Compile Data Set for Download or QSAR

Found 162 hits Enz. Inhib. hit(s) with all data for entry = 10622   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475654 (US10851102, Example 47 | US11339160, Ex No. 47) Show SMILES CCc1cc(O)c(F)cc1-c1cc(OC2CCN(CC2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C23H24FN3O3/c1-3-15-9-21(28)19(24)11-18(15)16-10-22(20-12-25-14-27(20)13-16)30-17-5-7-26(8-6-17)23(29)4-2/h4,9-14,17,28H,2-3,5-8H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475620 (US10851102, Example 15 | US11339160, Ex No. 15) Show SMILES C[C@@H]1C[C@@H](CCN1C(=O)C=C)Oc1cc(cn2cncc12)-c1ccc(O)cc1 |r| Show InChI InChI=1S/C22H23N3O3/c1-3-22(27)25-9-8-19(10-15(25)2)28-21-11-17(13-24-14-23-12-20(21)24)16-4-6-18(26)7-5-16/h3-7,11-15,19,26H,1,8-10H2,2H3/t15-,19-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475637 (US10851102, Example 30 | US11339160, Ex No. 30) Show SMILES Oc1ccc(cc1)-c1cc(OC2CCN(CC2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C21H21N3O3/c1-2-21(26)23-9-7-18(8-10-23)27-20-11-16(13-24-14-22-12-19(20)24)15-3-5-17(25)6-4-15/h2-6,11-14,18,25H,1,7-10H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475619 (US10851102, Example 14 | US11339160, Ex No. 14) Show SMILES Oc1ccc(cc1)-c1cc(OC2CCN(CC2(F)F)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C21H19F2N3O3/c1-2-20(28)25-8-7-19(21(22,23)12-25)29-18-9-15(11-26-13-24-10-17(18)26)14-3-5-16(27)6-4-14/h2-6,9-11,13,19,27H,1,7-8,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475635 (US10851102, Example 28 | US11339160, Ex No. 28) Show SMILES CC(C)(Oc1cc(cn2cncc12)-c1ccc(O)cc1)C1CN(C1)C(=O)C=C Show InChI InChI=1S/C22H23N3O3/c1-4-21(27)24-12-17(13-24)22(2,3)28-20-9-16(11-25-14-23-10-19(20)25)15-5-7-18(26)8-6-15/h4-11,14,17,26H,1,12-13H2,2-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475655 (US10851102, Example 48 | US11339160, Ex No. 48) Show SMILES CCc1cc(O)c(F)cc1-c1cc(O[C@H]2C[C@@H]3CC[C@H](C2)N3C(=O)C=C)c2cncn2c1 |r,TLB:22:21:18.17:14.20.15| Show InChI InChI=1S/C25H26FN3O3/c1-3-15-7-23(30)21(26)11-20(15)16-8-24(22-12-27-14-28(22)13-16)32-19-9-17-5-6-18(10-19)29(17)25(31)4-2/h4,7-8,11-14,17-19,30H,2-3,5-6,9-10H2,1H3/t17-,18+,19-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475648 (US10851102, Example 41 | US11339160, Ex No. 41) Show SMILES C[C@H]1CN(CC[C@H]1Oc1cc(cn2cncc12)-c1ccc(O)cc1)C(=O)C=C |r| Show InChI InChI=1S/C22H23N3O3/c1-3-22(27)24-9-8-20(15(2)12-24)28-21-10-17(13-25-14-23-11-19(21)25)16-4-6-18(26)7-5-16/h3-7,10-11,13-15,20,26H,1,8-9,12H2,2H3/t15-,20+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475646 (US10851102, Example 39 | US11339160, Ex No. 39) Show SMILES C[C@H]1C[C@@H](CCN1C(=O)C=C)Oc1cc(cn2cncc12)-c1ccc(O)cc1 |r| Show InChI InChI=1S/C22H23N3O3/c1-3-22(27)25-9-8-19(10-15(25)2)28-21-11-17(13-24-14-23-12-20(21)24)16-4-6-18(26)7-5-16/h3-7,11-15,19,26H,1,8-10H2,2H3/t15-,19+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475613 (US10851102, Example 8 | US11339160, Ex No. 8) Show SMILES Oc1ccc(c(F)c1F)-c1cc(OCC2CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C20H17F2N3O3/c1-2-18(27)24-7-12(8-24)10-28-17-5-13(9-25-11-23-6-15(17)25)14-3-4-16(26)20(22)19(14)21/h2-6,9,11-12,26H,1,7-8,10H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475610 (US10851102, Example 5 | US11339160, Ex No. 5) Show SMILES Oc1ccc(cc1)-c1cc(OCC2CN(C2)C(=O)C=C)c2nncn2c1 Show InChI InChI=1S/C19H18N4O3/c1-2-18(25)22-8-13(9-22)11-26-17-7-15(10-23-12-20-21-19(17)23)14-3-5-16(24)6-4-14/h2-7,10,12-13,24H,1,8-9,11H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475643 (US10851102, Example 36 | US11339160, Ex No. 36) Show SMILES Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C(=O)C=C)c2cncn2c1 |r,TLB:10:11:15.14:18| Show InChI InChI=1S/C23H23N3O3/c1-2-23(28)26-17-5-6-18(26)11-20(10-17)29-22-9-16(13-25-14-24-12-21(22)25)15-3-7-19(27)8-4-15/h2-4,7-9,12-14,17-18,20,27H,1,5-6,10-11H2/t17-,18+,20+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475631 (US10851102, Example 24 | US11339160, Ex No. 24) Show SMILES CCc1cc(O)c(F)cc1-c1cc(OCC2CN(C2)C(=O)\C=C\CN(C)C)c2cncn2c1 Show InChI InChI=1S/C25H29FN4O3/c1-4-18-8-23(31)21(26)10-20(18)19-9-24(22-11-27-16-30(22)14-19)33-15-17-12-29(13-17)25(32)6-5-7-28(2)3/h5-6,8-11,14,16-17,31H,4,7,12-13,15H2,1-3H3/b6-5+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475615 (US10851102, Example 10 | US11339160, Ex No. 10) Show SMILES Oc1ccc(cc1)-c1cc(O[C@H]2C[C@@H]3CC[C@H](C2)N3C(=O)C=C)c2cncn2c1 |r,THB:19:18:15.14:11.17.12| Show InChI InChI=1S/C23H23N3O3/c1-2-23(28)26-17-5-6-18(26)11-20(10-17)29-22-9-16(13-25-14-24-12-21(22)25)15-3-7-19(27)8-4-15/h2-4,7-9,12-14,17-18,20,27H,1,5-6,10-11H2/t17-,18+,20-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475640 (US10851102, Example 33 | US11339160, Ex No. 33) Show SMILES Oc1c(Cl)cc(cc1Cl)-c1cc(OCC2CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C20H17Cl2N3O3/c1-2-19(26)24-7-12(8-24)10-28-18-5-14(9-25-11-23-6-17(18)25)13-3-15(21)20(27)16(22)4-13/h2-6,9,11-12,27H,1,7-8,10H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475638 (US10851102, Example 31 | US11339160, Ex No. 31) Show SMILES Oc1c(F)cc(cc1Cl)-c1cc(OCC2CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C20H17ClFN3O3/c1-2-19(26)24-7-12(8-24)10-28-18-5-14(9-25-11-23-6-17(18)25)13-3-15(21)20(27)16(22)4-13/h2-6,9,11-12,27H,1,7-8,10H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475632 (US10851102, Example 25 | US11339160, Ex No. 25) Show SMILES CCc1cc(O)ccc1-c1cc(OCC2CN(C2)C(=O)\C=C\CN(C)C)c2cncn2c1 Show InChI InChI=1S/C25H30N4O3/c1-4-19-10-21(30)7-8-22(19)20-11-24(23-12-26-17-29(23)15-20)32-16-18-13-28(14-18)25(31)6-5-9-27(2)3/h5-8,10-12,15,17-18,30H,4,9,13-14,16H2,1-3H3/b6-5+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475633 (US10851102, Example 26 | US11339160, Ex No. 26) Show SMILES Oc1ccc(cc1)-c1cc(OC[C@H]2CCN(C2)C(=O)C=C)c2cncn2c1 |r| Show InChI InChI=1S/C21H21N3O3/c1-2-21(26)23-8-7-15(11-23)13-27-20-9-17(12-24-14-22-10-19(20)24)16-3-5-18(25)6-4-16/h2-6,9-10,12,14-15,25H,1,7-8,11,13H2/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475634 (US10851102, Example 27 | US11339160, Ex No. 27) Show SMILES Oc1ccc(cc1)-c1cc(O[C@H]2CCCN(C2)C(=O)C=C)c2cncn2c1 |r| Show InChI InChI=1S/C21H21N3O3/c1-2-21(26)23-9-3-4-18(13-23)27-20-10-16(12-24-14-22-11-19(20)24)15-5-7-17(25)8-6-15/h2,5-8,10-12,14,18,25H,1,3-4,9,13H2/t18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475636 (US10851102, Example 29 | US11339160, Ex No. 29) Show SMILES Oc1ccc(cc1)-c1cc(SCC2CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C20H19N3O2S/c1-2-20(25)22-9-14(10-22)12-26-19-7-16(11-23-13-21-8-18(19)23)15-3-5-17(24)6-4-15/h2-8,11,13-14,24H,1,9-10,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475639 (US10851102, Example 32 | US11339160, Ex No. 32) Show SMILES Oc1c(F)cc(cc1F)-c1cc(OCC2CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C20H17F2N3O3/c1-2-19(26)24-7-12(8-24)10-28-18-5-14(9-25-11-23-6-17(18)25)13-3-15(21)20(27)16(22)4-13/h2-6,9,11-12,27H,1,7-8,10H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475641 (US10851102, Example 34 | US11339160, Ex No. 34) Show SMILES Cc1cc(ccc1O)-c1cc(OCC2CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C21H21N3O3/c1-3-21(26)23-9-15(10-23)12-27-20-7-17(11-24-13-22-8-18(20)24)16-4-5-19(25)14(2)6-16/h3-8,11,13,15,25H,1,9-10,12H2,2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475642 (US10851102, Example 35 | US11339160, Ex No. 35) Show SMILES Cc1cc(cc(C)c1O)-c1cc(OCC2CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C22H23N3O3/c1-4-21(26)24-9-16(10-24)12-28-20-7-18(11-25-13-23-8-19(20)25)17-5-14(2)22(27)15(3)6-17/h4-8,11,13,16,27H,1,9-10,12H2,2-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475644 (US10851102, Example 37 | US11339160, Ex No. 37) Show SMILES Oc1ccc(cc1)-c1cc(OC2CC3(C2)CN(C3)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C22H21N3O3/c1-2-21(27)25-12-22(13-25)8-18(9-22)28-20-7-16(11-24-14-23-10-19(20)24)15-3-5-17(26)6-4-15/h2-7,10-11,14,18,26H,1,8-9,12-13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475645 (US10851102, Example 38 | US11339160, Ex No. 38) Show SMILES C[C@H]1C[C@H](CCN1C(=O)C=C)Oc1cc(cn2cncc12)-c1ccc(O)cc1 |r| Show InChI InChI=1S/C22H23N3O3/c1-3-22(27)25-9-8-19(10-15(25)2)28-21-11-17(13-24-14-23-12-20(21)24)16-4-6-18(26)7-5-16/h3-7,11-15,19,26H,1,8-10H2,2H3/t15-,19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475649 (US10851102, Example 42 | US11339160, Ex No. 42) Show SMILES Oc1ccc(-c2cc(OCC3CN(C3)C(=O)C=C)c3cncn3c2)c(c1)C(F)(F)F Show InChI