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Compile Data Set for Download or QSAR

Found 605 hits Enz. Inhib. hit(s) with all data for entry = 10679   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404662
PNG
(US10344025, Example 1 | US11370786, Example 1)
Show SMILES FC(F)(F)Oc1cccc(CC(=O)Nc2nnc(CCCCn3cc(nn3)C(=O)NCc3cccnc3)s2)c1
Show InChI InChI=1S/C24H23F3N8O3S/c25-24(26,27)38-18-7-3-5-16(11-18)12-20(36)30-23-33-32-21(39-23)8-1-2-10-35-15-19(31-34-35)22(37)29-14-17-6-4-9-28-13-17/h3-7,9,11,13,15H,1-2,8,10,12,14H2,(H,29,37)(H,30,33,36)
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TBA

Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404663
PNG
(US10344025, Example 2 | US11370786, Example 2)
Show SMILES CNC(=O)c1cn(CCCCc2nnc(NC(=O)Cc3cccc(OC(F)(F)F)c3)s2)nn1
Show InChI InChI=1S/C19H20F3N7O3S/c1-23-17(31)14-11-29(28-25-14)8-3-2-7-16-26-27-18(33-16)24-15(30)10-12-5-4-6-13(9-12)32-19(20,21)22/h4-6,9,11H,2-3,7-8,10H2,1H3,(H,23,31)(H,24,27,30)
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TBA

Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404666
PNG
(US10344025, Example 5 | US11370786, Example 5)
Show SMILES O=C(Cc1ccccc1)Nc1ccc(CCCCn2cc(nn2)C(=O)NCc2ccccc2)nn1
Show InChI InChI=1S/C26H27N7O2/c34-25(17-20-9-3-1-4-10-20)28-24-15-14-22(29-31-24)13-7-8-16-33-19-23(30-32-33)26(35)27-18-21-11-5-2-6-12-21/h1-6,9-12,14-15,19H,7-8,13,16-18H2,(H,27,35)(H,28,31,34)
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TBA

Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404667
PNG
(US10344025, Example 6 | US11370786, Example 6)
Show SMILES COCCNC(=O)c1nnc(CCCCc2ccc(NC(=O)Cc3cccc(OC(F)(F)F)c3)nn2)s1
Show InChI InChI=1S/C23H25F3N6O4S/c1-35-12-11-27-21(34)22-32-31-20(37-22)8-3-2-6-16-9-10-18(30-29-16)28-19(33)14-15-5-4-7-17(13-15)36-23(24,25)26/h4-5,7,9-10,13H,2-3,6,8,11-12,14H2,1H3,(H,27,34)(H,28,30,33)
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Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404672
PNG
(N-(cyclopropylmethyl)-1-[4- (5-{2-[3-(trifluoromet...)
Show SMILES FC(F)(F)Oc1cccc(CC(=O)Nc2nnc(CCCCn3cc(nn3)C(=O)NCC3CC3)s2)c1
Show InChI InChI=1S/C22H24F3N7O3S/c23-22(24,25)35-16-5-3-4-15(10-16)11-18(33)27-21-30-29-19(36-21)6-1-2-9-32-13-17(28-31-32)20(34)26-12-14-7-8-14/h3-5,10,13-14H,1-2,6-9,11-12H2,(H,26,34)(H,27,30,33)
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TBA

Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404673
PNG
(N-(oxolan-3-ylmethyl)-1-[4- (5-{2-[3-(trifluoromet...)
Show SMILES FC(F)(F)Oc1cccc(CC(=O)Nc2nnc(CCCCn3cc(nn3)C(=O)NCC3CCOC3)s2)c1
Show InChI InChI=1S/C23H26F3N7O4S/c24-23(25,26)37-17-5-3-4-15(10-17)11-19(34)28-22-31-30-20(38-22)6-1-2-8-33-13-18(29-32-33)21(35)27-12-16-7-9-36-14-16/h3-5,10,13,16H,1-2,6-9,11-12,14H2,(H,27,35)(H,28,31,34)
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Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404674
PNG
(1-{4-[5-(2-phenylacetamido)- 1,3,4-thiadiazol-2-yl...)
