Compile Data Set for Download or QSAR

Found 228 hits Enz. Inhib. hit(s) with all data for entry = 10857   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574934 (2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dih...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CCC(CC2)N2CCOCC2)c2ccccc12 |wU:18.19,20.21,(-.73,6.49,;.78,6.81,;1.81,5.66,;3.31,5.98,;4.34,4.84,;5.85,5.16,;3.87,3.37,;2.36,3.05,;1.88,1.59,;1.33,4.2,;-.18,3.88,;-.65,2.41,;-2.16,2.09,;-3.19,3.24,;-2.63,.63,;-1.73,-.62,;-.19,-.62,;-2.63,-1.86,;-2.16,-3.33,;-3.25,-4.42,;-.67,-3.73,;.42,-2.64,;1.91,-3.04,;2.3,-4.52,;1.22,-5.61,;-.27,-5.21,;3.79,-4.92,;4.19,-6.41,;5.68,-6.81,;6.77,-5.72,;6.37,-4.23,;4.88,-3.83,;-4.1,-1.39,;-5.43,-2.16,;-6.77,-1.39,;-6.77,.15,;-5.43,.92,;-4.1,.15,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574935 (2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dih...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CCC(CC2)N2CCOCC2)c2ccccc12 |wU:18.19,wD:20.26,(-.73,6.49,;.78,6.81,;1.81,5.66,;3.31,5.98,;4.34,4.84,;5.85,5.16,;3.87,3.37,;2.36,3.05,;1.88,1.59,;1.33,4.2,;-.18,3.88,;-.65,2.41,;-2.16,2.09,;-3.19,3.24,;-2.63,.63,;-1.73,-.62,;-.19,-.62,;-2.63,-1.86,;-2.16,-3.33,;-3.25,-4.42,;-.67,-3.73,;-.27,-5.21,;1.22,-5.61,;2.3,-4.52,;1.91,-3.04,;.42,-2.64,;3.79,-4.92,;4.19,-6.41,;5.68,-6.81,;6.77,-5.72,;6.37,-4.23,;4.88,-3.83,;-4.1,-1.39,;-5.43,-2.16,;-6.77,-1.39,;-6.77,.15,;-5.43,.92,;-4.1,.15,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574933 (2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dih...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CCOC2=O)c2ccccc12 |wU:18.19,(-.49,6.93,;1.02,7.25,;2.05,6.11,;3.56,6.43,;4.59,5.28,;6.09,5.6,;4.11,3.82,;2.6,3.5,;2.13,2.03,;1.57,4.64,;.07,4.32,;-.41,2.86,;-1.92,2.54,;-2.95,3.68,;-2.39,1.07,;-1.49,-.17,;.05,-.17,;-2.39,-1.42,;-1.92,-2.88,;-3,-3.97,;-.43,-3.28,;.66,-2.19,;2.15,-2.59,;2.55,-4.08,;1.46,-5.17,;-.03,-4.77,;4.03,-4.48,;5.23,-3.51,;6.52,-4.35,;6.12,-5.84,;4.59,-5.92,;3.82,-7.25,;-3.86,-.94,;-5.19,-1.71,;-6.52,-.94,;-6.52,.6,;-5.19,1.37,;-3.86,.6,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574936 (1-((R)-1-(4-(3-methoxyazetidin-1-yl)cyclohexyl)eth...) Show SMILES COC1CN(C1)C1CC[C@@H](CC1)[C@@H](C)n1c(C)c(C(=O)NCc2c(SC)cc(C)[nH]c2=O)c2cccnc12 |wU:12.14,9.9,(-7.98,8.49,;-6.47,8.81,;-5.44,7.67,;-5.52,6.13,;-3.98,6.05,;-3.9,7.59,;-2.95,4.9,;-3.43,3.44,;-2.4,2.3,;-.89,2.62,;-.41,4.08,;-1.45,5.22,;.14,1.47,;1.65,1.79,;-.34,.01,;.57,-1.24,;2.11,-1.24,;-.34,-2.49,;.14,-3.95,;-.95,-5.04,;1.63,-4.35,;2.03,-5.84,;3.51,-6.24,;4.6,-5.15,;4.2,-3.66,;2.72,-3.26,;6.09,-5.54,;6.49,-7.03,;7.98,-7.43,;5.4,-8.12,;3.91,-7.72,;2.82,-8.81,;-1.8,-2.01,;-3.13,-2.78,;-4.47,-2.01,;-4.47,-.47,;-3.13,.3,;-1.8,-.47,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574938 (7-((R)-1-(4-(3-methoxyazetidin-1-yl)cyclohexyl)eth...) Show SMILES COC1CN(C1)C1CCC(CC1)[C@@H](C)n1c(C)c(C(=O)NCc2c(SC)cc(C)[nH]c2=O)c2cncnc12 |wU:12.14,(-7.98,8.49,;-6.47,8.81,;-5.44,7.67,;-5.52,6.13,;-3.98,6.05,;-3.9,7.59,;-2.95,4.9,;-3.43,3.44,;-2.4,2.3,;-.89,2.62,;-.41,4.08,;-1.45,5.22,;.14,1.47,;1.65,1.79,;-.34,.01,;.57,-1.24,;2.11,-1.24,;-.34,-2.49,;.14,-3.95,;-.95,-5.04,;1.63,-4.35,;2.03,-5.84,;3.51,-6.24,;4.6,-5.15,;4.2,-3.66,;2.72,-3.26,;6.09,-5.54,;6.49,-7.03,;7.98,-7.43,;5.4,-8.12,;3.91,-7.72,;2.82,-8.81,;-1.8,-2.01,;-3.13,-2.78,;-4.47,-2.01,;-4.47,-.47,;-3.13,.3,;-1.8,-.47,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574939 (1-((R)-1-(5-(3,3-dimethylazetidin-1-yl)-1,3-dioxan...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2OCC(CO2)N2CC(C)(C)C2)c2ccccc12 |wU:18.19,20.26,(-1.04,6.37,;.47,6.69,;1.5,5.55,;3,5.87,;4.03,4.72,;5.54,5.04,;3.56,3.26,;2.05,2.94,;1.58,1.47,;1.02,4.08,;-.48,3.76,;-.96,2.3,;-2.47,1.98,;-3.5,3.12,;-2.94,.51,;-2.04,-.73,;-.5,-.73,;-2.94,-1.98,;-2.47,-3.44,;-3.56,-4.53,;-.98,-3.84,;.11,-2.75,;1.6,-3.15,;2,-4.64,;.91,-5.73,;-.58,-5.33,;3.48,-5.04,;4.82,-4.27,;5.59,-5.6,;7.07,-5.2,;6.68,-6.69,;4.25,-6.37,;-4.41,-1.5,;-5.74,-2.27,;-7.07,-1.5,;-7.07,.04,;-5.74,.81,;-4.41,.04,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574941 (1-((R)-1-(4-((R)-3-fluoropyrrolidin-1-yl)cyclohexy...