Found 110 hits Enz. Inhib. hit(s) with all data for entry = 7757 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259378
(US9505745, 55 | US9790212, Example 55)Show SMILES CCN(C1CCOCC1)c1sc(C#N)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C22H28N4O3S/c1-5-26(16-6-8-29-9-7-16)22-15(4)19(18(11-23)30-22)21(28)24-12-17-13(2)10-14(3)25-20(17)27/h10,16H,5-9,12H2,1-4H3,(H,24,28)(H,25,27) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259326
(US9505745, 3 | US9790212, Example 3)Show SMILES CCN(C1CCOCC1)c1c(Cl)sc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H28ClN3O3S/c1-5-25(15-6-8-28-9-7-15)17-14(4)18(29-19(17)22)21(27)23-11-16-12(2)10-13(3)24-20(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259344
(US9505745, 21)Show SMILES Cc1c(csc1C(O)C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259354
(US9505745, 31 | US9790212, Example 31)Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)n(C)c2=O)c1C Show InChI InChI=1S/C22H31N3O3S/c1-6-25(17-7-9-28-10-8-17)22-16(4)19(13-29-22)20(26)23-12-18-14(2)11-15(3)24(5)21(18)27/h11,13,17H,6-10,12H2,1-5H3,(H,23,26) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259401
(US9505745, 78 | US9790212, Example 78)Show SMILES CCN(C1CCOCC1)c1sc(-c2cnn(C)c2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C25H33N5O3S/c1-6-30(19-7-9-33-10-8-19)25-17(4)21(22(34-25)18-12-27-29(5)14-18)24(32)26-13-20-15(2)11-16(3)28-23(20)31/h11-12,14,19H,6-10,13H2,1-5H3,(H,26,32)(H,28,31) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259348
(US9505745, 25 | US9790212, Example 25)Show SMILES CC1CCCN1c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259357
(US9505745, 34 | US9790212, Example 35)Show SMILES C\C=C(/[C@H]1CC[C@@H](CC1)NC(=O)OC(C)(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,wD:6.9,(5.06,-1.28,;3.97,-.19,;2.48,-.59,;2.09,-2.07,;3.17,-3.16,;2.78,-4.65,;1.29,-5.05,;.2,-3.96,;.6,-2.47,;.89,-6.54,;1.98,-7.62,;1.58,-9.11,;3.47,-7.23,;4.56,-8.32,;6.04,-7.92,;4.16,-9.8,;5.64,-9.4,;1.4,.5,;-.14,.5,;-.62,1.97,;.63,2.87,;.63,4.41,;1.96,5.18,;-.71,5.18,;-.71,6.72,;-2.04,7.49,;-2.04,9.03,;-.71,9.8,;-3.38,9.8,;-4.71,9.03,;-6.04,9.8,;-4.71,7.49,;-3.38,6.72,;-3.38,5.18,;1.87,1.97,;3.21,2.74,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259393
(US9505745, 70 | US9790212, Example 70)Show SMILES Cc1c(csc1-c1cccc2CNCCc12)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI InChI=1S/C23H25N3O2S/c1-13-9-14(2)26-23(28)19(13)11-25-22(27)20-12-29-21(15(20)3)18-6-4-5-16-10-24-8-7-17(16)18/h4-6,9,12,24H,7-8,10-11H2,1-3H3,(H,25,27)(H,26,28) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259396
(US9505745, 73 | US9790212, Example 73)Show SMILES CCC(CCCN1CCN(C)CC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259372
(US9505745, 49 | US9790212, Example 49)Show SMILES Cc1c(csc1C(=C)C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI InChI=1S/C21H27N3O2S/c1-12-9-13(2)24-21(26)17(12)10-23-20(25)18-11-27-19(15(18)4)14(3)16-5-7-22-8-6-16/h9,11,16,22H,3,5-8,10H2,1-2,4H3,(H,23,25)(H,24,26) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259361
