Compile Data Set for Download or QSAR

Found 2795 hits of ic50 for UniProtKB: P07949   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM296817 (US10112942, Example 552 | US10137124, Example 552 ...) Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OC[C@H]3CNCCO3)cn3ncc(C#N)c23)cn1 |r| Show InChI InChI=1S/C29H31N9O3/c1-39-28-3-2-19(9-34-28)14-37-21-6-22(37)16-36(15-21)27-13-32-26(12-33-27)25-7-23(41-18-24-11-31-4-5-40-24)17-38-29(25)20(8-30)10-35-38/h2-3,7,9-10,12-13,17,21-22,24,31H,4-6,11,14-16,18H2,1H3/t21?,22?,24-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10555944 (2020) BindingDB Entry DOI: 10.7270/Q279473N
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM296817 (US10112942, Example 552 | US10137124, Example 552 ...) Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OC[C@H]3CNCCO3)cn3ncc(C#N)c23)cn1 |r| Show InChI InChI=1S/C29H31N9O3/c1-39-28-3-2-19(9-34-28)14-37-21-6-22(37)16-36(15-21)27-13-32-26(12-33-27)25-7-23(41-18-24-11-31-4-5-40-24)17-38-29(25)20(8-30)10-35-38/h2-3,7,9-10,12-13,17,21-22,24,31H,4-6,11,14-16,18H2,1H3/t21?,22?,24-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...				US Patent US10172851 (2019) BindingDB Entry DOI: 10.7270/Q2GM89CV
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM305704 (2-chloro-N-((3S,4S)-1-(5- (3-cyano-6- ethoxypyrazo...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CC[C@H](NC(=O)c3cc(F)ccc3Cl)[C@@H](O)C2)c2c(cnn2c1)C#N |r| Show InChI InChI=1S/C27H24ClFN6O3/c1-2-38-19-10-20(26-17(11-30)13-32-35(26)14-19)16-3-6-25(31-12-16)34-8-7-23(24(36)15-34)33-27(37)21-9-18(29)4-5-22(21)28/h3-6,9-10,12-14,23-24,36H,2,7-8,15H2,1H3,(H,33,37)/t23-,24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM296818 (US10112942, Example 553 | US10137124, Example 553 ...) Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OCC3(F)CNC3)cn3ncc(C#N)c23)cn1 Show InChI InChI=1S/C28H28FN9O2/c1-39-26-3-2-18(7-34-26)11-37-20-4-21(37)13-36(12-20)25-10-32-24(9-33-25)23-5-22(40-17-28(29)15-31-16-28)14-38-27(23)19(6-30)8-35-38/h2-3,5,7-10,14,20-21,31H,4,11-13,15-17H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...				US Patent US10172851 (2019) BindingDB Entry DOI: 10.7270/Q2GM89CV
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM296818 (US10112942, Example 553 | US10137124, Example 553 ...) Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OCC3(F)CNC3)cn3ncc(C#N)c23)cn1 Show InChI InChI=1S/C28H28FN9O2/c1-39-26-3-2-18(7-34-26)11-37-20-4-21(37)13-36(12-20)25-10-32-24(9-33-25)23-5-22(40-17-28(29)15-31-16-28)14-38-27(23)19(6-30)8-35-38/h2-3,5,7-10,14,20-21,31H,4,11-13,15-17H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10555944 (2020) BindingDB Entry DOI: 10.7270/Q279473N
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284360 (4-(6-(4-(5-cyclopropyl- 1H-pyrazole-3- carbonyl)pi...) Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)c2cc([nH]n2)C2CC2)c2c(cnn2c1)C#N Show InChI InChI=1S/C28H26N10O/c1-35-16-22(15-31-35)20-10-23(27-21(12-29)14-32-38(27)17-20)19-4-5-26(30-13-19)36-6-8-37(9-7-36)28(39)25-11-24(33-34-25)18-2-3-18/h4-5,10-11,13-18H,2-3,6-9H2,1H3,(H,33,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284117 (US10023570, Example 127 | US10174027, Example 127) Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)Nc2ccccc2)c2c(cnn2c1)C#N Show InChI InChI=1S/C28H25N9O/c1-34-18-23(17-31-34)21-13-25(27-22(14-29)16-32-37(27)19-21)20-7-8-26(30-15-20)35-9-11-36(12-10-35)28(38)33-24-5-3-2-4-6-24/h2-8,13,15-19H,9-12H2,1H3,(H,33,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284119 (N-benzyl-4-(5-(3-cyano-6- (1-methyl-1H-pyrazol-4- ...) Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)NCc2ccccc2)c2c(cnn2c1)C#N Show InChI InChI=1S/C29H27N9O/c1-35-19-25(18-33-35)23-13-26(28-24(14-30)17-34-38(28)20-23)22-7-8-27(31-16-22)36-9-11-37(12-10-36)29(39)32-15-21-5-3-2-4-6-21/h2-8,13,16-20H,9-12,15H2,1H3,(H,32,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM296816 (US10112942, Example 551 | US10137124, Example 551 ...) Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OC[C@@H]3CNCCO3)cn3ncc(C#N)c23)cn1 |r| Show InChI InChI=1S/C29H31N9O3/c1-39-28-3-2-19(9-34-28)14-37-21-6-22(37)16-36(15-21)27-13-32-26(12-33-27)25-7-23(41-18-24-11-31-4-5-40-24)17-38-29(25)20(8-30)10-35-38/h2-3,7,9-10,12-13,17,21-22,24,31H,4-6,11,14-16,18H2,1H3/t21?,22?,24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...				US Patent US10172851 (2019) BindingDB Entry DOI: 10.7270/Q2GM89CV
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM305765 (2-chloro-N-(1-(5-(3- cyano-6- hydroxypyrazolo [1,5...) Show SMILES Cc1cccc(Cl)c1C(=O)NC1(C)CCN(CC1)c1cnc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C26H24ClN7O2/c1-16-4-3-5-20(27)23(16)25(36)32-26(2)6-8-33(9-7-26)22-14-29-21(13-30-22)19-10-18(35)15-34-24(19)17(11-28)12-31-34/h3-5,10,12-15,35H,6-9H2,1-2H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM305759 (3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- ...) Show SMILES CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2nc(C)ccc2Cl)c2c(cnn2c1)C#N Show InChI InChI=1S/C27H27ClN8O2/c1-4-38-19-11-20(25-18(12-29)13-32-36(25)16-19)22-14-31-23(15-30-22)35-9-7-27(3,8-10-35)34-26(37)24-21(28)6-5-17(2)33-24/h5-6,11,13-16H,4,7-10H2,1-3H3,(H,34,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM305757 (3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- ...) Show SMILES CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2ncc(F)cc2Cl)c2c(cnn2c1)C#N Show InChI InChI=1S/C26H24ClFN8O2/c1-3-38-18-9-19(24-16(10-29)11-33-36(24)15-18)21-13-31-22(14-30-21)35-6-4-26(2,5-7-35)34-25(37)23-20(27)8-17(28)12-32-23/h8-9,11-15H,3-7H2,1-2H3,(H,34,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM305705 (2-chloro-N-((3S,4S)-1-(5- (3-cyano-6- ethoxypyrazo...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CC[C@H](NC(=O)c3c(F)cccc3Cl)[C@@H](O)C2)c2c(cnn2c1)C#N |r| Show InChI InChI=1S/C27H24ClFN6O3/c1-2-38-18-10-19(26-17(11-30)13-32-35(26)14-18)16-6-7-24(31-12-16)34-9-8-22(23(36)15-34)33-27(37)25-20(28)4-3-5-21(25)29/h3-7,10,12-14,22-23,36H,2,8-9,15H2,1H3,(H,33,37)/t22-,23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM296816 (US10112942, Example 551 | US10137124, Example 551 ...) Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OC[C@@H]3CNCCO3)cn3ncc(C#N)c23)cn1 |r| Show InChI InChI=1S/C29H31N9O3/c1-39-28-3-2-19(9-34-28)14-37-21-6-22(37)16-36(15-21)27-13-32-26(12-33-27)25-7-23(41-18-24-11-31-4-5-40-24)17-38-29(25)20(8-30)10-35-38/h2-3,7,9-10,12-13,17,21-22,24,31H,4-6,11,14-16,18H2,1H3/t21?,22?,24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10555944 (2020) BindingDB Entry DOI: 10.7270/Q279473N
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM283931 (US10023570, Example 4 | US10174027, Example 4) Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)[C@@H](O)Cc2ccccc2)c2c(cnn2c1)C#N |r| Show InChI InChI=1S/C30H28N8O2/c1-35-19-25(18-33-35)23-14-26(29-24(15-31)17-34-38(29)20-23)22-7-8-28(32-16-22)36-9-11-37(12-10-36)30(40)27(39)13-21-5-3-2-4-6-21/h2-8,14,16-20,27,39H,9-13H2,1H3/t27-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284552 (US10023570, Example 567 | US10174027, Example 567) Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCC(CC2)S(C)(=O)=O)c2c(cnn2c1)C#N Show InChI InChI=1S/C23H23N7O2S/c1-28-14-19(13-26-28)17-9-21(23-18(10-24)12-27-30(23)15-17)16-3-4-22(25-11-16)29-7-5-20(6-8-29)33(2,31)32/h3-4,9,11-15,20H,5-8H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284088 (4-(5-(3-cyano-6-(1-methyl-1H- pyrazol-4-yl)pyrazol...) Show SMILES CCN(CC)C(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1 Show InChI InChI=1S/C26H29N9O/c1-4-32(5-2)26(36)34-10-8-33(9-11-34)24-7-6-19(14-28-24)23-12-20(22-16-29-31(3)17-22)18-35-25(23)21(13-27)15-30-35/h6-7,12,14-18H,4-5,8-11H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM283981 ((S)-4-(6-(4-(3- hydroxy-3- phenylpropanoyl)piperaz...) Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)C[C@H](O)c2ccccc2)c2c(cnn2c1)C#N |r| Show InChI InChI=1S/C30H28N8O2/c1-35-19-25(18-33-35)23-13-26(30-24(15-31)17-34-38(30)20-23)22-7-8-28(32-16-22)36-9-11-37(12-10-36)29(40)14-27(39)21-5-3-2-4-6-21/h2-8,13,16-20,27,39H,9-12,14H2,1H3/t27-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM305672 (US10144734, Example 690 | US10172845, Example 690 ...) Show SMILES Cc1cccc(Cl)c1C(=O)NC1(C)CCN(CC1)c1cnc(cn1)-c1cc(OC[C@@H]2CNCCO2)cn2ncc(C#N)c12 |r| Show InChI InChI=1S/C31H33ClN8O3/c1-20-4-3-5-25(32)28(20)30(41)38-31(2)6-9-39(10-7-31)27-17-35-26(16-36-27)24-12-22(43-19-23-15-34-8-11-42-23)18-40-29(24)21(13-33)14-37-40/h3-5,12,14,16-18,23,34H,6-11,15,19H2,1-2H3,(H,38,41)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM305468 (US10144734, Example 485 | US10172845, Example 485 ...) Show SMILES Cc1ccc(F)cc1C(=O)NC1(C)CCN(CC1)c1ccc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C27H25FN6O2/c1-17-3-5-20(28)11-22(17)26(36)32-27(2)7-9-33(10-8-27)24-6-4-18(14-30-24)23-12-21(35)16-34-25(23)19(13-29)15-31-34/h3-6,11-12,14-16,35H,7-10H2,1-2H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284013 (US10023570, Example 23 | US10174027, Example 23) Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)C[C@H](N)c2ccccc2)c2c(cnn2c1)C#N |r| Show InChI InChI=1S/C30H29N9O/c1-36-19-25(18-34-36)23-13-26(30-24(15-31)17-35-39(30)20-23)22-7-8-28(33-16-22)37-9-11-38(12-10-37)29(40)14-27(32)21-5-3-2-4-6-21/h2-8,13,16-20,27H,9-12,14,32H2,1H3/t27-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284350 (4-(6-(4-(2-(5- fluoropyridin-2- yl)acetyl)piperazi...) Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)Cc2ccc(F)cn2)c2c(cnn2c1)C#N Show InChI InChI=1S/C28H24FN9O/c1-35-17-22(15-33-35)20-10-25(28-21(12-30)14-34-38(28)18-20)19-2-5-26(32-13-19)36-6-8-37(9-7-36)27(39)11-24-4-3-23(29)16-31-24/h2-5,10,13-18H,6-9,11H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.90	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM283980 ((R)-4-(6-(4-(3- hydroxy-3- phenylpropanoyl)piperaz...) Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)C[C@@H](O)c2ccccc2)c2c(cnn2c1)C#N |r| Show InChI InChI=1S/C30H28N8O2/c1-35-19-25(18-33-35)23-13-26(30-24(15-31)17-34-38(30)20-23)22-7-8-28(32-16-22)36-9-11-37(12-10-36)29(40)14-27(39)21-5-3-2-4-6-21/h2-8,13,16-20,27,39H,9-12,14H2,1H3/t27-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.90	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284355 (4-(6-(4-(2-(4- cyanophenyl)acetyl)pipera zin-1-yl)...) Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)Cc2ccc(cc2)C#N)c2c(cnn2c1)C#N Show InChI InChI=1S/C30H25N9O/c1-36-19-26(18-34-36)24-13-27(30-25(15-32)17-35-39(30)20-24)23-6-7-28(33-16-23)37-8-10-38(11-9-37)29(40)12-21-2-4-22(14-31)5-3-21/h2-7,13,16-20H,8-12H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM296809 (US10112942, Example 544 | US10137124, Example 544 ...) Show SMILES CCOc1cc(-c2cnc(cn2)N2CC3CC(C2)N3Cc2cnc(OC)c(F)c2)c2c(cnn2c1)C#N Show InChI InChI=1S/C26H25FN8O2/c1-3-37-20-6-21(25-17(7-28)9-32-35(25)15-20)23-10-30-24(11-29-23)33-13-18-5-19(14-33)34(18)12-16-4-22(27)26(36-2)31-8-16/h4,6,8-11,15,18-19H,3,5,12-14H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10555944 (2020) BindingDB Entry DOI: 10.7270/Q279473N
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM305752 (US10144734, Example 770 | US10172845, Example 770 ...) Show SMILES COc1cc(-c2cnc(cn2)N2CCC(Cc3ccccc3)(CC2)NC(=O)[C@H](O)CO)c2c(cnn2c1)C#N |r| Show InChI InChI=1S/C28H29N7O4/c1-39-21-11-22(26-20(13-29)14-32-35(26)17-21)23-15-31-25(16-30-23)34-9-7-28(8-10-34,33-27(38)24(37)18-36)12-19-5-3-2-4-6-19/h2-6,11,14-17,24,36-37H,7-10,12,18H2,1H3,(H,33,38)/t24-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM305724 (4-(6-(4-(3-fluorobenzyl)- 4-hydroxypiperidin-1- yl...) Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CCC(O)(Cc3cccc(F)c3)CC2)c2c(cnn2c1)C#N Show InChI InChI=1S/C29H30FN5O3/c1-28(2,36)19-38-24-13-25(27-22(15-31)17-33-35(27)18-24)21-6-7-26(32-16-21)34-10-8-29(37,9-11-34)14-20-4-3-5-23(30)12-20/h3-7,12-13,16-18,36-37H,8-11,14,19H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM305707 (N-((3S,4S)-1-(5-(3-cyano- 6-ethoxypyrazolo[1,5- a]...