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CCC(CC2)N2CC[C@@H](F)C2)c2ccccc12 |wU:18.19,20.21,wD:29.31,(-1.21,6.26,;.3,6.58,;1.33,5.44,;2.84,5.76,;3.87,4.61,;5.37,4.94,;3.39,3.15,;1.88,2.83,;1.41,1.37,;.85,3.97,;-.65,3.65,;-1.13,2.19,;-2.63,1.87,;-3.66,3.01,;-3.11,.4,;-2.2,-.84,;-.66,-.84,;-3.11,-2.09,;-2.63,-3.55,;-3.72,-4.64,;-1.15,-3.95,;-.06,-2.86,;1.43,-3.26,;1.83,-4.75,;.74,-5.84,;-.75,-5.44,;3.32,-5.15,;3.87,-6.58,;5.41,-6.5,;5.8,-5.02,;7.24,-4.46,;4.51,-4.18,;-4.57,-1.61,;-5.91,-2.38,;-7.24,-1.61,;-7.24,-.07,;-5.91,.7,;-4.57,-.07,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574942 (1-((R)-1-(4-((R)-3-fluoropyrrolidin-1-yl)cyclohexy...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CCC(CC2)N2CC[C@@H](F)C2)c2ccccc12 |wU:18.19,wD:20.26,29.31,(-1.21,6.26,;.3,6.58,;1.33,5.44,;2.84,5.76,;3.87,4.61,;5.37,4.94,;3.39,3.15,;1.88,2.83,;1.41,1.37,;.85,3.97,;-.65,3.65,;-1.13,2.19,;-2.63,1.87,;-3.66,3.01,;-3.11,.4,;-2.2,-.84,;-.66,-.84,;-3.11,-2.09,;-2.63,-3.55,;-3.72,-4.64,;-1.15,-3.95,;-.75,-5.44,;.74,-5.84,;1.83,-4.75,;1.43,-3.26,;-.06,-2.86,;3.32,-5.15,;3.87,-6.58,;5.41,-6.5,;5.8,-5.02,;7.24,-4.46,;4.51,-4.18,;-4.57,-1.61,;-5.91,-2.38,;-7.24,-1.61,;-7.24,-.07,;-5.91,.7,;-4.57,-.07,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574943 (1-((R)-1-(4-(3-fluoro-3-methylazetidin-1-yl)cycloh...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CC(C)(F)C2)c2ncccc12 |wU:18.19,(2.18,-3.44,;3.67,-3.84,;4.07,-5.33,;5.55,-5.73,;5.95,-7.21,;7.44,-7.61,;4.86,-8.3,;3.38,-7.9,;2.29,-8.99,;2.98,-6.42,;1.49,-6.02,;1.09,-4.53,;-.4,-4.13,;-1.49,-5.22,;-.87,-2.67,;.03,-1.42,;1.57,-1.42,;-.87,-.17,;-.4,1.29,;1.11,1.61,;-1.43,2.43,;-2.93,2.11,;-3.96,3.26,;-3.49,4.72,;-1.98,5.04,;-.95,3.9,;-4.52,5.87,;-6.06,5.95,;-5.98,7.49,;-6.3,8.99,;-7.44,7.96,;-4.44,7.41,;-2.34,-.65,;-3.67,.12,;-5,-.65,;-5,-2.19,;-3.67,-2.96,;-2.34,-2.19,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574944 ((R)-1-(1-(1-(3,3-difluorocyclobutyl)piperidin-4-yl...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCN(CC2)C2CC(F)(F)C2)c2ccccc12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574945 (7-fluoro-1-((R)-1-(4-(3-fluoroazetidin-1-yl)cycloh...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CC(F)C2)c2c(F)cccc12 |wU:18.19,(-1.04,6.21,;.47,6.53,;1.5,5.39,;3,5.71,;4.03,4.56,;5.54,4.88,;3.56,3.1,;2.05,2.78,;1.58,1.31,;1.02,3.92,;-.48,3.6,;-.96,2.14,;-2.47,1.82,;-3.5,2.96,;-2.94,.35,;-2.04,-.89,;-.5,-.89,;-2.94,-2.14,;-2.47,-3.6,;-3.56,-4.69,;-.98,-4,;.11,-2.91,;1.6,-3.31,;2,-4.8,;.91,-5.89,;-.58,-5.49,;3.48,-5.2,;4.82,-4.43,;5.59,-5.76,;7.07,-6.16,;4.25,-6.53,;-4.41,-1.66,;-5.74,-2.43,;-5.74,-3.97,;-7.07,-1.66,;-7.07,-.12,;-5.74,.65,;-4.41,-.12,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574946 ((R)-6-fluoro-1-(1-(4-(3-fluoroazetidin-1-yl)cycloh...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CC(F)C2)c2cc(F)ccc12 |wU:18.19,(.68,.82,;2.18,1.14,;2.66,2.6,;4.17,2.92,;4.64,4.38,;6.15,4.71,;3.61,5.53,;2.1,5.21,;1.07,6.35,;1.63,3.74,;.12,3.42,;-.35,1.96,;-1.86,1.64,;-2.89,2.78,;-2.34,.17,;-1.43,-1.07,;.11,-1.07,;-2.34,-2.32,;-1.86,-3.78,;-2.89,-4.93,;-.35,-4.1,;.68,-2.96,;2.18,-3.28,;2.66,-4.74,;1.63,-5.89,;.12,-5.57,;4.17,-5.06,;5.46,-4.22,;6.3,-5.51,;7.8,-5.84,;5,-6.35,;-3.8,-1.84,;-5.13,-2.61,;-6.47,-1.84,;-7.8,-2.61,;-6.47,-.3,;-5.13,.47,;-3.8,-.3,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574947 (5-fluoro-1-((R)-1-(4-(3-fluoroazetidin-1-yl)cycloh...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CCC(CC2)N2CC(F)C2)c2ncc(F)cc12 |wU:18.19,20.21,(1.96,-3.26,;3.45,-3.66,;3.85,-5.15,;5.34,-5.54,;5.74,-7.03,;7.22,-7.43,;4.65,-8.12,;3.16,-7.72,;2.07,-8.81,;2.76,-6.24,;1.27,-5.84,;.87,-4.35,;-.61,-3.95,;-1.7,-5.04,;-1.09,-2.49,;-.18,-1.24,;1.36,-1.24,;-1.09,.01,;-.61,1.47,;.89,1.79,;-1.64,2.62,;-3.15,2.3,;-4.18,3.44,;-3.7,4.9,;-2.2,5.22,;-1.17,4.08,;-4.74,6.05,;-6.27,6.13,;-6.19,7.67,;-7.22,8.81,;-4.65,7.59,;-2.55,-.47,;-3.89,.3,;-5.22,-.47,;-5.22,-2.01,;-6.55,-2.78,;-3.89,-2.78,;-2.55,-2.01,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574948 (5-fluoro-1-((R)-1-(4-(3-fluoroazetidin-1-yl)cycloh...