Compile Data Set for Download or QSAR

Found 132 hits Enz. Inhib. hit(s) with all data for entry = 1924   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347310 (2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cnc(c(c2)C(F)(F)F)C(C)(C)O)c(F)c1 Show InChI InChI=1S/C24H23F4N3O4/c1-4-35-19-8-15(11-30-22(19)33)13-5-6-14(18(25)7-13)9-20(32)31-16-10-17(24(26,27)28)21(29-12-16)23(2,3)34/h5-8,10-12,34H,4,9H2,1-3H3,(H,30,33)(H,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347311 (N-(6-Ethoxy-5-(trifluoromethyl)pyridin-3-yl)-2-(4-...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cnc(OCC)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C23H21F4N3O4/c1-3-33-19-8-15(11-28-21(19)32)13-5-6-14(18(24)7-13)9-20(31)30-16-10-17(23(25,26)27)22(29-12-16)34-4-2/h5-8,10-12H,3-4,9H2,1-2H3,(H,28,32)(H,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347313 (2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CO)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C27H28F4N2O4/c1-4-37-23-12-24(35)32-14-20(23)16-5-6-17(22(28)9-16)10-25(36)33-19-8-7-18(13-26(2,3)15-34)21(11-19)27(29,30)31/h5-9,11-12,14,34H,4,10,13,15H2,1-3H3,(H,32,35)(H,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347316 (2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2,3-...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(OCCO)c(c2)C(F)(F)F)c(F)c1F Show InChI InChI=1S/C24H21F5N2O5/c1-2-35-19-9-14(12-30-23(19)34)16-5-3-13(21(25)22(16)26)10-20(33)31-15-4-6-18(36-8-7-32)17(11-15)24(27,28)29/h3-6,9,11-12,32H,2,7-8,10H2,1H3,(H,30,34)(H,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347317 (2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CO)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C27H28F4N2O4/c1-4-37-23-10-19(14-32-25(23)36)16-5-6-17(22(28)9-16)11-24(35)33-20-8-7-18(13-26(2,3)15-34)21(12-20)27(29,30)31/h5-10,12,14,34H,4,11,13,15H2,1-3H3,(H,32,36)(H,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347319 (N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-(4-(4-etho...) Show SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(C#N)c(c2)C(F)(F)F)cc1F Show InChI InChI=1S/C23H17F4N3O3/c1-2-33-20-10-21(31)29-12-17(20)16-6-3-13(7-19(16)24)8-22(32)30-15-5-4-14(11-28)18(9-15)23(25,26)27/h3-7,9-10,12H,2,8H2,1H3,(H,29,31)(H,30,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347320 (2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2,6-...) Show SMILES CCOc1cc(c[nH]c1=O)-c1cc(F)c(CC(=O)Nc2ccc(OCCO)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C24H21F5N2O5/c1-2-35-21-9-14(12-30-23(21)34)13-7-18(25)16(19(26)8-13)11-22(33)31-15-3-4-20(36-6-5-32)17(10-15)24(27,28)29/h3-4,7-10,12,32H,2,5-6,11H2,1H3,(H,30,34)(H,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347321 (N-(4-Cyano-3-(trifluoro-methyl)phenyl)-2-(4-(5-eth...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(C#N)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C23H17F4N3O3/c1-2-33-20-8-16(12-29-22(20)32)13-3-4-14(19(24)7-13)9-21(31)30-17-6-5-15(11-28)18(10-17)23(25,26)27/h3-8,10,12H,2,9H2,1H3,(H,29,32)(H,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347323 (2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cc(cc(c2)C(F)(F)F)-n2cnc(C)c2)c(F)c1 Show InChI InChI=1S/C26H22F4N4O3/c1-3-37-23-7-18(12-31-25(23)36)16-4-5-17(22(27)6-16)8-24(35)33-20-9-19(26(28,29)30)10-21(11-20)34-13-15(2)32-14-34/h4-7,9-14H,3,8H2,1-2H3,(H,31,36)(H,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347324 (N-(6-(2-Cyanopropan-2-yl)-5-(trifluoromethyl)pyrid...