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Compile Data Set for Download or QSAR

Found 51 hits Enz. Inhib. hit(s) with all data for entry = 10866   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575632
PNG
(US11464802, Compound 1)
Show SMILES C[C@H]1CCCN(Cc2cc3C(=O)N(Cc3c(c2)C(F)(F)F)c2cccc(c2)C2(Cc3nncn3C)COC2)C1 |r|
PDB

UniProtKB/SwissProt

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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575633
PNG
(US11464802, Compound 2)
Show SMILES C[C@H]1C[C@@H](C)CN(Cc2cc3C(=O)N(Cc3c(c2)C(F)(F)F)c2cccc(c2)C2(Cc3nncn3C)COC2)C1 |r|
PDB

UniProtKB/SwissProt

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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575687
PNG
(US11464802, Compound 51)
Show SMILES C[C@H](N1CCC[C@H](C)C1)c1cc2C(=O)N(Cc2c(n1)C1CC1)c1cccc(c1)C1(Cc2nncn2C)COC1 |r|
PDB

UniProtKB/SwissProt

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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575686
PNG
(US11464802, Compound 50)
Show SMILES C[C@@H](N1CCC(F)(F)[C@H](C)C1)c1cc2C(=O)N(Cc2c(n1)C1CC1)c1cccc(c1)C1(Cc2nncn2C)COC1 |r|
PDB

UniProtKB/SwissProt

GoogleScholar
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575685
PNG
(US11464802, Compound 49)
Show SMILES C[C@H](N1CCC(F)(F)[C@H](C)C1)c1cc2C(=O)N(Cc2c(n1)C1CC1)c1cccc(c1)C1(Cc2nncn2C)COC1 |r|
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
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US Patent
n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575681
PNG
(US11464802, Compound 44)
Show SMILES CCNc1cc(cc(n1)N1Cc2c(cc(CN3CCC[C@H](C)C3)cc2C(F)(F)F)C1=O)C1(Cc2nncn2C)COC1 |r|
PDB

UniProtKB/SwissProt

GoogleScholar
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575677
PNG
(US11464802, Compound 40)
Show SMILES CCOc1cc(cc(n1)N1Cc2c(cc(CN3CCC[C@H](C)C3)nc2C2CC2)C1=O)C1(Cc2nncn2C)COC1 |r|
PDB

UniProtKB/SwissProt

GoogleScholar
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575676
PNG
(US11464802, Compound 39)
Show SMILES CCOc1cc(cc(n1)N1Cc2c(cc(CN3CCC[C@H](C)C3)cc2C(F)(F)F)C1=O)C1(Cc2nncn2C)COC1 |r|
PDB

UniProtKB/SwissProt

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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575673
PNG
(US11464802, Compound 36)
Show SMILES C[C@H]1CCCN(Cc2cc3C(=O)N(Cc3c(c2)C(F)(F)F)c2cccc(c2)C2(Cc3nncn3C(F)F)COC2)C1 |r|
PDB

UniProtKB/SwissProt

GoogleScholar
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575669
PNG
(US11464802, Compound 32)
Show SMILES C[C@@H]1CN(Cc2cc(nc(c2)C(=O)Nc2cccc(c2)C2(Cc3nncn3C)COC2)C2CC2)CCC1(F)F |r|
PDB

UniProtKB/SwissProt

GoogleScholar
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575661
PNG
(US11464802, Compound 24)
Show SMILES CC1CN(Cc2cc3C(=O)N(Cc3c(c2)C(F)(F)F)c2cccc(c2)C2(Cc3nncn3C)CC2)CCC1(F)F
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
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US Patent
n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575660
PNG
(US11464802, Compound 23)
Show SMILES C[C@H]1C[C@@H](CO)CN(Cc2cc3C(=O)N(Cc3c(c2)C(F)(F)F)c2cccc(c2)C2(Cc3nncn3C)COC2)C1 |r|
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575659
PNG
(US11464802, Compound 22)
Show SMILES C[C@H]1C[C@H](CO)CN(Cc2cc3C(=O)N(Cc3c(c2)C(F)(F)F)c2cccc(c2)C2(Cc3nncn3C)COC2)C1 |r|
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
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US Patent
n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575641
PNG
(US11464802, Compound 10)
Show SMILES Cn1cnnc1CC1(COC1)c1cccc(c1)N1Cc2c(cc(CN3CCC(F)(F)[C@H](C3)C#N)cc2C(F)(F)F)C1=O |r|
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575645
PNG
(US11464802, Compound 14)
Show SMILES Cn1cnnc1CC1(COC1)c1cccc(c1)N1Cc2c(cc(CN3CCC(F)(F)[C@@]4(CCOC4)C3)cc2C(F)(F)F)C1=O |r|
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575688
PNG
(US11464802, Compound 52)
Show SMILES C[C@@H](N1CCC[C@H](C)C1)c1cc2C(=O)N(Cc2c(n1)C1CC1)c1cccc(c1)C1(Cc2nncn2C)COC1 |r|
PDB

