Compile Data Set for Download or QSAR

Found 68 hits Enz. Inhib. hit(s) with all data for entry = 1734   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM266453 (US9718822, 1 | US9750744, Example 1 | US9902741, E...) Show SMILES Fc1cc2[C@H]3CCCN3c3ccn4ncc(C(=O)NCCCn(c1)c2=O)c4n3 |r| Show InChI InChI=1S/C19H19FN6O2/c20-12-9-13-15-3-1-7-25(15)16-4-8-26-17(23-16)14(10-22-26)18(27)21-5-2-6-24(11-12)19(13)28/h4,8-11,15H,1-3,5-7H2,(H,21,27)/t15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM266453 (US9718822, 1 | US9750744, Example 1 | US9902741, E...) Show SMILES Fc1cc2[C@H]3CCCN3c3ccn4ncc(C(=O)NCCCn(c1)c2=O)c4n3 |r| Show InChI InChI=1S/C19H19FN6O2/c20-12-9-13-15-3-1-7-25(15)16-4-8-26-17(23-16)14(10-22-26)18(27)21-5-2-6-24(11-12)19(13)28/h4,8-11,15H,1-3,5-7H2,(H,21,27)/t15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM266501 (US10688100, Compound 2 | US10966985, Compound 2 | ...) Show SMILES O=C1NCCCOc2cccc(n2)[C@H]2CCCN2c2ccn3ncc1c3n2 |r| Show InChI InChI=1S/C19H20N6O2/c26-19-13-12-21-25-10-7-16(23-18(13)25)24-9-2-5-15(24)14-4-1-6-17(22-14)27-11-3-8-20-19/h1,4,6-7,10,12,15H,2-3,5,8-9,11H2,(H,20,26)/t15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM266501 (US10688100, Compound 2 | US10966985, Compound 2 | ...) Show SMILES O=C1NCCCOc2cccc(n2)[C@H]2CCCN2c2ccn3ncc1c3n2 |r| Show InChI InChI=1S/C19H20N6O2/c26-19-13-12-21-25-10-7-16(23-18(13)25)24-9-2-5-15(24)14-4-1-6-17(22-14)27-11-3-8-20-19/h1,4,6-7,10,12,15H,2-3,5,8-9,11H2,(H,20,26)/t15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267407 (US10966985, Compound 3 | US9718822, 3 | US9750744,...) Show SMILES Fc1cnc2OCCCNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C19H19FN6O2/c20-12-9-13-15-3-1-6-25(15)16-4-7-26-17(24-16)14(11-23-26)18(27)21-5-2-8-28-19(13)22-10-12/h4,7,9-11,15H,1-3,5-6,8H2,(H,21,27)/t15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267407 (US10966985, Compound 3 | US9718822, 3 | US9750744,...) Show SMILES Fc1cnc2OCCCNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C19H19FN6O2/c20-12-9-13-15-3-1-6-25(15)16-4-7-26-17(24-16)14(11-23-26)18(27)21-5-2-8-28-19(13)22-10-12/h4,7,9-11,15H,1-3,5-6,8H2,(H,21,27)/t15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267410 (US9718822, 4 | US9718822, 6 | US9750744, Example 6...) Show SMILES OC1CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cnc2OC1 |r| Show InChI InChI=1S/C19H19FN6O3/c20-11-6-13-15-2-1-4-25(15)16-3-5-26-17(24-16)14(9-23-26)18(28)21-8-12(27)10-29-19(13)22-7-11/h3,5-7,9,12,15,27H,1-2,4,8,10H2,(H,21,28)/t12?,15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267410 (US9718822, 4 | US9718822, 6 | US9750744, Example 6...) Show SMILES OC1CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cnc2OC1 |r| Show InChI InChI=1S/C19H19FN6O3/c20-11-6-13-15-2-1-4-25(15)16-3-5-26-17(24-16)14(9-23-26)18(28)21-8-12(27)10-29-19(13)22-7-11/h3,5-7,9,12,15,27H,1-2,4,8,10H2,(H,21,28)/t12?,15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267411 (US9718822, 5 | US9750744, Example 5 | US9902741, E...) Show SMILES O[C@H]1CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cn(C1)c2=O |r| Show InChI InChI=1S/C19H19FN6O3/c20-11-6-13-15-2-1-4-25(15)16-3-5-26-17(23-16)14(8-22-26)18(28)21-7-12(27)10-24(9-11)19(13)29/h3,5-6,8-9,12,15,27H,1-2,4,7,10H2,(H,21,28)/t12-,15+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267411 (US9718822, 5 | US9750744, Example 5 | US9902741, E...) Show SMILES O[C@H]1CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cn(C1)c2=O |r| Show InChI InChI=1S/C19H19FN6O3/c20-11-6-13-15-2-1-4-25(15)16-3-5-26-17(23-16)14(8-22-26)18(28)21-7-12(27)10-24(9-11)19(13)29/h3,5-6,8-9,12,15,27H,1-2,4,7,10H2,(H,21,28)/t12-,15+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267410 (US9718822, 4 | US9718822, 6 | US9750744, Example 6...) Show SMILES OC1CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cnc2OC1 |r| Show InChI InChI=1S/C19H19FN6O3/c20-11-6-13-15-2-1-4-25(15)16-3-5-26-17(24-16)14(9-23-26)18(28)21-8-12(27)10-29-19(13)22-7-11/h3,5-7,9,12,15,27H,1-2,4,8,10H2,(H,21,28)/t12?,15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267410 (US9718822, 4 | US9718822, 6 | US9750744, Example 6...) Show SMILES OC1CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cnc2OC1 |r| Show InChI InChI=1S/C19H19FN6O3/c20-11-6-13-15-2-1-4-25(15)16-3-5-26-17(24-16)14(9-23-26)18(28)21-8-12(27)10-29-19(13)22-7-11/h3,5-7,9,12,15,27H,1-2,4,8,10H2,(H,21,28)/t12?,15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267414 (US10688100, Compound 7 | US10966985, Compound 7 | ...) Show SMILES O[C@@H]1CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cnc2OC1 |r| Show InChI InChI=1S/C19H19FN6O3/c20-11-6-13-15-2-1-4-25(15)16-3-5-26-17(24-16)14(9-23-26)18(28)21-8-12(27)10-29-19(13)22-7-11/h3,5-7,9,12,15,27H,1-2,4,8,10H2,(H,21,28)/t12-,15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267414 (US10688100, Compound 7 | US10966985, Compound 7 | ...) Show SMILES O[C@@H]1CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cnc2OC1 |r| Show InChI InChI=1S/C19H19FN6O3/c20-11-6-13-15-2-1-4-25(15)16-3-5-26-17(24-16)14(9-23-26)18(28)21-8-12(27)10-29-19(13)22-7-11/h3,5-7,9,12,15,27H,1-2,4,8,10H2,(H,21,28)/t12-,15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267415 (US9718822, 8 | US9750744, Example 8 | US9902741, E...) Show SMILES O[C@@H]1CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cn(C1)c2=O |r| Show InChI InChI=1S/C19H19FN6O3/c20-11-6-13-15-2-1-4-25(15)16-3-5-26-17(23-16)14(8-22-26)18(28)21-7-12(27)10-24(9-11)19(13)29/h3,5-6,8-9,12,15,27H,1-2,4,7,10H2,(H,21,28)/t12-,15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267415 (US9718822, 8 | US9750744, Example 8 | US9902741, E...) Show SMILES O[C@@H]1CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cn(C1)c2=O |r| Show InChI InChI=1S/C19H19FN6O3/c20-11-6-13-15-2-1-4-25(15)16-3-5-26-17(23-16)14(8-22-26)18(28)21-7-12(27)10-24(9-11)19(13)29/h3,5-6,8-9,12,15,27H,1-2,4,7,10H2,(H,21,28)/t12-,15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267416 (US10688100, Compound 9 | US10966985, Compound 9 | ...) Show SMILES Fc1cnc2OCCNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C18H17FN6O2/c19-11-8-12-14-2-1-5-24(14)15-3-6-25-16(23-15)13(10-22-25)17(26)20-4-7-27-18(12)21-9-11/h3,6,8-10,14H,1-2,4-5,7H2,(H,20,26)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267416 (US10688100, Compound 9 | US10966985, Compound 9 | ...) Show SMILES Fc1cnc2OCCNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C18H17FN6O2/c19-11-8-12-14-2-1-5-24(14)15-3-6-25-16(23-15)13(10-22-25)17(26)20-4-7-27-18(12)21-9-11/h3,6,8-10,14H,1-2,4-5,7H2,(H,20,26)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267416 (US10688100, Compound 9 | US10966985, Compound 9 | ...) Show SMILES Fc1cnc2OCCNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C18H17FN6O2/c19-11-8-12-14-2-1-5-24(14)15-3-6-25-16(23-15)13(10-22-25)17(26)20-4-7-27-18(12)21-9-11/h3,6,8-10,14H,1-2,4-5,7H2,(H,20,26)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267416 (US10688100, Compound 9 | US10966985, Compound 9 | ...) Show SMILES Fc1cnc2OCCNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C18H17FN6O2/c19-11-8-12-14-2-1-5-24(14)15-3-6-25-16(23-15)13(10-22-25)17(26)20-4-7-27-18(12)21-9-11/h3,6,8-10,14H,1-2,4-5,7H2,(H,20,26)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM337640 (US9750744, Example 11) Show SMILES Fc1cc2[C@H]3CCCN3c3ccn4ncc(CC(=O)NCCCCn(c1)c2=O)c4n3 |r| Show InChI InChI=1S/C21H23FN6O2/c22-15-11-16-17-4-3-8-27(17)18-5-9-28-20(25-18)14(12-24-28)10-19(29)23-6-1-2-7-26(13-15)21(16)30/h5,9,11-13,17H,1-4,6-8,10H2,(H,23,29)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM337640 (US9750744, Example 11) Show SMILES Fc1cc2[C@H]3CCCN3c3ccn4ncc(CC(=O)NCCCCn(c1)c2=O)c4n3 |r| Show InChI InChI=1S/C21H23FN6O2/c22-15-11-16-17-4-3-8-27(17)18-5-9-28-20(25-18)14(12-24-28)10-19(29)23-6-1-2-7-26(13-15)21(16)30/h5,9,11-13,17H,1-4,6-8,10H2,(H,23,29)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267420 (US9718822, 12 | US9750744, Example 12 | US9902741,...) Show SMILES Fc1cnc2NCCNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C18H18FN7O/c19-11-8-12-14-2-1-6-25(14)15-3-7-26-17(24-15)13(10-23-26)18(27)21-5-4-20-16(12)22-9-11/h3,7-10,14H,1-2,4-6H2,(H,20,22)(H,21,27)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267421 (US9718822, 13 | US9750744, Example 13) Show SMILES Fc1cnc2NCCCNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C19H20FN7O/c20-12-9-13-15-3-1-7-26(15)16-4-8-27-18(25-16)14(11-24-27)19(28)22-6-2-5-21-17(13)23-10-12/h4,8-11,15H,1-3,5-7H2,(H,21,23)(H,22,28)/t15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267424 (US10688100, Compound 14 | US10966985, Compound 14 ...) Show SMILES Fc1cnc2OCCOC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C18H16FN5O3/c19-11-8-12-14-2-1-4-23(14)15-3-5-24-16(22-15)13(10-21-24)18(25)27-7-6-26-17(12)20-9-11/h3,5,8-10,14H,1-2,4,6-7H2/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267429 (US9718822, 16 | US9750744, Example 16 | US9902741,...) Show SMILES Fc1cnc2OCCONC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C18H17FN6O3/c19-11-8-12-14-2-1-4-24(14)15-3-5-25-16(22-15)13(10-21-25)17(26)23-28-7-6-27-18(12)20-9-11/h3,5,8-10,14H,1-2,4,6-7H2,(H,23,26)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267429 (US9718822, 16 | US9750744, Example 16 | US9902741,...) Show SMILES Fc1cnc2OCCONC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C18H17FN6O3/c19-11-8-12-14-2-1-4-24(14)15-3-5-25-16(22-15)13(10-21-25)17(26)23-28-7-6-27-18(12)20-9-11/h3,5,8-10,14H,1-2,4,6-7H2,(H,23,26)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267430 (US9718822, 17 | US9750744, Example 17 | US9902741,...) Show SMILES F[C@@H]1CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cn(C1)c2=O |r| Show InChI InChI=1S/C19H18F2N6O2/c20-11-6-13-15-2-1-4-26(15)16-3-5-27-17(24-16)14(8-23-27)18(28)22-7-12(21)10-25(9-11)19(13)29/h3,5-6,8-9,12,15H,1-2,4,7,10H2,(H,22,28)/t12-,15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267431 (US9718822, 18 | US9750744, Example 18 | US9902741,...) Show SMILES CN1CCCOc2ncc(F)cc2[C@H]2CCCN2c2ccn3ncc(C1=O)c3n2 |r| Show InChI InChI=1S/C20H21FN6O2/c1-25-6-3-9-29-19-14(10-13(21)11-22-19)16-4-2-7-26(16)17-5-8-27-18(24-17)15(12-23-27)20(25)28/h5,8,10-12,16H,2-4,6-7,9H2,1H3/t16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267431 (US9718822, 18 | US9750744, Example 18 | US9902741,...) Show SMILES CN1CCCOc2ncc(F)cc2[C@H]2CCCN2c2ccn3ncc(C1=O)c3n2 |r| Show InChI InChI=1S/C20H21FN6O2/c1-25-6-3-9-29-19-14(10-13(21)11-22-19)16-4-2-7-26(16)17-5-8-27-18(24-17)15(12-23-27)20(25)28/h5,8,10-12,16H,2-4,6-7,9H2,1H3/t16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267434 (US10688100, Compound 19 | US10966985, Compound 19 ...) Show SMILES Fc1cnc2OCC(F)(F)CNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C19H17F3N6O2/c20-11-6-12-14-2-1-4-27(14)15-3-5-28-16(26-15)13(8-25-28)17(29)24-9-19(21,22)10-30-18(12)23-7-11/h3,5-8,14H,1-2,4,9-10H2,(H,24,29)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267434 (US10688100, Compound 19 | US10966985, Compound 19 ...) Show SMILES Fc1cnc2OCC(F)(F)CNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C19H17F3N6O2/c20-11-6-12-14-2-1-4-27(14)15-3-5-28-16(26-15)13(8-25-28)17(29)24-9-19(21,22)10-30-18(12)23-7-11/h3,5-8,14H,1-2,4,9-10H2,(H,24,29)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267436 (US10688100, Compound 20 | US10966985, Compound 20 ...) Show SMILES Fc1ccc2OCCCNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C20H20FN5O2/c21-13-4-5-17-14(11-13)16-3-1-8-25(16)18-6-9-26-19(24-18)15(12-23-26)20(27)22-7-2-10-28-17/h4-6,9,11-12,16H,1-3,7-8,10H2,(H,22,27)/t16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267436 (US10688100, Compound 20 | US10966985, Compound 20 ...) Show SMILES Fc1ccc2OCCCNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C20H20FN5O2/c21-13-4-5-17-14(11-13)16-3-1-8-25(16)18-6-9-26-19(24-18)15(12-23-26)20(27)22-7-2-10-28-17/h4-6,9,11-12,16H,1-3,7-8,10H2,(H,22,27)/t16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267438 (US10688100, Compound 22 | US10966985, Compound 22 ...) Show SMILES CC(=O)N1CCOc2ccc(F)cc2[C@H]2CCCN2c2ccn3ncc(C1)c3n2 |r| Show InChI InChI=1S/C21H22FN5O2/c1-14(28)25-9-10-29-19-5-4-16(22)11-17(19)18-3-2-7-26(18)20-6-8-27-21(24-20)15(13-25)12-23-27/h4-6,8,11-12,18H,2-3,7,9-10,13H2,1H3/t18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267440 (US9718822, 23 | US9750744, Example 23 | US9902741,...) Show SMILES OCC(=O)N1CCOc2ccc(F)cc2[C@H]2CCCN2c2ccn3ncc(C1)c3n2 |r| Show InChI InChI=1S/C21H22FN5O3/c22-15-3-4-18-16(10-15)17-2-1-6-26(17)19-5-7-27-21(24-19)14(11-23-27)12-25(8-9-30-18)20(29)13-28/h3-5,7,10-11,17,28H,1-2,6,8-9,12-13H2/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267440 (US9718822, 23 | US9750744, Example 23 | US9902741,...) Show SMILES OCC(=O)N1CCOc2ccc(F)cc2[C@H]2CCCN2c2ccn3ncc(C1)c3n2 |r| Show InChI InChI=1S/C21H22FN5O3/c22-15-3-4-18-16(10-15)17-2-1-6-26(17)19-5-7-27-21(24-19)14(11-23-27)12-25(8-9-30-18)20(29)13-28/h3-5,7,10-11,17,28H,1-2,6,8-9,12-13H2/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267442 (US9718822, 25 | US9750744, Example 25 | US9902741,...) Show SMILES CS(=O)(=O)N1CCOc2ccc(F)cc2[C@H]2CCCN2c2ccn3ncc(C1)c3n2 |r| Show InChI InChI=1S/C20H22FN5O3S/c1-30(27,28)24-9-10-29-18-5-4-15(21)11-16(18)17-3-2-7-25(17)19-6-8-26-20(23-19)14(13-24)12-22-26/h4-6,8,11-12,17H,2-3,7,9-10,13H2,1H3/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267445 (US9718822, 28 | US9750744, Example 28 | US9902741,...) Show SMILES CCNC(=O)N1CCCOc2ccc(F)cc2[C@H]2CCCN2c2ccn3ncc(C1)c3n2 |r| Show InChI InChI=1S/C23H27FN6O2/c1-2-25-23(31)28-9-4-12-32-20-7-6-17(24)13-18(20)19-5-3-10-29(19)21-8-11-30-22(27-21)16(15-28)14-26-30/h6-8,11,13-14,19H,2-5,9-10,12,15H2,1H3,(H,25,31)/t19-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267446 (US9718822, 29 | US9750744, Example 29 | US9902741,...) Show SMILES CCNC(=O)N1CCOc2ccc(F)cc2[C@H]2CCCN2c2ccn3ncc(C1)c3n2 |r| Show InChI InChI=1S/C22H25FN6O2/c1-2-24-22(30)27-10-11-31-19-6-5-16(23)12-17(19)18-4-3-8-28(18)20-7-9-29-21(26-20)15(14-27)13-25-29/h5-7,9,12-13,18H,2-4,8,10-11,14H2,1H3,(H,24,30)/t18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267447 (US9718822, 30 | US9750744, Example 30 | US9902741,...) Show SMILES Fc1cnc2OCCCNC(=O)c3cnn4ccc(nc34)N3[C@H](COC3=O)c2c1 |r| Show InChI InChI=1S/C18H15FN6O4/c19-10-6-11-13-9-29-18(27)25(13)14-2-4-24-15(23-14)12(8-22-24)16(26)20-3-1-5-28-17(11)21-7-10/h2,4,6-8,13H,1,3,5,9H2,(H,20,26)/t13-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267449 (US9718822, 32 | US9750744, Example 32 | US9902741,...) Show SMILES Fc1cnc2CCCNC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C19H19FN6O/c20-12-9-13-15(22-10-12)3-1-6-21-19(27)14-11-23-26-8-5-17(24-18(14)26)25-7-2-4-16(13)25/h5,8-11,16H,1-4,6-7H2,(H,21,27)/t16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267450 (US9718822, 33 | US9750744, Example 33 | US9902741,...) Show SMILES CC1CCc2ncc(F)cc2[C@H]2CCCN2c2ccn3ncc(C(=O)N1)c3n2 |r| Show InChI InChI=1S/C20H21FN6O/c1-12-4-5-16-14(9-13(21)10-22-16)17-3-2-7-26(17)18-6-8-27-19(25-18)15(11-23-27)20(28)24-12/h6,8-12,17H,2-5,7H2,1H3,(H,24,28)/t12?,17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267451 (BDBM337663 | US9718822, 34 | US9902741, Example 34) Show SMILES C[C@@H]1CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cn(C1)c2=O |r| Show InChI InChI=1S/C20H21FN6O2/c1-12-8-22-19(28)15-9-23-27-6-4-17(24-18(15)27)26-5-2-3-16(26)14-7-13(21)11-25(10-12)20(14)29/h4,6-7,9,11-12,16H,2-3,5,8,10H2,1H3,(H,22,28)/t12-,16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267452 (US10688100, Compound 35 | US10966985, Compound 35 ...) Show SMILES C[C@H]1CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cn(C1)c2=O |r| Show InChI InChI=1S/C20H21FN6O2/c1-12-8-22-19(28)15-9-23-27-6-4-17(24-18(15)27)26-5-2-3-16(26)14-7-13(21)11-25(10-12)20(14)29/h4,6-7,9,11-12,16H,2-3,5,8,10H2,1H3,(H,22,28)/t12-,16+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267453 (US10688100, Compound 36 | US10966985, Compound 36 ...) Show SMILES CC1(C)CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cnc2OC1 |r| Show InChI InChI=1S/C21H23FN6O2/c1-21(2)11-24-19(29)15-10-25-28-7-5-17(26-18(15)28)27-6-3-4-16(27)14-8-13(22)9-23-20(14)30-12-21/h5,7-10,16H,3-4,6,11-12H2,1-2H3,(H,24,29)/t16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267454 (US9718822, 37 | US9750744, Example 37 | US9902741,...) Show SMILES CC1(C)CCc2ncc(F)cc2[C@H]2CCCN2c2ccn3ncc(C(=O)N1)c3n2 |r| Show InChI InChI=1S/C21H23FN6O/c1-21(2)7-5-16-14(10-13(22)11-23-16)17-4-3-8-27(17)18-6-9-28-19(25-18)15(12-24-28)20(29)26-21/h6,9-12,17H,3-5,7-8H2,1-2H3,(H,26,29)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267457 (US9718822, 38 | US9750744, Example 38 | US9902741,...) Show SMILES Fc1cnc2OCCn3nccc3NC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C21H19FN8O2/c22-13-10-14-16-2-1-6-28(16)17-4-7-30-19(26-17)15(12-25-30)20(31)27-18-3-5-24-29(18)8-9-32-21(14)23-11-13/h3-5,7,10-12,16H,1-2,6,8-9H2,(H,27,31)/t16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267458 (US9718822, 39 | US9750744, Example 39 | US9902741,...) Show SMILES Fc1cnc2OCc3cccnc3NC(=O)c3cnn4ccc(nc34)N3CCC[C@@H]3c2c1 |r| Show InChI InChI=1S/C22H18FN7O2/c23-14-9-15-17-4-2-7-29(17)18-5-8-30-20(27-18)16(11-26-30)21(31)28-19-13(3-1-6-24-19)12-32-22(15)25-10-14/h1,3,5-6,8-11,17H,2,4,7,12H2,(H,24,28,31)/t17-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267460 (US9718822, 40 | US9750744, Example 40 | US9902741,...) Show SMILES CC1(C)CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)cn(C1)c2=O |r| Show InChI InChI=1S/C21H23FN6O2/c1-21(2)11-23-19(29)15-9-24-28-7-5-17(25-18(15)28)27-6-3-4-16(27)14-8-13(22)10-26(12-21)20(14)30/h5,7-10,16H,3-4,6,11-12H2,1-2H3,(H,23,29)/t16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair

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