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Compile Data Set for Download or QSAR

Found 14 hits of kd for UniProtKB: P35375   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50424384
PNG
(CHEMBL2315055)
Show SMILES Fc1cc(Cl)ccc1COc1ccc(Cl)cc1Cc1cccc(n1)C(=O)NS(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H18Cl3FN2O4S/c27-18-6-9-22(10-7-18)37(34,35)32-26(33)24-3-1-2-21(31-24)13-17-12-19(28)8-11-25(17)36-15-16-4-5-20(29)14-23(16)30/h1-12,14H,13,15H2,(H,32,33)
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n/an/an/a 41n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx

Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50424394
PNG
(CHEMBL1207972)
Show SMILES OC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1
Show InChI InChI=1S/C20H14Cl2FNO3/c21-14-6-7-19(27-11-12-4-5-15(22)10-17(12)23)13(8-14)9-16-2-1-3-18(24-16)20(25)26/h1-8,10H,9,11H2,(H,25,26)
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n/an/an/a 48n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx

Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50424383
PNG
(CHEMBL2315056)
Show SMILES Fc1cc(Cl)ccc1COc1ccc(Cl)cc1Cc1cccc(n1)C(=O)NS(=O)(=O)c1cc(Cl)ccc1Cl
Show InChI InChI=1S/C26H17Cl4FN2O4S/c27-17-7-9-24(37-14-15-4-5-18(28)12-22(15)31)16(10-17)11-20-2-1-3-23(32-20)26(34)33-38(35,36)25-13-19(29)6-8-21(25)30/h1-10,12-13H,11,14H2,(H,33,34)
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n/an/an/a 54n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx

Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50424381
PNG
(CHEMBL2315059)
Show SMILES Fc1cc(Cl)ccc1COc1ccc(Cl)cc1Cc1cccc(n1)C(=O)NS(=O)(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H17Cl4FN2O4S/c27-17-6-9-25(37-14-15-4-5-18(28)12-23(15)31)16(10-17)11-19-2-1-3-24(32-19)26(34)33-38(35,36)20-7-8-21(29)22(30)13-20/h1-10,12-13H,11,14H2,(H,33,34)
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n/an/an/a 214n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx

Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50424382
PNG
(CHEMBL2315057)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1
Show InChI InChI=1S/C27H21Cl2FN2O4S/c1-17-5-10-23(11-6-17)37(34,35)32-27(33)25-4-2-3-22(31-25)14-19-13-20(28)9-12-26(19)36-16-18-7-8-21(29)15-24(18)30/h2-13,15H,14,16H2,1H3,(H,32,33)
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n/an/an/a 214n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx

Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50424390
PNG
(CHEMBL2315049)
Show SMILES CC(C)CNC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1
Show InChI InChI=1S/C24H23Cl2FN2O2/c1-15(2)13-28-24(30)22-5-3-4-20(29-22)11-17-10-18(25)8-9-23(17)31-14-16-6-7-19(26)12-21(16)27/h3-10,12,15H,11,13-14H2,1-2H3,(H,28,30)
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n/an/an/a 302n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx

Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50424387
PNG
(CHEMBL2315052)
Show SMILES CCN(CC)C(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1
Show InChI InChI=1S/C24H23Cl2FN2O2/c1-3-29(4-2)24(30)22-7-5-6-20(28-22)13-17-12-18(25)10-11-23(17)31-15-16-8-9-19(26)14-21(16)27/h5-12,14H,3-4,13,15H2,1-2H3
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n/an/an/a 447n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx

Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50424393
PNG
(CHEMBL2315046)
Show SMILES Fc1cc(Cl)ccc1COc1ccc(Cl)cc1Cc1cccc(n1)C(=O)NCC1CC1
Show InChI InChI=1S/C24H21Cl2FN2O2/c25-18-8-9-23(31-14-16-6-7-19(26)12-21(16)27)17(10-18)11-20-2-1-3-22(29-20)24(30)28-13-15-4-5-15/h1-3,6-10,12,15H,4-5,11,13-14H2,(H,28,30)
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n/an/an/a 549n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx

Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50424391
PNG
(CHEMBL2315048)
Show SMILES Fc1cc(Cl)ccc1COc1ccc(Cl)cc1Cc1cccc(n1)C(=O)NC1CCC1
Show InChI InChI=1S/C24H21Cl2FN2O2/c25-17-9-10-23(31-14-15-7-8-18(26)13-21(15)27)16(11-17)12-20-5-2-6-22(28-20)24(30)29-19-3-1-4-19/h2,5-11,13,19H,1,3-4,12,14H2,(H,29,30)
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n/an/an/a 912n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx

Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50424389
PNG
(CHEMBL2315050)
Show SMILES CCC(C)NC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1
Show InChI InChI=1S/C24H23Cl2FN2O2/c1-3-15(2)28-24(30)22-6-4-5-20(29-22)12-17-11-18(25)9-10-23(17)31-14-16-7-8-19(26)13-21(16)27/h4-11,13,15H,3,12,14H2,1-2H3,(H,28,30)
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n/an/an/a 1.38E+3n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx

Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50424386
PNG
(CHEMBL2315053)
Show SMILES Fc1cc(Cl)ccc1COc1ccc(Cl)cc1Cc1cccc(n1)C(=O)NC1CC2CCC1C2
Show InChI InChI=1S/C27H25Cl2FN2O2/c28-20-8-9-26(34-15-18-6-7-21(29)14-23(18)30)19(12-20)13-22-2-1-3-24(31-22)27(33)32-25-11-16-4-5-17(25)10-16/h1-3,6-9,12,14,16-17,25H,4-5,10-11,13,15H2,(H,32,33)
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n/an/an/a 2.19E+3n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx

Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50424385
PNG
(CHEMBL2315054)
Show SMILES NC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1
Show InChI InChI=1S/C20H15Cl2FN2O2/c21-14-6-7-19(27-11-12-4-5-15(22)10-17(12)23)13(8-14)9-16-2-1-3-18(25-16)20(24)26/h1-8,10H,9,11H2,(H2,24,26)
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n/an/an/a 2.63E+3n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx

Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50424388
PNG
(CHEMBL2315051)
Show SMILES CC(C)(C)NC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1
Show InChI InChI=1S/C24H23Cl2FN2O2/c1-24(2,3)29-23(30)21-6-4-5-19(28-21)12-16-11-17(25)9-10-22(16)31-14-15-7-8-18(26)13-20(15)27/h4-11,13H,12,14H2,1-3H3,(H,29,30)
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n/an/an/a 4.36E+3n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx

Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype


(Mus musculus (Mouse))		BDBM50424392
PNG
(CHEMBL2315047)
Show SMILES Fc1cc(Cl)ccc1COc1ccc(Cl)cc1Cc1cccc(n1)C(=O)N1CCCC1
Show InChI InChI=1S/C24H21Cl2FN2O2/c25-18-8-9-23(31-15-16-6-7-19(26)14-21(16)27)17(12-18)13-20-4-3-5-22(28-20)24(30)29-10-1-2-11-29/h3-9,12,14H,1-2,10-11,13,15H2
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n/an/an/a 1.58E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx

Bioorg Med Chem Lett 23: 37-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.11.046
BindingDB Entry DOI: 10.7270/Q2WD41WD
More data for this
Ligand-Target Pair