Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50346951 (CHEMBL1795711 | CHEMBL1795714) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 0.0270 | n/a | n/a | n/a | n/a | n/a |
Memorial Sloan-Kettering Cancer Center Curated by ChEMBL | Assay Description Binding affinity to KOR-1 expressed in CHO cells after 90 mins | Bioorg Med Chem Lett 21: 4001-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.008 BindingDB Entry DOI: 10.7270/Q29C6ZDF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50346952 (CHEMBL1795712 | CHEMBL1795715) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a |
Memorial Sloan-Kettering Cancer Center Curated by ChEMBL | Assay Description Binding affinity to KOR-1 expressed in CHO cells after 90 mins | Bioorg Med Chem Lett 21: 4001-4 (2011) Article DOI: 10.1016/j.bmcl.2011.05.008 BindingDB Entry DOI: 10.7270/Q29C6ZDF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50491417 (22-THIOCYANATOSALVINORIN A) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 0.590 | n/a | n/a | n/a | n/a | n/a |
University of Catania Curated by ChEMBL | Assay Description Binding affinity to kappa opioid receptor (unknown origin) | Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111701 BindingDB Entry DOI: 10.7270/Q2668HN9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50001714 (2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-(1S,2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.10 | n/a | n/a | n/a | 7.4 | 25 |
University of North Carolina School of Medicine | Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar... | J Biol Chem 288: 34470-83 (2013) Article DOI: 10.1074/jbc.M113.515668 BindingDB Entry DOI: 10.7270/Q2P849RP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50528964 (CHEMBL4464797) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a |
University of Catania Curated by ChEMBL | Assay Description Binding affinity to kappa opioid receptor (unknown origin) | Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111701 BindingDB Entry DOI: 10.7270/Q2668HN9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50511257 (CHEMBL4577693) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a |
Julius Maximilian University of W£rzburg Curated by ChEMBL | Assay Description Binding affinity to recombinant human KOR transiently expressed in CHOK1 cells measured after 20 mins by TIRF microscopic analysis | J Med Chem 63: 3596-3609 (2020) Article DOI: 10.1021/acs.jmedchem.9b02011 BindingDB Entry DOI: 10.7270/Q2445QTK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50511255 (CHEMBL4463414) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | n/a |
Julius Maximilian University of W£rzburg Curated by ChEMBL | Assay Description Binding affinity to recombinant human KOR transiently expressed in CHOK1 cells measured after 20 mins by TIRF microscopic analysis | J Med Chem 63: 3596-3609 (2020) Article DOI: 10.1021/acs.jmedchem.9b02011 BindingDB Entry DOI: 10.7270/Q2445QTK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50511259 (CHEMBL4459592) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a |
Julius Maximilian University of W£rzburg Curated by ChEMBL | Assay Description Binding affinity to recombinant human KOR transiently expressed in CHOK1 cells measured after 20 mins by TIRF microscopic analysis | J Med Chem 63: 3596-3609 (2020) Article DOI: 10.1021/acs.jmedchem.9b02011 BindingDB Entry DOI: 10.7270/Q2445QTK | |||||||||||
More data for this Ligand-Target Pair |