using a 96-well plate. |
US Patent US8530504 (2013)
BindingDB Entry DOI: 10.7270/Q29885NS |
More data for this Ligand-Target Pair | |