InChI=1S/C21H18F3N3O3/c1-2-20(29)26-8-13(9-26)11-30-19-5-14(10-27-12-25-7-18(19)27)16-4-3-15(28)6-17(16)21(22,23)24/h2-7,10,12-13,28H,1,8-9,11H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475650 (US10851102, Example 43 | US11339160, Ex No. 43) Show SMILES Cc1cc(c(C)cc1O)-c1cc(OCC2CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C22H23N3O3/c1-4-22(27)24-9-16(10-24)12-28-21-7-17(11-25-13-23-8-19(21)25)18-5-15(3)20(26)6-14(18)2/h4-8,11,13,16,26H,1,9-10,12H2,2-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475651 (US10851102, Example 44 | US11339160, Ex No. 44) Show SMILES Cc1cc(O)ccc1-c1cc(OCC2CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C21H21N3O3/c1-3-21(26)23-9-15(10-23)12-27-20-7-16(11-24-13-22-8-19(20)24)18-5-4-17(25)6-14(18)2/h3-8,11,13,15,25H,1,9-10,12H2,2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475652 (US10851102, Example 45 | US11339160, Ex No. 45) Show SMILES COc1cc(O)ccc1-c1cc(OCC2CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C21H21N3O4/c1-3-21(26)23-9-14(10-23)12-28-20-6-15(11-24-13-22-8-18(20)24)17-5-4-16(25)7-19(17)27-2/h3-8,11,13-14,25H,1,9-10,12H2,2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475653 (US10851102, Example 46 | US11339160, Ex No. 46) Show SMILES CCc1cc(O)c(F)cc1-c1cc(OC2CCC22CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C24H24FN3O3/c1-3-15-7-20(29)18(25)9-17(15)16-8-21(19-10-26-14-27(19)11-16)31-22-5-6-24(22)12-28(13-24)23(30)4-2/h4,7-11,14,22,29H,2-3,5-6,12-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475630 (US10851102, Example 23 | US11339160, Ex No. 23) Show SMILES CN(C)C\C=C\C(=O)N1CC(COc2cc(cn3cncc23)-c2ccc(O)c(Cl)c2)C1 Show InChI InChI=1S/C23H25ClN4O3/c1-26(2)7-3-4-23(30)27-11-16(12-27)14-31-22-9-18(13-28-15-25-10-20(22)28)17-5-6-21(29)19(24)8-17/h3-6,8-10,13,15-16,29H,7,11-12,14H2,1-2H3/b4-3+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475629 (US10851102, Example 22 | US11339160, Ex No. 22) Show SMILES CN(C)C\C=C\C(=O)N1CC(COc2cc(cn3cncc23)-c2ccc(O)c(F)c2)C1 Show InChI InChI=1S/C23H25FN4O3/c1-26(2)7-3-4-23(30)27-11-16(12-27)14-31-22-9-18(13-28-15-25-10-20(22)28)17-5-6-21(29)19(24)8-17/h3-6,8-10,13,15-16,29H,7,11-12,14H2,1-2H3/b4-3+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475628 (US10851102, Example 21 | US11339160, Ex No. 21) Show SMILES CCc1cc(O)ccc1-c1cc(OCC2CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C22H23N3O3/c1-3-16-7-18(26)5-6-19(16)17-8-21(20-9-23-14-25(20)12-17)28-13-15-10-24(11-15)22(27)4-2/h4-9,12,14-15,26H,2-3,10-11,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475627 (US10851102, Example 20 | US11339160, Ex No. 20) Show SMILES Oc1ccc(cc1F)-c1cc(OCC2CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C20H18FN3O3/c1-2-20(26)23-8-13(9-23)11-27-19-6-15(10-24-12-22-7-17(19)24)14-3-4-18(25)16(21)5-14/h2-7,10,12-13,25H,1,8-9,11H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475626 (US10851102, Example 19 | US11339160, Ex No. 19) Show SMILES CN(C)C\C=C\C(=O)N1CC(COc2cc(cn3cncc23)-c2ccc(O)cc2)C1 Show InChI InChI=1S/C23H26N4O3/c1-25(2)9-3-4-23(29)26-12-17(13-26)15-30-22-10-19(14-27-16-24-11-21(22)27)18-5-7-20(28)8-6-18/h3-8,10-11,14,16-17,28H,9,12-13,15H2,1-2H3/b4-3+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475625 (US10851102, Example 18 | US11339160, Ex No. 18) Show SMILES CCc1cc(O)c(F)cc1-c1cc(O[C@H]2CCCN(C2)C(=O)\C=C\CN(C)C)c2cncn2c1 |r| Show InChI InChI=1S/C26H31FN4O3/c1-4-18-11-24(32)22(27)13-21(18)19-12-25(23-14-28-17-31(23)15-19)34-20-7-5-10-30(16-20)26(33)8-6-9-29(2)3/h6,8,11-15,17,20,32H,4-5,7,9-10,16H2,1-3H3/b8-6+/t20-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475623 (US10851102, Example 16 | US11339160, Ex No. 16) Show SMILES CCc1cc(O)c(F)cc1-c1cc(O[C@H]2CCCN(C2)C(=O)C=C)c2cncn2c1 |r| Show InChI InChI=1S/C23H24FN3O3/c1-3-15-8-21(28)19(24)10-18(15)16-9-22(20-11-25-14-27(20)12-16)30-17-6-5-7-26(13-17)23(29)4-2/h4,8-12,14,17,28H,2-3,5-7,13H2,1H3/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475618 (US10851102, Example 13 | US11339160, Ex No. 13) Show SMILES CCc1cc(O)c(F)cc1-c1cc(OCC2CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C22H22FN3O3/c1-3-15-5-20(27)18(23)7-17(15)16-6-21(19-8-24-13-26(19)11-16)29-12-14-9-25(10-14)22(28)4-2/h4-8,11,13-14,27H,2-3,9-10,12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475617 (US10851102, Example 12 | US11339160, Ex No. 12) Show SMILES Oc1ccc(cc1Cl)-c1cc(OCC2CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C20H18ClN3O3/c1-2-20(26)23-8-13(9-23)11-27-19-6-15(10-24-12-22-7-17(19)24)14-3-4-18(25)16(21)5-14/h2-7,10,12-13,25H,1,8-9,11H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475616 (US10851102, Example 11 | US11339160, Ex No. 11) Show SMILES Oc1ccc(cc1)-c1cc(OCC2CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C20H19N3O3/c1-2-20(25)22-9-14(10-22)12-26-19-7-16(11-23-13-21-8-18(19)23)15-3-5-17(24)6-4-15/h2-8,11,13-14,24H,1,9-10,12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475614 (US10851102, Example 9 | US11339160, Ex No. 9) Show SMILES COc1cc(cc(Cl)c1O)-c1cc(OCC2CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C21H20ClN3O4/c1-3-20(26)24-8-13(9-24)11-29-18-6-15(10-25-12-23-7-17(18)25)14-4-16(22)21(27)19(5-14)28-2/h3-7,10,12-13,27H,1,8-9,11H2,2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475612 (US10851102, Example 7 | US11339160, Ex No. 7) Show SMILES Oc1cc(F)c(c(F)c1)-c1cc(OCC2CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C20H17F2N3O3/c1-2-19(27)24-7-12(8-24)10-28-18-3-13(9-25-11-23-6-17(18)25)20-15(21)4-14(26)5-16(20)22/h2-6,9,11-12,26H,1,7-8,10H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475611 (US10851102, Example 6 | US11339160, Ex No. 6) Show SMILES Oc1ccc(cc1)-c1cn2cncc2c(OCC2CN(C2)C(=O)C=C)n1 