UniProtKB/SwissProt

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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575648
PNG
(US11464802, Compound 17)
Show SMILES C[C@H]1CN(Cc2cc3C(=O)N(Cc3c(c2)C(F)(F)F)c2cccc(c2)C2(Cc3nncn3C)COC2)C[C@@H](C)C1(F)F |r|
PDB

UniProtKB/SwissProt

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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575649
PNG
(US11464802, Compound 18)
Show SMILES Cn1cnnc1CC1(COC1)c1cccc(c1)N1Cc2c(cc(CN3CCC[C@@H](C3)C#N)cc2C(F)(F)F)C1=O |r|
PDB

UniProtKB/SwissProt

GoogleScholar
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US Patent
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575650
PNG
(US11464802, Compound 19)
Show SMILES C[C@H]1CCCN(Cc2cc3C(=O)N(Cc3c(c2)C(F)(F)F)c2cccc(c2)C2(Cc3nncn3C)COC2)[C@H]1C |r|
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
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US Patent
n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575651
PNG
(US11464802, Compound 20)
Show SMILES Cn1cnnc1CC1(COC1)c1cccc(c1)N1Cc2c(cc(CN3C[C@H](C[C@@H](C3)C(F)(F)F)C(F)(F)F)cc2C(F)(F)F)C1=O |r|
PDB

UniProtKB/SwissProt

GoogleScholar
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US Patent
n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575647
PNG
(US11464802, Compound 16)
Show SMILES Cn1cnnc1CC1(COC1)c1cccc(c1)N1Cc2c(cc(CN3CCC(F)(F)[C@@H](CO)C3)cc2C(F)(F)F)C1=O |r|
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575634
PNG
(US11464802, Compound 3)
Show SMILES C[C@@H]1CCCN(Cc2cc3C(=O)N(Cc3c(c2)C(F)(F)F)c2cccc(c2)C2(Cc3nncn3C)COC2)C1 |r|
PDB

UniProtKB/SwissProt

GoogleScholar
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PC sid
UniChem
US Patent
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575635
PNG
(US11464802, Compound 4)
Show SMILES Cn1cnnc1CC1(COC1)c1cccc(c1)N1Cc2c(cc(CN3CCCC(CC#N)C3)cc2C(F)(F)F)C1=O
PDB

UniProtKB/SwissProt

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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575682
PNG
(US11464802, Compound 45)
Show SMILES C[C@H]1C[C@@H](C)CN(Cc2cc3C(=O)N(Cc3c(c2)C(F)(F)F)c2cccc(c2)-c2c(cnn2C)-c2nncn2C)C1 |r|
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575642
PNG
(US11464802, Compound 11)
Show SMILES Cn1cnnc1CC1(COC1)c1cccc(c1)N1Cc2c(cc(CN3CCC(F)(F)[C@@H](C3)C#N)cc2C(F)(F)F)C1=O |r|
PDB

UniProtKB/SwissProt

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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575646
PNG
(US11464802, Compound 15)
Show SMILES Cn1cnnc1CC1(COC1)c1cccc(c1)N1Cc2c(cc(CN3CCC(F)(F)[C@H](CO)C3)cc2C(F)(F)F)C1=O |r|
PDB

UniProtKB/SwissProt

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US Patent
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575644
PNG
(US11464802, Compound 13)
Show SMILES Cn1cnnc1CC1(COC1)c1cccc(c1)N1Cc2c(cc(CN3CCC(F)(F)[C@]4(CCOC4)C3)cc2C(F)(F)F)C1=O |r|
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575675
PNG
(US11464802, Compound 38)
Show SMILES C[C@@H]1CN(Cc2cc3C(=O)N(Cc3c(n2)C2CC2)c2cccc(c2)C2(Cc3nncn3C(F)F)COC2)CCC1(F)F |r|
PDB

UniProtKB/SwissProt

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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575674
PNG
(US11464802, Compound 37)
Show SMILES C[C@H]1CCCN(Cc2cc3C(=O)N(Cc3c(n2)C2CC2)c2cccc(c2)C2(Cc3nncn3C(F)F)COC2)C1 |r|
PDB