(US9505745, 38 | US9790212, Example 38)Show SMILES CN(C)[C@H]1CC[C@@H](CC1)C(O)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,w:9.10,wU:3.2,wD:6.9,(4.68,-8.71,;3.59,-7.62,;2.1,-8.02,;3.99,-6.14,;2.9,-5.05,;3.3,-3.56,;4.78,-3.16,;5.87,-4.25,;5.47,-5.74,;5.18,-1.67,;6.67,-1.28,;4.09,-.59,;2.55,-.59,;2.08,.88,;3.32,1.78,;3.32,3.32,;1.99,4.09,;4.66,4.09,;4.66,5.63,;5.99,6.4,;5.99,7.94,;4.66,8.71,;7.33,8.71,;8.66,7.94,;9.99,8.71,;8.66,6.4,;7.33,5.63,;7.33,4.09,;4.57,.88,;5.9,1.65,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259343
(US9505745, 20 | US9790212, Example 20)Show SMILES COC(=O)c1csc(C(O)C2CCN(CC2)C(=O)OC(C)(C)C)c1C Show InChI InChI=1S/C18H27NO5S/c1-11-13(16(21)23-5)10-25-15(11)14(20)12-6-8-19(9-7-12)17(22)24-18(2,3)4/h10,12,14,20H,6-9H2,1-5H3 | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259326
(US9505745, 3 | US9790212, Example 3)Show SMILES CCN(C1CCOCC1)c1c(Cl)sc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H28ClN3O3S/c1-5-25(15-6-8-28-9-7-15)17-14(4)18(29-19(17)22)21(27)23-11-16-12(2)10-13(3)24-20(16)26/h10,15H,5-9,11H2,1-4H3,(H,23,27)(H,24,26) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259380
(US9505745, 57 | US9790212, Example 58)Show SMILES CCN(C1CCOCC1)c1sc(C2CCN(C2)C(=O)OC(C)(C)C)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259397
(US9505745, 74)Show SMILES C\C=C(/CCCN1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C27H40N4O2S/c1-7-21(9-8-12-31-13-10-22(11-14-31)30(5)6)25-20(4)24(17-34-25)26(32)28-16-23-18(2)15-19(3)29-27(23)33/h7,15,17,22H,8-14,16H2,1-6H3,(H,28,32)(H,29,33)/b21-7+ | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259388
(US9505745, 65 | US9790212, Example 65)Show SMILES CCOC(=O)N(CC)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C19H25N3O4S/c1-6-22(19(25)26-7-2)18-13(5)15(10-27-18)16(23)20-9-14-11(3)8-12(4)21-17(14)24/h8,10H,6-7,9H2,1-5H3,(H,20,23)(H,21,24) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259325
(US9505745, 2 | US9790212, Example 2)Show SMILES CCN(C1CCOCC1)c1csc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C21H29N3O3S/c1-5-24(16-6-8-27-9-7-16)18-12-28-19(15(18)4)21(26)22-11-17-13(2)10-14(3)23-20(17)25/h10,12,16H,5-9,11H2,1-4H3,(H,22,26)(H,23,25) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259347
(US9505745, 24 | US9790212, Example 24)Show SMILES Cc1c(csc1C1CCN(C1)C(=O)OC(C)(C)C)C(=O)NCc1c(C)cc(C)[nH]c1=O | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 251 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259395
(US9505745, 72)Show SMILES C\C=C(/CCCN1CCN(C)CC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C25H36N4O2S/c1-6-20(8-7-9-29-12-10-28(5)11-13-29)23-19(4)22(16-32-23)24(30)26-15-21-17(2)14-18(3)27-25(21)31/h6,14,16H,7-13,15H2,1-5H3,(H,26,30)(H,27,31)/b20-6+ | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 251 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259365
(US9505745, 42 | US9790212, Example 42)Show SMILES CC[C@@H](N1CCC(CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259375
