Compile Data Set for Download or QSAR

Found 345 hits Enz. Inhib. hit(s) with all data for entry = 7315   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320518 (2-(1-Methyl-1H-pyrazol-4-yl)-N-{2-[1-methylpyrroli...) Show SMILES CN1CCCC1CCNC(=O)c1nc2c(nc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320522 (2-(1-Methyl-1H-pyrazol-4-yl)-6-(morpholin-4-yl)-N-...) Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)NCCCN1CCCC1=O Show InChI InChI=1S/C21H27N9O3/c1-28-13-14(12-23-28)17-25-18-16(20(27-17)30-8-10-33-11-9-30)24-19(26-18)21(32)22-5-3-7-29-6-2-4-15(29)31/h12-13H,2-11H2,1H3,(H,22,32)(H,24,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320489 (US10174035, Compound 35 | [2-(1-Methyl-1H-pyrazol-...) Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)c1ccccc1 Show InChI InChI=1S/C25H28N8O2/c1-31-16-19(15-26-31)21-28-22-20(24(30-21)32-11-13-35-14-12-32)27-23(29-22)25(34)33-9-7-18(8-10-33)17-5-3-2-4-6-17/h2-6,15-16,18H,7-14H2,1H3,(H,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320518 (2-(1-Methyl-1H-pyrazol-4-yl)-N-{2-[1-methylpyrroli...) Show SMILES CN1CCCC1CCNC(=O)c1nc2c(nc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320522 (2-(1-Methyl-1H-pyrazol-4-yl)-6-(morpholin-4-yl)-N-...) Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)NCCCN1CCCC1=O Show InChI InChI=1S/C21H27N9O3/c1-28-13-14(12-23-28)17-25-18-16(20(27-17)30-8-10-33-11-9-30)24-19(26-18)21(32)22-5-3-7-29-6-2-4-15(29)31/h12-13H,2-11H2,1H3,(H,22,32)(H,24,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320581 (6-Fluoro-5-(1-methyl-1H-pyrazol-4-yl)-7-(morpholin...) Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)NCCCN1CCOCC1 Show InChI InChI=1S/C22H29FN8O3/c1-29-14-15(13-25-29)17-16(23)19(31-7-11-34-12-8-31)18-20(26-17)28-21(27-18)22(32)24-3-2-4-30-5-9-33-10-6-30/h13-14H,2-12H2,1H3,(H,24,32)(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320527 (US10174035, Compound 72 | [6-(Morpholin-4-yl)-2-(1...) Show SMILES O=C(N1CCC2(COC2)CC1)c1nc2c(nc(nc2[nH]1)-c1cn[nH]c1)N1CCOCC1 Show InChI InChI=1S/C20H24N8O3/c29-19(28-3-1-20(2-4-28)11-31-12-20)17-23-14-16(25-17)24-15(13-9-21-22-10-13)26-18(14)27-5-7-30-8-6-27/h9-10H,1-8,11-12H2,(H,21,22)(H,23,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320530 (N-{3-[cis-2,6-dimethylmorpholin-4-yl]propyl}-2-(1-...) Show SMILES C[C@H]1CN(CCCNC(=O)c2nc3c(nc(nc3[nH]2)-c2cnn(C)c2)N2CCOCC2)C[C@@H](C)O1 Show InChI InChI=1S/C23H33N9O3/c1-15-12-31(13-16(2)35-15)6-4-5-24-23(33)21-26-18-20(28-21)27-19(17-11-25-30(3)14-17)29-22(18)32-7-9-34-10-8-32/h11,14-16H,4-10,12-13H2,1-3H3,(H,24,33)(H,26,27,28,29)/t15-,16+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320527 (US10174035, Compound 72 | [6-(Morpholin-4-yl)-2-(1...) Show