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cnc(c(c2)C(F)(F)F)C(C)(C)C#N)c(F)c1 Show InChI InChI=1S/C25H22F4N4O3/c1-4-36-20-8-16(11-32-23(20)35)14-5-6-15(19(26)7-14)9-21(34)33-17-10-18(25(27,28)29)22(31-12-17)24(2,3)13-30/h5-8,10-12H,4,9H2,1-3H3,(H,32,35)(H,33,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347325 (2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(OCCO)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C24H22F4N2O5/c1-2-34-21-10-16(13-29-23(21)33)14-3-4-15(19(25)9-14)11-22(32)30-17-5-6-20(35-8-7-31)18(12-17)24(26,27)28/h3-6,9-10,12-13,31H,2,7-8,11H2,1H3,(H,29,33)(H,30,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347327 (N-(6-(1-Cyanoethyl)-5-(trifluoromethyl)pyridin-3-y...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cnc(C(C)C#N)c(c2)C(F)(F)F)c(F)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347329 (N-(4-((Dimethylamino)methyl)-3-(trifluoromethyl)ph...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(CN(C)C)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C25H25F4N3O3/c1-4-35-22-10-18(13-30-24(22)34)15-5-6-16(21(26)9-15)11-23(33)31-19-8-7-17(14-32(2)3)20(12-19)25(27,28)29/h5-10,12-13H,4,11,14H2,1-3H3,(H,30,34)(H,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347331 (2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C22H21F4N3O4/c1-4-32-16-8-14(11-27-20(16)31)12-5-6-13(15(23)7-12)9-19(30)28-18-10-17(33-29-18)21(2,3)22(24,25)26/h5-8,10-11H,4,9H2,1-3H3,(H,27,31)(H,28,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347332 (2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(OCCO)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C24H22F4N2O5/c1-2-34-21-12-22(32)29-13-17(21)14-3-4-15(19(25)9-14)10-23(33)30-16-5-6-20(35-8-7-31)18(11-16)24(26,27)28/h3-6,9,11-13,31H,2,7-8,10H2,1H3,(H,29,32)(H,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347333 (2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(CN3CCN(CC)CC3)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C29H32F4N4O3/c1-3-36-9-11-37(12-10-36)18-21-7-8-23(16-24(21)29(31,32)33)35-27(38)15-20-6-5-19(13-25(20)30)22-14-26(40-4-2)28(39)34-17-22/h5-8,13-14,16-17H,3-4,9-12,15,18H2,1-2H3,(H,34,39)(H,35,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347336 (US9789100, Example 24) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cc(c(F)cc2F)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C22H16F6N2O3/c1-2-33-19-6-13(10-29-21(19)32)11-3-4-12(15(23)5-11)7-20(31)30-18-8-14(22(26,27)28)16(24)9-17(18)25/h3-6,8-10H,2,7H2,1H3,(H,29,32)(H,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347337 (US9789100, Example 25) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C23H17F7N2O3/c1-2-35-19-6-14(11-31-21(19)34)12-3-4-13(18(24)5-12)7-20(33)32-17-9-15(22(25,26)27)8-16(10-17)23(28,29)30/h3-6,8-11H,2,7H2,1H3,(H,31,34)(H,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347338 (US9789100, Example 26) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cc(ccc2F)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C22H17F5N2O3/c1-2-32-19-8-14(11-28-21(19)31)12-3-4-13(17(24)7-12)9-20(30)29-18-10-15(22(25,26)27)5-6-16(18)23/h3-8,10-11H,2,9H2,1H3,(H,28,31)(H,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347341 (2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cc(cc(c2)C(F)(F)F)-c2nnc(C)o2)c(F)c1 Show InChI InChI=1S/C25H20F4N4O4/c1-3-36-21-9-17(12-30-23(21)35)14-4-5-15(20(26)8-14)10-22(34)31-19-7-16(24-33-32-13(2)37-24)6-18(11-19)25(27,28)29/h4-9,11-12H,3,10H2,1-2H3,(H,30,35)(H,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347343 (2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cnc(c(c2)C(F)(F)F)C(C)(C)CO)c(F)c1 Show InChI