(US9505745, 52 | US9790212, Example 52)Show SMILES CCN(CC)c1sc(Br)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C18H24BrN3O2S/c1-6-22(7-2)18-12(5)14(15(19)25-18)17(24)20-9-13-10(3)8-11(4)21-16(13)23/h8H,6-7,9H2,1-5H3,(H,20,24)(H,21,23) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259369
(US9505745, 46 | US9505745, 47 | US9790212, Example...)Show SMILES CCC([C@H]1CC[C@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,6.9,(2.06,-3.32,;1.29,-1.98,;-.25,-1.98,;-1.02,-3.32,;-.25,-4.65,;-1.02,-5.98,;-2.56,-5.98,;-3.33,-4.65,;-2.56,-3.32,;-3.33,-7.32,;-2.56,-8.65,;-4.87,-7.32,;-1.02,-.65,;-2.56,-.65,;-3.04,.82,;-1.79,1.72,;-1.79,3.26,;-3.13,4.03,;-.46,4.03,;-.46,5.57,;.87,6.34,;.87,7.88,;-.46,8.65,;2.21,8.65,;3.54,7.88,;4.87,8.65,;3.54,6.34,;2.21,5.57,;2.21,4.03,;-.55,.82,;.79,1.59,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259340
(US9505745, 17 | US9790212, Example 17)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc([nH]c2=O)C(F)(F)F)c1C |r,wU:6.9,wD:3.2,(9.44,-18.86,;8.11,-18.09,;6.78,-18.86,;6.78,-20.4,;5.44,-21.17,;5.44,-22.71,;6.78,-23.48,;8.11,-22.71,;8.11,-21.17,;6.78,-25.02,;8.11,-25.79,;5.44,-25.79,;5.44,-18.09,;3.98,-18.56,;3.07,-17.32,;3.98,-16.07,;3.58,-14.58,;2.09,-14.19,;4.67,-13.49,;4.27,-12.01,;5.36,-10.92,;6.85,-11.32,;7.24,-12.8,;7.94,-10.23,;7.54,-8.74,;6.05,-8.34,;4.96,-9.43,;3.47,-9.03,;8.63,-7.65,;10.11,-8.05,;8.23,-6.16,;9.71,-6.56,;5.44,-16.55,;6.78,-15.78,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259336
(US9505745, 13 | US9790212, Example 13)Show SMILES CC(N1CCC(CC1)N(C)C)c1cc(cs1)C(=O)NCc1c(C)cc(C)[nH]c1=O | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259344
(US9505745, 21)Show SMILES Cc1c(csc1C(O)C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259382
(US9505745, 59 | US9790212, Example 59)Show SMILES CCN(C1CCOCC1)c1sc(C2CCN(CC2)C(=O)OC(C)(C)C)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C31H46N4O5S/c1-8-35(23-11-15-39-16-12-23)29-21(4)25(28(37)32-18-24-19(2)17-20(3)33-27(24)36)26(41-29)22-9-13-34(14-10-22)30(38)40-31(5,6)7/h17,22-23H,8-16,18H2,1-7H3,(H,32,37)(H,33,36) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259352
(US9505745, 29 | US9790212, Example 29)Show SMILES CCC(N1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259345
(US9505745, 22 | US9790212, Example 22)Show SMILES Cc1c(csc1C1CCCN1C1CCOCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259379
(US9505745, 56 | US9790212, Example 56)Show SMILES CCN(C1CCOCC1)c1sc(N2CCN(C)CC2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C26H39N5O3S/c1-6-31(20-7-13-34-14-8-20)25-19(4)22(26(35-25)30-11-9-29(5)10-12-30)24(33)27-16-21-17(2)15-18(3)28-23(21)32/h15,20H,6-14,16H2,1-5H3,(H,27,33)(H,28,32) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259346
(US9505745, 23 | US9790212, Example 23)Show SMILES Cc1c(csc1-c1cnn(c1)C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI InChI=1S/C22H27N5O2S/c1-13-8-14(2)26-22(29)18(13)10-24-21(28)19-12-30-20(15(19)3)16-9-25-27(11-16)17-4-6-23-7-5-17/h8-9,11-12,17,23H,4-7,10H2,1-3H3,(H,24,28)(H,26,29) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259392