Show SMILES O=C(Cc1ccccc1)Nc1nnc(CCCCn2cc(nn2)C(=O)NCCc2ccccc2)s1
Show InChI InChI=1S/C25H27N7O2S/c33-22(17-20-11-5-2-6-12-20)27-25-30-29-23(35-25)13-7-8-16-32-18-21(28-31-32)24(34)26-15-14-19-9-3-1-4-10-19/h1-6,9-12,18H,7-8,13-17H2,(H,26,34)(H,27,30,33)
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Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404676
PNG
(N-benzyl-1-{4-[5-(2- phenylacetamido)-1,3,4- thiad...)
Show SMILES O=C(Cc1ccccc1)Nc1nnc(CCCCn2cc(nn2)C(=O)NCc2ccccc2)s1
Show InChI InChI=1S/C24H25N7O2S/c32-21(15-18-9-3-1-4-10-18)26-24-29-28-22(34-24)13-7-8-14-31-17-20(27-30-31)23(33)25-16-19-11-5-2-6-12-19/h1-6,9-12,17H,7-8,13-16H2,(H,25,33)(H,26,29,32)
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Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404677
PNG
(N-benzyl-[4-(5-{2-[3- (trifluoromethoxy)phenyl] ac...)
Show SMILES FC(F)(F)Oc1cccc(CC(=O)Nc2nnc(CCCCn3cc(nn3)C(=O)NCc3ccccc3)s2)c1
Show InChI InChI=1S/C25H24F3N7O3S/c26-25(27,28)38-19-10-6-9-18(13-19)14-21(36)30-24-33-32-22(39-24)11-4-5-12-35-16-20(31-34-35)23(37)29-15-17-7-2-1-3-8-17/h1-3,6-10,13,16H,4-5,11-12,14-15H2,(H,29,37)(H,30,33,36)
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TBA

Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404680
PNG
(N-(pyridin-2-ylmethyl)-1-[4- (5-{2-[3-(trifluorome...)
Show SMILES FC(F)(F)Oc1cccc(CC(=O)Nc2nnc(CCCCn3cc(nn3)C(=O)NCc3ccccn3)s2)c1
Show InChI InChI=1S/C24H23F3N8O3S/c25-24(26,27)38-18-8-5-6-16(12-18)13-20(36)30-23-33-32-21(39-23)9-2-4-11-35-15-19(31-34-35)22(37)29-14-17-7-1-3-10-28-17/h1,3,5-8,10,12,15H,2,4,9,11,13-14H2,(H,29,37)(H,30,33,36)
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Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404681
PNG
(1-[4-(5-{2-[3- (trifluoromethoxy)phenyl] acetamido...)
Show SMILES FC(F)(F)Oc1cccc(CNC(=O)c2cn(CCCCc3nnc(NC(=O)Cc4cccc(OC(F)(F)F)c4)s3)nn2)c1
Show InChI InChI=1S/C26H23F6N7O4S/c27-25(28,29)42-18-7-3-5-16(11-18)13-21(40)34-24-37-36-22(44-24)9-1-2-10-39-15-20(35-38-39)23(41)33-14-17-6-4-8-19(12-17)43-26(30,31)32/h3-8,11-12,15H,1-2,9-10,13-14H2,(H,33,41)(H,34,37,40)
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Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404682
PNG
(N-[(1R)-2-hydroxy-1- phenylethyl]-1- [4-(5-{2-[3- ...)
Show SMILES OC[C@H](NC(=O)c1cn(CCCCc2nnc(NC(=O)Cc3cccc(OC(F)(F)F)c3)s2)nn1)c1ccccc1 |r|
Show InChI InChI=1S/C26H26F3N7O4S/c27-26(28,29)40-19-10-6-7-17(13-19)14-22(38)31-25-34-33-23(41-25)11-4-5-12-36-15-20(32-35-36)24(39)30-21(16-37)18-8-2-1-3-9-18/h1-3,6-10,13,15,21,37H,4-5,11-12,14,16H2,(H,30,39)(H,31,34,38)/t21-/m0/s1
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Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404683
PNG
(N-[(2,4-dimethoxyphenyl) methyl]-1-[4-(5-{2-[3- (t...)
Show SMILES COc1ccc(CNC(=O)c2cn(CCCCc3nnc(NC(=O)Cc4cccc(OC(F)(F)F)c4)s3)nn2)c(OC)c1
Show InChI InChI=1S/C27H28F3N7O5S/c1-40-19-10-9-18(22(14-19)41-2)15-31-25(39)21-16-37(36-33-21)11-4-3-8-24-34-35-26(43-24)32-23(38)13-17-6-5-7-20(12-17)42-27(28,29)30/h5-7,9-10,12,14,16H,3-4,8,11,13,15H2,1-2H3,(H,31,39)(H,32,35,38)
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Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404684
PNG
(N-[(1S)-2-hydroxy-1- phenylethyl]-1-[4-(5-{2-[3- (...)