SMILES O=C(N1CCC2(COC2)CC1)c1nc2c(nc(nc2[nH]1)-c1cn[nH]c1)N1CCOCC1 Show InChI InChI=1S/C20H24N8O3/c29-19(28-3-1-20(2-4-28)11-31-12-20)17-23-14-16(25-17)24-15(13-9-21-22-10-13)26-18(14)27-5-7-30-8-6-27/h9-10H,1-8,11-12H2,(H,21,22)(H,23,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320530 (N-{3-[cis-2,6-dimethylmorpholin-4-yl]propyl}-2-(1-...) Show SMILES C[C@H]1CN(CCCNC(=O)c2nc3c(nc(nc3[nH]2)-c2cnn(C)c2)N2CCOCC2)C[C@@H](C)O1 Show InChI InChI=1S/C23H33N9O3/c1-15-12-31(13-16(2)35-15)6-4-5-24-23(33)21-26-18-20(28-21)27-19(17-11-25-30(3)14-17)29-22(18)32-7-9-34-10-8-32/h11,14-16H,4-10,12-13H2,1-3H3,(H,24,33)(H,26,27,28,29)/t15-,16+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320542 (1-{[5-(1,3-Dimethyl-1H-pyrazol-4-yl)-6-fluoro-7-(m...) Show SMILES Cc1nn(C)cc1-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(CC1)C(N)=O Show InChI InChI=1S/C22H27FN8O3/c1-12-14(11-29(2)28-12)16-15(23)18(30-7-9-34-10-8-30)17-20(25-16)27-21(26-17)22(33)31-5-3-13(4-6-31)19(24)32/h11,13H,3-10H2,1-2H3,(H2,24,32)(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320559 (US10174035, Compound 102 | [5-(1-Methyl-1H-pyrazol...) Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1 Show InChI InChI=1S/C24H32N8O3/c1-29-16-17(15-25-29)19-14-20(31-8-12-35-13-9-31)21-22(26-19)28-23(27-21)24(33)32-4-2-18(3-5-32)30-6-10-34-11-7-30/h14-16,18H,2-13H2,1H3,(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320566 (US10174035, Compound 109 | {4-[cis-2,6-Dimethylmor...) Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(cc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1 Show InChI InChI=1S/C26H36N8O3/c1-17-14-34(15-18(2)37-17)20-4-6-33(7-5-20)26(35)25-29-23-22(32-8-10-36-11-9-32)12-21(28-24(23)30-25)19-13-27-31(3)16-19/h12-13,16-18,20H,4-11,14-15H2,1-3H3,(H,28,29,30)/t17-,18+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320573 (5-(1-Methyl-1H-pyrazol-4-yl)-7-(morpholin-4-yl)-N-...) Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)NCCCN1CCCC1=O Show InChI InChI=1S/C22H28N8O3/c1-28-14-15(13-24-28)16-12-17(29-8-10-33-11-9-29)19-20(25-16)27-21(26-19)22(32)23-5-3-7-30-6-2-4-18(30)31/h12-14H,2-11H2,1H3,(H,23,32)(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320573 (5-(1-Methyl-1H-pyrazol-4-yl)-7-(morpholin-4-yl)-N-...) Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)NCCCN1CCCC1=O Show InChI InChI=1S/C22H28N8O3/c1-28-14-15(13-24-28)16-12-17(29-8-10-33-11-9-29)19-20(25-16)27-21(26-19)22(32)23-5-3-7-30-6-2-4-18(30)31/h12-14H,2-11H2,1H3,(H,23,32)(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320590 (US10174035, Compound 133 | [4-(Morpholin-4-yl)pipe...) Show SMILES O=C(N1CCC(CC1)N1CCOCC1)c1nc2c(cc(nc2[nH]1)-c1cn[nH]c1)N1CCOCC1 Show InChI InChI=1S/C23H30N8O3/c32-23(31-3-1-17(2-4-31)29-5-9-33-10-6-29)22-27-20-19(30-7-11-34-12-8-30)13-18(26-21(20)28-22)16-14-24-25-15-16/h13-15,17H,1-12H2,(H,24,25)(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320592 (US10174035, Compound 135 | [5-(1-Methyl-1H-pyrazol...) Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCN(CC1)C1CCOCC1 Show InChI InChI=1S/C24H32N8O3/c1-29-16-17(15-25-29)19-14-20(31-8-12-35-13-9-31)21-22(26-19)28-23(27-21)24(33)32-6-4-30(5-7-32)18-2-10-34-11-3-18/h14-16,18H,2-13H2,1H3,(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320542 (1-{[5-(1,3-Dimethyl-1H-pyrazol-4-yl)-6-fluoro-7-(m...) Show SMILES Cc1nn(C)cc1-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(CC1)C(N)=O Show InChI InChI=1S/C22H27FN8O3/c1-12-14(11-29(2)28-12)16-15(23)18(30-7-9-34-10-8-30)17-20(25-16)27-21(26-17)22(33)31-5-3-13(4-6-31)19(24)32/h11,13H,3-10H2,1-2H3,(H2,24,32)(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320585 (4-(1-{[5-(1-Methyl-1H-pyrazol-4-yl)-7-(morpholin-4...) Show SMILES Cn1cc(cn1)-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CC(C1)N1CCNC(=O)C1 Show InChI InChI=1S/C22H27N9O3/c1-28-10-14(9-24-28)16-8-17(29-4-6-34-7-5-29)19-20(25-16)27-21(26-19)22(33)31-11-15(12-31)30-3-2-23-18(32)13-30/h8-10,15H,2-7,11-13H2,1H3,(H,23,32)(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320535 (US10174035, Compound 79 | [6-Fluoro-5-(1-methyl-1H...) Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC2(COC2)CC1 Show InChI InChI=1S/C22H26FN7O3/c1-28-11-14(10-24-28)16-15(23)18(29-6-8-32-9-7-29)17-19(25-16)27-20(26-17)21(31)30-4-2-22(3-5-30)12-33-13-22/h10-11H,2-9,12-13H2,1H3,(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320492 (N-[(3R)-1-{[2-(1-methyl-1H-pyrazol-4-yl)-6-(morpho...) Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CC[C@H](C1)NS(C)(=O)=O Show InChI InChI=1S/C19H25N9O4S/c1-26-10-12(9-20-26)15-22-16-14(18(24-15)27-5-7-32-8-6-27)21-17(23-16)19(29)28-4-3-13(11-28)25-33(2,30)31/h9-10,13,25H,3-8,11H2,1-2H3,(H,21,22,23,24)/t13-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320535 (US10174035, Compound 79 | [6-Fluoro-5-(1-methyl-1H...) Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC2(COC2)CC1 Show InChI InChI=1S/C22H26FN7O3/c1-28-11-14(10-24-28)16-15(23)18(29-6-8-32-9-7-29)17-19(25-16)27-20(26-17)21(31)30-4-2-22(3-5-30)12-33-13-22/h10-11H,2-9,12-13H2,1H3,(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320579 (8-{[2-(1-Methyl-1H-pyrazol-4-yl)-6-(morpholin-4-yl...) Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC2(CNC(=O)C2)CC1 Show InChI InChI=1S/C22H27N9O3/c1-29-12-14(11-24-29)17-26-18-16(20(28-17)30-6-8-34-9-7-30)25-19(27-18)21(33)31-4-2-22(3-5-31)10-15(32)23-13-22/h11-12H,2-10,13H2,1H3,(H,23,32)(H,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320520 (US10174035, Compound 66 | [2-(3-Methyl-1H-pyrazol-...) Show SMILES Cc1n[nH]cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1 Show InChI InChI=1S/C23H31N9O3/c1-15-17(14-24-29-15)19-26-20-18(22(28-19)31-8-12-35-13-9-31)25-21(27-20)23(33)32-4-2-16(3-5-32)30-6-10-34-11-7-30/h14,16H,2-13H2,1H3,(H,24,29)(H,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320517 (2-(1-Methyl-1H-pyrazol-4-yl)-6-(morpholin-4-yl)-N-...) Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)NCCCN1CCOCC1 Show InChI InChI=1S/C21H29N9O3/c1-28-14-15(13-23-28)17-25-18-16(20(27-17)30-7-11-33-12-8-30)24-19(26-18)21(31)22-3-2-4-29-5-9-32-10-6-29/h13-14H,2-12H2,1H3,(H,22,31)(H,24,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320561 (US10174035, Compound 104 | [5-(1,3-Dimethyl-1H-pyr...) Show SMILES Cc1nn(C)cc1-c1cc(N2CCOCC2)c2nc(C(=O)N3CCC(CC3)N3CCOCC3)n(C)c2n1 Show InChI InChI=1S/C26H36N8O3/c1-18-20(17-30(2)29-18)21-16-22(33-10-14-37-15-11-33)23-24(27-21)31(3)25(28-23)26(35)34-6-4-19(5-7-34)32-8-12-36-13-9-32/h16-17,19H,4-15H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320583 (US10174035, Compound 126 | [6-Fluoro-5-(1-methyl-1...) Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CC(C1)N1CCOCC1 Show InChI InChI=1S/C22H27FN8O3/c1-28-11-14(10-24-28)17-16(23)19(30-4-8-34-9-5-30)18-20(25-17)27-21(26-18)22(32)31-12-15(13-31)29-2-6-33-7-3-29/h10-11,15H,2-9,12-13H2,1H3,(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320464 (2-Methyl-2-(4-{[2-(1-methyl-1H-pyrazol-4-yl)-6-(mo...) Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCN(CC1)C(C)(C)C(N)=O Show InChI InChI=1S/C22H30N10O3/c1-22(2,21(23)34)32-6-4-31(5-7-32)20(33)18-25-15-17(27-18)26-16(14-12-24-29(3)13-14)28-19(15)30-8-10-35-11-9-30/h12-13H,4-11H2,1-3H3,(H2,23,34)(H,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320464 (2-Methyl-2-(4-{[2-(1-methyl-1H-pyrazol-4-yl)-6-(mo...) Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCN(CC1)C(C)(C)C(N)=O Show InChI InChI=1S/C22H30N10O3/c1-22(2,21(23)34)32-6-4-31(5-7-32)20(33)18-25-15-17(27-18)26-16(14-12-24-29(3)13-14)28-19(15)30-8-10-35-11-9-30/h12-13H,4-11H2,1-3H3,(H2,23,34)(H,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320550 (US10174035, Compound 93 | [6-Fluoro-7-(morpholin-4...) Show SMILES Cc1nn(C)c(C)c1-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(CC1)N1CCOCC1 |(-3.68,-6.05,;-4.83,-5.02,;-6.33,-5.34,;-7.1,-4.01,;-8.63,-3.85,;-6.07,-2.86,;-6.39,-1.36,;-4.67,-3.49,;-3.33,-2.72,;-2,-3.49,;-.66,-2.72,;.8,-3.2,;1.7,-1.95,;.8,-.7,;-.66,-1.18,;-2,-.41,;-2,1.13,;-3.33,1.9,;-3.33,3.44,;-2,4.21,;-.66,3.44,;-.66,1.9,;-3.33,-1.18,;-4.67,-.41,;3.24,-1.95,;4.01,-3.28,;4.01,-.62,;3.24,.72,;4.01,2.05,;5.55,2.05,;6.32,.72,;5.55,-.62,;6.32,3.38,;5.55,4.72,;6.32,6.05,;7.86,6.05,;8.63,4.72,;7.86,3.38,)| Show