InChI=1S/C25H25F4N3O4/c1-4-36-20-10-21(34)30-12-17(20)14-5-6-15(19(26)7-14)8-22(35)32-16-9-18(25(27,28)29)23(31-11-16)24(2,3)13-33/h5-7,9-12,33H,4,8,13H2,1-3H3,(H,30,34)(H,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347344 (2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-3-fl...) Show SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CO)c(c2)C(F)(F)F)cc1F Show InChI InChI=1S/C27H28F4N2O4/c1-4-37-23-12-24(35)32-14-20(23)19-8-5-16(9-22(19)28)10-25(36)33-18-7-6-17(13-26(2,3)15-34)21(11-18)27(29,30)31/h5-9,11-12,14,34H,4,10,13,15H2,1-3H3,(H,32,35)(H,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347346 (2-(4-(5-ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cc(cc(c2)C(F)(F)F)-n2cc(C)cn2)c(F)c1 Show InChI InChI=1S/C26H22F4N4O3/c1-3-37-23-7-18(13-31-25(23)36)16-4-5-17(22(27)6-16)8-24(35)33-20-9-19(26(28,29)30)10-21(11-20)34-14-15(2)12-32-34/h4-7,9-14H,3,8H2,1-2H3,(H,31,36)(H,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347347 (2-(4-(5-ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cc(cc(c2)C(F)(F)F)-n2ccc(C)n2)c(F)c1 Show InChI InChI=1S/C26H22F4N4O3/c1-3-37-23-9-18(14-31-25(23)36)16-4-5-17(22(27)8-16)10-24(35)32-20-11-19(26(28,29)30)12-21(13-20)34-7-6-15(2)33-34/h4-9,11-14H,3,10H2,1-2H3,(H,31,36)(H,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347349 (2-(4-(4-ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(nc2)C(C)(C)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C24H23F4N3O3/c1-4-34-19-11-21(32)30-13-17(19)14-5-6-15(18(25)9-14)10-22(33)31-16-7-8-20(29-12-16)23(2,3)24(26,27)28/h5-9,11-13H,4,10H2,1-3H3,(H,30,32)(H,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347350 (N-(4-cyano-3-(trifluoromethyl)phenyl)-2-(4-(4-etho...) Show SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(C#N)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C23H17F4N3O3/c1-2-33-20-10-21(31)29-12-17(20)13-3-4-14(19(24)7-13)8-22(32)30-16-6-5-15(11-28)18(9-16)23(25,26)27/h3-7,9-10,12H,2,8H2,1H3,(H,29,31)(H,30,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347339 (2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cc(no2)C(C)(C)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C22H21F4N3O4/c1-4-32-16-9-18(30)27-11-14(16)12-5-6-13(15(23)7-12)8-19(31)28-20-10-17(29-33-20)21(2,3)22(24,25)26/h5-7,9-11H,4,8H2,1-3H3,(H,27,30)(H,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347353 (2-(4-(5-ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cc(nn2C)C(C)(C)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C23H24F4N4O3/c1-5-34-17-9-15(12-28-21(17)33)13-6-7-14(16(24)8-13)10-20(32)29-19-11-18(30-31(19)4)22(2,3)23(25,26)27/h6-9,11-12H,5,10H2,1-4H3,(H,28,33)(H,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347354 (2-(4-(5-ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cc(n[nH]2)C(C)(C)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C22H22F4N4O3/c1-4-33-16-8-14(11-27-20(16)32)12-5-6-13(15(23)7-12)9-19(31)28-18-10-17(29-30-18)21(2,3)22(24,25)26/h5-8,10-11H,4,9H2,1-3H3,(H,27,32)(H2,28,29,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347355 (N-(4-(2,2-difluoro-3-hydroxypropyl)-3-(trifluorome...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(CC(F)(F)CO)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C25H22F6N2O4/c1-2-37-21-8-17(12-32-23(21)36)14-3-4-15(20(26)7-14)9-22(35)33-18-6-5-16(11-24(27,28)13-34)19(10-18)25(29,30)31/h3-8,10,12,34H,2,9,11,13H2,1H3,(H,32,36)(H,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347356 (N-(3-(2H-tetrazol-5-yl)-5-(trifluoromethyl)phenyl)...