Show SMILES OC[C@@H](NC(=O)c1cn(CCCCc2nnc(NC(=O)Cc3cccc(OC(F)(F)F)c3)s2)nn1)c1ccccc1 |r|
Show InChI InChI=1S/C26H26F3N7O4S/c27-26(28,29)40-19-10-6-7-17(13-19)14-22(38)31-25-34-33-23(41-25)11-4-5-12-36-15-20(32-35-36)24(39)30-21(16-37)18-8-2-1-3-9-18/h1-3,6-10,13,15,21,37H,4-5,11-12,14,16H2,(H,30,39)(H,31,34,38)/t21-/m1/s1
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Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404685
PNG
(N-(2-methylpropyl)-1-{4-[6-(2- phenylacetamido)pyr...)
Show SMILES CC(C)CNC(=O)c1cn(CCCCc2ccc(NC(=O)Cc3ccccc3)nn2)nn1
Show InChI InChI=1S/C23H29N7O2/c1-17(2)15-24-23(32)20-16-30(29-27-20)13-7-6-10-19-11-12-21(28-26-19)25-22(31)14-18-8-4-3-5-9-18/h3-5,8-9,11-12,16-17H,6-7,10,13-15H2,1-2H3,(H,24,32)(H,25,28,31)
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Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404686
PNG
(5-(4-{6-[(2S)-2-hydroxy-2- phenylacetamido]pyridaz...)
Show SMILES O[C@H](C(=O)Nc1ccc(CCCCc2nnc(s2)C(=O)NCCc2ccccc2)nn1)c1ccccc1 |r|
Show InChI InChI=1S/C27H28N6O3S/c34-24(20-11-5-2-6-12-20)25(35)29-22-16-15-21(30-31-22)13-7-8-14-23-32-33-27(37-23)26(36)28-18-17-19-9-3-1-4-10-19/h1-6,9-12,15-16,24,34H,7-8,13-14,17-18H2,(H,28,36)(H,29,31,35)/t24-/m0/s1
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Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404687
PNG
(5-{4-[6-(2-phenylacetamido) pyridazin-3-yl]butyl}-...)
Show SMILES O=C(Cc1ccccc1)Nc1ccc(CCCCc2nnc(s2)C(=O)NCCc2ccccc2)nn1
Show InChI InChI=1S/C27H28N6O2S/c34-24(19-21-11-5-2-6-12-21)29-23-16-15-22(30-31-23)13-7-8-14-25-32-33-27(36-25)26(35)28-18-17-20-9-3-1-4-10-20/h1-6,9-12,15-16H,7-8,13-14,17-19H2,(H,28,35)(H,29,31,34)
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Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404688
PNG
(N-(2-phenylethyl)-5-(4-{6- [2-(pyridin-3-yl)acetam...)
Show SMILES O=C(Cc1cccnc1)Nc1ccc(CCCCc2nnc(s2)C(=O)NCCc2ccccc2)nn1
Show InChI InChI=1S/C26H27N7O2S/c34-23(17-20-9-6-15-27-18-20)29-22-13-12-21(30-31-22)10-4-5-11-24-32-33-26(36-24)25(35)28-16-14-19-7-2-1-3-8-19/h1-3,6-9,12-13,15,18H,4-5,10-11,14,16-17H2,(H,28,35)(H,29,31,34)
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Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404689
PNG
(N-benzyl-5-{4-[6-(2- phenylacetamido)pyridazin-3- ...)
Show SMILES O=C(Cc1ccccc1)Nc1ccc(CCCCc2nnc(s2)C(=O)NCc2ccccc2)nn1
Show InChI InChI=1S/C26H26N6O2S/c33-23(17-19-9-3-1-4-10-19)28-22-16-15-21(29-30-22)13-7-8-14-24-31-32-26(35-24)25(34)27-18-20-11-5-2-6-12-20/h1-6,9-12,15-16H,7-8,13-14,17-18H2,(H,27,34)(H,28,30,33)
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Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404690
PNG
(N-benzyl-5-(4-{6-[(2S)-2- hydroxy-2-phenylacetamid...)