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CCC(CC2)N2CC(F)C2)c2ncc(F)cc12 |wU:18.19,wD:20.26,(1.96,-3.26,;3.45,-3.66,;3.85,-5.15,;5.34,-5.54,;5.74,-7.03,;7.22,-7.43,;4.65,-8.12,;3.16,-7.72,;2.07,-8.81,;2.76,-6.24,;1.27,-5.84,;.87,-4.35,;-.61,-3.95,;-1.7,-5.04,;-1.09,-2.49,;-.18,-1.24,;1.36,-1.24,;-1.09,.01,;-.61,1.47,;.89,1.79,;-1.64,2.62,;-1.17,4.08,;-2.2,5.22,;-3.7,4.9,;-4.18,3.44,;-3.15,2.3,;-4.74,6.05,;-6.27,6.13,;-6.19,7.67,;-7.22,8.81,;-4.65,7.59,;-2.55,-.47,;-3.89,.3,;-5.22,-.47,;-5.22,-2.01,;-6.55,-2.78,;-3.89,-2.78,;-2.55,-2.01,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574949 (1-((R)-1-(5-(3,3-difluoroazetidin-1-yl)-1,3-dioxan...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2OCC(CO2)N2CC(F)(F)C2)c2ccccc12 |wU:18.19,20.26,(-1.04,6.37,;.47,6.69,;1.5,5.55,;3,5.87,;4.03,4.72,;5.54,5.04,;3.56,3.26,;2.05,2.94,;1.58,1.47,;1.02,4.08,;-.48,3.76,;-.96,2.3,;-2.47,1.98,;-3.5,3.12,;-2.94,.51,;-2.04,-.73,;-.5,-.73,;-2.94,-1.98,;-2.47,-3.44,;-3.56,-4.53,;-.98,-3.84,;.11,-2.75,;1.6,-3.15,;2,-4.64,;.91,-5.73,;-.58,-5.33,;3.48,-5.04,;4.82,-4.27,;5.59,-5.6,;6.68,-6.69,;7.07,-5.2,;4.25,-6.37,;-4.41,-1.5,;-5.74,-2.27,;-7.07,-1.5,;-7.07,.04,;-5.74,.81,;-4.41,.04,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574953 ((R)-2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCN(CCC(F)(F)F)CC2)c2ccccc12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574954 (6-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dih...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)NCC(F)(F)F)c2ncncc12 |wU:18.19,(2.74,-3.02,;4.23,-3.42,;4.63,-4.91,;6.11,-5.31,;6.51,-6.8,;8,-7.19,;5.42,-7.88,;3.94,-7.49,;2.85,-8.57,;3.54,-6,;2.05,-5.6,;1.65,-4.11,;.16,-3.71,;-.92,-4.8,;-.31,-2.25,;.59,-1,;2.13,-1,;-.31,.24,;.16,1.71,;1.67,2.03,;-.87,2.85,;-2.37,2.53,;-3.4,3.68,;-2.93,5.14,;-1.42,5.46,;-.39,4.32,;-3.96,6.29,;-5.46,5.97,;-6.49,7.11,;-6.02,8.57,;-7.52,8.25,;-8,6.79,;-1.78,-.23,;-3.11,.54,;-4.44,-.23,;-4.44,-1.77,;-3.11,-2.54,;-1.78,-1.77,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574955 (1-((R)-1-(4-(3-methoxy-3-methylazetidin-1-yl)cyclo...) Show SMILES COC1(C)CN(C1)C1CC[C@@H](CC1)[C@@H](C)n1c(C)c(C(=O)NCc2c(SC)cc(C)[nH]c2=O)c2ccccc12 |wU:13.15,10.10,(7.62,-6.29,;6.53,-5.2,;5.04,-5.6,;6.13,-6.69,;4.27,-4.27,;2.94,-5.04,;3.71,-6.37,;1.45,-4.64,;1.05,-3.15,;-.43,-2.75,;-1.52,-3.84,;-1.13,-5.33,;.36,-5.73,;-3.01,-3.44,;-4.1,-4.53,;-3.49,-1.98,;-2.58,-.73,;-1.04,-.73,;-3.49,.51,;-3.01,1.98,;-4.04,3.12,;-1.5,2.3,;-1.03,3.76,;.48,4.08,;.95,5.55,;-.08,6.69,;-1.58,6.37,;2.46,5.87,;3.49,4.72,;5,5.04,;3.01,3.26,;1.51,2.94,;1.03,1.47,;-4.95,.04,;-6.29,.81,;-7.62,.04,;-7.62,-1.5,;-6.29,-2.27,;-4.95,-1.5,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574956 (1-((R)-1-(4-(3-methoxy-3-methylazetidin-1-yl)cyclo...) Show SMILES COC1(C)CN(C1)C1CC[C@@H](CC1)[C@@H](C)n1c(C)c(C(=O)NCc2c(SC)cc(C)[nH]c2=O)c2ccccc12 |wU:13.15,wD:10.11,(7.62,-6.29,;6.53,-5.2,;5.04,-5.6,;6.13,-6.69,;4.27,-4.27,;2.94,-5.04,;3.71,-6.37,;1.45,-4.64,;.36,-5.73,;-1.13,-5.33,;-1.52,-3.84,;-.43,-2.75,;1.05,-3.15,;-3.01,-3.44,;-4.1,-4.53,;-3.49,-1.98,;-2.58,-.73,;-1.04,-.73,;-3.49,.51,;-3.01,1.98,;-4.04,3.12,;-1.5,2.3,;-1.03,3.76,;.48,4.08,;.95,5.55,;-.08,6.69,;-1.58,6.37,;2.46,5.87,;3.49,4.72,;5,5.04,;3.01,3.26,;1.51,2.94,;1.03,1.47,;-4.95,.04,;-6.29,.81,;-7.62,.04,;-7.62,-1.5,;-6.29,-2.27,;-4.95,-1.5,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574957 (1-((R)-1-(4-(3-ethoxyazetidin-1-yl)cyclohexyl)ethy...) Show SMILES CCOC1CN(C1)C1CC[C@@H](CC1)[C@@H](C)n1c(C)c(C(=O)NCc2c(SC)cc(C)[nH]c2=O)c2cccnc12 |wU:13.15,10.10,(-8.49,9.22,;-7.46,8.08,;-5.95,8.4,;-4.92,7.25,;-5,5.72,;-3.47,5.64,;-3.39,7.17,;-2.44,4.49,;-2.91,3.03,;-1.88,1.88,;-.38,2.2,;.1,3.67,;-.93,4.81,;.66,1.06,;2.16,1.38,;.18,-.41,;1.08,-1.65,;2.62,-1.65,;.18,-2.9,;.66,-4.36,;-.43,-5.45,;2.14,-4.76,;2.54,-6.25,;4.03,-6.65,;5.12,-5.56,;4.72,-4.07,;3.23,-3.67,;6.61,-5.96,;7,-7.44,;8.49,-7.84,;5.91,-8.53,;4.43,-8.13,;3.34,-9.22,;-1.29,-2.42,;-2.62,-3.19,;-3.95,-2.42,;-3.95,-.88,;-2.62,-.11,;-1.29,-.88,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574958 (1-((R)-1-(4-(3-ethoxyazetidin-1-yl)cyclohexyl)ethy...) Show SMILES CCOC1CN(C1)C1CC[C@@H](CC1)[C@@H](C)n1c(C)c(C(=O)NCc2c(SC)cc(C)[nH]c2=O)c2cccnc12 |wU:13.15,wD:10.11,(-8.49,9.22,;-7.46,8.08,;-5.95,8.4,;-4.92,7.25,;-5,5.72,;-3.47,5.64,;-3.39,7.17,;-2.44,4.49,;-.93,4.81,;.1,3.67,;-.38,2.2,;-1.88,1.88,;-2.91,3.03,;.66,1.06,;2.16,1.38,;.18,-.41,;1.08,-1.65,;2.62,-1.65,;.18,-2.9,;.66,-4.36,;-.43,-5.45,;2.14,-4.76,;2.54,-6.25,;4.03,-6.65,;5.12,-5.56,;4.72,-4.07,;3.23,-3.67,;6.61,-5.96,;7,-7.44,;8.49,-7.84,;5.91,-8.53,;4.43,-8.13,;3.34,-9.22,;-1.29,-2.42,;-2.62,-3.19,;-3.95,-2.42,;-3.95,-.88,;-2.62,-.11,;-1.29,-.88,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574959 ((R)-6-fluoro-2-methyl-N-((6-methyl-4-(methylthio)-...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCN(CC(F)(F)F)CC2)c2cc(F)ccc12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574960 (N-((4-((fluoromethyl)thio)-6-methyl-2-oxo-1,2-dihy...) Show SMILES COC1CN(C1)C1CCC(CC1)[C@@H](C)n1c(C)c(C(=O)NCc2c(SCF)cc(C)[nH]c2=O)c2ccccc12 |wU:12.14,(7.62,-5.48,;6.53,-6.57,;5.04,-6.17,;4.27,-4.84,;2.94,-5.61,;3.71,-6.94,;1.45,-5.21,;1.05,-3.72,;-.43,-3.33,;-1.52,-4.41,;-1.13,-5.9,;.36,-6.3,;-3.01,-4.02,;-4.1,-5.1,;-3.49,-2.55,;-2.58,-1.31,;-1.04,-1.31,;-3.49,-.06,;-3.01,1.41,;-4.04,2.55,;-1.5,1.73,;-1.03,3.19,;.48,3.51,;.95,4.98,;-.08,6.12,;-1.58,5.8,;-2.61,6.94,;2.46,5.3,;3.49,4.15,;5,4.47,;3.01,2.69,;1.51,2.37,;1.03,.9,;-4.95,-.54,;-6.29,.23,;-7.62,-.54,;-7.62,-2.08,;-6.29,-2.85,;-4.95,-2.08,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574961 (5-fluoro-1-((R)-1-(4-(3-methoxyazetidin-1-yl)cyclo...) Show SMILES COC1CN(C1)C1CC[C@@H](CC1)[C@@H](C)n1c(C)c(C(=O)NCc2c(SC)cc(C)[nH]c2=O)c2cc(F)cnc12 |wU:12.14,9.9,(-7.98,8.49,;-6.47,8.81,;-5.44,7.67,;-5.52,6.13,;-3.98,6.05,;-3.9,7.59,;-2.95,4.9,;-3.43,3.44,;-2.4,2.3,;-.89,2.62,;-.41,4.08,;-1.45,5.22,;.14,1.47,;1.65,1.79,;-.34,.01,;.57,-1.24,;2.11,-1.24,;-.34,-2.49,;.14,-3.95,;-.95,-5.04,;1.63,-4.35,;2.03,-5.84,;3.51,-6.24,;4.6,-5.15,;4.2,-3.66,;2.72,-3.26,;6.09,-5.54,;6.49,-7.03,;7.98,-7.43,;5.4,-8.12,;3.91,-7.72,;2.82,-8.81,;-1.8,-2.01,;-3.13,-2.78,;-4.47,-2.01,;-5.8,-2.78,;-4.47,-.47,;-3.13,.3,;-1.8,-.47,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574963 (1-((R)-1-(4-(3,3-difluoropyrrolidin-1-yl)cyclohexy...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CCC(F)(F)C2)c2ccccc12 |wU:18.19,(-1.25,6.26,;.26,6.58,;1.29,5.44,;2.79,5.76,;3.83,4.61,;5.33,4.94,;3.35,3.15,;1.84,2.83,;1.37,1.37,;.81,3.97,;-.69,3.65,;-1.17,2.19,;-2.68,1.87,;-3.71,3.01,;-3.15,.4,;-2.25,-.84,;-.71,-.84,;-3.15,-2.09,;-2.68,-3.55,;-3.76,-4.64,;-1.19,-3.95,;-.1,-2.86,;1.39,-3.26,;1.79,-4.75,;.7,-5.84,;-.79,-5.44,;3.27,-5.15,;3.83,-6.58,;5.36,-6.5,;5.76,-5.02,;7.28,-5.26,;6.73,-3.82,;4.47,-4.18,;-4.62,-1.61,;-5.95,-2.38,;-7.28,-1.61,;-7.28,-.07,;-5.95,.7,;-4.62,-.07,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574964 (1-((R)-1-(4-(3-(difluoromethyl)azetidin-1-yl)cyclo...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CC(C2)C(F)F)c2ncccc12 |wU:18.19,(2.72,-3.99,;4.2,-4.39,;4.6,-5.88,;6.09,-6.28,;6.49,-7.76,;7.98,-8.16,;5.4,-8.85,;3.91,-8.45,;2.82,-9.54,;3.51,-6.97,;2.03,-6.57,;1.63,-5.08,;.14,-4.68,;-.95,-5.77,;-.34,-3.22,;.57,-1.97,;2.11,-1.97,;-.34,-.73,;.14,.74,;1.65,1.06,;-.89,1.88,;-2.4,1.56,;-3.43,2.71,;-2.95,4.17,;-1.45,4.49,;-.41,3.35,;-3.98,5.32,;-5.52,5.4,;-5.44,6.93,;-3.9,6.85,;-6.47,8.08,;-5.99,9.54,;-7.98,7.76,;-1.8,-1.2,;-3.13,-.43,;-4.47,-1.2,;-4.47,-2.74,;-3.13,-3.51,;-1.8,-2.74,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574966 (5-chloro-1-((R)-1-(4-(3-fluoroazetidin-1-yl)cycloh...