InChI InChI=1S/C26H35FN8O3/c1-16-19(17(2)32(3)31-16)21-20(27)23(34-10-14-38-15-11-34)22-24(28-21)30-25(29-22)26(36)35-6-4-18(5-7-35)33-8-12-37-13-9-33/h18H,4-15H2,1-3H3,(H,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320493 (1-(4-{[2-(1-Methyl-1H-pyrazol-4-yl)-6-(morpholin-4...) Show SMILES CC(=O)N1CCN(CC1)C(=O)c1nc2c(nc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1 Show InChI InChI=1S/C20H25N9O3/c1-13(30)27-3-5-29(6-4-27)20(31)18-22-15-17(24-18)23-16(14-11-21-26(2)12-14)25-19(15)28-7-9-32-10-8-28/h11-12H,3-10H2,1-2H3,(H,22,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320465 (US10174035, Compound 11 | [2-(1-Methyl-1H-pyrazol-...) Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCN(CC1)C1CCOCC1 Show InChI InChI=1S/C23H31N9O3/c1-29-15-16(14-24-29)19-26-20-18(22(28-19)31-8-12-35-13-9-31)25-21(27-20)23(33)32-6-4-30(5-7-32)17-2-10-34-11-3-17/h14-15,17H,2-13H2,1H3,(H,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320543 (US10174035, Compound 86 | [5-(1,3-Dimethyl-1H-pyra...) Show SMILES Cc1nn(C)cc1-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(O)CC1 Show InChI InChI=1S/C21H26FN7O3/c1-12-14(11-27(2)26-12)16-15(22)18(28-7-9-32-10-8-28)17-19(23-16)25-20(24-17)21(31)29-5-3-13(30)4-6-29/h11,13,30H,3-10H2,1-2H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320457 ((3-Hydroxyazetidin-1-yl)[2-(1-methyl-1H-pyrazol-4-...) Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CC(O)C1 Show InChI InChI=1S/C17H20N8O3/c1-23-7-10(6-18-23)13-20-14-12(16(22-13)24-2-4-28-5-3-24)19-15(21-14)17(27)25-8-11(26)9-25/h6-7,11,26H,2-5,8-9H2,1H3,(H,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320543 (US10174035, Compound 86 | [5-(1,3-Dimethyl-1H-pyra...) Show SMILES Cc1nn(C)cc1-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)N1CCC(O)CC1 Show InChI InChI=1S/C21H26FN7O3/c1-12-14(11-27(2)26-12)16-15(22)18(28-7-9-32-10-8-28)17-19(23-16)25-20(24-17)21(31)29-5-3-13(30)4-6-29/h11,13,30H,3-10H2,1-2H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320494 (US10174035, Compound 40 | [2-(1,5-Dimethyl-1H-pyra...) Show SMILES Cc1c(cnn1C)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1 Show InChI InChI=1S/C24H33N9O3/c1-16-18(15-25-30(16)2)20-27-21-19(23(29-20)32-9-13-36-14-10-32)26-22(28-21)24(34)33-5-3-17(4-6-33)31-7-11-35-12-8-31/h15,17H,3-14H2,1-2H3,(H,26,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320556 (US10174035, Compound 99 | [4-(Dimethylamino)piperi...) Show SMILES CN(C)C1CCN(CC1)C(=O)c1nc2c(N3CCOCC3)c(F)c(nc2[nH]1)-c1cnn(C)c1 Show InChI