(US9505745, 69 | US9790212, Example 69)Show SMILES Cc1c(csc1N1CCCCC1C1CCNCC1)C(=O)NCc1c(C)cc(C)[nH]c1=O | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259384
(US9505745, 61 | US9790212, Example 61)Show SMILES CCN(C1CCOCC1)c1sc(c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1=CCN(C)CC1 |t:31| Show InChI InChI=1S/C27H38N4O3S/c1-6-31(21-9-13-34-14-10-21)27-19(4)23(24(35-27)20-7-11-30(5)12-8-20)26(33)28-16-22-17(2)15-18(3)29-25(22)32/h7,15,21H,6,8-14,16H2,1-5H3,(H,28,33)(H,29,32) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259360
(US9505745, 37 | US9790212, Example 37)Show SMILES Cc1c(csc1C(O)[C@H]1CC[C@H](N)CC1)C(=O)NCc1c(C)cc(C)[nH]c1=O |r,w:6.7,wU:11.12,wD:8.8,(-.09,1.1,;-1.42,.33,;-2.67,1.24,;-3.91,.33,;-3.44,-1.13,;-1.9,-1.13,;-.81,-2.22,;.68,-1.82,;-1.21,-3.71,;-2.69,-4.11,;-3.09,-5.59,;-2,-6.68,;-2.4,-8.17,;-.52,-6.28,;-.12,-4.8,;-2.67,2.78,;-4,3.55,;-1.33,3.55,;-1.33,5.09,;,5.86,;,7.4,;-1.33,8.17,;1.33,8.17,;2.67,7.4,;4,8.17,;2.67,5.86,;1.33,5.09,;1.33,3.55,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259386
(US9505745, 63 | US9790212, Example 63)Show SMILES CCN(C1CCOCC1)c1sc(C2CCN(CC2)S(C)(=O)=O)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C27H40N4O5S2/c1-6-31(21-9-13-36-14-10-21)27-19(4)23(24(37-27)20-7-11-30(12-8-20)38(5,34)35)26(33)28-16-22-17(2)15-18(3)29-25(22)32/h15,20-21H,6-14,16H2,1-5H3,(H,28,33)(H,29,32) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259385
(US9505745, 62 | US9790212, Example 62)Show SMILES CCN(C1CCOCC1)c1sc(C2CCN(C2)S(C)(=O)=O)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259348
(US9505745, 25 | US9790212, Example 25)Show SMILES CC1CCCN1c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259338
(US9505745, 15 | US9790212, Example 15)Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(cc(C)[nH]c2=O)C(F)(F)F)c1C Show InChI InChI=1S/C21H26F3N3O3S/c1-4-27(14-5-7-30-8-6-14)20-13(3)16(11-31-20)18(28)25-10-15-17(21(22,23)24)9-12(2)26-19(15)29/h9,11,14H,4-8,10H2,1-3H3,(H,25,28)(H,26,29) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259340
(US9505745, 17 | US9790212, Example 17)Show SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc([nH]c2=O)C(F)(F)F)c1C |r,wU:6.9,wD:3.2,(9.44,-18.86,;8.11,-18.09,;6.78,-18.86,;6.78,-20.4,;5.44,-21.17,;5.44,-22.71,;6.78,-23.48,;8.11,-22.71,;8.11,-21.17,;6.78,-25.02,;8.11,-25.79,;5.44,-25.79,;5.44,-18.09,;3.98,-18.56,;3.07,-17.32,;3.98,-16.07,;3.58,-14.58,;2.09,-14.19,;4.67,-13.49,;4.27,-12.01,;5.36,-10.92,;6.85,-11.32,;7.24,-12.8,;7.94,-10.23,;7.54,-8.74,;6.05,-8.34,;4.96,-9.43,;3.47,-9.03,;8.63,-7.65,;10.11,-8.05,;8.23,-6.16,;9.71,-6.56,;5.44,-16.55,;6.78,-15.78,)| | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259349
(US9505745, 26 | US9790212, Example 26)Show SMILES CC(N1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259337
(US9505745, 14 | US9790212, Example 14)Show SMILES CCN(C1CCOCC1)c1c(C)c(nn1C)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI InChI=1S/C21H31N5O3/c1-6-26(16-7-9-29-10-8-16)21-15(4)18(24-25(21)5)20(28)22-12-17-13(2)11-14(3)23-19(17)27/h11,16H,6-10,12H2,1-5H3,(H,22,28)(H,23,27) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259383
(US9505745, 60 | US9790212, Example 60)Show SMILES CCN(C1CCOCC1)c1sc(C2CCNCC2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C26H38N4O3S/c1-5-30(20-8-12-33-13-9-20)26-18(4)22(23(34-26)19-6-10-27-11-7-19)25(32)28-15-21-16(2)14-17(3)29-24(21)31/h14,19-20,27H,5-13,15H2,1-4H3,(H,28,32)(H,29,31) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 631 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259354
(US9505745, 31 | US9790212, Example 31)Show SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)n(C)c2=O)c1C Show InChI InChI=1S/C22H31N3O3S/c1-6-25(17-7-9-28-10-8-17)22-16(4)19(13-29-22)20(26)23-12-18-14(2)11-15(3)24(5)21(18)27/h11,13,17H,6-10,12H2,1-5H3,(H,23,26) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259381
(US9505745, 58)Show SMILES CCN(C1CCOCC1)c1sc(C2CCNC2)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259394
(US9505745, 71)Show SMILES C\C=C(/CCN1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C23H31N3O3S/c1-5-18(6-7-26-8-10-29-11-9-26)21-17(4)20(14-30-21)22(27)24-13-19-15(2)12-16(3)25-23(19)28/h5,12,14H,6-11,13H2,1-4H3,(H,24,27)(H,25,28)/b18-5+ | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259343
(US9505745, 20 | US9790212, Example 20)Show SMILES COC(=O)c1csc(C(O)C2CCN(CC2)C(=O)OC(C)(C)C)c1C Show InChI InChI=1S/C18H27NO5S/c1-11-13(16(21)23-5)10-25-15(11)14(20)12-6-8-19(9-7-12)17(22)24-18(2,3)4/h10,12,14,20H,6-9H2,1-5H3 | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259337
(US9505745, 14 | US9790212, Example 14)Show SMILES CCN(C1CCOCC1)c1c(C)c(nn1C)C(=O)NCc1c(C)cc(C)[nH]c1=O Show InChI InChI=1S/C21H31N5O3/c1-6-26(16-7-9-29-10-8-16)21-15(4)18(24-25(21)5)20(28)22-12-17-13(2)11-14(3)23-19(17)27/h11,16H,6-10,12H2,1-5H3,(H,22,28)(H,23,27) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259336
(US9505745, 13 | US9790212, Example 13)Show SMILES CC(N1CCC(CC1)N(C)C)c1cc(cs1)C(=O)NCc1c(C)cc(C)[nH]c1=O | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259352
(US9505745, 29 | US9790212, Example 29)Show SMILES CCC(N1CCOCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259324
(US9505745, 1 | US9790212, Example 1)Show InChI InChI=1S/C17H22N2O3S/c1-9(2)22-14-8-23-15(12(14)5)17(21)18-7-13-10(3)6-11(4)19-16(13)20/h6,8-9H,7H2,1-5H3,(H,18,21)(H,19,20) | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM259347
(US9505745, 24 | US9790212, Example 24)Show SMILES Cc1c(csc1C1CCN(C1)C(=O)OC(C)(C)C)C(=O)NCc1c(C)cc(C)[nH]c1=O | PDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited
US Patent
| Assay Description
Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... |
US Patent US9505745 (2016)
BindingDB Entry DOI: 10.7270/Q23B5Z3T |
More data for this
Ligand-Target Pair | |
Search and Browse