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CC(F)C2)c2ncc(Cl)cc12 |wU:18.19,(1.96,-3.26,;3.45,-3.66,;3.85,-5.15,;5.34,-5.54,;5.74,-7.03,;7.22,-7.43,;4.65,-8.12,;3.16,-7.72,;2.07,-8.81,;2.76,-6.24,;1.27,-5.84,;.87,-4.35,;-.61,-3.95,;-1.7,-5.04,;-1.09,-2.49,;-.18,-1.24,;1.36,-1.24,;-1.09,.01,;-.61,1.47,;.89,1.79,;-1.64,2.62,;-3.15,2.3,;-4.18,3.44,;-3.7,4.9,;-2.2,5.22,;-1.17,4.08,;-4.74,6.05,;-6.27,6.13,;-6.19,7.67,;-7.22,8.81,;-4.65,7.59,;-2.55,-.47,;-3.89,.3,;-5.22,-.47,;-5.22,-2.01,;-6.55,-2.78,;-3.89,-2.78,;-2.55,-2.01,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574967 (N-((4-(cyclopropylthio)-6-methyl-2-oxo-1,2-dihydro...) Show SMILES COC1CN(C1)C1CCC(CC1)[C@@H](C)n1c(C)c(C(=O)NCc2c(SC3CC3)cc(C)[nH]c2=O)c2ccccc12 |wU:12.14,(7.62,-5.15,;6.53,-6.24,;5.04,-5.84,;4.27,-4.51,;2.94,-5.28,;3.71,-6.61,;1.45,-4.88,;1.05,-3.39,;-.43,-2.99,;-1.52,-4.08,;-1.13,-5.57,;.36,-5.97,;-3.01,-3.68,;-4.1,-4.77,;-3.49,-2.22,;-2.58,-.97,;-1.04,-.97,;-3.49,.27,;-3.01,1.74,;-4.04,2.88,;-1.5,2.06,;-1.03,3.52,;.48,3.84,;.95,5.31,;-.08,6.45,;-1.58,6.13,;-2.73,5.1,;-3.05,6.61,;2.46,5.63,;3.49,4.49,;5,4.81,;3.01,3.02,;1.51,2.7,;1.03,1.24,;-4.95,-.2,;-6.29,.57,;-7.62,-.2,;-7.62,-1.74,;-6.29,-2.51,;-4.95,-1.74,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574968 (1-((R)-1-(4-(3-cyclopropoxyazetidin-1-yl)cyclohexy...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CC(C2)OC2CC2)c2ccccc12 |wU:18.19,(-1.78,7.51,;-.28,7.83,;.75,6.69,;2.26,7.01,;3.29,5.86,;4.8,6.18,;2.81,4.4,;1.31,4.08,;.83,2.62,;.28,5.22,;-1.23,4.9,;-1.7,3.44,;-3.21,3.12,;-4.24,4.26,;-3.69,1.65,;-2.78,.41,;-1.24,.41,;-3.69,-.84,;-3.21,-2.3,;-4.3,-3.39,;-1.72,-2.7,;-.63,-1.61,;.85,-2.01,;1.25,-3.5,;.16,-4.59,;-1.32,-4.19,;2.74,-3.9,;4.07,-3.13,;4.84,-4.46,;3.51,-5.23,;6.33,-4.86,;6.73,-6.35,;7.82,-7.43,;6.33,-7.83,;-5.15,-.36,;-6.48,-1.13,;-7.82,-.36,;-7.82,1.18,;-6.48,1.95,;-5.15,1.18,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574970 (7-((R)-1-(4-(3-cyclopropoxyazetidin-1-yl)cyclohexy...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CCC(CC2)N2CC(C2)OC2CC2)c2ncncc12 |wU:18.19,20.21,(3.45,-3.34,;4.94,-3.74,;5.33,-5.22,;6.82,-5.62,;7.22,-7.11,;8.71,-7.51,;6.13,-8.2,;4.64,-7.8,;3.56,-8.89,;4.25,-6.31,;2.76,-5.91,;2.36,-4.43,;.87,-4.03,;-.22,-5.12,;.4,-2.56,;1.3,-1.32,;2.84,-1.32,;.4,-.07,;.87,1.39,;2.38,1.71,;-.16,2.54,;-1.66,2.22,;-2.7,3.36,;-2.22,4.83,;-.71,5.15,;.32,4,;-3.25,5.97,;-4.79,6.05,;-4.71,7.59,;-3.17,7.51,;-5.74,8.73,;-7.24,8.41,;-8.39,7.38,;-8.71,8.89,;-1.07,-.55,;-2.4,.22,;-3.74,-.55,;-3.74,-2.09,;-2.4,-2.86,;-1.07,-2.09,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574971 (7-((R)-1-(4-(3-cyclopropoxyazetidin-1-yl)cyclohexy...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CCC(CC2)N2CC(C2)OC2CC2)c2ncncc12 |wU:18.19,wD:20.26,(3.45,-3.34,;4.94,-3.74,;5.33,-5.22,;6.82,-5.62,;7.22,-7.11,;8.71,-7.51,;6.13,-8.2,;4.64,-7.8,;3.56,-8.89,;4.25,-6.31,;2.76,-5.91,;2.36,-4.43,;.87,-4.03,;-.22,-5.12,;.4,-2.56,;1.3,-1.32,;2.84,-1.32,;.4,-.07,;.87,1.39,;2.38,1.71,;-.16,2.54,;.32,4,;-.71,5.15,;-2.22,4.83,;-2.7,3.36,;-1.66,2.22,;-3.25,5.97,;-4.79,6.05,;-4.71,7.59,;-3.17,7.51,;-5.74,8.73,;-7.24,8.41,;-8.39,7.38,;-8.71,8.89,;-1.07,-.55,;-2.4,.22,;-3.74,-.55,;-3.74,-2.09,;-2.4,-2.86,;-1.07,-2.09,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574972 ((R)-4-chloro-2-methyl-N-((6-methyl-4-(methylthio)-...