Show InChI InChI=1S/C19H18N4O3/c1-2-18(25)22-8-13(9-22)11-26-19-17-7-20-12-23(17)10-16(21-19)14-3-5-15(24)6-4-14/h2-7,10,12-13,24H,1,8-9,11H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475608 (US10851102, Example 3 | US11339160, Ex No. 3) Show SMILES Oc1ccc(cc1)-c1cc(OC2CCC22CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C22H21N3O3/c1-2-21(27)25-12-22(13-25)8-7-20(22)28-19-9-16(11-24-14-23-10-18(19)24)15-3-5-17(26)6-4-15/h2-6,9-11,14,20,26H,1,7-8,12-13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475605 (US10851102, Example 1 | US11339160, Ex No. 1) Show SMILES Oc1ccc(cc1)-c1cc(O[C@H]2CCN(C2)C(=O)C=C)c2cncn2c1 |r| Show InChI InChI=1S/C20H19N3O3/c1-2-20(25)22-8-7-17(12-22)26-19-9-15(11-23-13-21-10-18(19)23)14-3-5-16(24)6-4-14/h2-6,9-11,13,17,24H,1,7-8,12H2/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475606 (US10851102, Example 2 | US11339160, Ex No. 2) Show SMILES Oc1ccc(cc1)-c1cc(OCC2CCN(CC2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C22H23N3O3/c1-2-22(27)24-9-7-16(8-10-24)14-28-21-11-18(13-25-15-23-12-20(21)25)17-3-5-19(26)6-4-17/h2-6,11-13,15-16,26H,1,7-10,14H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475609 (US10851102, Example 4 | US11339160, Ex No. 4) Show SMILES Oc1ccc(cc1)-c1cc(NC2CCN(CC2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C21H22N4O2/c1-2-21(27)24-9-7-17(8-10-24)23-19-11-16(13-25-14-22-12-20(19)25)15-3-5-18(26)6-4-15/h2-6,11-14,17,23,26H,1,7-10H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM555155 (US11339160, Ex No. 17) Show SMILES CN(C1CCN(CC1)C(=O)C=C)c1cc(cn2cncc12)-c1ccc(O)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475647 (US10851102, Example 40 | US11339160, Ex No. 40) Show SMILES C[C@H]1C[C@H](C[C@@H](C)N1C(=O)C=C)Oc1cc(cn2cncc12)-c1ccc(O)cc1 |r| Show InChI InChI=1S/C23H25N3O3/c1-4-23(28)26-15(2)9-20(10-16(26)3)29-22-11-18(13-25-14-24-12-21(22)25)17-5-7-19(27)8-6-17/h4-8,11-16,20,27H,1,9-10H2,2-3H3/t15-,16+,20+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475657 (US10851102, Example 50 | US11339160, Ex No. 50) Show SMILES Oc1ccc(cc1)-c1cc(N[C@H]2C[C@@H]3CC[C@H](C2)N3C(=O)C=C)c2cncn2c1 |r,TLB:19:18:14.15:17.11.12| Show InChI InChI=1S/C23H24N4O2/c1-2-23(29)27-18-5-6-19(27)11-17(10-18)25-21-9-16(13-26-14-24-12-22(21)26)15-3-7-20(28)8-4-15/h2-4,7-9,12-14,17-19,25,28H,1,5-6,10-11H2/t17-,18-,19+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM475658 (US10851102, Example 51 | US11339160, Ex No. 51) Show SMILES Oc1ccc(cc1)-c1cc(N[C@H]2CCCN(C2)C(=O)C=C)c2cncn2c1 |r| Show InChI InChI=1S/C21H22N4O2/c1-2-21(27)24-9-3-4-17(13-24)23-19-10-16(12-25-14-22-11-20(19)25)15-5-7-18(26)8-6-15/h2,5-8,10-12,14,17,23,26H,1,3-4,9,13H2/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CF9T9W
					More data for this Ligand-Target Pair

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