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Compile Data Set for Download or QSAR

Found 199 hits Enz. Inhib. hit(s) with all data for entry = 1266   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314097
PNG
(3-(benzylamino)pyridazine-4-carboxylic acid | US10...)
Show SMILES OC(=O)c1ccnnc1NCc1ccccc1
Show InChI InChI=1S/C12H11N3O2/c16-12(17)10-6-7-14-15-11(10)13-8-9-4-2-1-3-5-9/h1-7H,8H2,(H,13,15)(H,16,17)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314097
PNG
(3-(benzylamino)pyridazine-4-carboxylic acid | US10...)
Show SMILES OC(=O)c1ccnnc1NCc1ccccc1
Show InChI InChI=1S/C12H11N3O2/c16-12(17)10-6-7-14-15-11(10)13-8-9-4-2-1-3-5-9/h1-7H,8H2,(H,13,15)(H,16,17)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314098
PNG
(3-[(2-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1F
Show InChI InChI=1S/C13H11FN2O2/c14-11-4-2-1-3-9(11)7-16-12-8-15-6-5-10(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314098
PNG
(3-[(2-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1F
Show InChI InChI=1S/C13H11FN2O2/c14-11-4-2-1-3-9(11)7-16-12-8-15-6-5-10(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314098
PNG
(3-[(2-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1F
Show InChI InChI=1S/C13H11FN2O2/c14-11-4-2-1-3-9(11)7-16-12-8-15-6-5-10(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314099
PNG
(3-[(3-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(F)c1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-2-9(6-10)7-16-12-8-15-5-4-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314099
PNG
(3-[(3-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(F)c1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-2-9(6-10)7-16-12-8-15-5-4-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314099
PNG
(3-[(3-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1cccc(F)c1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-2-9(6-10)7-16-12-8-15-5-4-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314100
PNG
(3-[(4-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(F)cc1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314100
PNG
(3-[(4-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(F)cc1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314100
PNG
(3-[(4-fluorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(F)cc1
Show InChI InChI=1S/C13H11FN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314101
PNG
(3[(4-cyanobenzyl)amino]pyridine-4-carboxylic acid ...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C#N
Show InChI InChI=1S/C14H11N3O2/c15-7-10-1-3-11(4-2-10)8-17-13-9-16-6-5-12(13)14(18)19/h1-6,9,17H,8H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314101
PNG
(3[(4-cyanobenzyl)amino]pyridine-4-carboxylic acid ...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C#N
Show InChI InChI=1S/C14H11N3O2/c15-7-10-1-3-11(4-2-10)8-17-13-9-16-6-5-12(13)14(18)19/h1-6,9,17H,8H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314101
PNG
(3[(4-cyanobenzyl)amino]pyridine-4-carboxylic acid ...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C#N
Show InChI InChI=1S/C14H11N3O2/c15-7-10-1-3-11(4-2-10)8-17-13-9-16-6-5-12(13)14(18)19/h1-6,9,17H,8H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314102
PNG
(3-{[4-hydroxymethyl)benzyl]amino}pyridine-4-carbox...)
Show SMILES OCc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O3/c17-9-11-3-1-10(2-4-11)7-16-13-8-15-6-5-12(13)14(18)19/h1-6,8,16-17H,7,9H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314102
PNG
(3-{[4-hydroxymethyl)benzyl]amino}pyridine-4-carbox...)
Show SMILES OCc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O3/c17-9-11-3-1-10(2-4-11)7-16-13-8-15-6-5-12(13)14(18)19/h1-6,8,16-17H,7,9H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314102
PNG
(3-{[4-hydroxymethyl)benzyl]amino}pyridine-4-carbox...)
Show SMILES OCc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O3/c17-9-11-3-1-10(2-4-11)7-16-13-8-15-6-5-12(13)14(18)19/h1-6,8,16-17H,7,9H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314103
PNG
(3-[(4-methoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES COc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O3/c1-19-11-4-2-10(3-5-11)8-16-13-9-15-7-6-12(13)14(17)18/h2-7,9,16H,8H2,1H3,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314103
PNG
(3-[(4-methoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES COc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O3/c1-19-11-4-2-10(3-5-11)8-16-13-9-15-7-6-12(13)14(17)18/h2-7,9,16H,8H2,1H3,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314103
PNG
(3-[(4-methoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES COc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C14H14N2O3/c1-19-11-4-2-10(3-5-11)8-16-13-9-15-7-6-12(13)14(17)18/h2-7,9,16H,8H2,1H3,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314104
PNG
(3-{[4-(trifluoromethyl)benzyl]amino}pyridine-4-car...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O2/c15-14(16,17)10-3-1-9(2-4-10)7-19-12-8-18-6-5-11(12)13(20)21/h1-6,8,19H,7H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314104
PNG
(3-{[4-(trifluoromethyl)benzyl]amino}pyridine-4-car...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O2/c15-14(16,17)10-3-1-9(2-4-10)7-19-12-8-18-6-5-11(12)13(20)21/h1-6,8,19H,7H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314104
PNG
(3-{[4-(trifluoromethyl)benzyl]amino}pyridine-4-car...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O2/c15-14(16,17)10-3-1-9(2-4-10)7-19-12-8-18-6-5-11(12)13(20)21/h1-6,8,19H,7H2,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314105
PNG
(3-[(biphenyl-4-ylmethyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H16N2O2/c22-19(23)17-10-11-20-13-18(17)21-12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-11,13,21H,12H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314106
PNG
(3-[(4-chlorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1
Show InChI InChI=1S/C13H11ClN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314106
PNG
(3-[(4-chlorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1
Show InChI InChI=1S/C13H11ClN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314106
PNG
(3-[(4-chlorobenzyl)amino]pyridine-4-carboxylic aci...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1
Show InChI InChI=1S/C13H11ClN2O2/c14-10-3-1-9(2-4-10)7-16-12-8-15-6-5-11(12)13(17)18/h1-6,8,16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314107
PNG
(3-{[4-(propan-2-yloxy)benzyl]amino}pyridine-4-carb...)
Show SMILES CC(C)Oc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C16H18N2O3/c1-11(2)21-13-5-3-12(4-6-13)9-18-15-10-17-8-7-14(15)16(19)20/h3-8,10-11,18H,9H2,1-2H3,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314107
PNG
(3-{[4-(propan-2-yloxy)benzyl]amino}pyridine-4-carb...)
Show SMILES CC(C)Oc1ccc(CNc2cnccc2C(O)=O)cc1
Show InChI InChI=1S/C16H18N2O3/c1-11(2)21-13-5-3-12(4-6-13)9-18-15-10-17-8-7-14(15)16(19)20/h3-8,10-11,18H,9H2,1-2H3,(H,19,20)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314108
PNG
(3-[(4-phenoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C19H16N2O3/c22-19(23)17-10-11-20-13-18(17)21-12-14-6-8-16(9-7-14)24-15-4-2-1-3-5-15/h1-11,13,21H,12H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314108
PNG
(3-[(4-phenoxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C19H16N2O3/c22-19(23)17-10-11-20-13-18(17)21-12-14-6-8-16(9-7-14)24-15-4-2-1-3-5-15/h1-11,13,21H,12H2,(H,22,23)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314109
PNG
(3-({2-[(dimethylamino)methyl]benzyl}amino)pyridine...)
Show SMILES CN(C)Cc1ccccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C16H19N3O2/c1-19(2)11-13-6-4-3-5-12(13)9-18-15-10-17-8-7-14(15)16(20)21/h3-8,10,18H,9,11H2,1-2H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314109
PNG
(3-({2-[(dimethylamino)methyl]benzyl}amino)pyridine...)
Show SMILES CN(C)Cc1ccccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C16H19N3O2/c1-19(2)11-13-6-4-3-5-12(13)9-18-15-10-17-8-7-14(15)16(20)21/h3-8,10,18H,9,11H2,1-2H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314109
PNG
(3-({2-[(dimethylamino)methyl]benzyl}amino)pyridine...)
Show SMILES CN(C)Cc1ccccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C16H19N3O2/c1-19(2)11-13-6-4-3-5-12(13)9-18-15-10-17-8-7-14(15)16(20)21/h3-8,10,18H,9,11H2,1-2H3,(H,20,21)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314110
PNG
(3-[(3,4-dichlorobenzyl)amino]pyridine-4-carboxylic...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C13H10Cl2N2O2/c14-10-2-1-8(5-11(10)15)6-17-12-7-16-4-3-9(12)13(18)19/h1-5,7,17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314110
PNG
(3-[(3,4-dichlorobenzyl)amino]pyridine-4-carboxylic...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C13H10Cl2N2O2/c14-10-2-1-8(5-11(10)15)6-17-12-7-16-4-3-9(12)13(18)19/h1-5,7,17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314110
PNG
(3-[(3,4-dichlorobenzyl)amino]pyridine-4-carboxylic...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C13H10Cl2N2O2/c14-10-2-1-8(5-11(10)15)6-17-12-7-16-4-3-9(12)13(18)19/h1-5,7,17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314111
PNG
(3-[(4-chloro-2-methylbenzyl)amino]pyridine-4-carbo...)
Show SMILES Cc1cc(Cl)ccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C14H13ClN2O2/c1-9-6-11(15)3-2-10(9)7-17-13-8-16-5-4-12(13)14(18)19/h2-6,8,17H,7H2,1H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314111
PNG
(3-[(4-chloro-2-methylbenzyl)amino]pyridine-4-carbo...)
Show SMILES Cc1cc(Cl)ccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C14H13ClN2O2/c1-9-6-11(15)3-2-10(9)7-17-13-8-16-5-4-12(13)14(18)19/h2-6,8,17H,7H2,1H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314111
PNG
(3-[(4-chloro-2-methylbenzyl)amino]pyridine-4-carbo...)
Show SMILES Cc1cc(Cl)ccc1CNc1cnccc1C(O)=O
Show InChI InChI=1S/C14H13ClN2O2/c1-9-6-11(15)3-2-10(9)7-17-13-8-16-5-4-12(13)14(18)19/h2-6,8,17H,7H2,1H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314112
PNG
(3-[(2,4-dimethyoxybenzyl)amino]pyridine-4-carboxyl...)
Show SMILES COc1ccc(CNc2cnccc2C(O)=O)c(OC)c1
Show InChI InChI=1S/C15H16N2O4/c1-20-11-4-3-10(14(7-11)21-2)8-17-13-9-16-6-5-12(13)15(18)19/h3-7,9,17H,8H2,1-2H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314112
PNG
(3-[(2,4-dimethyoxybenzyl)amino]pyridine-4-carboxyl...)
Show SMILES COc1ccc(CNc2cnccc2C(O)=O)c(OC)c1
Show InChI InChI=1S/C15H16N2O4/c1-20-11-4-3-10(14(7-11)21-2)8-17-13-9-16-6-5-12(13)15(18)19/h3-7,9,17H,8H2,1-2H3,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314113
PNG
(3-[(2-hydroxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1O
Show InChI InChI=1S/C13H12N2O3/c16-12-4-2-1-3-9(12)7-15-11-8-14-6-5-10(11)13(17)18/h1-6,8,15-16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314113
PNG
(3-[(2-hydroxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1O
Show InChI InChI=1S/C13H12N2O3/c16-12-4-2-1-3-9(12)7-15-11-8-14-6-5-10(11)13(17)18/h1-6,8,15-16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314113
PNG
(3-[(2-hydroxybenzyl)amino]pyridine-4-carboxylic ac...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1O
Show InChI InChI=1S/C13H12N2O3/c16-12-4-2-1-3-9(12)7-15-11-8-14-6-5-10(11)13(17)18/h1-6,8,15-16H,7H2,(H,17,18)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314114
PNG
(3-[(2,4-dichlorobenzyl)amino]pyridine-4-carboxylic...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H10Cl2N2O2/c14-9-2-1-8(11(15)5-9)6-17-12-7-16-4-3-10(12)13(18)19/h1-5,7,17H,6H2,(H,18,19)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314114
PNG
(3-[(2,4-dichlorobenzyl)amino]pyridine-4-carboxylic...)
Show SMILES OC(=O)c1ccncc1NCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H10Cl2N2O2/c14-9-2-1-8(11(15)5-9)6-17-12-7-16-4-3-10(12)13(18)19/h1-5,7,17H,6H2,(H,18,19)
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM314115
PNG
(3-[(2-cyclopropylbenzyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1C1CC1
Show InChI InChI=1S/C16H16N2O2/c19-16(20)14-7-8-17-10-15(14)18-9-12-3-1-2-4-13(12)11-5-6-11/h1-4,7-8,10-11,18H,5-6,9H2,(H,19,20)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B


(Homo sapiens (Human))
BDBM314115
PNG
(3-[(2-cyclopropylbenzyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1C1CC1
Show InChI InChI=1S/C16H16N2O2/c19-16(20)14-7-8-17-10-15(14)18-9-12-3-1-2-4-13(12)11-5-6-11/h1-4,7-8,10-11,18H,5-6,9H2,(H,19,20)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM314115
PNG
(3-[(2-cyclopropylbenzyl)amino]pyridine-4-carboxyli...)
Show SMILES OC(=O)c1ccncc1NCc1ccccc1C1CC1
Show InChI InChI=1S/C16H16N2O2/c19-16(20)14-7-8-17-10-15(14)18-9-12-3-1-2-4-13(12)11-5-6-11/h1-4,7-8,10-11,18H,5-6,9H2,(H,19,20)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...


US Patent US9611221 (2017)


BindingDB Entry DOI: 10.7270/Q26975NT
More data for this
Ligand-Target Pair
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