Compile Data Set for Download or QSAR

Found 3 hits of ic50 for monomerid = 50514221   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM50514221 (CHEMBL4543603 | US11274105, Example 90) Show SMILES [H][C@@]12CC[C@@]1([H])[C@@H](OC)\C=C\CCN(C)C(=O)C[C@](O)(CO)c1ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C2)c3c1 |r,t:10| Show InChI InChI=1S/C34H43ClN2O5/c1-36-15-4-3-7-30(41-2)27-11-8-24(27)19-37-20-33(14-5-6-23-16-26(35)10-12-28(23)33)22-42-31-13-9-25(17-29(31)37)34(40,21-38)18-32(36)39/h3,7,9-10,12-13,16-17,24,27,30,38,40H,4-6,8,11,14-15,18-22H2,1-2H3/b7-3+/t24-,27+,30-,33-,34-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2V40ZDQ
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human))	BDBM50514221 (CHEMBL4543603 | US11274105, Example 90) Show SMILES [H][C@@]12CC[C@@]1([H])[C@@H](OC)\C=C\CCN(C)C(=O)C[C@](O)(CO)c1ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C2)c3c1 |r,t:10| Show InChI InChI=1S/C34H43ClN2O5/c1-36-15-4-3-7-30(41-2)27-11-8-24(27)19-37-20-33(14-5-6-23-16-26(35)10-12-28(23)33)22-42-31-13-9-25(17-29(31)37)34(40,21-38)18-32(36)39/h3,7,9-10,12-13,16-17,24,27,30,38,40H,4-6,8,11,14-15,18-22H2,1-2H3/b7-3+/t24-,27+,30-,33-,34-/m0/s1	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	281	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of recombinant C-terminal His6x-tagged human Mcl-1 (171 to 327 residues) interaction with biotinylated human Bim (51 to 76 residues) incub...				J Med Chem 62: 10258-10271 (2019) Article DOI: 10.1021/acs.jmedchem.9b01310 BindingDB Entry DOI: 10.7270/Q2TQ64WW
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM50514221 (CHEMBL4543603 | US11274105, Example 90) Show SMILES [H][C@@]12CC[C@@]1([H])[C@@H](OC)\C=C\CCN(C)C(=O)C[C@](O)(CO)c1ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C2)c3c1 |r,t:10| Show InChI InChI=1S/C34H43ClN2O5/c1-36-15-4-3-7-30(41-2)27-11-8-24(27)19-37-20-33(14-5-6-23-16-26(35)10-12-28(23)33)22-42-31-13-9-25(17-29(31)37)34(40,21-38)18-32(36)39/h3,7,9-10,12-13,16-17,24,27,30,38,40H,4-6,8,11,14-15,18-22H2,1-2H3/b7-3+/t24-,27+,30-,33-,34-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	743	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...				Citation and Details BindingDB Entry DOI: 10.7270/Q2V40ZDQ
					More data for this Ligand-Target Pair