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cc(cc(c2)C(F)(F)F)-c2nn[nH]n2)c(F)c1 Show InChI InChI=1S/C23H18F4N6O3/c1-2-36-19-8-15(11-28-22(19)35)12-3-4-13(18(24)7-12)9-20(34)29-17-6-14(21-30-32-33-31-21)5-16(10-17)23(25,26)27/h3-8,10-11H,2,9H2,1H3,(H,28,35)(H,29,34)(H,30,31,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347357 (2-(4-(5-ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cc(cc(c2)C(F)(F)F)-c2cnn(C)c2)c(F)c1 Show InChI InChI=1S/C26H22F4N4O3/c1-3-37-23-9-18(12-31-25(23)36)15-4-5-16(22(27)8-15)10-24(35)33-21-7-17(19-13-32-34(2)14-19)6-20(11-21)26(28,29)30/h4-9,11-14H,3,10H2,1-2H3,(H,31,36)(H,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347358 (N-(3-(2-(dimethylamino)ethoxy)-5-(trifluoromethyl)...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cc(OCCN(C)C)cc(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C26H27F4N3O4/c1-4-36-23-10-18(15-31-25(23)35)16-5-6-17(22(27)9-16)11-24(34)32-20-12-19(26(28,29)30)13-21(14-20)37-8-7-33(2)3/h5-6,9-10,12-15H,4,7-8,11H2,1-3H3,(H,31,35)(H,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347313 (2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CO)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C27H28F4N2O4/c1-4-37-23-12-24(35)32-14-20(23)16-5-6-17(22(28)9-16)10-25(36)33-19-8-7-18(13-26(2,3)15-34)21(11-19)27(29,30)31/h5-9,11-12,14,34H,4,10,13,15H2,1-3H3,(H,32,35)(H,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347317 (2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CO)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C27H28F4N2O4/c1-4-37-23-10-19(14-32-25(23)36)16-5-6-17(22(28)9-16)11-24(35)33-20-8-7-18(13-26(2,3)15-34)21(12-20)27(29,30)31/h5-10,12,14,34H,4,11,13,15H2,1-3H3,(H,32,36)(H,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347318 (2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-3-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CO)c(c2)C(F)(F)F)cc1F Show InChI InChI=1S/C27H28F4N2O4/c1-4-37-23-11-18(14-32-25(23)36)20-8-5-16(9-22(20)28)10-24(35)33-19-7-6-17(13-26(2,3)15-34)21(12-19)27(29,30)31/h5-9,11-12,14,34H,4,10,13,15H2,1-3H3,(H,32,36)(H,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347331 (2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C22H21F4N3O4/c1-4-32-16-8-14(11-27-20(16)31)12-5-6-13(15(23)7-12)9-19(30)28-18-10-17(33-29-18)21(2,3)22(24,25)26/h5-8,10-11H,4,9H2,1-3H3,(H,27,31)(H,28,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347333 (2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(CN3CCN(CC)CC3)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C29H32F4N4O3/c1-3-36-9-11-37(12-10-36)18-21-7-8-23(16-24(21)29(31,32)33)35-27(38)15-20-6-5-19(13-25(20)30)22-14-26(40-4-2)28(39)34-17-22/h5-8,13-14,16-17H,3-4,9-12,15,18H2,1-2H3,(H,34,39)(H,35,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347340 (2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cc(no2)C(C)(C)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C22H21F4N3O4/c1-4-32-16-8-14(11-27-20(16)31)12-5-6-13(15(23)7-12)9-18(30)28-19-10-17(29-33-19)21(2,3)22(24,25)26/h5-8,10-11H,4,9H2,1-3H3,(H,27,31)(H,28,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347341 (2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cc(cc(c2)C(F)(F)F)-c2nnc(C)o2)c(F)c1 Show InChI InChI=1S/C25H20F4N4O4/c1-3-36-21-9-17(12-30-23(21)35)14-4-5-15(20(26)8-14)10-22(34)31-19-7-16(24-33-32-13(2)37-24)6-18(11-19)25(27,28)29/h4-9,11-12H,3,10H2,1-2H3,(H,30,35)(H,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347342 (2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C22H21F4N3O4/c1-4-32-16-9-19(30)27-11-14(16)12-5-6-13(15(23)7-12)8-20(31)28-18-10-17(33-29-18)21(2,3)22(24,25)26/h5-7,9-11H,4,8H2,1-3H3,(H,27,30)(H,28,29,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347343 (2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cnc(c(c2)C(F)(F)F)C(C)(C)CO)c(F)c1 Show InChI InChI=1S/C25H25F4N3O4/c1-4-36-20-10-21(34)30-12-17(20)14-5-6-15(19(26)7-14)8-22(35)32-16-9-18(25(27,28)29)23(31-11-16)24(2,3)13-33/h5-7,9-12,33H,4,8,13H2,1-3H3,(H,30,34)(H,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347344 (2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-3-fl...) Show SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CO)c(c2)C(F)(F)F)cc1F Show InChI InChI=1S/C27H28F4N2O4/c1-4-37-23-12-24(35)32-14-20(23)19-8-5-16(9-22(19)28)10-25(36)33-18-7-6-17(13-26(2,3)15-34)21(11-18)27(29,30)31/h5-9,11-12,14,34H,4,10,13,15H2,1-3H3,(H,32,35)(H,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347339 (2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cc(no2)C(C)(C)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C22H21F4N3O4/c1-4-32-16-9-18(30)27-11-14(16)12-5-6-13(15(23)7-12)8-19(31)28-20-10-17(29-33-20)21(2,3)22(24,25)26/h5-7,9-11H,4,8H2,1-3H3,(H,27,30)(H,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347354 (2-(4-(5-ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cc(n[nH]2)C(C)(C)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C22H22F4N4O3/c1-4-33-16-8-14(11-27-20(16)32)12-5-6-13(15(23)7-12)9-19(31)28-18-10-17(29-30-18)21(2,3)22(24,25)26/h5-8,10-11H,4,9H2,1-3H3,(H,27,32)(H2,28,29,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347355 (N-(4-(2,2-difluoro-3-hydroxypropyl)-3-(trifluorome...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(CC(F)(F)CO)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C25H22F6N2O4/c1-2-37-21-8-17(12-32-23(21)36)14-3-4-15(20(26)7-14)9-22(35)33-18-6-5-16(11-24(27,28)13-34)19(10-18)25(29,30)31/h3-8,10,12,34H,2,9,11,13H2,1H3,(H,32,36)(H,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347313 (2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CO)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C27H28F4N2O4/c1-4-37-23-12-24(35)32-14-20(23)16-5-6-17(22(28)9-16)10-25(36)33-19-8-7-18(13-26(2,3)15-34)21(11-19)27(29,30)31/h5-9,11-12,14,34H,4,10,13,15H2,1-3H3,(H,32,35)(H,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347317 (2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CO)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C27H28F4N2O4/c1-4-37-23-10-19(14-32-25(23)36)16-5-6-17(22(28)9-16)11-24(35)33-20-8-7-18(13-26(2,3)15-34)21(12-20)27(29,30)31/h5-10,12,14,34H,4,11,13,15H2,1-3H3,(H,32,36)(H,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347318 (2-(4-(5-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-3-fl...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CO)c(c2)C(F)(F)F)cc1F Show InChI InChI=1S/C27H28F4N2O4/c1-4-37-23-11-18(14-32-25(23)36)20-8-5-16(9-22(20)28)10-24(35)33-19-7-6-17(13-26(2,3)15-34)21(12-19)27(29,30)31/h5-9,11-12,14,34H,4,10,13,15H2,1-3H3,(H,32,36)(H,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM347328 (N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-(4-(5-eth...) Show SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C22H17ClF4N2O3/c1-2-32-19-8-14(11-28-21(19)31)12-3-4-13(18(24)7-12)9-20(30)29-15-5-6-17(23)16(10-15)22(25,26)27/h3-8,10-11H,2,9H2,1H3,(H,28,31)(H,29,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED US Patent					Assay Description Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...				US Patent US9789100 (2017) BindingDB Entry DOI: 10.7270/Q2445PMG
					More data for this Ligand-Target Pair

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