Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Isocitrate dehydrogenase [NADP], mitochondrial [40-452,R172K] (Homo sapiens (Human)) | BDBM497335 (7-[[(1S)-1-[4-[(1S)-2- cyclopropyl-1-(4-prop-2- en...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 11.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company US Patent | Assay Description IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas... | US Patent US11001596 (2021) BindingDB Entry DOI: 10.7270/Q21V5J2Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP], mitochondrial [40-452,R172K] (Homo sapiens (Human)) | BDBM497337 (7-[[(1S)-1-[4-[2- Cyclopropyl-1-(4-prop-2- enoylpi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 15.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company US Patent | Assay Description IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas... | US Patent US11001596 (2021) BindingDB Entry DOI: 10.7270/Q21V5J2Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP], mitochondrial [40-452,R172K] (Homo sapiens (Human)) | BDBM497348 (1-Ethyl-7-[[(1S)-1-[4-[3- methyl-1-(4-prop-2- enoy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company US Patent | Assay Description IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas... | US Patent US11001596 (2021) BindingDB Entry DOI: 10.7270/Q21V5J2Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP], mitochondrial [40-452,R172K] (Homo sapiens (Human)) | BDBM497353 (1-Ethyl-7-[[(1S)-1-[4- [(1R/S)-1-(4-prop-2- enoylp...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company US Patent | Assay Description IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas... | US Patent US11001596 (2021) BindingDB Entry DOI: 10.7270/Q21V5J2Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP], mitochondrial [40-452,R172K] (Homo sapiens (Human)) | BDBM497348 (1-Ethyl-7-[[(1S)-1-[4-[3- methyl-1-(4-prop-2- enoy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 22.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company US Patent | Assay Description IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas... | US Patent US11001596 (2021) BindingDB Entry DOI: 10.7270/Q21V5J2Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP], mitochondrial [40-452,R172K] (Homo sapiens (Human)) | BDBM50503254 (CHEMBL4550500 | US10745383, Example 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 22.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; Centaurus Biopharma Co., Ltd. US Patent | Assay Description The inhibitory activity of a compound against IDH2 (R172K, 40-end) was determined by the decrease of a helper factor NADPH. The test compound was pre... | US Patent US10745383 (2020) BindingDB Entry DOI: 10.7270/Q2X06B3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP], mitochondrial [40-452,R172K] (Homo sapiens (Human)) | BDBM497353 (1-Ethyl-7-[[(1S)-1-[4- [(1R/S)-1-(4-prop-2- enoylp...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 26.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company US Patent | Assay Description IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas... | US Patent US11001596 (2021) BindingDB Entry DOI: 10.7270/Q21V5J2Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP], mitochondrial [40-452,R172K] (Homo sapiens (Human)) | BDBM497337 (7-[[(1S)-1-[4-[2- Cyclopropyl-1-(4-prop-2- enoylpi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company US Patent | Assay Description IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas... | US Patent US11001596 (2021) BindingDB Entry DOI: 10.7270/Q21V5J2Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP], mitochondrial [40-452,R172K] (Homo sapiens (Human)) | BDBM458488 (4-(isopropylamino)-6-(6-(trifluoromethyl)pyridin-2...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 28.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; Centaurus Biopharma Co., Ltd. US Patent | Assay Description The inhibitory activity of a compound against IDH2 (R172K, 40-end) was determined by the decrease of a helper factor NADPH. The test compound was pre... | US Patent US10745383 (2020) BindingDB Entry DOI: 10.7270/Q2X06B3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP], mitochondrial [40-452,R172K] (Homo sapiens (Human)) | BDBM50503278 (CHEMBL4456102 | US10745383, Example 3) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 31.