Compile Data Set for Download or QSAR

Found 82 hits Enz. Inhib. hit(s) with all data for entry = 10514   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM84747 ((B) ZD6474 | US10155768, Vandetanib | US10183928, ...) Show SMILES CN1CCC(COc2cc3ncnc(Nc4ccc(Br)cc4F)c3cc2C)CC1 Show InChI InChI=1S/C23H25BrFN3O/c1-15-9-19-21(10-17-3-4-18(24)11-20(17)25)26-14-27-22(19)12-23(15)29-13-16-5-7-28(2)8-6-16/h3-4,9,11-12,14,16H,5-8,10,13H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM16673 (4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...) Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank US Patent	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM435017 (US10584114, Compound 142 | US11279688, Compound 14...) Show SMILES CO[C@]1(CC[C@](F)(CC1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1 |r,wU:2.25,26.29,5.5,wD:2.1,(1.11,-1.56,;1.11,-.02,;-.22,.75,;-.99,2.08,;-2.53,2.08,;-3.3,.75,;-4.07,-.59,;-2.53,-.59,;-.99,-.59,;-4.84,.75,;-5.61,2.08,;-7.15,2.08,;-7.92,3.41,;-7.92,.75,;-7.15,-.59,;-7.92,-1.92,;-9.46,-1.92,;-10.37,-.67,;-11.83,-1.15,;-13.08,-.24,;-11.83,-2.69,;-10.37,-3.17,;-5.61,-.59,;1.11,1.52,;1.11,3.06,;2.44,.75,;3.78,1.52,;3.78,3.06,;5.11,.75,;6.44,1.52,;7.78,.75,;7.78,-.79,;6.44,-1.56,;5.11,-.79,;9.11,-1.56,;10.52,-.94,;11.55,-2.08,;13.08,-1.92,;10.78,-3.41,;9.27,-3.09,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM435018 (US10584114, Compound 144 | US11279688, Compound 14...) Show SMILES C[C@H](NC(=O)C1CCC(=CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1 |r,c:8| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM435018 (US10584114, Compound 144 | US11279688, Compound 14...) Show SMILES C[C@H](NC(=O)C1CCC(=CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1 |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM435019 (US10584114, Compound 146 | US11279688, Compound 14...) Show SMILES C[C@H](NC(=O)[C@@H]1CC[C@](O)(CO1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM435019 (US10584114, Compound 146 | US11279688, Compound 14...) Show SMILES C[C@H](NC(=O)[C@@H]1CC[C@](O)(CO1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM435021 (US10584114, Compound 148 | US11279688, Compound 14...) Show SMILES C[C@H](NC(=O)[C@@]1(C)CC[C@@](O)(CO1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM435021 (US10584114, Compound 148 | US11279688, Compound 14...) Show SMILES C[C@H](NC(=O)[C@@]1(C)CC[C@@](O)(CO1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM435023 (US10584114, Compound 150 | US11279688, Compound 15...) Show SMILES CO[C@@]1(CC[C@@H](CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)NCc1cnc(cn1)-n1cc(F)cn1 |r,wU:2.1,5.8,wD:2.24,(1.11,-1.56,;1.11,-.02,;-.22,.75,;-.99,2.08,;-2.53,2.08,;-3.3,.75,;-2.53,-.59,;-.99,-.59,;-4.84,.75,;-5.61,2.08,;-7.15,2.08,;-7.92,3.41,;-7.92,.75,;-7.15,-.59,;-7.92,-1.92,;-9.46,-1.92,;-10.37,-.67,;-11.83,-1.15,;-13.08,-.24,;-11.83,-2.69,;-10.37,-3.17,;-5.61,-.59,;1.11,1.52,;1.11,3.06,;2.44,.75,;3.78,1.52,;5.11,.75,;5.11,-.79,;6.44,-1.56,;7.78,-.79,;7.78,.75,;6.44,1.52,;9.11,-1.56,;10.52,-.94,;11.55,-2.08,;13.08,-1.92,;10.78,-3.41,;9.27,-3.09,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM435023 (US10584114, Compound 150 | US11279688, Compound 15...) Show SMILES CO[C@@]1(CC[C@@H](CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)NCc1cnc(cn1)-n1cc(F)cn1 |r,wU:2.1,5.8,wD:2.24,(1.11,-1.56,;1.11,-.02,;-.22,.75,;-.99,2.08,;-2.53,2.08,;-3.3,.75,;-2.53,-.59,;-.99,-.59,;-4.84,.75,;-5.61,2.08,;-7.15,2.08,;-7.92,3.41,;-7.92,.75,;-7.15,-.59,;-7.92,-1.92,;-9.46,-1.92,;-10.37,-.67,;-11.83,-1.15,;-13.08,-.24,;-11.83,-2.69,;-10.37,-3.17,;-5.61,-.59,;1.11,1.52,;1.11,3.06,;2.44,.75,;3.78,1.52,;5.11,.75,;5.11,-.79,;6.44,-1.56,;7.78,-.79,;7.78,.75,;6.44,1.52,;9.11,-1.56,;10.52,-.94,;11.55,-2.08,;13.08,-1.92,;10.78,-3.41,;9.27,-3.09,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM435024 (US10584114, Compound 151 | US11279688, Compound 15...) Show SMILES CO[C@@]1(CC[C@@H](CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@H](C)c1ccc(nc1)-n1cc(F)cn1 |r,wU:2.1,5.8,wD:2.24,25.28,(1.11,-1.56,;1.11,-.02,;-.22,.75,;-.99,2.08,;-2.53,2.08,;-3.3,.75,;-2.53,-.59,;-.99,-.59,;-4.84,.75,;-5.61,2.08,;-7.15,2.08,;-7.92,3.41,;-7.92,.75,;-7.15,-.59,;-7.92,-1.92,;-9.46,-1.92,;-10.37,-.67,;-11.83,-1.15,;-13.08,-.24,;-11.83,-2.69,;-10.37,-3.17,;-5.61,-.59,;1.11,1.52,;1.11,3.06,;2.44,.75,;3.78,1.52,;3.78,3.06,;5.11,.75,;6.44,1.52,;7.78,.75,;7.78,-.79,;6.44,-1.56,;5.11,-.79,;9.11,-1.56,;10.52,-.94,;11.55,-2.08,;13.08,-1.92,;10.78,-3.41,;9.27,-3.09,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM435024 (US10584114, Compound 151 | US11279688, Compound 15...) Show SMILES CO[C@@]1(CC[C@@H](CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@H](C)c1ccc(nc1)-n1cc(F)cn1 |r,wU:2.1,5.8,wD:2.24,25.28,(1.11,-1.56,;1.11,-.02,;-.22,.75,;-.99,2.08,;-2.53,2.08,;-3.3,.75,;-2.53,-.59,;-.99,-.59,;-4.84,.75,;-5.61,2.08,;-7.15,2.08,;-7.92,3.41,;-7.92,.75,;-7.15,-.59,;-7.92,-1.92,;-9.46,-1.92,;-10.37,-.67,;-11.83,-1.15,;-13.08,-.24,;-11.83,-2.69,;-10.37,-3.17,;-5.61,-.59,;1.11,1.52,;1.11,3.06,;2.44,.75,;3.78,1.52,;3.78,3.06,;5.11,.75,;6.44,1.52,;7.78,.75,;7.78,-.79,;6.44,-1.56,;5.11,-.79,;9.11,-1.56,;10.52,-.94,;11.55,-2.08,;13.08,-1.92,;10.78,-3.41,;9.27,-3.09,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM434989 (US10584114, Compound 101 | US11279688, Compound 10...) Show SMILES Cc1cc(Nc2cc(C)nc(n2)[C@H]2CC[C@@H](CC2)C(=O)NCc2ccc(nc2)-n2cccn2)n[nH]1 |r,wU:12.12,wD:15.19,(-12.54,-.74,;-11.01,-.9,;-9.98,.24,;-8.57,-.39,;-7.24,.38,;-5.9,-.39,;-5.9,-1.93,;-4.57,-2.7,;-4.57,-4.24,;-3.24,-1.93,;-3.24,-.39,;-4.57,.38,;-1.9,.38,;-1.9,1.93,;-.57,2.69,;.77,1.93,;.77,.38,;-.57,-.38,;2.1,2.7,;2.1,4.24,;3.43,1.93,;4.77,2.7,;6.1,1.93,;7.43,2.7,;8.77,1.93,;8.77,.39,;7.43,-.38,;6.1,.39,;10.1,-.38,;11.51,.24,;12.54,-.9,;11.77,-2.24,;10.26,-1.92,;-8.73,-1.92,;-10.24,-2.24,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM434989 (US10584114, Compound 101 | US11279688, Compound 10...) Show SMILES Cc1cc(Nc2cc(C)nc(n2)[C@H]2CC[C@@H](CC2)C(=O)NCc2ccc(nc2)-n2cccn2)n[nH]1 |r,wU:12.12,wD:15.19,(-12.54,-.74,;-11.01,-.9,;-9.98,.24,;-8.57,-.39,;-7.24,.38,;-5.9,-.39,;-5.9,-1.93,;-4.57,-2.7,;-4.57,-4.24,;-3.24,-1.93,;-3.24,-.39,;-4.57,.38,;-1.9,.38,;-1.9,1.93,;-.57,2.69,;.77,1.93,;.77,.38,;-.57,-.38,;2.1,2.7,;2.1,4.24,;3.43,1.93,;4.77,2.7,;6.1,1.93,;7.43,2.7,;8.77,1.93,;8.77,.39,;7.43,-.38,;6.1,.39,;10.1,-.38,;11.51,.24,;12.54,-.9,;11.77,-2.24,;10.26,-1.92,;-8.73,-1.92,;-10.24,-2.24,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM434991 (US10584114, Compound 103 | US11279688, Compound 10...) Show SMILES C[C@H](NC(=O)[C@H]1CC[C@@H](CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cccn1 |r,wU:8.11,1.0,wD:5.4,(4.77,4.24,;4.77,2.7,;3.43,1.93,;2.1,2.7,;2.1,4.24,;.77,1.93,;-.57,2.69,;-1.9,1.93,;-1.9,.38,;-.57,-.38,;.77,.38,;-3.24,-.39,;-3.24,-1.93,;-4.57,-2.7,;-4.57,-4.24,;-5.9,-1.93,;-5.9,-.39,;-7.24,.38,;-8.57,-.39,;-9.98,.24,;-11.01,-.9,;-12.54,-.74,;-10.24,-2.24,;-8.73,-1.92,;-4.57,.38,;6.1,1.93,;6.1,.39,;7.43,-.38,;8.77,.39,;8.77,1.93,;7.43,2.7,;10.1,-.38,;10.26,-1.92,;11.77,-2.24,;12.54,-.9,;11.51,.24,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM434991 (US10584114, Compound 103 | US11279688, Compound 10...) Show SMILES C[C@H](NC(=O)[C@H]1CC[C@@H](CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cccn1 |r,wU:8.11,1.0,wD:5.4,(4.77,4.24,;4.77,2.7,;3.43,1.93,;2.1,2.7,;2.1,4.24,;.77,1.93,;-.57,2.69,;-1.9,1.93,;-1.9,.38,;-.57,-.38,;.77,.38,;-3.24,-.39,;-3.24,-1.93,;-4.57,-2.7,;-4.57,-4.24,;-5.9,-1.93,;-5.9,-.39,;-7.24,.38,;-8.57,-.39,;-9.98,.24,;-11.01,-.9,;-12.54,-.74,;-10.24,-2.24,;-8.73,-1.92,;-4.57,.38,;6.1,1.93,;6.1,.39,;7.43,-.38,;8.77,.39,;8.77,1.93,;7.43,2.7,;10.1,-.38,;10.26,-1.92,;11.77,-2.24,;12.54,-.9,;11.51,.24,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM434994 (US10584114, Compound 106 | US11279688, Compound 10...) Show SMILES Cc1cc(C)n(n1)-c1ccc(CNC(=O)[C@H]2CC[C@@H](CC2)c2nc(C)cc(Nc3cc(C)[nH]n3)n2)cn1 |r,wU:18.22,wD:15.15,(13.3,-.74,;11.77,-.9,;11,-2.24,;9.5,-1.92,;8.35,-2.95,;9.34,-.38,;10.74,.24,;8,.39,;8,1.93,;6.67,2.7,;5.33,1.93,;4,2.7,;2.67,1.93,;1.33,2.7,;1.33,4.24,;,1.93,;-1.33,2.69,;-2.67,1.93,;-2.67,.38,;-1.33,-.38,;,.38,;-4,-.39,;-4,-1.93,;-5.33,-2.7,;-5.33,-4.24,;-6.67,-1.93,;-6.67,-.39,;-8,.38,;-9.34,-.39,;-10.74,.24,;-11.77,-.9,;-13.3,-.74,;-11,-2.24,;-9.5,-1.92,;-5.33,.38,;5.33,.39,;6.67,-.38,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM434995 (US10584114, Compound 107 | US11279688, Compound 10...) Show SMILES C[C@@H]1C[C@](O)(CC[C@@H]1C(=O)NCc1ccc(nc1)-n1cccn1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM434995 (US10584114, Compound 107 | US11279688, Compound 10...) Show SMILES C[C@@H]1C[C@](O)(CC[C@@H]1C(=O)NCc1ccc(nc1)-n1cccn1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM434996 (US10584114, Compound 109 | US11279688, Compound 10...) Show SMILES C[C@H](NC(=O)[C@H]1CC[C@@H](CC1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1 |r,wU:8.11,1.0,wD:5.4,(4,4.24,;4,2.7,;2.67,1.93,;1.33,2.7,;1.33,4.24,;,1.93,;-1.33,2.69,;-2.67,1.93,;-2.67,.38,;-1.33,-.38,;,.38,;-4,-.39,;-4,-1.93,;-5.33,-2.7,;-5.33,-4.24,;-6.67,-1.93,;-6.67,-.39,;-8,.38,;-9.34,-.39,;-10.74,.24,;-11.77,-.9,;-13.3,-.74,;-11,-2.24,;-9.5,-1.92,;-5.33,.38,;5.33,1.93,;5.33,.39,;6.67,-.38,;8,.39,;8,1.93,;6.67,2.7,;9.34,-.38,;10.74,.24,;11.77,-.9,;13.3,-.74,;11,-2.24,;9.5,-1.92,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM434996 (US10584114, Compound 109 | US11279688, Compound 10...) Show