UniProtKB/SwissProt

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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575684
PNG
(US11464802, Compound 48)
Show SMILES C[C@H]1CCCN(Cc2cc3C(=O)N(Cc3c(c2)C(F)(F)F)c2cc(ccn2)C2(Cc3nncn3C)COC2)C1 |r|
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575672
PNG
(US11464802, Compound 35)
Show SMILES C[C@H]1CCCN(Cc2cc3C(=O)N(Cc3c(n2)C2CC2)c2cccc(c2)C2(Cc3nncn3C)COC2)C1 |r|
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575678
PNG
(US11464802, Compound 41)
Show SMILES CCOc1cc(cc(n1)N1Cc2c(cc(CN3CCC(F)(F)[C@H](C)C3)nc2C2CCC2)C1=O)C1(Cc2nncn2C)COC1 |r|
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575679
PNG
(US11464802, Compound 42)
Show SMILES CCNc1cc(cc(n1)N1Cc2c(cc(CN3CCC(F)(F)[C@H](C)C3)nc2C2CC2)C1=O)C1(Cc2nncn2C)COC1 |r|
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575662
PNG
(US11464802, Compound 25)
Show SMILES CC1CN(Cc2cc3C(=O)N(Cc3c(c2)C(F)(F)F)c2cccc(c2)C2(CC2)[C@H](F)c2nncn2C)CCC1(F)F |r|
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575663
PNG
(US11464802, Compound 26)
Show SMILES CC1CN(Cc2cc3C(=O)N(Cc3c(c2)C(F)(F)F)c2cccc(c2)C2(CC2)[C@@H](F)c2nncn2C)CCC1(F)F |r|
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575665
PNG
(US11464802, Compound 28)
Show SMILES CCOc1cc(cc(n1)N1Cc2c(cc(CN3CCC(F)(F)[C@H](C)C3)cc2C(F)(F)F)C1=O)C1(Cc2nncn2C)COC1 |r|
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575668
PNG
(US11464802, Compound 31)
Show SMILES C[C@@H]1CN(Cc2cc3C(=O)N(Cc3c(c2)C(F)(F)F)c2cccc(c2)C2(Cc3nncn3C(F)F)COC2)CCC1(F)F |r|
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575680
PNG
(US11464802, Compound 43)
Show SMILES CCNc1cc(cc(n1)N1Cc2c(cc(CN3CCC[C@H](C)C3)nc2C2CC2)C1=O)C1(Cc2nncn2C)COC1 |r|
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575670
PNG
(US11464802, Compound 33)
Show SMILES C[C@H]1CN(Cc2cc(nc(c2)C(=O)Nc2cccc(c2)C2(Cc3nncn3C)COC2)C2CC2)CCC1(F)F |r|
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575671
PNG
(US11464802, Compound 34)
Show SMILES C[C@@H]1CN(Cc2cc3C(=O)N(Cc3c(n2)C2CC2)c2cccc(c2)C2(Cc3nncn3C)COC2)CCC1(F)F |r|
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575636
PNG
(US11464802, Compound 5)
Show SMILES Cn1cnnc1CC1(COC1)c1cccc(c1)N1Cc2c(cc(CN3CCC[C@](C)(F)C3)cc2C(F)(F)F)C1=O |r|
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575667
PNG
(US11464802, Compound 30)
Show SMILES C[C@@H]1CN(Cc2cc3C(=O)N(Cc3c(c2)C(F)(F)F)c2cc(cc(n2)C2CC2)C2(Cc3nncn3C)COC2)CCC1(F)F |r|
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575666
PNG
(US11464802, Compound 29)
Show SMILES C[C@@H]1CN(Cc2cc3C(=O)N(Cc3c(c2)C(F)(F)F)c2cc(cc(NC3COC3)n2)C2(Cc3nncn3C)COC2)CCC1(F)F |r|
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575637
PNG
(US11464802, Compound 6)
Show SMILES Cn1cnnc1CC1(COC1)c1cccc(c1)N1Cc2c(cc(CN3CCC[C@@](C)(F)C3)cc2C(F)(F)F)C1=O |r|
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575664
PNG
(US11464802, Compound 27)
Show SMILES CCNc1cc(cc(n1)N1Cc2c(cc(CN3CCC(F)(F)[C@H](C)C3)cc2C(F)(F)F)C1=O)C1(Cc2nncn2C)COC1 |r|
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575652
PNG
(US11464802, Compound 21)
Show SMILES Cn1cnnc1CC1(COC1)c1cccc(c1)N1Cc2c(cc(CN3CC(C[C@@H](C3)C(F)(F)F)C(F)(F)F)cc2C(F)(F)F)C1=O |r|
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575638
PNG
(US11464802, Compound 7)
Show SMILES Cn1cnnc1CC1(COC1)c1cccc(c1)N1Cc2c(cc(CN3CCCC4(CC4)C3)cc2C(F)(F)F)C1=O
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575639
PNG
(US11464802, Compound 8)
Show SMILES C[C@@H]1CN(Cc2cc3C(=O)N(Cc3c(c2)C(F)(F)F)c2cccc(c2)C2(Cc3nncn3C)COC2)CCC1(F)F |r|
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n/an/a 52.5n/an/an/an/an/an/a


TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575640
PNG
(US11464802, Compound 9)
Show SMILES C[C@H]1CN(Cc2cc3C(=O)N(Cc3c(c2)C(F)(F)F)c2cccc(c2)C2(Cc3nncn3C)COC2)CCC1(F)F |r|
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]


(Homo sapiens (Human))
BDBM575683
PNG
(US11464802, Compound 47)
Show SMILES C[C@H]1CCCN(Cc2cc3C(=O)N(Cc3c(c2)C(F)(F)F)c2cc(cc(Cl)n2)C2(Cc3nncn3C)COC2)C1 |r|
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TBA

Assay Description
Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2V98CBJ
More data for this
Ligand-Target Pair
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