Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G-protein coupled receptor 6 (Homo sapiens (Human)) | BDBM412953 (US10406157, Compound Formula 1) | UniProtKB/SwissProt GoogleScholar AffyNet | UniChem | US Patent | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited US Patent | Assay Description The inhibition constant (Ki) from a GPR6 competition binding assay and the IC50 values from a hERG functional assay for the compound of Formula 1 (Ex... | US Patent US10406157 (2019) BindingDB Entry DOI: 10.7270/Q2J105HQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 6 (Homo sapiens (Human)) | BDBM191037 (US10077266, Example 149 | US10406157, Compound A |...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited US Patent | Assay Description The inhibition constant (Ki) from a GPR6 competition binding assay and the IC50 values from a hERG functional assay for the compound of Formula 1 (Ex... | US Patent US10406157 (2019) BindingDB Entry DOI: 10.7270/Q2J105HQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 6 (Homo sapiens (Human)) | BDBM50582430 (CHEMBL4598390) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02081 BindingDB Entry DOI: 10.7270/Q2JW8JSH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 6 (Homo sapiens (Human)) | BDBM50582450 (CHEMBL4778540) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 9.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02081 BindingDB Entry DOI: 10.7270/Q2JW8JSH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 6 (Homo sapiens (Human)) | BDBM50582449 (CHEMBL5093828) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02081 BindingDB Entry DOI: 10.7270/Q2JW8JSH | |||||||||||
More data for this Ligand-Target Pair |