Compile Data Set for Download or QSAR

Found 434 hits Enz. Inhib. hit(s) with all data for entry = 1976   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349654 (2-((4-(6-((4-Chloro-2-fluorobenzyl)oxy)pyridin-2-y...) Show SMILES Cn1c(CN2CCC(CC2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C27H26ClFN4O3/c1-32-24-13-18(27(34)35)6-8-23(24)30-25(32)15-33-11-9-17(10-12-33)22-3-2-4-26(31-22)36-16-19-5-7-20(28)14-21(19)29/h2-8,13-14,17H,9-12,15-16H2,1H3,(H,34,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	81	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349654 (2-((4-(6-((4-Chloro-2-fluorobenzyl)oxy)pyridin-2-y...) Show SMILES Cn1c(CN2CCC(CC2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C27H26ClFN4O3/c1-32-24-13-18(27(34)35)6-8-23(24)30-25(32)15-33-11-9-17(10-12-33)22-3-2-4-26(31-22)36-16-19-5-7-20(28)14-21(19)29/h2-8,13-14,17H,9-12,15-16H2,1H3,(H,34,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	910	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349655 (2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-y...) Show SMILES COCCn1c(CN2CCC(CC2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C29H30ClFN4O4/c1-38-14-13-35-26-15-20(29(36)37)6-8-25(26)32-27(35)17-34-11-9-19(10-12-34)24-3-2-4-28(33-24)39-18-21-5-7-22(30)16-23(21)31/h2-8,15-16,19H,9-14,17-18H2,1H3,(H,36,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349655 (2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-y...) Show SMILES COCCn1c(CN2CCC(CC2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C29H30ClFN4O4/c1-38-14-13-35-26-15-20(29(36)37)6-8-25(26)32-27(35)17-34-11-9-19(10-12-34)24-3-2-4-28(33-24)39-18-21-5-7-22(30)16-23(21)31/h2-8,15-16,19H,9-14,17-18H2,1H3,(H,36,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	320	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349656 (2-{[(2S)-4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin...) Show SMILES COCCn1c(CN2CCN(C[C@@H]2C)c2cccc(OCc3ccc(cc3F)C#N)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C30H31FN6O4/c1-20-17-36(27-4-3-5-29(34-27)41-19-23-7-6-21(16-32)14-24(23)31)11-10-35(20)18-28-33-25-9-8-22(30(38)39)15-26(25)37(28)12-13-40-2/h3-9,14-15,20H,10-13,17-19H2,1-2H3,(H,38,39)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4.30	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349656 (2-{[(2S)-4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin...) Show SMILES COCCn1c(CN2CCN(C[C@@H]2C)c2cccc(OCc3ccc(cc3F)C#N)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C30H31FN6O4/c1-20-17-36(27-4-3-5-29(34-27)41-19-23-7-6-21(16-32)14-24(23)31)11-10-35(20)18-28-33-25-9-8-22(30(38)39)15-26(25)37(28)12-13-40-2/h3-9,14-15,20H,10-13,17-19H2,1-2H3,(H,38,39)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	92	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349657 (2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]-5-fluoropy...) Show SMILES COCCn1c(CN2CCC(CC2)c2ccc(F)c(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C29H29ClF2N4O4/c1-39-13-12-36-26-14-19(29(37)38)3-6-25(26)33-27(36)16-35-10-8-18(9-11-35)24-7-5-22(31)28(34-24)40-17-20-2-4-21(30)15-23(20)32/h2-7,14-15,18H,8-13,16-17H2,1H3,(H,37,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	21	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349657 (2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]-5-fluoropy...) Show SMILES COCCn1c(CN2CCC(CC2)c2ccc(F)c(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C29H29ClF2N4O4/c1-39-13-12-36-26-14-19(29(37)38)3-6-25(26)33-27(36)16-35-10-8-18(9-11-35)24-7-5-22(31)28(34-24)40-17-20-2-4-21(30)15-23(20)32/h2-7,14-15,18H,8-13,16-17H2,1H3,(H,37,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	350	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349658 (2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]-3-fluoropy...) Show SMILES COCCn1c(CN2CCN(CC2)c2nc(OCc3ccc(Cl)cc3F)ccc2F)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C28H28ClF2N5O4/c1-39-13-12-36-24-14-18(28(37)38)3-6-23(24)32-25(36)16-34-8-10-35(11-9-34)27-21(30)5-7-26(33-27)40-17-19-2-4-20(29)15-22(19)31/h2-7,14-15H,8-13,16-17H2,1H3,(H,37,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	42	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349658 (2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]-3-fluoropy...) Show SMILES COCCn1c(CN2CCN(CC2)c2nc(OCc3ccc(Cl)cc3F)ccc2F)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C28H28ClF2N5O4/c1-39-13-12-36-24-14-18(28(37)38)3-6-23(24)32-25(36)16-34-8-10-35(11-9-34)27-21(30)5-7-26(33-27)40-17-19-2-4-20(29)15-22(19)31/h2-7,14-15H,8-13,16-17H2,1H3,(H,37,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	