InChI=1S/C22H29FN8O2/c1-28(2)15-4-6-31(7-5-15)22(32)21-26-18-19(30-8-10-33-11-9-30)16(23)17(25-20(18)27-21)14-12-24-29(3)13-14/h12-13,15H,4-11H2,1-3H3,(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320563 (US10174035, Compound 106 | [3-Methyl-5-(1-methyl-1...) Show SMILES CN1C(C2CN(CCC2N2CCOCC2)C=O)[N](C)(c2cn[nH]c2)c2c1nccc2N1CCOCC1 |(-1.22,-3.12,;-1.7,-1.66,;-.79,-.41,;1.21,-.41,;1.98,.92,;3.52,.92,;4.29,-.41,;3.52,-1.75,;1.98,-1.75,;1.21,-3.08,;1.98,-4.41,;1.21,-5.75,;-.33,-5.75,;-1.1,-4.41,;-.33,-3.08,;4.29,2.25,;5.83,2.25,;-1.7,.83,;-2.02,2.34,;-.55,1.86,;.95,1.54,;1.72,2.88,;.69,4.02,;-.71,3.4,;-3.16,.36,;-3.16,-1.18,;-4.5,-1.95,;-5.83,-1.18,;-5.83,.36,;-4.5,1.13,;-4.5,2.67,;-5.83,3.44,;-5.83,4.98,;-4.5,5.75,;-3.16,4.98,;-3.16,3.44,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320526 (2-(1,3-Dimethyl-1H-pyrazol-4-yl)-N-{[3-(hydroxymet...) Show SMILES Cc1nn(C)cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)NCC1(CO)COC1 Show InChI InChI=1S/C20H26N8O4/c1-12-13(7-27(2)26-12)15-23-16-14(18(25-15)28-3-5-31-6-4-28)22-17(24-16)19(30)21-8-20(9-29)10-32-11-20/h7,29H,3-6,8-11H2,1-2H3,(H,21,30)(H,22,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320548 (US10174035, Compound 91 | [6-Chloro-5-(1,3-dimethy...) Show SMILES Cc1nn(C)cc1-c1nc2[nH]c(nc2c(N2CCOCC2)c1Cl)C(=O)N1CCC(CC1)N1CCOCC1 Show InChI InChI=1S/C25H33ClN8O3/c1-16-18(15-31(2)30-16)20-19(26)22(33-9-13-37-14-10-33)21-23(27-20)29-24(28-21)25(35)34-5-3-17(4-6-34)32-7-11-36-12-8-32/h15,17H,3-14H2,1-2H3,(H,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320508 (US10174035, Compound 54 | [4-(Dimethylamino)piperi...) Show SMILES CN(C)C1CCN(CC1)C(=O)c1nc2c(nc(nc2[nH]1)-c1cn[nH]c1)N1CCOCC1 Show InChI InChI=1S/C20H27N9O2/c1-27(2)14-3-5-29(6-4-14)20(30)18-23-15-17(25-18)24-16(13-11-21-22-12-13)26-19(15)28-7-9-31-10-8-28/h11-12,14H,3-10H2,1-2H3,(H,21,22)(H,23,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320491 (N-[(3S)-1-{[2-(1-methyl-1H-pyrazol-4-yl)-6-(morpho...) Show SMILES CC(=O)N[C@H]1CCN(C1)C(=O)c1nc2c(nc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1 Show InChI InChI=1S/C20H25N9O3/c1-12(30)22-14-3-4-29(11-14)20(31)18-23-15-17(25-18)24-16(13-9-21-27(2)10-13)26-19(15)28-5-7-32-8-6-28/h9-10,14H,3-8,11H2,1-2H3,(H,22,30)(H,23,24,25,26)/t14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320562 (6-Fluoro-5-(1-methyl-1H-pyrazol-4-yl)-7-(morpholin...) Show SMILES Cn1cc(cn1)-c1nc2[nH]c(nc2c(N2CCOCC2)c1F)C(=O)NCCN1CCOCC1 Show InChI InChI=1S/C21H27FN8O3/c1-28-13-14(12-24-28)16-15(22)18(30-6-10-33-11-7-30)17-19(25-16)27-20(26-17)21(31)23-2-3-29-4-8-32-9-5-29/h12-13H,2-11H2,1H3,(H,23,31)(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320466 (US10174035, Compound 12 | [2-(1,3-Dimethyl-1H-pyra...) Show SMILES Cc1nn(C)cc1-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)C(C)(C)O