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCN(CC(F)(F)F)CC2)c2cccc(Cl)c12 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574976 (5-chloro-1-((R)-1-(4-(3-methoxyazetidin-1-yl)cyclo...) Show SMILES COC1CN(C1)C1CC[C@@H](CC1)[C@@H](C)n1c(C)c(C(=O)NCc2c(SC)cc(C)[nH]c2=O)c2cc(Cl)cnc12 |wU:12.14,9.9,(-7.98,8.49,;-6.47,8.81,;-5.44,7.67,;-5.52,6.13,;-3.98,6.05,;-3.9,7.59,;-2.95,4.9,;-3.43,3.44,;-2.4,2.3,;-.89,2.62,;-.41,4.08,;-1.45,5.22,;.14,1.47,;1.65,1.79,;-.34,.01,;.57,-1.24,;2.11,-1.24,;-.34,-2.49,;.14,-3.95,;-.95,-5.04,;1.63,-4.35,;2.03,-5.84,;3.51,-6.24,;4.6,-5.15,;4.2,-3.66,;2.72,-3.26,;6.09,-5.54,;6.49,-7.03,;7.98,-7.43,;5.4,-8.12,;3.91,-7.72,;2.82,-8.81,;-1.8,-2.01,;-3.13,-2.78,;-4.47,-2.01,;-5.8,-2.78,;-4.47,-.47,;-3.13,.3,;-1.8,-.47,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574977 (5-chloro-1-((R)-1-(4-(3-methoxyazetidin-1-yl)cyclo...) Show SMILES COC1CN(C1)C1CC[C@@H](CC1)[C@@H](C)n1c(C)c(C(=O)NCc2c(SC)cc(C)[nH]c2=O)c2cc(Cl)cnc12 |wU:12.14,wD:9.10,(-7.98,8.49,;-6.47,8.81,;-5.44,7.67,;-5.52,6.13,;-3.98,6.05,;-3.9,7.59,;-2.95,4.9,;-1.45,5.22,;-.41,4.08,;-.89,2.62,;-2.4,2.3,;-3.43,3.44,;.14,1.47,;1.65,1.79,;-.34,.01,;.57,-1.24,;2.11,-1.24,;-.34,-2.49,;.14,-3.95,;-.95,-5.04,;1.63,-4.35,;2.03,-5.84,;3.51,-6.24,;4.6,-5.15,;4.2,-3.66,;2.72,-3.26,;6.09,-5.54,;6.49,-7.03,;7.98,-7.43,;5.4,-8.12,;3.91,-7.72,;2.82,-8.81,;-1.8,-2.01,;-3.13,-2.78,;-4.47,-2.01,;-5.8,-2.78,;-4.47,-.47,;-3.13,.3,;-1.8,-.47,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574978 (5-chloro-1-((R)-1-(4-((R)-3-fluoropyrrolidin-1-yl)...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CC[C@@H](F)C2)c2ncc(Cl)cc12 |wU:18.19,wD:29.31,(2.55,-3.02,;4.04,-3.42,;4.44,-4.9,;5.92,-5.3,;6.32,-6.79,;7.81,-7.19,;5.23,-7.88,;3.75,-7.48,;2.66,-8.57,;3.35,-5.99,;1.86,-5.59,;1.46,-4.11,;-.03,-3.71,;-1.11,-4.8,;-.5,-2.24,;.4,-1,;1.94,-1,;-.5,.25,;-.03,1.71,;1.48,2.03,;-1.06,2.86,;-2.56,2.54,;-3.59,3.68,;-3.12,5.15,;-1.61,5.47,;-.58,4.32,;-4.15,6.29,;-3.83,7.8,;-5.16,8.57,;-6.3,7.54,;-7.81,7.86,;-5.68,6.13,;-1.97,-.23,;-3.3,.54,;-4.63,-.23,;-4.63,-1.77,;-5.97,-2.54,;-3.3,-2.54,;-1.97,-1.77,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574979 (7-((R)-1-(4-(3-(difluoromethoxy)azetidin-1-yl)cycl...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CC(C2)OC(F)F)c2ncncc12 |wU:18.19,(3.23,-3.67,;4.72,-4.07,;5.12,-5.56,;6.61,-5.96,;7,-7.44,;8.49,-7.84,;5.91,-8.53,;4.43,-8.13,;3.34,-9.22,;4.03,-6.65,;2.54,-6.25,;2.14,-4.76,;.66,-4.36,;-.43,-5.45,;.18,-2.9,;1.08,-1.65,;2.62,-1.65,;.18,-.41,;.66,1.06,;2.16,1.38,;-.38,2.2,;-1.88,1.88,;-2.91,3.03,;-2.44,4.49,;-.93,4.81,;.1,3.67,;-3.47,5.64,;-5,5.72,;-4.92,7.25,;-3.39,7.17,;-5.95,8.4,;-7.46,8.08,;-7.94,6.61,;-8.49,9.22,;-1.29,-.88,;-2.62,-.11,;-3.95,-.88,;-3.95,-2.42,;-2.62,-3.19,;-1.29,-2.42,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM50541897 (CHEMBL4634390 | US11459315, Example 109) Show SMILES C[C@H](C1CCN(CC(F)(F)F)CC1)n1c(C)c(C(=O)NCc2c(SC3CCC3)cc(C)[nH]c2=O)c2ccccc12 |r| Show InChI InChI=1S/C30H37F3N4O2S/c1-18-15-26(40-22-7-6-8-22)24(28(38)35-18)16-34-29(39)27-20(3)37(25-10-5-4-9-23(25)27)19(2)21-11-13-36(14-12-21)17-30(31,32)33/h4-5,9-10,15,19,21-22H,6-8,11-14,16-17H2,1-3H3,(H,34,39)(H,35,38)/t19-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574981 (2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dih...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CC(C2)C(F)(F)F)c2ncccc12 |wU:18.19,(2.72,-3.99,;4.2,-4.39,;4.6,-5.88,;6.09,-6.28,;6.49,-7.76,;7.98,-8.16,;5.4,-8.85,;3.91,-8.45,;2.82,-9.54,;3.51,-6.97,;2.03,-6.57,;1.63,-5.08,;.14,-4.68,;-.95,-5.77,;-.34,-3.22,;.57,-1.97,;2.11,-1.97,;-.34,-.73,;.14,.74,;1.65,1.06,;-.89,1.88,;-2.4,1.56,;-3.43,2.71,;-2.95,4.17,;-1.45,4.49,;-.41,3.35,;-3.98,5.32,;-5.52,5.4,;-5.44,6.93,;-3.9,6.85,;-6.47,8.08,;-5.99,9.54,;-7.5,9.22,;-7.98,7.76,;-1.8,-1.2,;-3.13,-.43,;-4.47,-1.2,;-4.47,-2.74,;-3.13,-3.51,;-1.8,-2.74,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574982 (1-((1R)-1-(4-(3-cyclopropoxypyrrolidin-1-yl)cycloh...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CCC(C2)OC2CC2)c2ncccc12 |wU:18.19,(3.36,-4.15,;4.85,-4.55,;5.25,-6.03,;6.74,-6.43,;7.13,-7.92,;8.62,-8.32,;6.04,-9.01,;4.56,-8.61,;3.47,-9.7,;4.16,-7.12,;2.67,-6.72,;2.27,-5.24,;.79,-4.84,;-.3,-5.93,;.31,-3.37,;1.21,-2.13,;2.75,-2.13,;.31,-.88,;.79,.58,;2.29,.9,;-.25,1.73,;-1.75,1.41,;-2.78,2.55,;-2.31,4.02,;-.8,4.34,;.23,3.19,;-3.34,5.16,;-3.02,6.67,;-4.35,7.44,;-5.49,6.41,;-4.87,5,;-7,6.73,;-7.48,8.19,;-8.62,9.22,;-7.16,9.7,;-1.16,-1.36,;-2.49,-.59,;-3.82,-1.36,;-3.82,-2.9,;-2.49,-3.67,;-1.16,-2.9,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574985 (1-((R)-1-(4-(3-cyclopropoxyazetidin-1-yl)cyclohexy...