Compile Data Set for Download or QSAR

Found 4 hits of kd for UniProtKB: P11387   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase 1 (Homo sapiens (Human))	BDBM50378911 (CHEMBL1813808) Show SMILES CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4c(\C=N\c4ccccc4C)c3Cn1c2=O |r| Show InChI InChI=1S/C28H23N3O4/c1-3-28(34)21-12-24-25-19(14-31(24)26(32)20(21)15-35-27(28)33)18(17-9-5-7-11-23(17)30-25)13-29-22-10-6-4-8-16(22)2/h4-13,34H,3,14-15H2,1-2H3/b29-13+/t28-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	0.296	n/a	n/a	n/a	n/a	n/a
Universita di Salerno Curated by ChEMBL					Assay Description Binding affinity to topoisomerase 1				J Nat Prod 74: 1401-7 (2011) Article DOI: 10.1021/np100935s BindingDB Entry DOI: 10.7270/Q20V8DSJ
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Homo sapiens (Human))	BDBM50378912 (CHEMBL1813809) Show SMILES CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4c(\C=N/OCCCO)c3Cn1c2=O |r| Show InChI InChI=1S/C24H23N3O6/c1-2-24(31)18-10-20-21-16(12-27(20)22(29)17(18)13-32-23(24)30)15(11-25-33-9-5-8-28)14-6-3-4-7-19(14)26-21/h3-4,6-7,10-11,28,31H,2,5,8-9,12-13H2,1H3/b25-11-/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.65	n/a	n/a	n/a	n/a	n/a
Universita di Salerno Curated by ChEMBL					Assay Description Binding affinity to topoisomerase 1				J Nat Prod 74: 1401-7 (2011) Article DOI: 10.1021/np100935s BindingDB Entry DOI: 10.7270/Q20V8DSJ
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Homo sapiens (Human))	BDBM50008935 ((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...) Show SMILES CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O |r| Show InChI InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	26.5	n/a	n/a	n/a	n/a	n/a
Universita di Salerno Curated by ChEMBL					Assay Description Binding affinity to topoisomerase 1				J Nat Prod 74: 1401-7 (2011) Article DOI: 10.1021/np100935s BindingDB Entry DOI: 10.7270/Q20V8DSJ
					More data for this Ligand-Target Pair				3D Structure (crystal)
DNA topoisomerase 1 (Homo sapiens (Human))	BDBM50247528 (CHEMBL4099866) Show SMILES CN(C)c1ccc(cc1)-c1c2ccc(n2)c(-c2ccc(cc2)N(C)C)c2ccc([nH]2)c(-c2ccc(cc2)C(O)=O)c2ccc(n2)c(-c2ccc(cc2)C(O)=O)c2ccc1[nH]2 Show InChI InChI=1S/C50H40N6O4/c1-55(2)35-17-13-31(14-18-35)47-41-25-23-39(52-41)45(29-5-9-33(10-6-29)49(57)58)37-21-22-38(51-37)46(30-7-11-34(12-8-30)50(59)60)40-24-26-42(53-40)48(44-28-27-43(47)54-44)32-15-19-36(20-16-32)56(3)4/h5-28,52-53H,1-4H3,(H,57,58)(H,59,60)/b45-37-,45-39-,46-38-,46-40-,47-41-,47-43-,48-42-,48-44-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	381	n/a	n/a	n/a	n/a	n/a
Ahmedabad University Curated by ChEMBL					Assay Description Binding affinity to recombinant human topoisomerase-1 expressed in baculovirus infected sf9 cells by spectrofluorimetric method				J Med Chem 61: 804-817 (2018) Article DOI: 10.1021/acs.jmedchem.7b01297 BindingDB Entry DOI: 10.7270/Q23J3GDC
					More data for this Ligand-Target Pair