Show SMILES O[C@H](C(=O)Nc1ccc(CCCCc2nnc(s2)C(=O)NCc2ccccc2)nn1)c1ccccc1 |r|
Show InChI InChI=1S/C26H26N6O3S/c33-23(19-11-5-2-6-12-19)24(34)28-21-16-15-20(29-30-21)13-7-8-14-22-31-32-26(36-22)25(35)27-17-18-9-3-1-4-10-18/h1-6,9-12,15-16,23,33H,7-8,13-14,17H2,(H,27,35)(H,28,30,34)/t23-/m0/s1
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Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404691
PNG
(N-benzyl-5-(4-{6-[2-(pyridin-3- yl)acetamido]pyrid...)
Show SMILES O=C(Cc1cccnc1)Nc1ccc(CCCCc2nnc(s2)C(=O)NCc2ccccc2)nn1
Show InChI InChI=1S/C25H25N7O2S/c33-22(15-19-9-6-14-26-16-19)28-21-13-12-20(29-30-21)10-4-5-11-23-31-32-25(35-23)24(34)27-17-18-7-2-1-3-8-18/h1-3,6-9,12-14,16H,4-5,10-11,15,17H2,(H,27,34)(H,28,30,33)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404692
PNG
(N-(2-methylpropyl)-5-[4-(6- {2-[3-(trifluoromethox...)
Show SMILES CC(C)CNC(=O)c1nnc(CCCCc2ccc(NC(=O)Cc3cccc(OC(F)(F)F)c3)nn2)s1
Show InChI InChI=1S/C24H27F3N6O3S/c1-15(2)14-28-22(35)23-33-32-21(37-23)9-4-3-7-17-10-11-19(31-30-17)29-20(34)13-16-6-5-8-18(12-16)36-24(25,26)27/h5-6,8,10-12,15H,3-4,7,9,13-14H2,1-2H3,(H,28,35)(H,29,31,34)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404693
PNG
(N-(pyridin-2-ylmethyl)-5-[4-(6- {2-[3-(trifluorome...)
Show SMILES FC(F)(F)Oc1cccc(CC(=O)Nc2ccc(CCCCc3nnc(s3)C(=O)NCc3ccccn3)nn2)c1
Show InChI InChI=1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)32-21-12-11-18(33-34-21)7-1-2-10-23-35-36-25(40-23)24(38)31-16-19-8-3-4-13-30-19/h3-6,8-9,11-14H,1-2,7,10,15-16H2,(H,31,38)(H,32,34,37)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404694
PNG
(N-(oxetan-3-ylmethyl)-5-[4-(6- {2-[3-(trifluoromet...)
Show SMILES FC(F)(F)Oc1cccc(CC(=O)Nc2ccc(CCCCc3nnc(s3)C(=O)NCC3COC3)nn2)c1
Show InChI InChI=1S/C24H25F3N6O4S/c25-24(26,27)37-18-6-3-4-15(10-18)11-20(34)29-19-9-8-17(30-31-19)5-1-2-7-21-32-33-23(38-21)22(35)28-12-16-13-36-14-16/h3-4,6,8-10,16H,1-2,5,7,11-14H2,(H,28,35)(H,29,31,34)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404695
PNG
(N-(2-hydroxy-2-methylpropyl)- 5-[4-(6-{2-[3- (trif...)
Show SMILES CC(C)(O)CNC(=O)c1nnc(CCCCc2ccc(NC(=O)Cc3cccc(OC(F)(F)F)c3)nn2)s1
Show InChI InChI=1S/C24H27F3N6O4S/c1-23(2,36)14-28-21(35)22-33-32-20(38-22)9-4-3-7-16-10-11-18(31-30-16)29-19(34)13-15-6-5-8-17(12-15)37-24(25,26)27/h5-6,8,10-12,36H,3-4,7,9,13-14H2,1-2H3,(H,28,35)(H,29,31,34)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404696
PNG
(N-benzyl-5-[4-(6-{2-[3- (trifluoromethoxy)phenyl] ...)
Show SMILES FC(F)(F)Oc1cccc(CC(=O)Nc2ccc(CCCCc3nnc(s3)C(=O)NCc3ccccc3)nn2)c1
Show InChI InChI=1S/C27H25F3N6O3S/c28-27(29,30)39-21-11-6-9-19(15-21)16-23(37)32-22-14-13-20(33-34-22)10-4-5-12-24-35-36-26(40-24)25(38)31-17-18-7-2-1-3-8-18/h1-3,6-9,11,13-15H,4-5,10,12,16-17H2,(H,31,38)(H,32,34,37)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404697
PNG
(N-(2-hydroxyethyl)-5-[4-(6- {2-[3-(trifluoromethox...)
Show SMILES OCCNC(=O)c1nnc(CCCCc2ccc(NC(=O)Cc3cccc(OC(F)(F)F)c3)nn2)s1
Show InChI InChI=1S/C22H23F3N6O4S/c23-22(24,25)35-16-6-3-4-14(12-16)13-18(33)27-17-9-8-15(28-29-17)5-1-2-7-19-30-31-21(36-19)20(34)26-10-11-32/h3-4,6,8-9,12,32H,1-2,5,7,10-11,13H2,(H,26,34)(H,27,29,33)
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Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404702
PNG
(N-{[3- (trifluoromethoxy)phenyl] methyl}-5-{4-[4-(...)
Show SMILES FC(F)(F)Oc1cccc(CNC(=O)c2cn(CCCCc3nnc(s3)C(=O)NCc3cccc(OC(F)(F)F)c3)nn2)c1
Show InChI InChI=1S/C26H23F6N7O4S/c27-25(28,29)42-18-7-3-5-16(11-18)13-33-22(40)20-15-39(38-35-20)10-2-1-9-21-36-37-24(44-21)23(41)34-14-17-6-4-8-19(12-17)43-26(30,31)32/h3-8,11-12,15H,1-2,9-10,13-14H2,(H,33,40)(H,34,41)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404703
PNG
(N-(pyridin-2-ylmethyl)-5- {4-[4-({[3-(trifluoromet...)
Show SMILES FC(F)(F)Oc1cccc(CNC(=O)c2cn(CCCCc3nnc(s3)C(=O)NCc3ccccn3)nn2)c1
Show InChI InChI=1S/C24H23F3N8O3S/c25-24(26,27)38-18-8-5-6-16(12-18)13-29-21(36)19-15-35(34-31-19)11-4-2-9-20-32-33-23(39-20)22(37)30-14-17-7-1-3-10-28-17/h1,3,5-8,10,12,15H,2,4,9,11,13-14H2,(H,29,36)(H,30,37)
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Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404712
PNG
(2-methylpropyl N-[(1-{4-[4-({[3- (trifluoromethoxy...)
Show SMILES CC(C)COC(=O)NCc1cn(CCCCn2cc(nn2)C(=O)NCc2cccc(OC(F)(F)F)c2)nn1
Show InChI InChI=1S/C23H29F3N8O4/c1-16(2)15-37-22(36)28-12-18-13-33(31-29-18)8-3-4-9-34-14-20(30-32-34)21(35)27-11-17-6-5-7-19(10-17)38-23(24,25)26/h5-7,10,13-14,16H,3-4,8-9,11-12,15H2,1-2H3,(H,27,35)(H,28,36)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404716
PNG
(N-[(6-methylpyridin-3-yl)methyl]- 5-{4-[4-({[3- (t...)
Show SMILES Cc1ccc(CNC(=O)c2nnc(CCCCn3cc(nn3)C(=O)NCc3cccc(OC(F)(F)F)c3)s2)cn1
Show InChI InChI=1S/C25H25F3N8O3S/c1-16-8-9-18(13-29-16)14-31-23(38)24-34-33-21(40-24)7-2-3-10-36-15-20(32-35-36)22(37)30-12-17-5-4-6-19(11-17)39-25(26,27)28/h4-6,8-9,11,13,15H,2-3,7,10,12,14H2,1H3,(H,30,37)(H,31,38)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404717
PNG
(5-[4-(4-{[(6-methylpyridin-3- yl)methyl]carbamoyl}...)
Show SMILES Cc1ccc(CNC(=O)c2cn(CCCCc3nnc(s3)C(=O)NCc3cccc(OC(F)(F)F)c3)nn2)cn1
Show InChI InChI=1S/C25H25F3N8O3S/c1-16-8-9-18(13-29-16)14-30-22(37)20-15-36(35-32-20)10-3-2-7-21-33-34-24(40-21)23(38)31-12-17-5-4-6-19(11-17)39-25(26,27)28/h4-6,8-9,11,13,15H,2-3,7,10,12,14H2,1H3,(H,30,37)(H,31,38)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404720
PNG
(N-[(6-methylpyridin-3-yl)methyl]- 5-[4-(4-{[(6-met...)
Show SMILES Cc1ccc(CNC(=O)c2cn(CCCCc3nnc(s3)C(=O)NCc3ccc(C)nc3)nn2)cn1
Show InChI InChI=1S/C24H27N9O2S/c1-16-6-8-18(11-25-16)13-27-22(34)20-15-33(32-29-20)10-4-3-5-21-30-31-24(36-21)23(35)28-14-19-9-7-17(2)26-12-19/h6-9,11-12,15H,3-5,10,13-14H2,1-2H3,(H,27,34)(H,28,35)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404721
PNG
(5-(4-{4-[(pyridin-2- ylmethyl)carbamoyl]-1H- 1,2,3...)
Show SMILES FC(F)(F)Oc1cccc(CNC(=O)c2nnc(CCCCn3cc(nn3)C(=O)NCc3ccccn3)s2)c1
Show InChI InChI=1S/C24H23F3N8O3S/c25-24(26,27)38-18-8-5-6-16(12-18)13-29-22(37)23-33-32-20(39-23)9-2-4-11-35-15-19(31-34-35)21(36)30-14-17-7-1-3-10-28-17/h1,3,5-8,10,12,15H,2,4,9,11,13-14H2,(H,29,37)(H,30,36)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404728
PNG
(1-[4-(4-{[(6-methylpyridin-3- yl)methyl]carbamoyl}...)
Show SMILES Cc1ccc(CNC(=O)c2cn(CCCCn3cc(nn3)C(=O)NCc3cccc(OC(F)(F)F)c3)nn2)cn1
Show InChI InChI=1S/C25H26F3N9O3/c1-17-7-8-19(13-29-17)14-31-24(39)22-16-37(35-33-22)10-3-2-9-36-15-21(32-34-36)23(38)30-12-18-5-4-6-20(11-18)40-25(26,27)28/h4-8,11,13,15-16H,2-3,9-10,12,14H2,1H3,(H,30,38)(H,31,39)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404729
PNG
(US10344025, Example 73 | US11370786, Example 73 | ...)
Show SMILES CC(C)(C)OC(=O)N1CC(CNC(=O)c2nnc(CCCCn3cc(nn3)C(=O)NCc3cccc(OC(F)(F)F)c3)s2)C1
Show InChI InChI=1S/C27H33F3N8O5S/c1-26(2,3)43-25(41)37-14-18(15-37)13-32-23(40)24-35-34-21(44-24)9-4-5-10-38-16-20(33-36-38)22(39)31-12-17-7-6-8-19(11-17)42-27(28,29)30/h6-8,11,16,18H,4-5,9-10,12-15H2,1-3H3,(H,31,39)(H,32,40)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404731
PNG
(5-{4-[4-({[3- (trifluoromethoxy)phenyl]methyl} car...)
Show SMILES FC(F)(F)Oc1cccc(CNC(=O)c2cn(CCCCc3nnc(s3)C(=O)NCc3cc(ccn3)C(F)(F)F)nn2)c1
Show InChI InChI=1S/C25H22F6N8O3S/c26-24(27,28)16-7-8-32-17(11-16)13-34-22(41)23-37-36-20(43-23)6-1-2-9-39-14-19(35-38-39)21(40)33-12-15-4-3-5-18(10-15)42-25(29,30)31/h3-5,7-8,10-11,14H,1-2,6,9,12-13H2,(H,33,40)(H,34,41)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404732
PNG
(5-{4-[4-({[3- (trifluoromethoxy)phenyl]methyl} car...)
Show SMILES FC(F)(F)Oc1cccc(CNC(=O)c2cn(CCCCc3nnc(s3)C(=O)NCc3cncc(c3)C(F)(F)F)nn2)c1
Show InChI InChI=1S/C25H22F6N8O3S/c26-24(27,28)17-8-16(10-32-13-17)12-34-22(41)23-37-36-20(43-23)6-1-2-7-39-14-19(35-38-39)21(40)33-11-15-4-3-5-18(9-15)42-25(29,30)31/h3-5,8-10,13-14H,1-2,6-7,11-12H2,(H,33,40)(H,34,41)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404733
PNG
(5-{4-[4-({[3- (trifluoromethoxy)phenyl]methyl} car...)