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CCC(CC2)N2CC(C2)OC2CC2)c2c(F)cccc12 |wU:18.19,20.21,(-1.78,7.51,;-.28,7.83,;.75,6.69,;2.26,7.01,;3.29,5.86,;4.8,6.18,;2.81,4.4,;1.31,4.08,;.83,2.62,;.28,5.22,;-1.23,4.9,;-1.7,3.44,;-3.21,3.12,;-4.24,4.26,;-3.69,1.65,;-2.78,.41,;-1.24,.41,;-3.69,-.84,;-3.21,-2.3,;-4.3,-3.39,;-1.72,-2.7,;-.63,-1.61,;.85,-2.01,;1.25,-3.5,;.16,-4.59,;-1.32,-4.19,;2.74,-3.9,;4.07,-3.13,;4.84,-4.46,;3.51,-5.23,;6.33,-4.86,;6.73,-6.35,;7.82,-7.43,;6.33,-7.83,;-5.15,-.36,;-6.48,-1.13,;-6.48,-2.67,;-7.82,-.36,;-7.82,1.18,;-6.48,1.95,;-5.15,1.18,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574983 (1-((R)-1-(4-(3-(tert-butoxy)azetidin-1-yl)cyclohex...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CCC(CC2)N2CC(C2)OC(C)(C)C)c2ncccc12 |wU:18.19,20.21,(3.47,-3.67,;4.96,-4.07,;5.36,-5.56,;6.84,-5.96,;7.24,-7.44,;8.73,-7.84,;6.15,-8.53,;4.67,-8.13,;3.58,-9.22,;4.27,-6.65,;2.78,-6.25,;2.38,-4.76,;.89,-4.36,;-.2,-5.45,;.42,-2.9,;1.32,-1.65,;2.86,-1.65,;.42,-.41,;.89,1.06,;2.4,1.38,;-.14,2.2,;-1.64,1.88,;-2.67,3.03,;-2.2,4.49,;-.69,4.81,;.34,3.67,;-3.23,5.64,;-4.77,5.72,;-4.69,7.25,;-3.15,7.17,;-5.72,8.4,;-7.22,8.08,;-7.7,6.61,;-8.73,7.76,;-8.25,9.22,;-1.05,-.88,;-2.38,-.11,;-3.71,-.88,;-3.71,-2.42,;-2.38,-3.19,;-1.05,-2.42,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574984 (1-((R)-1-(4-(3-(tert-butoxy)azetidin-1-yl)cyclohex...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CCC(CC2)N2CC(C2)OC(C)(C)C)c2ncccc12 |wU:18.19,wD:20.26,(3.47,-3.67,;4.96,-4.07,;5.36,-5.56,;6.84,-5.96,;7.24,-7.44,;8.73,-7.84,;6.15,-8.53,;4.67,-8.13,;3.58,-9.22,;4.27,-6.65,;2.78,-6.25,;2.38,-4.76,;.89,-4.36,;-.2,-5.45,;.42,-2.9,;1.32,-1.65,;2.86,-1.65,;.42,-.41,;.89,1.06,;2.4,1.38,;-.14,2.2,;.34,3.67,;-.69,4.81,;-2.2,4.49,;-2.67,3.03,;-1.64,1.88,;-3.23,5.64,;-4.77,5.72,;-4.69,7.25,;-3.15,7.17,;-5.72,8.4,;-7.22,8.08,;-7.7,6.61,;-8.73,7.76,;-8.25,9.22,;-1.05,-.88,;-2.38,-.11,;-3.71,-.88,;-3.71,-2.42,;-2.38,-3.19,;-1.05,-2.42,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574986 (1-((R)-1-(4-(3-cyclopropoxyazetidin-1-yl)cyclohexy...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CCC(CC2)N2CC(C2)OC2CC2)c2c(F)cccc12 |wU:18.19,wD:20.26,(-1.78,7.51,;-.28,7.83,;.75,6.69,;2.26,7.01,;3.29,5.86,;4.8,6.18,;2.81,4.4,;1.31,4.08,;.83,2.62,;.28,5.22,;-1.23,4.9,;-1.7,3.44,;-3.21,3.12,;-4.24,4.26,;-3.69,1.65,;-2.78,.41,;-1.24,.41,;-3.69,-.84,;-3.21,-2.3,;-4.3,-3.39,;-1.72,-2.7,;-1.32,-4.19,;.16,-4.59,;1.25,-3.5,;.85,-2.01,;-.63,-1.61,;2.74,-3.9,;4.07,-3.13,;4.84,-4.46,;3.51,-5.23,;6.33,-4.86,;6.73,-6.35,;7.82,-7.43,;6.33,-7.83,;-5.15,-.36,;-6.48,-1.13,;-6.48,-2.67,;-7.82,-.36,;-7.82,1.18,;-6.48,1.95,;-5.15,1.18,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574988 (1-((R)-1-(4-(3-(difluoromethoxy)azetidin-1-yl)cycl...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CC(C2)OC(F)F)c2ncc(C)cc12 |wU:18.19,(3.23,-3.67,;4.72,-4.07,;5.12,-5.56,;6.61,-5.96,;7,-7.44,;8.49,-7.84,;5.91,-8.53,;4.43,-8.13,;3.34,-9.22,;4.03,-6.65,;2.54,-6.25,;2.14,-4.76,;.66,-4.36,;-.43,-5.45,;.18,-2.9,;1.08,-1.65,;2.62,-1.65,;.18,-.41,;.66,1.06,;2.16,1.38,;-.38,2.2,;-1.88,1.88,;-2.91,3.03,;-2.44,4.49,;-.93,4.81,;.1,3.67,;-3.47,5.64,;-5,5.72,;-4.92,7.25,;-3.39,7.17,;-5.95,8.4,;-7.46,8.08,;-7.94,6.61,;-8.49,9.22,;-1.29,-.88,;-2.62,-.11,;-3.95,-.88,;-3.95,-2.42,;-5.29,-3.19,;-2.62,-3.19,;-1.29,-2.42,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574989 (1-((R)-1-(4-(3-(2,2-difluoroethoxy)azetidin-1-yl)c...