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; Centaurus Biopharma Co., Ltd. US Patent | Assay Description The inhibitory activity of a compound against IDH2 (R172K, 40-end) was determined by the decrease of a helper factor NADPH. The test compound was pre... | US Patent US10745383 (2020) BindingDB Entry DOI: 10.7270/Q2X06B3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP], mitochondrial [40-452,R172K] (Homo sapiens (Human)) | BDBM497334 (7-[[(1S)-1-[4-[(1R)-2-Cyclopropyl-1-(4-prop-2-enoy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 32.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company US Patent | Assay Description IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas... | US Patent US11001596 (2021) BindingDB Entry DOI: 10.7270/Q21V5J2Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP], mitochondrial [40-452,R172K] (Homo sapiens (Human)) | BDBM50503252 (CHEMBL4448671 | US10745383, Example 4) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 38.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; Centaurus Biopharma Co., Ltd. US Patent | Assay Description The inhibitory activity of a compound against IDH2 (R172K, 40-end) was determined by the decrease of a helper factor NADPH. The test compound was pre... | US Patent US10745383 (2020) BindingDB Entry DOI: 10.7270/Q2X06B3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP], mitochondrial [40-452,R172K] (Homo sapiens (Human)) | BDBM497355 (1-Ethyl-7-[[(1S)-1-[4-[3-methoxy-1-(4-prop-2-enoyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company US Patent | Assay Description IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas... | US Patent US11001596 (2021) BindingDB Entry DOI: 10.7270/Q21V5J2Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP], mitochondrial [40-452,R172K] (Homo sapiens (Human)) | BDBM50503253 (CHEMBL4532902 | US10745383, Example 6) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 46.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; Centaurus Biopharma Co., Ltd. US Patent | Assay Description The inhibitory activity of a compound against IDH2 (R172K, 40-end) was determined by the decrease of a helper factor NADPH. The test compound was pre... | US Patent US10745383 (2020) BindingDB Entry DOI: 10.7270/Q2X06B3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP], mitochondrial [40-452,R172K] (Homo sapiens (Human)) | BDBM458494 (4-(tert-butoxyamino)-6-phenyl-N-(2-(trifluoromethy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 51.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; Centaurus Biopharma Co., Ltd. US Patent | Assay Description The inhibitory activity of a compound against IDH2 (R172K, 40-end) was determined by the decrease of a helper factor NADPH. The test compound was pre... | US Patent US10745383 (2020) BindingDB Entry DOI: 10.7270/Q2X06B3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP], mitochondrial [40-452,R172K] (Homo sapiens (Human)) | BDBM458492 (2-methyl-2-(((4-(6-(trifluoromethyl)pyridin-2-yl)-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 154 | n/a | n/a | n/a | n/a | n/a | n/a |
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; Centaurus Biopharma Co., Ltd. US Patent | Assay Description The inhibitory activity of a compound against IDH2 (R172K, 40-end) was determined by the decrease of a helper factor NADPH. The test compound was pre... | US Patent US10745383 (2020) BindingDB Entry DOI: 10.7270/Q2X06B3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP], mitochondrial [40-452,R172K] (Homo sapiens (Human)) | BDBM497355 (1-Ethyl-7-[[(1S)-1-[4-[3-methoxy-1-(4-prop-2-enoyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 162 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company US Patent | Assay Description IDH1-R132H, IDH1-R132C, IDH2-R172K and IDH2-R140Q mutant enzymes catalyze the conversion of αKG to 2HG. 2HG is analyzed using in-line solid phas... | US Patent US11001596 (2021) BindingDB Entry DOI: 10.7270/Q21V5J2Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isocitrate dehydrogenase [NADP], mitochondrial [40-452,R172K] (Homo sapiens (Human)) | BDBM458493 (4-((benzyloxy)amino)-6-(6-(trifluoromethyl)pyridin...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 239 | n/a | n/a | n/a | n/a | n/a | n/a |
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; Centaurus Biopharma Co., Ltd. US Patent | Assay Description The inhibitory activity of a compound against IDH2 (R172K, 40-end) was determined by the decrease of a helper factor NADPH. The test compound was pre... | US Patent US10745383 (2020) BindingDB Entry DOI: 10.7270/Q2X06B3R | |||||||||||
More data for this Ligand-Target Pair |