Show SMILES FC(F)(F)Oc1cccc(CNC(=O)c2cn(CCCCc3nnc(s3)C(=O)NCc3ccc(cn3)C(F)(F)F)nn2)c1
Show InChI InChI=1S/C25H22F6N8O3S/c26-24(27,28)16-7-8-17(32-12-16)13-34-22(41)23-37-36-20(43-23)6-1-2-9-39-14-19(35-38-39)21(40)33-11-15-4-3-5-18(10-15)42-25(29,30)31/h3-5,7-8,10,12,14H,1-2,6,9,11,13H2,(H,33,40)(H,34,41)
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Assay Description
The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404734
PNG
(5-{4-[4-({[3- (trifluoromethoxy)phenyl]methyl} car...)
Show SMILES FC(F)(F)Oc1cccc(CNC(=O)c2cn(CCCCc3nnc(s3)C(=O)NCc3ccc(nc3)C(F)(F)F)nn2)c1
Show InChI InChI=1S/C25H22F6N8O3S/c26-24(27,28)19-8-7-16(12-32-19)13-34-22(41)23-37-36-20(43-23)6-1-2-9-39-14-18(35-38-39)21(40)33-11-15-4-3-5-17(10-15)42-25(29,30)31/h3-5,7-8,10,12,14H,1-2,6,9,11,13H2,(H,33,40)(H,34,41)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404735
PNG
(US10344025, Example 79 | US11370786, Example 79 | ...)
Show SMILES CC(C)(C)OC(=O)N1CC(CNC(=O)c2cn(CCCCn3cc(nn3)C(=O)NCc3cccc(OC(F)(F)F)c3)nn2)C1
Show InChI InChI=1S/C27H34F3N9O5/c1-26(2,3)44-25(42)37-14-19(15-37)13-32-24(41)22-17-39(36-34-22)10-5-4-9-38-16-21(33-35-38)23(40)31-12-18-7-6-8-20(11-18)43-27(28,29)30/h6-8,11,16-17,19H,4-5,9-10,12-15H2,1-3H3,(H,31,40)(H,32,41)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404736
PNG
(1-{4-[4-({[3- (trifluoromethoxy)phenyl]methyl} car...)
Show SMILES FC(F)(F)Oc1cccc(CNC(=O)c2cn(CCCCn3cc(nn3)C(=O)NCc3cncc(c3)C(F)(F)F)nn2)c1
Show InChI InChI=1S/C25H23F6N9O3/c26-24(27,28)18-8-17(10-32-13-18)12-34-23(42)21-15-40(38-36-21)7-2-1-6-39-14-20(35-37-39)22(41)33-11-16-4-3-5-19(9-16)43-25(29,30)31/h3-5,8-10,13-15H,1-2,6-7,11-12H2,(H,33,41)(H,34,42)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404737
PNG
(1-{4-[4-({[3- (trifluoromethoxy)phenyl]methyl} car...)
Show SMILES FC(F)(F)Oc1cccc(CNC(=O)c2cn(CCCCn3cc(nn3)C(=O)NCc3ccc(cn3)C(F)(F)F)nn2)c1
Show InChI InChI=1S/C25H23F6N9O3/c26-24(27,28)17-6-7-18(32-12-17)13-34-23(42)21-15-40(38-36-21)9-2-1-8-39-14-20(35-37-39)22(41)33-11-16-4-3-5-19(10-16)43-25(29,30)31/h3-7,10,12,14-15H,1-2,8-9,11,13H2,(H,33,41)(H,34,42)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404738
PNG
(1-{4-[4-({[3- (trifluoromethoxy)phenyl]methyl} car...)
Show SMILES FC(F)(F)Oc1cccc(CNC(=O)c2cn(CCCCn3cc(nn3)C(=O)NCc3ccc(nc3)C(F)(F)F)nn2)c1
Show InChI InChI=1S/C25H23F6N9O3/c26-24(27,28)21-7-6-17(12-32-21)13-34-23(42)20-15-40(38-36-20)9-2-1-8-39-14-19(35-37-39)22(41)33-11-16-4-3-5-18(10-16)43-25(29,30)31/h3-7,10,12,14-15H,1-2,8-9,11,13H2,(H,33,41)(H,34,42)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404739
PNG
(N-{[3- (trifluoromethoxy)phenyl]methyl}- 1-{4-[4-(...)