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CC(C2)OCC(F)F)c2ncccc12 |wU:18.19,(3.98,-4.4,;5.47,-4.8,;5.87,-6.29,;7.36,-6.69,;7.76,-8.18,;9.24,-8.58,;6.67,-9.27,;5.18,-8.87,;4.09,-9.96,;4.78,-7.38,;3.29,-6.98,;2.9,-5.49,;1.41,-5.09,;.32,-6.18,;.93,-3.63,;1.84,-2.38,;3.38,-2.38,;.93,-1.14,;1.41,.33,;2.91,.65,;.38,1.47,;-1.13,1.15,;-2.16,2.3,;-1.68,3.76,;-.18,4.08,;.85,2.94,;-2.71,4.9,;-4.25,4.98,;-4.17,6.52,;-2.63,6.44,;-5.2,7.67,;-6.71,7.35,;-7.74,8.49,;-7.26,9.96,;-9.24,8.17,;-.53,-1.61,;-1.87,-.84,;-3.2,-1.61,;-3.2,-3.15,;-1.87,-3.92,;-.53,-3.15,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574991 (1-((R)-1-(4-(3-(difluoromethoxy)azetidin-1-yl)cycl...) Show SMILES CC[C@H](C1CCC(CC1)N1CC(C1)OC(F)F)n1c(C)c(C(=O)NCc2c(SC)cc(C)[nH]c2=O)c2cccnc12 |wU:2.18,(3.19,.23,;2.16,1.38,;.66,1.06,;-.38,2.2,;-1.88,1.88,;-2.91,3.03,;-2.44,4.49,;-.93,4.81,;.1,3.67,;-3.47,5.64,;-5,5.72,;-4.92,7.25,;-3.39,7.17,;-5.95,8.4,;-7.46,8.08,;-7.94,6.61,;-8.49,9.22,;.18,-.41,;1.08,-1.65,;2.62,-1.65,;.18,-2.9,;.66,-4.36,;-.43,-5.45,;2.14,-4.76,;2.54,-6.25,;4.03,-6.65,;5.12,-5.56,;4.72,-4.07,;3.23,-3.67,;6.61,-5.96,;7,-7.44,;8.49,-7.84,;5.91,-8.53,;4.43,-8.13,;3.34,-9.22,;-1.29,-2.42,;-2.62,-3.19,;-3.95,-2.42,;-3.95,-.88,;-2.62,-.11,;-1.29,-.88,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574992 (1-((R)-1-(4-((R)-3-(difluoromethoxy)pyrrolidin-1-y...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CC[C@H](C2)OC(F)F)c2ncccc12 |wU:18.19,wD:29.33,(3.84,-3.02,;5.33,-3.42,;5.73,-4.9,;7.21,-5.3,;7.61,-6.79,;9.1,-7.19,;6.52,-7.88,;5.04,-7.48,;3.95,-8.57,;4.64,-5.99,;3.15,-5.59,;2.75,-4.11,;1.26,-3.71,;.17,-4.8,;.79,-2.24,;1.69,-1,;3.23,-1,;.79,.25,;1.26,1.71,;2.77,2.03,;.23,2.86,;-1.27,2.54,;-2.3,3.68,;-1.83,5.15,;-.32,5.47,;.71,4.32,;-2.86,6.29,;-2.54,7.8,;-3.87,8.57,;-5.02,7.54,;-4.39,6.13,;-6.52,7.86,;-7.61,6.77,;-7.21,5.28,;-9.1,7.17,;-.68,-.23,;-2.01,.54,;-3.34,-.23,;-3.34,-1.77,;-2.01,-2.54,;-.68,-1.77,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574993 (1-((R)-1-(4-((S)-3-(difluoromethoxy)pyrrolidin-1-y...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CC[C@@H](C2)OC(F)F)c2ncccc12 |wU:18.19,29.33,(3.84,-3.02,;5.33,-3.42,;5.73,-4.9,;7.21,-5.3,;7.61,-6.79,;9.1,-7.19,;6.52,-7.88,;5.04,-7.48,;3.95,-8.57,;4.64,-5.99,;3.15,-5.59,;2.75,-4.11,;1.26,-3.71,;.17,-4.8,;.79,-2.24,;1.69,-1,;3.23,-1,;.79,.25,;1.26,1.71,;2.77,2.03,;.23,2.86,;-1.27,2.54,;-2.3,3.68,;-1.83,5.15,;-.32,5.47,;.71,4.32,;-2.86,6.29,;-2.54,7.8,;-3.87,8.57,;-5.02,7.54,;-4.39,6.13,;-6.52,7.86,;-7.61,6.77,;-7.21,5.28,;-9.1,7.17,;-.68,-.23,;-2.01,.54,;-3.34,-.23,;-3.34,-1.77,;-2.01,-2.54,;-.68,-1.77,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574994 (1-((R)-1-(4-(3-(difluoromethoxy)azetidin-1-yl)cycl...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CC(C2)OC(F)F)c2c(F)cccc12 |wU:18.19,(-2.33,6.21,;-.82,6.53,;.21,5.39,;1.72,5.71,;2.75,4.56,;4.25,4.88,;2.27,3.1,;.76,2.78,;.29,1.31,;-.27,3.92,;-1.77,3.6,;-2.25,2.14,;-3.75,1.82,;-4.79,2.96,;-4.23,.35,;-3.33,-.89,;-1.79,-.89,;-4.23,-2.14,;-3.75,-3.6,;-4.84,-4.69,;-2.27,-4,;-1.18,-2.91,;.31,-3.31,;.71,-4.8,;-.38,-5.89,;-1.87,-5.49,;2.2,-5.2,;3.53,-4.43,;4.3,-5.76,;2.97,-6.53,;5.79,-6.16,;6.88,-5.07,;6.48,-3.58,;8.36,-5.47,;-5.7,-1.66,;-7.03,-2.43,;-7.03,-3.97,;-8.36,-1.66,;-8.36,-.12,;-7.03,.65,;-5.7,-.12,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM574996 (1-((R)-1-(4-(3-(difluoromethoxy)azetidin-1-yl)cycl...) Show SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CC(C2)OC(F)F)c2ncc(F)cc12 |wU:18.19,(3.23,-3.67,;4.72,-4.07,;5.12,-5.56,;6.61,-5.96,;7,-7.44,;8.49,-7.84,;5.91,-8.53,;4.43,-8.13,;3.34,-9.22,;4.03,-6.65,;2.54,-6.25,;2.14,-4.76,;.66,-4.36,;-.43,-5.45,;.18,-2.9,;1.08,-1.65,;2.62,-1.65,;.18,-.41,;.66,1.06,;2.16,1.38,;-.38,2.2,;-1.88,1.88,;-2.91,3.03,;-2.44,4.49,;-.93,4.81,;.1,3.67,;-3.47,5.64,;-5,5.72,;-4.92,7.25,;-3.39,7.17,;-5.95,8.4,;-7.46,8.08,;-7.94,6.61,;-8.49,9.22,;-1.29,-.88,;-2.62,-.11,;-3.95,-.88,;-3.95,-2.42,;-5.29,-3.19,;-2.62,-3.19,;-1.29,-2.42,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM PRC2 containing wt EZH2 (pentame...				Citation and Details BindingDB Entry DOI: 10.7270/Q20Z76H4
					More data for this Ligand-Target Pair

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