SMILES C[C@H](NC(=O)[C@H]1CC[C@@H](CC1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1 |r,wU:8.11,1.0,wD:5.4,(4,4.24,;4,2.7,;2.67,1.93,;1.33,2.7,;1.33,4.24,;,1.93,;-1.33,2.69,;-2.67,1.93,;-2.67,.38,;-1.33,-.38,;,.38,;-4,-.39,;-4,-1.93,;-5.33,-2.7,;-5.33,-4.24,;-6.67,-1.93,;-6.67,-.39,;-8,.38,;-9.34,-.39,;-10.74,.24,;-11.77,-.9,;-13.3,-.74,;-11,-2.24,;-9.5,-1.92,;-5.33,.38,;5.33,1.93,;5.33,.39,;6.67,-.38,;8,.39,;8,1.93,;6.67,2.7,;9.34,-.38,;10.74,.24,;11.77,-.9,;13.3,-.74,;11,-2.24,;9.5,-1.92,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM434998 (US10584114, Compound 111 | US11279688, Compound 11...) Show SMILES C[C@H](NC(=O)[C@H]1CC[C@H](CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1 |r,wU:1.0,wD:8.11,5.4,(4,4.24,;4,2.7,;2.67,1.93,;1.33,2.7,;1.33,4.24,;,1.93,;-1.33,2.69,;-2.67,1.93,;-2.67,.38,;-1.33,-.38,;,.38,;-4,-.39,;-4,-1.93,;-5.33,-2.7,;-5.33,-4.24,;-6.67,-1.93,;-6.67,-.39,;-8,.38,;-9.34,-.39,;-10.74,.24,;-11.77,-.9,;-13.3,-.74,;-11,-2.24,;-9.5,-1.92,;-5.33,.38,;5.33,1.93,;5.33,.39,;6.67,-.38,;8,.39,;8,1.93,;6.67,2.7,;9.34,-.38,;10.74,.24,;11.77,-.9,;13.3,-.74,;11,-2.24,;9.5,-1.92,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM434999 (US10584114, Compound 112 | US11279688, Compound 11...) Show SMILES C[C@H](NC(=O)[C@H]1CC[C@@H](CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1 |r,wU:8.11,1.0,wD:5.4,(4,4.24,;4,2.7,;2.67,1.93,;1.33,2.7,;1.33,4.24,;,1.93,;-1.33,2.69,;-2.67,1.93,;-2.67,.38,;-1.33,-.38,;,.38,;-4,-.39,;-4,-1.93,;-5.33,-2.7,;-5.33,-4.24,;-6.67,-1.93,;-6.67,-.39,;-8,.38,;-9.34,-.39,;-10.74,.24,;-11.77,-.9,;-13.3,-.74,;-11,-2.24,;-9.5,-1.92,;-5.33,.38,;5.33,1.93,;5.33,.39,;6.67,-.38,;8,.39,;8,1.93,;6.67,2.7,;9.34,-.38,;10.74,.24,;11.77,-.9,;13.3,-.74,;11,-2.24,;9.5,-1.92,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM434999 (US10584114, Compound 112 | US11279688, Compound 11...) Show SMILES C[C@H](NC(=O)[C@H]1CC[C@@H](CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1 |r,wU:8.11,1.0,wD:5.4,(4,4.24,;4,2.7,;2.67,1.93,;1.33,2.7,;1.33,4.24,;,1.93,;-1.33,2.69,;-2.67,1.93,;-2.67,.38,;-1.33,-.38,;,.38,;-4,-.39,;-4,-1.93,;-5.33,-2.7,;-5.33,-4.24,;-6.67,-1.93,;-6.67,-.39,;-8,.38,;-9.34,-.39,;-10.74,.24,;-11.77,-.9,;-13.3,-.74,;-11,-2.24,;-9.5,-1.92,;-5.33,.38,;5.33,1.93,;5.33,.39,;6.67,-.38,;8,.39,;8,1.93,;6.67,2.7,;9.34,-.38,;10.74,.24,;11.77,-.9,;13.3,-.74,;11,-2.24,;9.5,-1.92,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM435000 (US10584114, Compound 113 | US11279688, Compound 11...) Show SMILES Cc1cc(Nc2cc(C)nc(n2)[C@H]2CC[C@@H](CC2)C(=O)NCc2ccc(nc2)-n2cc(Cl)cn2)n[nH]1 |r,wU:12.12,wD:15.19,(-13.3,-.74,;-11.77,-.9,;-10.74,.24,;-9.34,-.39,;-8,.38,;-6.67,-.39,;-6.67,-1.93,;-5.33,-2.7,;-5.33,-4.24,;-4,-1.93,;-4,-.39,;-5.33,.38,;-2.67,.38,;-2.67,1.93,;-1.33,2.69,;,1.93,;,.38,;-1.33,-.38,;1.33,2.7,;1.33,4.24,;2.67,1.93,;4,2.7,;5.33,1.93,;6.67,2.7,;8,1.93,;8,.39,;6.67,-.38,;5.33,.39,;9.34,-.38,;10.74,.24,;11.77,-.9,;13.3,-.74,;11,-2.24,;9.5,-1.92,;-9.5,-1.92,;-11,-2.24,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM435000 (US10584114, Compound 113 | US11279688, Compound 11...) Show SMILES Cc1cc(Nc2cc(C)nc(n2)[C@H]2CC[C@@H](CC2)C(=O)NCc2ccc(nc2)-n2cc(Cl)cn2)n[nH]1 |r,wU:12.12,wD:15.19,(-13.3,-.74,;-11.77,-.9,;-10.74,.24,;-9.34,-.39,;-8,.38,;-6.67,-.39,;-6.67,-1.93,;-5.33,-2.7,;-5.33,-4.24,;-4,-1.93,;-4,-.39,;-5.33,.38,;-2.67,.38,;-2.67,1.93,;-1.33,2.69,;,1.93,;,.38,;-1.33,-.38,;1.33,2.7,;1.33,4.24,;2.67,1.93,;4,2.7,;5.33,1.93,;6.67,2.7,;8,1.93,;8,.39,;6.67,-.38,;5.33,.39,;9.34,-.38,;10.74,.24,;11.77,-.9,;13.3,-.74,;11,-2.24,;9.5,-1.92,;-9.5,-1.92,;-11,-2.24,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM435001 (US10584114, Compound 114 | US11279688, Compound 11...) Show SMILES Cc1cc(Nc2cc(C)cc(n2)[C@]2(O)CC[C@@H](C(=O)NCc3ccc(nc3)-n3cccn3)C(C)(C)C2)n[nH]1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM435001 (US10584114, Compound 114 | US11279688, Compound 11...) Show SMILES Cc1cc(Nc2cc(C)cc(n2)[C@]2(O)CC[C@@H](C(=O)NCc3ccc(nc3)-n3cccn3)C(C)(C)C2)n[nH]1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM435004 (US10584114, Compound 120 | US11279688, Compound 12...) Show SMILES C[C@H](NC(=O)[C@H]1CC[C@@](O)(CC1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1 |r,wU:1.0,wD:5.4,8.8,(4,4.24,;4,2.7,;2.66,1.93,;1.33,2.7,;1.33,4.24,;-.01,1.93,;-1.34,2.69,;-2.67,1.93,;-2.67,.38,;-2.67,-1.16,;-1.34,-.38,;-.01,.38,;-4.01,-.39,;-4.01,-1.93,;-5.34,-2.7,;-5.34,-4.24,;-6.67,-1.93,;-6.67,-.39,;-8.01,.38,;-9.34,-.39,;-10.75,.24,;-11.78,-.9,;-13.31,-.74,;-11.01,-2.24,;-9.5,-1.92,;-5.34,.38,;5.33,1.93,;5.33,.39,;6.66,-.38,;8,.39,;8,1.93,;6.66,2.7,;9.33,-.38,;10.64,.43,;11.82,-.56,;13.31,-.18,;11.24,-1.99,;9.7,-1.88,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM435004 (US10584114, Compound 120 | US11279688, Compound 12...) Show SMILES C[C@H](NC(=O)[C@H]1CC[C@@](O)(CC1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1 |r,wU:1.0,wD:5.4,8.8,(4,4.24,;4,2.7,;2.66,1.93,;1.33,2.7,;1.33,4.24,;-.01,1.93,;-1.34,2.69,;-2.67,1.93,;-2.67,.38,;-2.67,-1.16,;-1.34,-.38,;-.01,.38,;-4.01,-.39,;-4.01,-1.93,;-5.34,-2.7,;-5.34,-4.24,;-6.67,-1.93,;-6.67,-.39,;-8.01,.38,;-9.34,-.39,;-10.75,.24,;-11.78,-.9,;-13.31,-.74,;-11.01,-2.24,;-9.5,-1.92,;-5.34,.38,;5.33,1.93,;5.33,.39,;6.66,-.38,;8,.39,;8,1.93,;6.66,2.7,;9.33,-.38,;10.64,.43,;11.82,-.56,;13.31,-.18,;11.24,-1.99,;9.7,-1.88,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM435005 (US10584114, Compound 121 | US11279688, Compound 12...) Show SMILES C[C@H](NC(=O)[C@H]1CC[C@@](F)(CC1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1 |r,wU:1.0,wD:5.4,8.8,(3.99,4.24,;3.99,2.7,;2.66,1.93,;1.33,2.7,;1.33,4.24,;-.01,1.93,;-1.34,2.69,;-2.67,1.93,;-2.67,.38,;-2.67,-1.16,;-1.34,-.38,;-.01,.38,;-4.01,-.39,;-4.01,-1.93,;-5.34,-2.7,;-5.34,-4.24,;-6.68,-1.93,;-6.68,-.39,;-8.01,.38,;-9.34,-.39,;-10.75,.24,;-11.78,-.9,;-13.31,-.74,;-11.01,-2.24,;-9.5,-1.92,;-5.34,.38,;5.33,1.93,;5.33,.39,;6.66,-.38,;7.99,.39,;7.99,1.93,;6.66,2.7,;9.33,-.38,;10.69,.34,;11.8,-.73,;13.31,-.46,;11.12,-2.12,;9.6,-1.9,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM435005 (US10584114, Compound 121 | US11279688, Compound 12...) Show SMILES C[C@H](NC(=O)[C@H]1CC[C@@](F)(CC1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1 |r,wU:1.0,wD:5.4,8.8,(3.99,4.24,;3.99,2.7,;2.66,1.93,;1.33,2.7,;1.33,4.24,;-.01,1.93,;-1.34,2.69,;-2.67,1.93,;-2.67,.38,;-2.67,-1.16,;-1.34,-.38,;-.01,.38,;-4.01,-.39,;-4.01,-1.93,;-5.34,-2.7,;-5.34,-4.24,;-6.68,-1.93,;-6.68,-.39,;-8.01,.38,;-9.34,-.39,;-10.75,.24,;-11.78,-.9,;-13.31,-.74,;-11.01,-2.24,;-9.5,-1.92,;-5.34,.38,;5.33,1.93,;5.33,.39,;6.66,-.38,;7.99,.39,;7.99,1.93,;6.66,2.7,;9.33,-.38,;10.69,.34,;11.8,-.73,;13.31,-.46,;11.12,-2.12,;9.6,-1.9,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM435008 (US10584114, Compound 128 | US11279688, Compound 12...) Show SMILES C[C@H](NC(=O)[C@H]1CC[C@@](O)(C[C@H]1C)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1 |r| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM435008 (US10584114, Compound 128 | US11279688, Compound 12...) Show SMILES C[C@H](NC(=O)[C@H]1CC[C@@](O)(C[C@H]1C)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM435010 (US10584114, Compound 130 | US11279688, Compound 13...) Show SMILES CO[C@@]1(CC[C@@H](CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1 |r,wU:2.1,5.8,25.28,wD:2.24,(1.11,-1.56,;1.11,-.02,;-.22,.75,;-.99,2.08,;-2.53,2.08,;-3.3,.75,;-2.53,-.59,;-.99,-.59,;-4.84,.75,;-5.61,2.08,;-7.15,2.08,;-7.92,3.41,;-7.92,.75,;-7.15,-.59,;-7.92,-1.92,;-9.46,-1.92,;-10.37,-.67,;-11.83,-1.15,;-13.08,-.24,;-11.83,-2.69,;-10.37,-3.17,;-5.61,-.59,;1.11,1.52,;1.11,3.06,;2.44,.75,;3.78,1.52,;3.78,3.06,;5.11,.75,;6.44,1.52,;7.78,.75,;7.78,-.79,;6.44,-1.56,;5.11,-.79,;9.11,-1.56,;10.52,-.94,;11.55,-2.08,;13.08,-1.92,;10.78,-3.41,;9.27,-3.09,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM435010 (US10584114, Compound 130 | US11279688, Compound 13...) Show SMILES CO[C@@]1(CC[C@@H](CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1 |r,wU:2.1,5.8,25.28,wD:2.24,(1.11,-1.56,;1.11,-.02,;-.22,.75,;-.99,2.08,;-2.53,2.08,;-3.3,.75,;-2.53,-.59,;-.99,-.59,;-4.84,.75,;-5.61,2.08,;-7.15,2.08,;-7.92,3.41,;-7.92,.75,;-7.15,-.59,;-7.92,-1.92,;-9.46,-1.92,;-10.37,-.67,;-11.83,-1.15,;-13.08,-.24,;-11.83,-2.69,;-10.37,-3.17,;-5.61,-.59,;1.11,1.52,;1.11,3.06,;2.44,.75,;3.78,1.52,;3.78,3.06,;5.11,.75,;6.44,1.52,;7.78,.75,;7.78,-.79,;6.44,-1.56,;5.11,-.79,;9.11,-1.56,;10.52,-.94,;11.55,-2.08,;13.08,-1.92,;10.78,-3.41,;9.27,-3.09,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM435011 (US10584114, Compound 131 | US11279688, Compound 13...) Show SMILES CO[C@@]1(CC[C@@H](CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@@H](C)c1cnc(cn1)-n1cc(F)cn1 |r,wU:2.1,5.8,25.28,wD:2.24,(1.11,-1.56,;1.11,-.02,;-.22,.75,;-.99,2.08,;-2.53,2.08,;-3.3,.75,;-2.53,-.59,;-.99,-.59,;-4.84,.75,;-5.61,2.08,;-7.15,2.08,;-7.92,3.41,;-7.92,.75,;-7.15,-.59,;-7.92,-1.92,;-9.46,-1.92,;-10.37,-.67,;-11.83,-1.15,;-13.08,-.24,;-11.83,-2.69,;-10.37,-3.17,;-5.61,-.59,;1.11,1.52,;1.11,3.06,;2.44,.75,;3.78,1.52,;3.78,3.06,;5.11,.75,;5.11,-.79,;6.44,-1.56,;7.78,-.79,;7.78,.75,;6.44,1.52,;9.11,-1.56,;10.52,-.94,;11.55,-2.08,;13.08,-1.92,;10.78,-3.41,;9.27,-3.09,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM435011 (US10584114, Compound 131 | US11279688, Compound 13...) Show SMILES CO[C@@]1(CC[C@@H](CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@@H](C)c1cnc(cn1)-n1cc(F)cn1 |r,wU:2.1,5.8,25.28,wD:2.24,(1.11,-1.56,;1.11,-.02,;-.22,.75,;-.99,2.08,;-2.53,2.08,;-3.3,.75,;-2.53,-.59,;-.99,-.59,;-4.84,.75,;-5.61,2.08,;-7.15,2.08,;-7.92,3.41,;-7.92,.75,;-7.15,-.59,;-7.92,-1.92,;-9.46,-1.92,;-10.37,-.67,;-11.83,-1.15,;-13.08,-.24,;-11.83,-2.69,;-10.37,-3.17,;-5.61,-.59,;1.11,1.52,;1.11,3.06,;2.44,.75,;3.78,1.52,;3.78,3.06,;5.11,.75,;5.11,-.79,;6.44,-1.56,;7.78,-.79,;7.78,.75,;6.44,1.52,;9.11,-1.56,;10.52,-.94,;11.55,-2.08,;13.08,-1.92,;10.78,-3.41,;9.27,-3.09,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM435013 (US10584114, Compound 136 | US11279688, Compound 13...) Show SMILES CCO[C@@]1(CC[C@@H](CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1 |r,wU:3.2,6.9,26.29,wD:3.25,(2.44,-2.33,;1.11,-1.56,;1.11,-.02,;-.22,.75,;-.99,2.08,;-2.53,2.08,;-3.3,.75,;-2.53,-.59,;-.99,-.59,;-4.84,.75,;-5.61,2.08,;-7.15,2.08,;-7.92,3.41,;-7.92,.75,;-7.15,-.59,;-7.92,-1.92,;-9.46,-1.92,;-10.37,-.67,;-11.83,-1.15,;-13.08,-.24,;-11.83,-2.69,;-10.37,-3.17,;-5.61,-.59,;1.11,1.52,;1.11,3.06,;2.44,.75,;3.78,1.52,;3.78,3.06,;5.11,.75,;6.44,1.52,;7.78,.75,;7.78,-.79,;6.44,-1.56,;5.11,-.79,;9.11,-1.56,;10.52,-.94,;11.55,-2.08,;13.08,-1.92,;10.78,-3.41,;9.27,-3.09,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM435013 (US10584114, Compound 136 | US11279688, Compound 13...) Show SMILES CCO[C@@]1(CC[C@@H](CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1 |r,wU:3.2,6.9,26.29,wD:3.25,(2.44,-2.33,;1.11,-1.56,;1.11,-.02,;-.22,.75,;-.99,2.08,;-2.53,2.08,;-3.3,.75,;-2.53,-.59,;-.99,-.59,;-4.84,.75,;-5.61,2.08,;-7.15,2.08,;-7.92,3.41,;-7.92,.75,;-7.15,-.59,;-7.92,-1.92,;-9.46,-1.92,;-10.37,-.67,;-11.83,-1.15,;-13.08,-.24,;-11.83,-2.69,;-10.37,-3.17,;-5.61,-.59,;1.11,1.52,;1.11,3.06,;2.44,.75,;3.78,1.52,;3.78,3.06,;5.11,.75,;6.44,1.52,;7.78,.75,;7.78,-.79,;6.44,-1.56,;5.11,-.79,;9.11,-1.56,;10.52,-.94,;11.55,-2.08,;13.08,-1.92,;10.78,-3.41,;9.27,-3.09,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM435015 (US10584114, Compound 138 | US11279688, Compound 13...) Show SMILES CO[C@@]1(CC[C@](O)(CC1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1 |r,wU:2.1,26.29,5.5,wD:2.25,(1.11,-1.56,;1.11,-.02,;-.22,.75,;-.99,2.08,;-2.53,2.08,;-3.3,.75,;-4.07,-.59,;-2.53,-.59,;-.99,-.59,;-4.84,.75,;-5.61,2.08,;-7.15,2.08,;-7.92,3.41,;-7.92,.75,;-7.15,-.59,;-7.92,-1.92,;-9.46,-1.92,;-10.37,-.67,;-11.83,-1.15,;-13.08,-.24,;-11.83,-2.69,;-10.37,-3.17,;-5.61,-.59,;1.11,1.52,;1.11,3.06,;2.44,.75,;3.78,1.52,;3.78,3.06,;5.11,.75,;6.44,1.52,;7.78,.75,;7.78,-.79,;6.44,-1.56,;5.11,-.79,;9.11,-1.56,;10.52,-.94,;11.55,-2.08,;13.08,-1.92,;10.78,-3.41,;9.27,-3.09,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM435015 (US10584114, Compound 138 | US11279688, Compound 13...) Show SMILES CO[C@@]1(CC[C@](O)(CC1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1 |r,wU:2.1,26.29,5.5,wD:2.25,(1.11,-1.56,;1.11,-.02,;-.22,.75,;-.99,2.08,;-2.53,2.08,;-3.3,.75,;-4.07,-.59,;-2.53,-.59,;-.99,-.59,;-4.84,.75,;-5.61,2.08,;-7.15,2.08,;-7.92,3.41,;-7.92,.75,;-7.15,-.59,;-7.92,-1.92,;-9.46,-1.92,;-10.37,-.67,;-11.83,-1.15,;-13.08,-.24,;-11.83,-2.69,;-10.37,-3.17,;-5.61,-.59,;1.11,1.52,;1.11,3.06,;2.44,.75,;3.78,1.52,;3.78,3.06,;5.11,.75,;6.44,1.52,;7.78,.75,;7.78,-.79,;6.44,-1.56,;5.11,-.79,;9.11,-1.56,;10.52,-.94,;11.55,-2.08,;13.08,-1.92,;10.78,-3.41,;9.27,-3.09,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM435017 (US10584114, Compound 142 | US11279688, Compound 14...) Show SMILES CO[C@]1(CC[C@](F)(CC1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1 |r,wU:2.25,26.29,5.5,wD:2.1,(1.11,-1.56,;1.11,-.02,;-.22,.75,;-.99,2.08,;-2.53,2.08,;-3.3,.75,;-4.07,-.59,;-2.53,-.59,;-.99,-.59,;-4.84,.75,;-5.61,2.08,;-7.15,2.08,;-7.92,3.41,;-7.92,.75,;-7.15,-.59,;-7.92,-1.92,;-9.46,-1.92,;-10.37,-.67,;-11.83,-1.15,;-13.08,-.24,;-11.83,-2.69,;-10.37,-3.17,;-5.61,-.59,;1.11,1.52,;1.11,3.06,;2.44,.75,;3.78,1.52,;3.78,3.06,;5.11,.75,;6.44,1.52,;7.78,.75,;7.78,-.79,;6.44,-1.56,;5.11,-.79,;9.11,-1.56,;10.52,-.94,;11.55,-2.08,;13.08,-1.92,;10.78,-3.41,;9.27,-3.09,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50021574 (BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...) Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50363397 (CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...) Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c(F)c2)ccn1 Show InChI InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars	DrugBank US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM50021574 (BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...) Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM50363397 (CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...) Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c(F)c2)ccn1 Show InChI InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Homo sapiens (Human))	BDBM435022 (US10584114, Compound 149 | US11279688, Compound 14...) Show SMILES CO[C@@]1(CC[C@@H](CC1)c1cc(C)nc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1 |r,wU:2.1,5.8,25.28,wD:2.24,(1.11,-1.56,;1.11,-.02,;-.22,.75,;-.99,2.08,;-2.53,2.08,;-3.3,.75,;-2.53,-.59,;-.99,-.59,;-4.84,.75,;-5.61,2.08,;-7.15,2.08,;-7.92,3.41,;-7.92,.75,;-7.15,-.59,;-7.92,-1.92,;-9.46,-1.92,;-10.37,-.67,;-11.83,-1.15,;-13.08,-.24,;-11.83,-2.69,;-10.37,-3.17,;-5.61,-.59,;1.11,1.52,;1.11,3.06,;2.44,.75,;3.78,1.52,;3.78,3.06,;5.11,.75,;6.44,1.52,;7.78,.75,;7.78,-.79,;6.44,-1.56,;5.11,-.79,;9.11,-1.56,;10.52,-.94,;11.55,-2.08,;13.08,-1.92,;10.78,-3.41,;9.27,-3.09,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM435022 (US10584114, Compound 149 | US11279688, Compound 14...) Show SMILES CO[C@@]1(CC[C@@H](CC1)c1cc(C)nc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1 |r,wU:2.1,5.8,25.28,wD:2.24,(1.11,-1.56,;1.11,-.02,;-.22,.75,;-.99,2.08,;-2.53,2.08,;-3.3,.75,;-2.53,-.59,;-.99,-.59,;-4.84,.75,;-5.61,2.08,;-7.15,2.08,;-7.92,3.41,;-7.92,.75,;-7.15,-.59,;-7.92,-1.92,;-9.46,-1.92,;-10.37,-.67,;-11.83,-1.15,;-13.08,-.24,;-11.83,-2.69,;-10.37,-3.17,;-5.61,-.59,;1.11,1.52,;1.11,3.06,;2.44,.75,;3.78,1.52,;3.78,3.06,;5.11,.75,;6.44,1.52,;7.78,.75,;7.78,-.79,;6.44,-1.56,;5.11,-.79,;9.11,-1.56,;10.52,-.94,;11.55,-2.08,;13.08,-1.92,;10.78,-3.41,;9.27,-3.09,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				Citation and Details BindingDB Entry DOI: 10.7270/Q2B56NZ4
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 82 total )  |  Next  |  Last  >>

Jump to: