Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM8979 (CHEMBL486901 | N-[2-(1-benzylpiperidin-4-yl)ethyl]...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | 8.0 | 25 |
Shanghai Institute of Materia Medica | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. The appearance of product was monitored at 412 nm for 5 min us... | Bioorg Med Chem Lett 14: 4639-42 (2004) Article DOI: 10.1016/j.bmcl.2004.07.005 BindingDB Entry DOI: 10.7270/Q23X84VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM8980 (N-[(1-benzylpiperidin-4-yl)methyl]-2-(1,2,3,4-tetr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10.2 | n/a | n/a | n/a | n/a | 8.0 | 25 |
Shanghai Institute of Materia Medica | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. The appearance of product was monitored at 412 nm for 5 min us... | Bioorg Med Chem Lett 14: 4639-42 (2004) Article DOI: 10.1016/j.bmcl.2004.07.005 BindingDB Entry DOI: 10.7270/Q23X84VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Rattus norvegicus (rat)) | BDBM8980 (N-[(1-benzylpiperidin-4-yl)methyl]-2-(1,2,3,4-tetr...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 12.4 | n/a | n/a | n/a | n/a | 8.0 | 25 |
Shanghai Institute of Materia Medica | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. The appearance of product was monitored at 412 nm for 5 min us... | Bioorg Med Chem Lett 14: 4639-42 (2004) Article DOI: 10.1016/j.bmcl.2004.07.005 BindingDB Entry DOI: 10.7270/Q23X84VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Rattus norvegicus (rat)) | BDBM8979 (CHEMBL486901 | N-[2-(1-benzylpiperidin-4-yl)ethyl]...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 76 | n/a | n/a | n/a | n/a | 8.0 | 25 |
Shanghai Institute of Materia Medica | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. The appearance of product was monitored at 412 nm for 5 min us... | Bioorg Med Chem Lett 14: 4639-42 (2004) Article DOI: 10.1016/j.bmcl.2004.07.005 BindingDB Entry DOI: 10.7270/Q23X84VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Rattus norvegicus (rat)) | BDBM8961 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 92 | n/a | n/a | n/a | n/a | 8.0 | 25 |
Shanghai Institute of Materia Medica | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. The appearance of product was monitored at 412 nm for 5 min us... | Bioorg Med Chem Lett 14: 4639-42 (2004) Article DOI: 10.1016/j.bmcl.2004.07.005 BindingDB Entry DOI: 10.7270/Q23X84VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM8961 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 223 | n/a | n/a | n/a | n/a | 8.0 | 25 |
Shanghai Institute of Materia Medica | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. The appearance of product was monitored at 412 nm for 5 min us... | Bioorg Med Chem Lett 14: 4639-42 (2004) Article DOI: 10.1016/j.bmcl.2004.07.005 BindingDB Entry DOI: 10.7270/Q23X84VR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM8982 (N-[2-(1-benzylpiperidin-4-yl)ethyl]-2-(2,3-dihydro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 230 | n/a | n/a | n/a | n/a | 8.0 | 25 |
Shanghai Institute of Materia Medica | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. The appearance of product was monitored at 412 nm for 5 min us... | Bioorg Med Chem Lett 14: 4639-42 (2004) Article DOI: 10.1016/j.bmcl.2004.07.005 BindingDB Entry DOI: 10.7270/Q23X84VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM8981 (N-[2-(1-benzylpiperidin-4-yl)ethyl]-2-[(3,4-dimeth...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 662 | n/a | n/a | n/a | n/a | 8.0 | 25 |
Shanghai Institute of Materia Medica | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. The appearance of product was monitored at 412 nm for 5 min us... | Bioorg Med Chem Lett 14: 4639-42 (2004) Article DOI: 10.1016/j.bmcl.2004.07.005 BindingDB Entry DOI: 10.7270/Q23X84VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Rattus norvegicus (rat)) | BDBM8983 (N-[2-(1-benzylpiperidin-4-yl)ethyl]-2-{5H,10H-inde...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 869 | n/a | n/a | n/a | n/a | 8.0 | 25 |
Shanghai Institute of Materia Medica | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. The appearance of product was monitored at 412 nm for 5 min us... | Bioorg Med Chem Lett 14: 4639-42 (2004) Article DOI: 10.1016/j.bmcl.2004.07.005 BindingDB Entry DOI: 10.7270/Q23X84VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Rattus norvegicus (rat)) | BDBM8982 (N-[2-(1-benzylpiperidin-4-yl)ethyl]-2-(2,3-dihydro...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.92E+3 | n/a | n/a | n/a | n/a | 8.0 | 25 |
Shanghai Institute of Materia Medica | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. The appearance of product was monitored at 412 nm for 5 min us... | Bioorg Med Chem Lett 14: 4639-42 (2004) Article DOI: 10.1016/j.bmcl.2004.07.005 BindingDB Entry DOI: 10.7270/Q23X84VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Rattus norvegicus (rat)) | BDBM8983 (N-[2-(1-benzylpiperidin-4-yl)ethyl]-2-{5H,10H-inde...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.78E+4 | n/a | n/a | n/a | n/a | 8.0 | 25 |
Shanghai Institute of Materia Medica | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. The appearance of product was monitored at 412 nm for 5 min us... | Bioorg Med Chem Lett 14: 4639-42 (2004) Article DOI: 10.1016/j.bmcl.2004.07.005 BindingDB Entry DOI: 10.7270/Q23X84VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carboxylic ester hydrolase (Rattus norvegicus (rat)) | BDBM8981 (N-[2-(1-benzylpiperidin-4-yl)ethyl]-2-[(3,4-dimeth...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.92E+4 | n/a | n/a | n/a | n/a | 8.0 | 25 |
Shanghai Institute of Materia Medica | Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. The appearance of product was monitored at 412 nm for 5 min us... | Bioorg Med Chem Lett 14: 4639-42 (2004) Article DOI: 10.1016/j.bmcl.2004.07.005 BindingDB Entry DOI: 10.7270/Q23X84VR | |||||||||||
More data for this Ligand-Target Pair |