Show InChI InChI=1S/C23H32N8O3/c1-14-16(13-29(4)28-14)18-25-19-17(21(27-18)30-9-11-34-12-10-30)24-20(26-19)22(32)31-7-5-15(6-8-31)23(2,3)33/h13,15,33H,5-12H2,1-4H3,(H,24,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320584 (US10174035, Compound 127 | {3-[(2R,6S)-2,6-dimethy...) Show SMILES C[C@H]1CN(C[C@@H](C)O1)C1CN(C1)C(=O)c1nc2c(N3CCOCC3)c(F)c(nc2[nH]1)-c1cnn(C)c1 Show InChI InChI=1S/C24H31FN8O3/c1-14-9-32(10-15(2)36-14)17-12-33(13-17)24(34)23-28-20-21(31-4-6-35-7-5-31)18(25)19(27-22(20)29-23)16-8-26-30(3)11-16/h8,11,14-15,17H,4-7,9-10,12-13H2,1-3H3,(H,27,28,29)/t14-,15+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320459 ((9aR)-8-{[2-(1-Methyl-1H-pyrazol-4-yl)-6-(morpholi...) Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCN2[C@@H](COCC2=O)C1 Show InChI InChI=1S/C21H25N9O4/c1-27-9-13(8-22-27)17-24-18-16(20(26-17)28-4-6-33-7-5-28)23-19(25-18)21(32)29-2-3-30-14(10-29)11-34-12-15(30)31/h8-9,14H,2-7,10-12H2,1H3,(H,23,24,25,26)/t14-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320558 (US10174035, Compound 101 | [4-(Dimethylamino)piper...) Show SMILES CN(C)C1CCN(CC1)C(=O)c1nc2c(cc(nc2[nH]1)-c1cnn(C)c1)N1CCOCC1 Show InChI InChI=1S/C22H30N8O2/c1-27(2)16-4-6-30(7-5-16)22(31)21-25-19-18(29-8-10-32-11-9-29)12-17(24-20(19)26-21)15-13-23-28(3)14-15/h12-14,16H,4-11H2,1-3H3,(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320460 (4-(1-{[2-(1-Methyl-1H-pyrazol-4-yl)-6-(morpholin-4...) Show SMILES Cn1cc(cn1)-c1nc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1=O Show InChI InChI=1S/C23H29N9O4/c1-29-13-15(12-24-29)19-26-20-18(22(28-19)30-6-9-35-10-7-30)25-21(27-20)23(34)31-4-2-16(3-5-31)32-8-11-36-14-17(32)33/h12-13,16H,2-11,14H2,1H3,(H,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320582 (US10174035, Compound 125 | [6-Fluoro-7-(morpholin-...) Show SMILES Fc1c(nc2[nH]c(nc2c1N1CCOCC1)C(=O)N1CCC(CC1)N1CCOCC1)-c1cn[nH]c1 Show InChI InChI=1S/C23H29FN8O3/c24-17-18(15-13-25-26-14-15)27-21-19(20(17)31-7-11-35-12-8-31)28-22(29-21)23(33)32-3-1-16(2-4-32)30-5-9-34-10-6-30/h13-14,16H,1-12H2,(H,25,26)(H,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM320546 (US10174035, Compound 89 | [5-(1,3-Dimethyl-1H-pyra...) Show SMILES Cc1nn(C)cc1-c1nc2[nH]c(nc2c(N2CCOCC2)c1C)C(=O)N1CCC(CC1)N1CCOCC1 Show InChI InChI=1S/C26H36N8O3/c1-17-21(20-16-31(3)30-18(20)2)27-24-22(23(17)33-10-14-37-15-11-33)28-25(29-24)26(35)34-6-4-19(5-7-34)32-8-12-36-13-9-32/h16,19H,4-15H2,1-3H3,(H,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...				US Patent US10174035 (2019) BindingDB Entry DOI: 10.7270/Q2FB552Z
					More data for this Ligand-Target Pair

<<  First   |  Previous   |  Displayed 51 to 100 (of 345 total )  |  Next  |  Last  >>

Jump to: