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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Neuromedin-K receptor (Homo sapiens (Human)) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet  | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Euroscreen SA Curated by ChEMBL | Assay Description Displacement of [3H]-SB222200 from recombinant human NK3R expressed in CHO cell membranes after 90 mins by scintillation counting analysis | J Med Chem 58: 3060-82 (2015) Article DOI: 10.1021/jm5017413 BindingDB Entry DOI: 10.7270/Q2ZP47TC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuromedin-K receptor (Homo sapiens (Human)) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Euroscreen SA Curated by ChEMBL | Assay Description Binding affinity to human recombinant NK3R by radioligand binding assay | ACS Med Chem Lett 6: 736-40 (2015) Article DOI: 10.1021/acsmedchemlett.5b00117 BindingDB Entry DOI: 10.7270/Q2TQ639V | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuromedin-K receptor (Homo sapiens (Human)) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ogeda SA US Patent | Assay Description NK3: The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vit... | US Patent US10941151 (2021) BindingDB Entry DOI: 10.7270/Q2PC35G3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuromedin-K receptor (Homo sapiens (Human)) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ogeda SA. US Patent | Assay Description The antagonist activity of compounds of the invention is measured following pre-incubation (3 minutes) of the compound with the cells, followed by ad... | US Patent US10065961 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K4R | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuromedin-K receptor (Homo sapiens (Human)) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ogeda SA US Patent | Assay Description NK3: The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vit... | US Patent US10941151 (2021) BindingDB Entry DOI: 10.7270/Q2PC35G3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuromedin-K receptor (Homo sapiens (Human)) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ogeda SA US Patent | Assay Description NK3: The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vit... | US Patent US10683295 (2020) BindingDB Entry DOI: 10.7270/Q2S75KC1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuromedin-K receptor (Homo sapiens (Human)) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | 16 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Ogeda SA. US Patent | Assay Description The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vitro ra... | US Patent US10065961 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K4R | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuromedin-K receptor (Homo sapiens (Human)) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ogeda SA US Patent | Assay Description NK3: The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vit... | US Patent US10683295 (2020) BindingDB Entry DOI: 10.7270/Q2S75KC1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuromedin-K receptor (Homo sapiens (Human)) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | 16 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Euroscreen S.A. US Patent | Assay Description The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an in vitro ra... | US Patent US9475814 (2016) BindingDB Entry DOI: 10.7270/Q2B8571Q | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuromedin-K receptor (Macaca mulatta) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Euroscreen SA Curated by ChEMBL | Assay Description Displacement of [3H]-SB222200 from monkey NK3R after 90 mins by scintillation counting analysis | J Med Chem 58: 3060-82 (2015) Article DOI: 10.1021/jm5017413 BindingDB Entry DOI: 10.7270/Q2ZP47TC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuromedin-K receptor (Rattus norvegicus) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 76 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Euroscreen SA Curated by ChEMBL | Assay Description Displacement of [3H]-SB222200 from rat NK3R after 90 mins by scintillation counting analysis | J Med Chem 58: 3060-82 (2015) Article DOI: 10.1021/jm5017413 BindingDB Entry DOI: 10.7270/Q2ZP47TC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuromedin-K receptor (Rattus norvegicus) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 76 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Euroscreen SA Curated by ChEMBL | Assay Description Binding affinity to rat NK3R | ACS Med Chem Lett 6: 736-40 (2015) Article DOI: 10.1021/acsmedchemlett.5b00117 BindingDB Entry DOI: 10.7270/Q2TQ639V | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Neuromedin-K receptor (Rattus norvegicus) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 79 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Euroscreen SA Curated by ChEMBL | Assay Description Displacement of [3H]-SB222200 from rat NK3R after 90 mins by scintillation counting analysis | J Med Chem 58: 3060-82 (2015) Article DOI: 10.1021/jm5017413 BindingDB Entry DOI: 10.7270/Q2ZP47TC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Substance-K receptor (Homo sapiens (Human)) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Euroscreen SA Curated by ChEMBL | Assay Description Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis | J Med Chem 58: 3060-82 (2015) Article DOI: 10.1021/jm5017413 BindingDB Entry DOI: 10.7270/Q2ZP47TC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Substance-P receptor (Homo sapiens (Human)) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Euroscreen SA Curated by ChEMBL | Assay Description Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis | J Med Chem 58: 3060-82 (2015) Article DOI: 10.1021/jm5017413 BindingDB Entry DOI: 10.7270/Q2ZP47TC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Substance-P receptor (Homo sapiens (Human)) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | 1.27E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ogeda SA US Patent | Assay Description NK1: The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 ... | US Patent US10683295 (2020) BindingDB Entry DOI: 10.7270/Q2S75KC1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Substance-P receptor (Homo sapiens (Human)) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | 1.27E+4 | -27.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Ogeda SA. US Patent | Assay Description The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane... | US Patent US10065961 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K4R | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Substance-P receptor (Homo sapiens (Human)) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | 1.27E+4 | -27.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Euroscreen S.A. US Patent | Assay Description The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane... | US Patent US9475814 (2016) BindingDB Entry DOI: 10.7270/Q2B8571Q | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Substance-P receptor (Homo sapiens (Human)) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | 1.27E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ogeda SA US Patent | Assay Description NK1: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Mem... | US Patent US10941151 (2021) BindingDB Entry DOI: 10.7270/Q2PC35G3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Substance-K receptor (Homo sapiens (Human)) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | 1.40E+4 | -27.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Euroscreen S.A. US Patent | Assay Description The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane... | US Patent US9475814 (2016) BindingDB Entry DOI: 10.7270/Q2B8571Q | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Substance-K receptor (Homo sapiens (Human)) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ogeda SA US Patent | Assay Description NK2: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Mem... | US Patent US10941151 (2021) BindingDB Entry DOI: 10.7270/Q2PC35G3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Substance-K receptor (Homo sapiens (Human)) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | 1.40E+4 | -27.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Ogeda SA. US Patent | Assay Description The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane... | US Patent US10065961 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K4R | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Substance-K receptor (Homo sapiens (Human)) | BDBM50081195 (CHEMBL3422010 | US10065961, Compound 1 | US1068329...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ogeda SA US Patent | Assay Description NK2: Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 &... | US Patent US10683295 (2020) BindingDB Entry DOI: 10.7270/Q2S75KC1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
