Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium- and chloride-dependent GABA transporter 1 (Homo sapiens (Human)) | BDBM50039251 ((R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-enyl)pi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a |
Ludwig-Maximilians-Universit£t M£nchen Curated by ChEMBL | Assay Description Competitive inhibition of human GAT1 expressed in COS cells assessed as reduction in [2H6]GABA uptake by measuring [2H6]GABA Kd(app) at 100 nM preinc... | J Med Chem 61: 10310-10332 (2018) Article DOI: 10.1021/acs.jmedchem.8b01602 BindingDB Entry DOI: 10.7270/Q2NS0Z8M | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Homo sapiens (Human)) | BDBM50518146 (CHEMBL4525620) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a |
Ludwig-Maximilians-Universit£t M£nchen Curated by ChEMBL | Assay Description Non-competitive inhibition of human GAT1 expressed in COS cells assessed as reduction in [2H6]GABA uptake by measuring [2H6]GABA Kd(app) at 1 uM prei... | J Med Chem 61: 10310-10332 (2018) Article DOI: 10.1021/acs.jmedchem.8b01602 BindingDB Entry DOI: 10.7270/Q2NS0Z8M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Homo sapiens (Human)) | BDBM50518149 (CHEMBL4537310) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a |
Ludwig-Maximilians-Universit£t M£nchen Curated by ChEMBL | Assay Description Non-competitive inhibition of human GAT1 expressed in COS cells assessed as reduction in [2H6]GABA uptake by measuring [2H6]GABA Kd(app) at 1 uM prei... | J Med Chem 61: 10310-10332 (2018) Article DOI: 10.1021/acs.jmedchem.8b01602 BindingDB Entry DOI: 10.7270/Q2NS0Z8M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Homo sapiens (Human)) | BDBM50518146 (CHEMBL4525620) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 112 | n/a | n/a | n/a | n/a | n/a |
Ludwig-Maximilians-Universit£t M£nchen Curated by ChEMBL | Assay Description Non-competitive inhibition of human GAT1 expressed in COS cells assessed as reduction in [2H6]GABA uptake by measuring [2H6]GABA Kd(app) at 10 uM pre... | J Med Chem 61: 10310-10332 (2018) Article DOI: 10.1021/acs.jmedchem.8b01602 BindingDB Entry DOI: 10.7270/Q2NS0Z8M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Homo sapiens (Human)) | BDBM50039251 ((R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-enyl)pi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | n/a | 147 | n/a | n/a | n/a | n/a | n/a |
Ludwig-Maximilians-Universit£t M£nchen Curated by ChEMBL | Assay Description Competitive inhibition of human GAT1 expressed in COS cells assessed as reduction in [2H6]GABA uptake by measuring [2H6]GABA Kd(app) at 1 uM preincub... | J Med Chem 61: 10310-10332 (2018) Article DOI: 10.1021/acs.jmedchem.8b01602 BindingDB Entry DOI: 10.7270/Q2NS0Z8M | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Homo sapiens (Human)) | BDBM50518149 (CHEMBL4537310) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 154 | n/a | n/a | n/a | n/a | n/a |
Ludwig-Maximilians-Universit£t M£nchen Curated by ChEMBL | Assay Description Non-competitive inhibition of human GAT1 expressed in COS cells assessed as reduction in [2H6]GABA uptake by measuring [2H6]GABA Kd(app) at 10 uM pre... | J Med Chem 61: 10310-10332 (2018) Article DOI: 10.1021/acs.jmedchem.8b01602 BindingDB Entry DOI: 10.7270/Q2NS0Z8M | |||||||||||
More data for this Ligand-Target Pair |