Compile Data Set for Download or QSAR

Found 199 hits Enz. Inhib. hit(s) with all data for entry = 10712   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM478990 ((R)-1-(5-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...) Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc3N(CCc3c2)C(=O)C=C)nc1 |r| Show InChI InChI=1S/C20H20ClN5O2/c1-2-18(27)26-8-5-13-9-14(3-4-17(13)26)19(28)25-7-6-16(12-25)24-20-22-10-15(21)11-23-20/h2-4,9-11,16H,1,5-8,12H2,(H,22,23,24)/t16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479012 ((R)-N-(4-(3-((5-chloro-4- methylpyrimidin-2- yl)am...) Show SMILES Cc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C19H20ClN5O2/c1-3-17(26)23-14-6-4-13(5-7-14)18(27)25-9-8-15(11-25)24-19-21-10-16(20)12(2)22-19/h3-7,10,15H,1,8-9,11H2,2H3,(H,23,26)(H,21,22,24)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479014 ((R)-N-(4-(3-((5-chloro-4- methoxypyridin-2- yl)ami...) Show SMILES COc1cc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C20H21ClN4O3/c1-3-19(26)24-14-6-4-13(5-7-14)20(27)25-9-8-15(12-25)23-18-10-17(28-2)16(21)11-22-18/h3-7,10-11,15H,1,8-9,12H2,2H3,(H,22,23)(H,24,26)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479014 ((R)-N-(4-(3-((5-chloro-4- methoxypyridin-2- yl)ami...) Show SMILES COc1cc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C20H21ClN4O3/c1-3-19(26)24-14-6-4-13(5-7-14)20(27)25-9-8-15(12-25)23-18-10-17(28-2)16(21)11-22-18/h3-7,10-11,15H,1,8-9,12H2,2H3,(H,22,23)(H,24,26)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479015 ((R)-N-(4-(3-((5-chloro-4- methylpyridin-2- yl)amin...) Show SMILES Cc1cc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C20H21ClN4O2/c1-3-19(26)24-15-6-4-14(5-7-15)20(27)25-9-8-16(12-25)23-18-10-13(2)17(21)11-22-18/h3-7,10-11,16H,1,8-9,12H2,2H3,(H,22,23)(H,24,26)/t16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM478981 ((R)-N-(4-(3-((5-chloro-4- cyclopropoxypyrimidin-2-...) Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1OC1CC1 |r| Show InChI InChI=1S/C21H22ClN5O3/c1-2-18(28)24-14-5-3-13(4-6-14)20(29)27-10-9-15(12-27)25-21-23-11-17(22)19(26-21)30-16-7-8-16/h2-6,11,15-16H,1,7-10,12H2,(H,24,28)(H,23,25,26)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479018 ((R)-N-(4-(3-((5- cyclopropylpyrimidin-2- yl)amino)...) Show SMILES C=CC(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(cn1)C1CC1 |r| Show InChI InChI=1S/C21H23N5O2/c1-2-19(27)24-17-7-5-15(6-8-17)20(28)26-10-9-18(13-26)25-21-22-11-16(12-23-21)14-3-4-14/h2,5-8,11-12,14,18H,1,3-4,9-10,13H2,(H,24,27)(H,22,23,25)/t18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479022 ((R)-N-(4-(3-((5-chloro-4- (methylamino)pyrimidin-2...) Show SMILES CNc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C19H21ClN6O2/c1-3-16(27)23-13-6-4-12(5-7-13)18(28)26-9-8-14(11-26)24-19-22-10-15(20)17(21-2)25-19/h3-7,10,14H,1,8-9,11H2,2H3,(H,23,27)(H2,21,22,24,25)/t14-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479022 ((R)-N-(4-(3-((5-chloro-4- (methylamino)pyrimidin-2...) Show SMILES CNc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C19H21ClN6O2/c1-3-16(27)23-13-6-4-12(5-7-13)18(28)26-9-8-14(11-26)24-19-22-10-15(20)17(21-2)25-19/h3-7,10,14H,1,8-9,11H2,2H3,(H,23,27)(H2,21,22,24,25)/t14-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM478963 ((R)-1-(6-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...) Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc3N(CCCc3c2)C(=O)C=C)ncc1Cl |r| Show InChI InChI=1S/C22H24ClN5O3/c1-3-19(29)28-9-4-5-14-11-15(6-7-18(14)28)21(30)27-10-8-16(13-27)25-22-24-12-17(23)20(26-22)31-2/h3,6-7,11-12,16H,1,4-5,8-10,13H2,2H3,(H,24,25,26)/t16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM478965 ((R)-N-(2-chloro-4-(3-((5-chloro-4- methoxypyrimidi...) Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(Cl)c2)ncc1Cl |r| Show InChI InChI=1S/C19H19Cl2N5O3/c1-3-16(27)24-15-5-4-11(8-13(15)20)18(28)26-7-6-12(10-26)23-19-22-9-14(21)17(25-19)29-2/h3-5,8-9,12H,1,6-7,10H2,2H3,(H,24,27)(H,22,23,25)/t12-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM478967 ((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...) Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2csc(NC(=O)C=C)n2)ncc1Cl |r| Show InChI InChI=1S/C16H17ClN6O3S/c1-3-12(24)21-16-20-11(8-27-16)14(25)23-5-4-9(7-23)19-15-18-6-10(17)13(22-15)26-2/h3,6,8-9H,1,4-5,7H2,2H3,(H,18,19,22)(H,20,21,24)/t9-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM478970 ((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...) Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(c2)N2CCOCC2)ncc1Cl |r| Show InChI InChI=1S/C23H27ClN6O4/c1-3-20(31)27-18-5-4-15(12-19(18)29-8-10-34-11-9-29)22(32)30-7-6-16(14-30)26-23-25-13-17(24)21(28-23)33-2/h3-5,12-13,16H,1,6-11,14H2,2H3,(H,27,31)(H,25,26,28)/t16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM478966 ((R)-N-(2-chloro-4-(3-((5- chloropyrimidin-2- yl)am...) Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(Cl)c2)nc1 |r| Show InChI InChI=1S/C18H17Cl2N5O2/c1-2-16(26)24-15-4-3-11(7-14(15)20)17(27)25-6-5-13(10-25)23-18-21-8-12(19)9-22-18/h2-4,7-9,13H,1,5-6,10H2,(H,24,26)(H,21,22,23)/t13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM478971 ((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...) Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(c2)N2CCCCC2)ncc1Cl |r| Show InChI InChI=1S/C24H29ClN6O3/c1-3-21(32)28-19-8-7-16(13-20(19)30-10-5-4-6-11-30)23(33)31-12-9-17(15-31)27-24-26-14-18(25)22(29-24)34-2/h3,7-8,13-14,17H,1,4-6,9-12,15H2,2H3,(H,28,32)(H,26,27,29)/t17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479036 ((R)-N-(4-(3-((5-bromopyrimidin-2- yl)amino)pyrroli...) Show SMILES Cc1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Br)cn1 |r| Show InChI InChI=1S/C19H20BrN5O2/c1-3-17(26)24-16-5-4-13(8-12(16)2)18(27)25-7-6-15(11-25)23-19-21-9-14(20)10-22-19/h3-5,8-10,15H,1,6-7,11H2,2H3,(H,24,26)(H,21,22,23)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479038 ((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...) Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(c2)N2CCN(C)CC2)ncc1Cl |r| Show InChI InChI=1S/C24H30ClN7O3/c1-4-21(33)28-19-6-5-16(13-20(19)31-11-9-30(2)10-12-31)23(34)32-8-7-17(15-32)27-24-26-14-18(25)22(29-24)35-3/h4-6,13-14,17H,1,7-12,15H2,2-3H3,(H,28,33)(H,26,27,29)/t17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479039 ((R)-N-(2-methyl-4-(3-((5- (trifluoromethyl)pyrimid...) Show SMILES Cc1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(cn1)C(F)(F)F |r| Show InChI InChI=1S/C20H20F3N5O2/c1-3-17(29)27-16-5-4-13(8-12(16)2)18(30)28-7-6-15(11-28)26-19-24-9-14(10-25-19)20(21,22)23/h3-5,8-10,15H,1,6-7,11H2,2H3,(H,27,29)(H,24,25,26)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479046 ((R)-N-(4-(3-((5-chloro-4- (dimethylamino)pyrimidin...) Show SMILES CN(C)c1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C20H23ClN6O2/c1-4-17(28)23-14-7-5-13(6-8-14)19(29)27-10-9-15(12-27)24-20-22-11-16(21)18(25-20)26(2)3/h4-8,11,15H,1,9-10,12H2,2-3H3,(H,23,28)(H,22,24,25)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479048 ((R)-N-(4-(3-((5-chloro-4-(2- methoxyethoxy)pyrimid...) Show SMILES COCCOc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C21H24ClN5O4/c1-3-18(28)24-15-6-4-14(5-7-15)20(29)27-9-8-16(13-27)25-21-23-12-17(22)19(26-21)31-11-10-30-2/h3-7,12,16H,1,8-11,13H2,2H3,(H,24,28)(H,23,25,26)/t16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479050 ((R)-N-(4-(3-((4-amino-5- chloropyrimidin-2- yl)ami...) Show SMILES Nc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C18H19ClN6O2/c1-2-15(26)22-12-5-3-11(4-6-12)17(27)25-8-7-13(10-25)23-18-21-9-14(19)16(20)24-18/h2-6,9,13H,1,7-8,10H2,(H,22,26)(H3,20,21,23,24)/t13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479051 ((R)-N-(4-(3-((4-amino-5- (trifluoromethyl)pyrimidi...) Show SMILES Nc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1C(F)(F)F |r| Show InChI InChI=1S/C19H19F3N6O2/c1-2-15(29)25-12-5-3-11(4-6-12)17(30)28-8-7-13(10-28)26-18-24-9-14(16(23)27-18)19(20,21)22/h2-6,9,13H,1,7-8,10H2,(H,25,29)(H3,23,24,26,27)/t13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479052 ((R)-N-(4-(3-((5-chloro-4- (trifluoromethyl)pyrimid...) Show SMILES FC(F)(F)c1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C19H17ClF3N5O2/c1-2-15(29)25-12-5-3-11(4-6-12)17(30)28-8-7-13(10-28)26-18-24-9-14(20)16(27-18)19(21,22)23/h2-6,9,13H,1,7-8,10H2,(H,25,29)(H,24,26,27)/t13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479007 ((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...) Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C19H20ClN5O3/c1-3-16(26)22-13-6-4-12(5-7-13)18(27)25-9-8-14(11-25)23-19-21-10-15(20)17(24-19)28-2/h3-7,10,14H,1,8-9,11H2,2H3,(H,22,26)(H,21,23,24)/t14-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479055 ((R)-N-(4-(3-((5-chloro-4- phenoxypyrimidin-2- yl)a...) Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1Oc1ccccc1 |r| Show InChI InChI=1S/C24H22ClN5O3/c1-2-21(31)27-17-10-8-16(9-11-17)23(32)30-13-12-18(15-30)28-24-26-14-20(25)22(29-24)33-19-6-4-3-5-7-19/h2-11,14,18H,1,12-13,15H2,(H,27,31)(H,26,28,29)/t18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479056 ((R)-N-(4-(3-((5-chloro-4- ethoxypyrimidin-2- yl)am...) Show SMILES CCOc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C20H22ClN5O3/c1-3-17(27)23-14-7-5-13(6-8-14)19(28)26-10-9-15(12-26)24-20-22-11-16(21)18(25-20)29-4-2/h3,5-8,11,15H,1,4,9-10,12H2,2H3,(H,23,27)(H,22,24,25)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479062 ((R)-N-(4-(3-((5-chloro-4-(2- cyanoethoxy)pyrimidin...) Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)nc1OCCC#N |r| Show InChI InChI=1S/C21H21ClN6O3/c1-2-18(29)25-15-6-4-14(5-7-15)20(30)28-10-8-16(13-28)26-21-24-12-17(22)19(27-21)31-11-3-9-23/h2,4-7,12,16H,1,3,8,10-11,13H2,(H,25,29)(H,24,26,27)/t16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479064 ((R)-N-(4-(3-((5-bromopyrimidin-2- yl)amino)pyrroli...) Show SMILES CN(C(=O)C=C)c1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(Br)cn1 |r| Show InChI InChI=1S/C19H20BrN5O2/c1-3-17(26)24(2)16-6-4-13(5-7-16)18(27)25-9-8-15(12-25)23-19-21-10-14(20)11-22-19/h3-7,10-11,15H,1,8-9,12H2,2H3,(H,21,22,23)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479022 ((R)-N-(4-(3-((5-chloro-4- (methylamino)pyrimidin-2...) Show SMILES CNc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C19H21ClN6O2/c1-3-16(27)23-13-6-4-12(5-7-13)18(28)26-9-8-14(11-26)24-19-22-10-15(20)17(21-2)25-19/h3-7,10,14H,1,8-9,11H2,2H3,(H,23,27)(H2,21,22,24,25)/t14-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479080 ((R)-N-(4-(3-((4-(methylamino)-5- (trifluoromethyl)...) Show SMILES CNc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1C(F)(F)F |r| Show InChI InChI=1S/C20H21F3N6O2/c1-3-16(30)26-13-6-4-12(5-7-13)18(31)29-9-8-14(11-29)27-19-25-10-15(20(21,22)23)17(24-2)28-19/h3-7,10,14H,1,8-9,11H2,2H3,(H,26,30)(H2,24,25,27,28)/t14-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479084 ((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...) Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C#C)cc2)ncc1Cl |r| Show InChI InChI=1S/C19H18ClN5O3/c1-3-16(26)22-13-6-4-12(5-7-13)18(27)25-9-8-14(11-25)23-19-21-10-15(20)17(24-19)28-2/h1,4-7,10,14H,8-9,11H2,2H3,(H,22,26)(H,21,23,24)/t14-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479085 ((R)-N-(4-(3-((5-chloropyrimidin-2- yl)amino)pyrrol...) Show SMILES Clc1cnc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C#C)cc2)nc1 |r| Show InChI InChI=1S/C18H16ClN5O2/c1-2-16(25)22-14-5-3-12(4-6-14)17(26)24-8-7-15(11-24)23-18-20-9-13(19)10-21-18/h1,3-6,9-10,15H,7-8,11H2,(H,22,25)(H,20,21,23)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479097 ((R)-N-(4-(3-((5-chloro-4-(2- hydroxyethoxy)pyrimid...) Show SMILES OCCOc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C20H22ClN5O4/c1-2-17(28)23-14-5-3-13(4-6-14)19(29)26-8-7-15(12-26)24-20-22-11-16(21)18(25-20)30-10-9-27/h2-6,11,15,27H,1,7-10,12H2,(H,23,28)(H,22,24,25)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479007 ((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...) Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C19H20ClN5O3/c1-3-16(26)22-13-6-4-12(5-7-13)18(27)25-9-8-14(11-25)23-19-21-10-15(20)17(24-19)28-2/h3-7,10,14H,1,8-9,11H2,2H3,(H,22,26)(H,21,23,24)/t14-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479046 ((R)-N-(4-(3-((5-chloro-4- (dimethylamino)pyrimidin...) Show SMILES CN(C)c1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C20H23ClN6O2/c1-4-17(28)23-14-7-5-13(6-8-14)19(29)27-10-9-15(12-27)24-20-22-11-16(21)18(25-20)26(2)3/h4-8,11,15H,1,9-10,12H2,2-3H3,(H,23,28)(H,22,24,25)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479103 (N-(4-((R)-3-((5-chloro-4- ethoxypyrimidin-2- yl)am...) Show SMILES CCOc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(OC3CCOC3)c2)ncc1Cl |r| Show InChI InChI=1S/C24H28ClN5O5/c1-3-21(31)28-19-6-5-15(11-20(19)35-17-8-10-33-14-17)23(32)30-9-7-16(13-30)27-24-26-12-18(25)22(29-24)34-4-2/h3,5-6,11-12,16-17H,1,4,7-10,13-14H2,2H3,(H,28,31)(H,26,27,29)/t16-,17?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479104 ((R)-N-(4-(3-((5-chloro-4- ethoxypyrimidin-2- yl)am...) Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(OCCN(C)C)c2)ncc1Cl |r| Show InChI InChI=1S/C23H29ClN6O4/c1-5-20(31)27-18-7-6-15(12-19(18)34-11-10-29(2)3)22(32)30-9-8-16(14-30)26-23-25-13-17(24)21(28-23)33-4/h5-7,12-13,16H,1,8-11,14H2,2-4H3,(H,27,31)(H,25,26,28)/t16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479111 ((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...) Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C#CC)cc2)ncc1Cl |r| Show InChI InChI=1S/C20H20ClN5O3/c1-3-4-17(27)23-14-7-5-13(6-8-14)19(28)26-10-9-15(12-26)24-20-22-11-16(21)18(25-20)29-2/h5-8,11,15H,9-10,12H2,1-2H3,(H,23,27)(H,22,24,25)/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479112 ((R)-N-(6-(3-((5-chloro-4- ethoxypyrimidin-2- yl)am...) Show SMILES CCOc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cn2)ncc1Cl |r| Show InChI InChI=1S/C19H21ClN6O3/c1-3-16(27)23-12-5-6-15(21-9-12)18(28)26-8-7-13(11-26)24-19-22-10-14(20)17(25-19)29-4-2/h3,5-6,9-10,13H,1,4,7-8,11H2,2H3,(H,23,27)(H,22,24,25)/t13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479084 ((R)-N-(4-(3-((5-chloro-4- methoxypyrimidin-2- yl)a...) Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C#C)cc2)ncc1Cl |r| Show InChI InChI=1S/C19H18ClN5O3/c1-3-16(26)22-13-6-4-12(5-7-13)18(27)25-9-8-14(11-25)23-19-21-10-15(20)17(24-19)28-2/h1,4-7,10,14H,8-9,11H2,2H3,(H,22,26)(H,21,23,24)/t14-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479117 ((R)-N-(4-(3-((5-bromopyrimidin-2- yl)amino)pyrroli...) Show SMILES CN(C)CCOc1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Br)cn1 |r| Show InChI InChI=1S/C22H27BrN6O3/c1-4-20(30)27-18-6-5-15(11-19(18)32-10-9-28(2)3)21(31)29-8-7-17(14-29)26-22-24-12-16(23)13-25-22/h4-6,11-13,17H,1,7-10,14H2,2-3H3,(H,27,30)(H,24,25,26)/t17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479122 (N-(4-((R)-3-((5-bromopyrimidin-2- yl)amino)pyrroli...) Show SMILES CN1CC[C@H](C1)Oc1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Br)cn1 |r| Show InChI InChI=1S/C23H27BrN6O3/c1-3-21(31)28-19-5-4-15(10-20(19)33-18-7-8-29(2)14-18)22(32)30-9-6-17(13-30)27-23-25-11-16(24)12-26-23/h3-5,10-12,17-18H,1,6-9,13-14H2,2H3,(H,28,31)(H,25,26,27)/t17-,18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479123 (N-(4-((R)-3-((5-bromopyrimidin-2- yl)amino)pyrroli...) Show SMILES CN1CC[C@@H](C1)Oc1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Br)cn1 |r| Show InChI InChI=1S/C23H27BrN6O3/c1-3-21(31)28-19-5-4-15(10-20(19)33-18-7-8-29(2)14-18)22(32)30-9-6-17(13-30)27-23-25-11-16(24)12-26-23/h3-5,10-12,17-18H,1,6-9,13-14H2,2H3,(H,28,31)(H,25,26,27)/t17-,18+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479124 ((R)-N-(4-(3-((5-cyano-4- methoxypyrimidin-2- yl)am...) Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)c(OCCN(C)C)c2)ncc1C#N |r| Show InChI InChI=1S/C24H29N7O4/c1-5-21(32)28-19-7-6-16(12-20(19)35-11-10-30(2)3)23(33)31-9-8-18(15-31)27-24-26-14-17(13-25)22(29-24)34-4/h5-7,12,14,18H,1,8-11,15H2,2-4H3,(H,28,32)(H,26,27,29)/t18-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479126 ((E)-N-(4-((R)-3-((5-chloro-4- methoxypyrimidin-2- ...) Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)\C=C\CN3CC[C@@H](F)C3)cc2)ncc1Cl |r| Show InChI InChI=1S/C24H28ClFN6O3/c1-35-22-20(25)13-27-24(30-22)29-19-9-12-32(15-19)23(34)16-4-6-18(7-5-16)28-21(33)3-2-10-31-11-8-17(26)14-31/h2-7,13,17,19H,8-12,14-15H2,1H3,(H,28,33)(H,27,29,30)/b3-2+/t17-,19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479128 ((E)-N-(4-((R)-3-((5-chloro-4- methoxypyrimidin-2- ...) Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)\C=C\CN3CC[C@H](F)C3)cc2)ncc1Cl |r| Show InChI InChI=1S/C24H28ClFN6O3/c1-35-22-20(25)13-27-24(30-22)29-19-9-12-32(15-19)23(34)16-4-6-18(7-5-16)28-21(33)3-2-10-31-11-8-17(26)14-31/h2-7,13,17,19H,8-12,14-15H2,1H3,(H,28,33)(H,27,29,30)/b3-2+/t17-,19+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479139 (N-(4-((2S,4R)-4-((5-chloro-4- methoxypyrimidin-2-y...) Show SMILES COc1nc(N[C@@H]2C[C@H](C)N(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C20H22ClN5O3/c1-4-17(27)23-14-7-5-13(6-8-14)19(28)26-11-15(9-12(26)2)24-20-22-10-16(21)18(25-20)29-3/h4-8,10,12,15H,1,9,11H2,2-3H3,(H,23,27)(H,22,24,25)/t12-,15+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479140 ((R)-N-(4-(3-((5-ethynylpyrimidin-2- yl)amino)pyrro...) Show SMILES C=CC(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(cn1)C#C |r| Show InChI InChI=1S/C20H19N5O2/c1-3-14-11-21-20(22-12-14)24-17-9-10-25(13-17)19(27)15-5-7-16(8-6-15)23-18(26)4-2/h1,4-8,11-12,17H,2,9-10,13H2,(H,23,26)(H,21,22,24)/t17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479141 ((R)-N-(4-(3-((5-ethynyl-4- methoxypyrimidin-2- yl)...) Show SMILES COc1nc(N[C@@H]2CCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1C#C |r| Show InChI InChI=1S/C21H21N5O3/c1-4-14-12-22-21(25-19(14)29-3)24-17-10-11-26(13-17)20(28)15-6-8-16(9-7-15)23-18(27)5-2/h1,5-9,12,17H,2,10-11,13H2,3H3,(H,23,27)(H,22,24,25)/t17-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair
Cyclin-K/Cyclin-dependent kinase 12 (Homo sapiens (Human))	BDBM479142 (N-(4-((2R,4R)-4-((5-chloro-4- methoxypyrimidin-2-y...) Show SMILES COc1nc(N[C@@H]2C[C@@H](C)N(C2)C(=O)c2ccc(NC(=O)C=C)cc2)ncc1Cl |r| Show InChI InChI=1S/C20H22ClN5O3/c1-4-17(27)23-14-7-5-13(6-8-14)19(28)26-11-15(9-12(26)2)24-20-22-10-16(21)18(25-20)29-3/h4-8,10,12,15H,1,9,11H2,2-3H3,(H,23,27)(H,22,24,25)/t12-,15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JFB
					More data for this Ligand-Target Pair

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