Show SMILES FC(F)(F)Oc1cccc(CNC(=O)c2cn(CCCCn3cc(nn3)C(=O)NCc3cc(ccn3)C(F)(F)F)nn2)c1
Show InChI InChI=1S/C25H23F6N9O3/c26-24(27,28)17-6-7-32-18(11-17)13-34-23(42)21-15-40(38-36-21)9-2-1-8-39-14-20(35-37-39)22(41)33-12-16-4-3-5-19(10-16)43-25(29,30)31/h3-7,10-11,14-15H,1-2,8-9,12-13H2,(H,33,41)(H,34,42)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404753
PNG
(1-{4-[4-({[3- (trifluoromethyl)phenyl]methyl} carb...)
Show SMILES FC(F)(F)c1cccc(CNC(=O)c2cn(CCCCn3cc(nn3)C(=O)NCc3cc(ccn3)C(F)(F)F)nn2)c1
Show InChI InChI=1S/C25H23F6N9O2/c26-24(27,28)17-5-3-4-16(10-17)12-33-22(41)20-14-39(37-35-20)8-1-2-9-40-15-21(36-38-40)23(42)34-13-19-11-18(6-7-32-19)25(29,30)31/h3-7,10-11,14-15H,1-2,8-9,12-13H2,(H,33,41)(H,34,42)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404761
PNG
(1-[4-(4-{[(3- cyclopropylphenyl)methyl] carbamoyl}...)
Show SMILES FC(F)(F)c1ccnc(CNC(=O)c2cn(CCCCn3cc(nn3)C(=O)NCc3cccc(c3)C3CC3)nn2)c1
Show InChI InChI=1S/C27H28F3N9O2/c28-27(29,30)21-8-9-31-22(13-21)15-33-26(41)24-17-39(37-35-24)11-2-1-10-38-16-23(34-36-38)25(40)32-14-18-4-3-5-20(12-18)19-6-7-19/h3-5,8-9,12-13,16-17,19H,1-2,6-7,10-11,14-15H2,(H,32,40)(H,33,41)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404762
PNG
(N-[(4-cyclopropylpyridin-2-yl) methyl]-1-{4-[4-({[...)
Show SMILES FC(F)(F)Oc1cccc(CNC(=O)c2cn(CCCCn3cc(nn3)C(=O)NCc3cc(ccn3)C3CC3)nn2)c1
Show InChI InChI=1S/C27H28F3N9O3/c28-27(29,30)42-22-5-3-4-18(12-22)14-32-25(40)23-16-38(36-34-23)10-1-2-11-39-17-24(35-37-39)26(41)33-15-21-13-20(8-9-31-21)19-6-7-19/h3-5,8-9,12-13,16-17,19H,1-2,6-7,10-11,14-15H2,(H,32,40)(H,33,41)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404763
PNG
(1-[4-(4-{[(2-chloro-5- fluorophenyl)methyl]carbamo...)
Show SMILES Fc1ccc(Cl)c(CNC(=O)c2cn(CCCCn3cc(nn3)C(=O)NCc3cc(ccn3)C(F)(F)F)nn2)c1
Show InChI InChI=1S/C24H22ClF4N9O2/c25-19-4-3-17(26)9-15(19)11-31-22(39)20-13-37(35-33-20)7-1-2-8-38-14-21(34-36-38)23(40)32-12-18-10-16(5-6-30-18)24(27,28)29/h3-6,9-10,13-14H,1-2,7-8,11-12H2,(H,31,39)(H,32,40)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM404764
PNG
(1-[4-(4-{[(3- methoxyphenyl)methyl]carbamoyl}- 1H-...)
Show SMILES COc1cccc(CNC(=O)c2cn(CCCCn3cc(nn3)C(=O)NCc3cc(ccn3)C(F)(F)F)nn2)c1
Show InChI InChI=1S/C25H26F3N9O3/c1-40-20-6-4-5-17(11-20)13-30-23(38)21-15-36(34-32-21)9-2-3-10-37-16-22(33-35-37)24(39)31-14-19-12-18(7-8-29-19)25(26,27)28/h4-8,11-12,15-16H,2-3,9-10,13-14H2,1H3,(H,30,38)(H,31,39)
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The inhibition of purified recombinant human GAC by varying concentrations of inhibitors is assessed via a dual-coupled enzymatic assay. The glutamat...

Citation and Details

BindingDB Entry DOI: 10.7270/Q20Z76GP
More data for this
Ligand-Target Pair
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