Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM495019![]() (US10994015, Example 319) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM495017![]() (US10994015, Example 313 | US10994015, Example 314) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM495012![]() (US10994015, Example 308) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM495016![]() (US10994015, Example 312) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM495010![]() (US10994015, Example 306) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM495005![]() (2-(2,6-dioxopiperidin-3-yl)-5-(4-(3-(4-(4-(2-((1-i...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM495011![]() (2-(7-((4-(3-(4-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM494872![]() (US10994015, Example 6) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM494929![]() (2-(2,6-dioxopiperidin-3-yl)-5-(4-(2-((1-isopropyl-...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM494873![]() (US10994015, Example 7) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM494875![]() (US10994015, Example 9) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM495015![]() (US10994015, Example 311) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM494874![]() (4-((17-(4-(4-(4-((2-chlorobenzyl)amino)-7H-pyrrolo...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM495013![]() (US10994015, Example 309) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM495017![]() (US10994015, Example 313 | US10994015, Example 314) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM494867![]() ((2S,4R)-1-((S)-2-(tert-butyl)-14-(4-(4-(4-((2-chlo...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM494869![]() (US10994015, Example 3) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 6.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM494931![]() (US10994015, Example 73) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM494868![]() (US10994015, Example 2) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 7.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM494871![]() (US10994015, Example 5) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM494879![]() (US10994015, Example 12) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM495014![]() (US10994015, Example 310) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM494928![]() (2-(2,6-dioxopiperidin-3-yl)-5-(2-(2-(2-((1-isoprop...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM494877![]() (US10994015, Example 11) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM494870![]() (US10994015, Example 4) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM494876![]() (US10994015, Example 10) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM494923![]() ((2S,4R)-1-((S)-2-(tert-butyl)-14-(4-(4-((2-chlorob...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM494924![]() (US10994015, Example 15) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | KEGG PC cid PC sid UniChem | US Patent | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-745,747-749,751-1210,T790M] (Homo sapiens (Human)) | BDBM494922![]() (US10994015, Example 13) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ARVINAS OPERATIONS, INC.; YALE UNIVERSITY US Patent | Assay Description All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A... | US Patent US10994015 (2021) BindingDB Entry DOI: 10.7270/Q2NS0Z1G | |||||||||||
More data for this Ligand-Target Pair |