Found 4 hits of kd for UniProtKB: P42226 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Signal transducer and activator of transcription 6
(Homo sapiens (Human)) | BDBM50557878
(CHEMBL4776801)Show SMILES [H][C@]12CC[C@H](N1C(=O)[C@H](CN(CC2)C(=O)CCCCCC#Cc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O)NC(=O)c1cc2cc(ccc2[nH]1)C(=O)P(O)(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c1ccccc1)c1ccccc1 |r| | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | >10 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to human recombinant STAT6 assessed as dissociation constant incubated for 15 mins by biolayer interferometry |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00155
BindingDB Entry DOI: 10.7270/Q20R9T2F |
More data for this
Ligand-Target Pair | |
Signal transducer and activator of transcription 6
(Homo sapiens (Human)) | BDBM50401026
(CHEMBL2204367)Show SMILES CC(C)[C@@H](C)NC(=O)c1cc(cc(n1)C(=O)NCCc1ccccn1)-c1cc2ccccc2n1C |r| Show InChI InChI=1S/C28H31N5O2/c1-18(2)19(3)31-28(35)24-16-21(26-17-20-9-5-6-11-25(20)33(26)4)15-23(32-24)27(34)30-14-12-22-10-7-8-13-29-22/h5-11,13,15-19H,12,14H2,1-4H3,(H,30,34)(H,31,35)/t19-/m1/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 656 | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description
Binding affinity at human recombinant STAT6 by SPR analysis |
Bioorg Med Chem 20: 750-8 (2012)
Article DOI: 10.1016/j.bmc.2011.12.006
BindingDB Entry DOI: 10.7270/Q2FX7BMT |
More data for this
Ligand-Target Pair | |
Signal transducer and activator of transcription 6
(Homo sapiens (Human)) | BDBM50401024
(CHEMBL2204366)Show SMILES CC(C)[C@@H](C)NC(=O)c1cc(cc(n1)C(=O)NCCc1ccccn1)-c1cc2ccccc2s1 |r| Show InChI InChI=1S/C27H28N4O2S/c1-17(2)18(3)30-27(33)23-15-20(25-16-19-8-4-5-10-24(19)34-25)14-22(31-23)26(32)29-13-11-21-9-6-7-12-28-21/h4-10,12,14-18H,11,13H2,1-3H3,(H,29,32)(H,30,33)/t18-/m1/s1 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 701 | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description
Binding affinity at human recombinant STAT6 by SPR analysis |
Bioorg Med Chem 20: 750-8 (2012)
Article DOI: 10.1016/j.bmc.2011.12.006
BindingDB Entry DOI: 10.7270/Q2FX7BMT |
More data for this
Ligand-Target Pair | |
Signal transducer and activator of transcription 6
(Homo sapiens (Human)) | BDBM50401025
(CHEMBL2203687)Show InChI InChI=1S/C18H20N2O2S/c1-20(11-10-13-6-3-2-4-7-13)18(21)15-12-23-17-14(15)8-5-9-16(17)19-22/h2-4,6-7,12,16H,5,8-11H2,1H3 | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 7.40E+4 | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description
Binding affinity at human recombinant STAT6 by SPR analysis |
Bioorg Med Chem 20: 750-8 (2012)
Article DOI: 10.1016/j.bmc.2011.12.006
BindingDB Entry DOI: 10.7270/Q2FX7BMT |
More data for this
Ligand-Target Pair | |
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