Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ephrin type-A receptor 4 [29-209] (Homo sapiens (Human)) | BDBM223311 (123C4) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 640 | -8.44 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
Sanford-Burnham-Prebys Medical Discovery Institute | Assay Description For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7.... | Cell Chem Biol 24: 293-305 (2017) Article DOI: 10.1016/j.chembiol.2017.01.006 BindingDB Entry DOI: 10.7270/Q2GX49FB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ephrin type-A receptor 4 (Homo sapiens (Human)) | BDBM223311 (123C4) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 640 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01511 BindingDB Entry DOI: 10.7270/Q22Z19M2 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ephrin type-A receptor 4 [29-209] (Homo sapiens (Human)) | BDBM223301 (120H10) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 960 | -8.20 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
Sanford-Burnham-Prebys Medical Discovery Institute | Assay Description For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7.... | Cell Chem Biol 24: 293-305 (2017) Article DOI: 10.1016/j.chembiol.2017.01.006 BindingDB Entry DOI: 10.7270/Q2GX49FB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ephrin type-A receptor 4 [29-209] (Homo sapiens (Human)) | BDBM223310 (123C7) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.59E+3 | -7.90 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
Sanford-Burnham-Prebys Medical Discovery Institute | Assay Description For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7.... | Cell Chem Biol 24: 293-305 (2017) Article DOI: 10.1016/j.chembiol.2017.01.006 BindingDB Entry DOI: 10.7270/Q2GX49FB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ephrin type-A receptor 4 [29-209] (Homo sapiens (Human)) | BDBM223305 (123C2) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.59E+3 | -7.90 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
Sanford-Burnham-Prebys Medical Discovery Institute | Assay Description For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7.... | Cell Chem Biol 24: 293-305 (2017) Article DOI: 10.1016/j.chembiol.2017.01.006 BindingDB Entry DOI: 10.7270/Q2GX49FB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ephrin type-A receptor 4 [29-209] (Homo sapiens (Human)) | BDBM223300 (EphA4-LBC inhibitor, Compound 22) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 2.14E+3 | -7.73 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
Sanford-Burnham-Prebys Medical Discovery Institute | Assay Description For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7.... | Cell Chem Biol 24: 293-305 (2017) Article DOI: 10.1016/j.chembiol.2017.01.006 BindingDB Entry DOI: 10.7270/Q2GX49FB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ephrin type-A receptor 4 [29-209] (Homo sapiens (Human)) | BDBM223307 (123C3) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 2.22E+3 | -7.71 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
Sanford-Burnham-Prebys Medical Discovery Institute | Assay Description For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7.... | Cell Chem Biol 24: 293-305 (2017) Article DOI: 10.1016/j.chembiol.2017.01.006 BindingDB Entry DOI: 10.7270/Q2GX49FB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ephrin type-A receptor 4 [29-209] (Homo sapiens (Human)) | BDBM223308 (123C5) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 2.57E+3 | -7.62 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
Sanford-Burnham-Prebys Medical Discovery Institute | Assay Description For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7.... | Cell Chem Biol 24: 293-305 (2017) Article DOI: 10.1016/j.chembiol.2017.01.006 BindingDB Entry DOI: 10.7270/Q2GX49FB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ephrin type-A receptor 4 [29-209] (Homo sapiens (Human)) | BDBM223302 (123B1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 3.04E+3 | -7.52 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
Sanford-Burnham-Prebys Medical Discovery Institute | Assay Description For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7.... | Cell Chem Biol 24: 293-305 (2017) Article DOI: 10.1016/j.chembiol.2017.01.006 BindingDB Entry DOI: 10.7270/Q2GX49FB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ephrin type-A receptor 4 [29-209] (Homo sapiens (Human)) | BDBM223309 (123C6) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 3.14E+3 | -7.50 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
Sanford-Burnham-Prebys Medical Discovery Institute | Assay Description For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7.... | Cell Chem Biol 24: 293-305 (2017) Article DOI: 10.1016/j.chembiol.2017.01.006 BindingDB Entry DOI: 10.7270/Q2GX49FB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ephrin type-A receptor 4 [29-209] (Homo sapiens (Human)) | BDBM223306 (123C12) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 7.67E+3 | -6.97 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
Sanford-Burnham-Prebys Medical Discovery Institute | Assay Description For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7.... | Cell Chem Biol 24: 293-305 (2017) Article DOI: 10.1016/j.chembiol.2017.01.006 BindingDB Entry DOI: 10.7270/Q2GX49FB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ephrin type-A receptor 4 (Homo sapiens (Human)) | BDBM50463479 (CHEMBL4249925) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc Curated by ChEMBL | Assay Description Inhibition of EphA4 (unknown origin) | Bioorg Med Chem Lett 28: 2622-2626 (2018) Article DOI: 10.1016/j.bmcl.2018.06.040 BindingDB Entry DOI: 10.7270/Q2ZC85HX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ephrin type-A receptor 4 (Homo sapiens (Human)) | BDBM50463483 (CHEMBL4245242) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc Curated by ChEMBL | Assay Description Inhibition of EphA4 (unknown origin) | Bioorg Med Chem Lett 28: 2622-2626 (2018) Article DOI: 10.1016/j.bmcl.2018.06.040 BindingDB Entry DOI: 10.7270/Q2ZC85HX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ephrin type-A receptor 4 [29-209] (Homo sapiens (Human)) | BDBM223303 (120G1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.40E+4 | -6.62 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
Sanford-Burnham-Prebys Medical Discovery Institute | Assay Description For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7.... | Cell Chem Biol 24: 293-305 (2017) Article DOI: 10.1016/j.chembiol.2017.01.006 BindingDB Entry DOI: 10.7270/Q2GX49FB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ephrin type-A receptor 4 [29-209] (Homo sapiens (Human)) | BDBM223304 (120G2) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.00E+5 | -5.45 | n/a | n/a | n/a | n/a | n/a | 7.2 | 25 |
Sanford-Burnham-Prebys Medical Discovery Institute | Assay Description For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7.... | Cell Chem Biol 24: 293-305 (2017) Article DOI: 10.1016/j.chembiol.2017.01.006 BindingDB Entry DOI: 10.7270/Q2GX49FB | |||||||||||
More data for this Ligand-Target Pair |