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CC[C@H](NC(=O)c3cc(F)ccc3C)[C@@H](O)C2)c2c(cnn2c1)C#N |r| Show InChI InChI=1S/C28H27FN6O3/c1-3-38-21-11-23(27-19(12-30)14-32-35(27)15-21)18-5-7-26(31-13-18)34-9-8-24(25(36)16-34)33-28(37)22-10-20(29)6-4-17(22)2/h4-7,10-11,13-15,24-25,36H,3,8-9,16H2,1-2H3,(H,33,37)/t24-,25-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM296821 (US10112942, Example 556 | US10137124, Example 556 ...) Show SMILES COc1cc(-c2cnc(cn2)N2CC3CC(C2)N3Cc2ccc(OC)nc2)c2c(Cl)cnn2c1 Show InChI InChI=1S/C24H24ClN7O2/c1-33-18-6-19(24-20(25)8-29-32(24)14-18)21-9-27-22(10-26-21)30-12-16-5-17(13-30)31(16)11-15-3-4-23(34-2)28-7-15/h3-4,6-10,14,16-17H,5,11-13H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...				US Patent US10172851 (2019) BindingDB Entry DOI: 10.7270/Q2GM89CV
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM296809 (US10112942, Example 544 | US10137124, Example 544 ...) Show SMILES CCOc1cc(-c2cnc(cn2)N2CC3CC(C2)N3Cc2cnc(OC)c(F)c2)c2c(cnn2c1)C#N Show InChI InChI=1S/C26H25FN8O2/c1-3-37-20-6-21(25-17(7-28)9-32-35(25)15-20)23-10-30-24(11-29-23)33-13-18-5-19(14-33)34(18)12-16-4-22(27)26(36-2)31-8-16/h4,6,8-11,15,18-19H,3,5,12-14H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...				US Patent US10172851 (2019) BindingDB Entry DOI: 10.7270/Q2GM89CV
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM296821 (US10112942, Example 556 | US10137124, Example 556 ...) Show SMILES COc1cc(-c2cnc(cn2)N2CC3CC(C2)N3Cc2ccc(OC)nc2)c2c(Cl)cnn2c1 Show InChI InChI=1S/C24H24ClN7O2/c1-33-18-6-19(24-20(25)8-29-32(24)14-18)21-9-27-22(10-26-21)30-12-16-5-17(13-30)31(16)11-15-3-4-23(34-2)28-7-15/h3-4,6-10,14,16-17H,5,11-13H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10555944 (2020) BindingDB Entry DOI: 10.7270/Q279473N
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284226 (1-(5-(3-cyano-6-(1- methyl-1H-pyrazol-4- yl)pyrazo...) Show SMILES COC(CNC(=O)C1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1)C(C)C Show InChI InChI=1S/C29H34N8O2/c1-19(2)26(39-4)16-32-29(38)20-7-9-36(10-8-20)27-6-5-21(13-31-27)25-11-22(24-15-33-35(3)17-24)18-37-28(25)23(12-30)14-34-37/h5-6,11,13-15,17-20,26H,7-10,16H2,1-4H3,(H,32,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284174 (US10023570, Example 184 | US10174028, Example 184) Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCC(CC2)NC(=O)c2ccccc2)c2c(cnn2c1)C#N Show InChI InChI=1S/C29H26N8O/c1-35-18-24(17-32-35)22-13-26(28-23(14-30)16-33-37(28)19-22)21-7-8-27(31-15-21)36-11-9-25(10-12-36)34-29(38)20-5-3-2-4-6-20/h2-8,13,15-19,25H,9-12H2,1H3,(H,34,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284705 (US10023570, Example 740 | US10174027, Example 740) Show SMILES COc1ccc(CN2CCN(CC2)c2ccc(cc2)-c2cc(cn3ncc(C#N)c23)-c2cnn(C)c2)cn1 Show InChI InChI=1S/C29H28N8O/c1-34-19-25(17-32-34)23-13-27(29-24(14-30)16-33-37(29)20-23)22-4-6-26(7-5-22)36-11-9-35(10-12-36)18-21-3-8-28(38-2)31-15-21/h3-8,13,15-17,19-20H,9-12,18H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284041 (4-(6-(4-(2,6- difluorobenzoyl)piperazin- 1-yl)pyri...) Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)c2c(F)cccc2F)c2c(cnn2c1)C#N Show InChI InChI=1S/C28H22F2N8O/c1-35-16-21(15-33-35)19-11-22(27-20(12-31)14-34-38(27)17-19)18-5-6-25(32-13-18)36-7-9-37(10-8-36)28(39)26-23(29)3-2-4-24(26)30/h2-6,11,13-17H,7-10H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.10	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM305355 (US10144734, Example 371 | US10172845, Example 371 ...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CCC(C)(CC2)S(=O)(=O)CC(C)C)c2c(cnn2c1)C#N Show InChI InChI=1S/C25H31N5O3S/c1-5-33-21-12-22(24-20(13-26)15-28-30(24)16-21)19-6-7-23(27-14-19)29-10-8-25(4,9-11-29)34(31,32)17-18(2)3/h6-7,12,14-16,18H,5,8-11,17H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284555 (US10023570, Example 570 | US10174027, Example 570) Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCC(Cc3ccccn3)CC2)c2c(cnn2c1)C#N Show InChI InChI=1S/C28H26N8/c1-34-18-24(17-32-34)22-13-26(28-23(14-29)16-33-36(28)19-22)21-5-6-27(31-15-21)35-10-7-20(8-11-35)12-25-4-2-3-9-30-25/h2-6,9,13,15-20H,7-8,10-12H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284123 (4-(5-(3-cyano-6-(1-methyl- 1H-pyrazol-4- yl)pyrazo...) Show SMILES CC(C)CNC(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1 Show InChI InChI=1S/C26H29N9O/c1-18(2)12-29-26(36)34-8-6-33(7-9-34)24-5-4-19(13-28-24)23-10-20(22-15-30-32(3)16-22)17-35-25(23)21(11-27)14-31-35/h4-5,10,13-18H,6-9,12H2,1-3H3,(H,29,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284472 (US10023570, Example 482 | US10174027, Example 482) Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(Cc3ccccc3)C(=O)C2)c2c(cnn2c1)C#N Show InChI InChI=1S/C28H24N8O/c1-33-17-24(15-31-33)22-11-25(28-23(12-29)14-32-36(28)18-22)21-7-8-26(30-13-21)34-9-10-35(27(37)19-34)16-20-5-3-2-4-6-20/h2-8,11,13-15,17-18H,9-10,16,19H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM305346 (US10144734, Example 362 | US10172845, Example 362 ...) Show SMILES CCOc1cc(-c2ccc(nc2)N2C[C@H](N)[C@H](C2)Oc2ccccn2)c2c(cnn2c1)C#N |r| Show InChI InChI=1S/C24H23N7O2/c1-2-32-18-9-19(24-17(10-25)12-29-31(24)13-18)16-6-7-22(28-11-16)30-14-20(26)21(15-30)33-23-5-3-4-8-27-23/h3-9,11-13,20-21H,2,14-15,26H2,1H3/t20-,21-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284043 (US10023570, Example 53 | US10174027, Example 53) Show SMILES CC(C)C[C@@H](O)C(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C27H30N8O2/c1-18(2)10-24(36)27(37)34-8-6-33(7-9-34)25-5-4-19(13-29-25)23-11-20(22-15-30-32(3)16-22)17-35-26(23)21(12-28)14-31-35/h4-5,11,13-18,24,36H,6-10H2,1-3H3/t24-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM283987 ((R)-6-(1-methyl-1H- pyrazol-4-yl)-4-(6-(4- (2- phe...) Show SMILES C[C@@H](C(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1)c1ccccc1 |r| Show InChI InChI=1S/C30H28N8O/c1-21(22-6-4-3-5-7-22)30(39)37-12-10-36(11-13-37)28-9-8-23(16-32-28)27-14-24(26-18-33-35(2)19-26)20-38-29(27)25(15-31)17-34-38/h3-9,14,16-21H,10-13H2,1-2H3/t21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284059 (4-(6-(4-benzoylpiperazin-1- yl)pyridin-3-yl)-6-(1-...) Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)c2ccccc2)c2c(cnn2c1)C#N Show InChI InChI=1S/C28H24N8O/c1-33-18-24(17-31-33)22-13-25(27-23(14-29)16-32-36(27)19-22)21-7-8-26(30-15-21)34-9-11-35(12-10-34)28(37)20-5-3-2-4-6-20/h2-8,13,15-19H,9-12H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284068 (6-(1-methyl-1H-pyrazol-4- yl)-4-(6-(4-(2- phenylac...) Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)Cc2ccccc2)c2c(cnn2c1)C#N Show InChI InChI=1S/C29H26N8O/c1-34-19-25(18-32-34)23-14-26(29-24(15-30)17-33-37(29)20-23)22-7-8-27(31-16-22)35-9-11-36(12-10-35)28(38)13-21-5-3-2-4-6-21/h2-8,14,16-20H,9-13H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284548 (US10023570, Example 563 | US10174027, Example 563) Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCC(CC2)C(=O)NOCC2CC2)c2c(cnn2c1)C#N Show InChI InChI=1S/C27H28N8O2/c1-33-15-23(14-30-33)21-10-24(26-22(11-28)13-31-35(26)16-21)20-4-5-25(29-12-20)34-8-6-19(7-9-34)27(36)32-37-17-18-2-3-18/h4-5,10,12-16,18-19H,2-3,6-9,17H2,1H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284476 (US10023570, Example 489 | US10174027, Example 489) Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CC3CC(C2)N3Cc2ccccc2)c2c(cnn2c1)C#N Show InChI InChI=1S/C29H26N8/c1-34-16-24(14-32-34)22-9-27(29-23(11-30)13-33-37(29)17-22)21-7-8-28(31-12-21)35-18-25-10-26(19-35)36(25)15-20-5-3-2-4-6-20/h2-9,12-14,16-17,25-26H,10,15,18-19H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284464 (US10023570, Example 474 | US10174027, Example 474) Show SMILES COc1ccc(CN2CCN(CC2)c2ccc(cn2)-c2cc(cn3ncc(C#N)c23)-c2cnn(C)c2)cn1 Show InChI InChI=1S/C28H27N9O/c1-34-18-24(16-32-34)22-11-25(28-23(12-29)15-33-37(28)19-22)21-4-5-26(30-14-21)36-9-7-35(8-10-36)17-20-3-6-27(38-2)31-13-20/h3-6,11,13-16,18-19H,7-10,17H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284232 (US10023570, Example 242 | US10174027, Example 242) Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCC(CC2)C(=O)NCCC(F)(F)F)c2c(cnn2c1)C#N Show InChI InChI=1S/C26H25F3N8O/c1-35-15-21(14-33-35)19-10-22(24-20(11-30)13-34-37(24)16-19)18-2-3-23(32-12-18)36-8-4-17(5-9-36)25(38)31-7-6-26(27,28)29/h2-3,10,12-17H,4-9H2,1H3,(H,31,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM284129 (US10023570, Example 139 | US10174027, Example 139) Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(Cc3ccccc3)CC2)c2c(cnn2c1)C#N Show InChI InChI=1S/C28H26N8/c1-33-19-25(17-31-33)23-13-26(28-24(14-29)16-32-36(28)20-23)22-7-8-27(30-15-22)35-11-9-34(10-12-35)18-21-5-3-2-4-6-21/h2-8,13,15-17,19-20H,9-12,18H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...				US Patent US10023570 (2018) BindingDB Entry DOI: 10.7270/Q2Q81G4V
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM296696 (US10112942, Example 431 | US10137124, Example 431 ...) Show SMILES COCCOc1cc(-c2ccc(nc2)N2CC3CC(C2)N3Cc2ccc(OC)nc2)c2c(cnn2c1)C#N Show InChI InChI=1S/C28H29N7O3/c1-36-7-8-38-24-10-25(28-21(11-29)14-32-35(28)18-24)20-4-5-26(30-13-20)33-16-22-9-23(17-33)34(22)15-19-3-6-27(37-2)31-12-19/h3-6,10,12-14,18,22-23H,7-9,15-17H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...				US Patent US10172851 (2019) BindingDB Entry DOI: 10.7270/Q2GM89CV
					More data for this Ligand-Target Pair

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