530	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349659 (2-{[(2S)-4-{6-[(4-chloro-2-fluorobenzyl)oxy]-3-flu...) Show SMILES COCCn1c(CN2CCN(C[C@@H]2C)c2nc(OCc3ccc(Cl)cc3F)ccc2F)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C29H30ClF2N5O4/c1-18-15-36(28-22(31)6-8-27(34-28)41-17-20-3-5-21(30)14-23(20)32)10-9-35(18)16-26-33-24-7-4-19(29(38)39)13-25(24)37(26)11-12-40-2/h3-8,13-14,18H,9-12,15-17H2,1-2H3,(H,38,39)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	29	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349659 (2-{[(2S)-4-{6-[(4-chloro-2-fluorobenzyl)oxy]-3-flu...) Show SMILES COCCn1c(CN2CCN(C[C@@H]2C)c2nc(OCc3ccc(Cl)cc3F)ccc2F)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C29H30ClF2N5O4/c1-18-15-36(28-22(31)6-8-27(34-28)41-17-20-3-5-21(30)14-23(20)32)10-9-35(18)16-26-33-24-7-4-19(29(38)39)13-25(24)37(26)11-12-40-2/h3-8,13-14,18H,9-12,15-17H2,1-2H3,(H,38,39)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	350	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349660 (2-{[(2S)-4-{6-[(4-chloro-2-fluorobenzyl)oxy]-5-flu...) Show SMILES COCCn1c(CN2CCN(C[C@@H]2C)c2ccc(F)c(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C29H30ClF2N5O4/c1-18-15-36(26-8-6-22(31)28(34-26)41-17-20-3-5-21(30)14-23(20)32)10-9-35(18)16-27-33-24-7-4-19(29(38)39)13-25(24)37(27)11-12-40-2/h3-8,13-14,18H,9-12,15-17H2,1-2H3,(H,38,39)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.90	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349660 (2-{[(2S)-4-{6-[(4-chloro-2-fluorobenzyl)oxy]-5-flu...) Show SMILES COCCn1c(CN2CCN(C[C@@H]2C)c2ccc(F)c(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C29H30ClF2N5O4/c1-18-15-36(26-8-6-22(31)28(34-26)41-17-20-3-5-21(30)14-23(20)32)10-9-35(18)16-27-33-24-7-4-19(29(38)39)13-25(24)37(27)11-12-40-2/h3-8,13-14,18H,9-12,15-17H2,1-2H3,(H,38,39)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	45	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349661 (2-{[(2S)-4-{6-[(4-cyanobenzyl)oxy]-5-fluoropyridin...) Show SMILES COCCn1c(CN2CCN(C[C@@H]2C)c2ccc(F)c(OCc3ccc(cc3)C#N)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C30H31FN6O4/c1-20-17-36(27-10-8-24(31)29(34-27)41-19-22-5-3-21(16-32)4-6-22)12-11-35(20)18-28-33-25-9-7-23(30(38)39)15-26(25)37(28)13-14-40-2/h3-10,15,20H,11-14,17-19H2,1-2H3,(H,38,39)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7.10	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349661 (2-{[(2S)-4-{6-[(4-cyanobenzyl)oxy]-5-fluoropyridin...) Show SMILES COCCn1c(CN2CCN(C[C@@H]2C)c2ccc(F)c(OCc3ccc(cc3)C#N)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C30H31FN6O4/c1-20-17-36(27-10-8-24(31)29(34-27)41-19-22-5-3-21(16-32)4-6-22)12-11-35(20)18-28-33-25-9-7-23(30(38)39)15-26(25)37(28)13-14-40-2/h3-10,15,20H,11-14,17-19H2,1-2H3,(H,38,39)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349662 (2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...) Show SMILES OC(=O)c1ccc2nc(CN3CCC(CC3)c3cccc(OCc4ccc(cc4F)C#N)n3)n(C[C@@H]3CCO3)c2c1 Show InChI InChI=1S/C31H30FN5O4/c32-25-14-20(16-33)4-5-23(25)19-41-30-3-1-2-26(35-30)21-8-11-36(12-9-21)18-29-34-27-7-6-22(31(38)39)15-28(27)37(29)17-24-10-13-40-24/h1-7,14-15,21,24H,8-13,17-19H2,(H,38,39)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	n/a	n/a	0.950	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349662 (2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...) Show SMILES OC(=O)c1ccc2nc(CN3CCC(CC3)c3cccc(OCc4ccc(cc4F)C#N)n3)n(C[C@@H]3CCO3)c2c1 Show InChI InChI=1S/C31H30FN5O4/c32-25-14-20(16-33)4-5-23(25)19-41-30-3-1-2-26(35-30)21-8-11-36(12-9-21)18-29-34-27-7-6-22(31(38)39)15-28(27)37(29)17-24-10-13-40-24/h1-7,14-15,21,24H,8-13,17-19H2,(H,38,39)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	n/a	n/a	17	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349663 (2-({4-[6-(benzyloxy)pyridin-2-yl]piperidin-1-yl}me...) Show SMILES COCCn1c(CN2CCC(CC2)c2cccc(OCc3ccccc3)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C29H32N4O4/c1-36-17-16-33-26-18-23(29(34)35)10-11-25(26)30-27(33)19-32-14-12-22(13-15-32)24-8-5-9-28(31-24)37-20-21-6-3-2-4-7-21/h2-11,18,22H,12-17,19-20H2,1H3,(H,34,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	930	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349663 (2-({4-[6-(benzyloxy)pyridin-2-yl]piperidin-1-yl}me...) Show SMILES COCCn1c(CN2CCC(CC2)c2cccc(OCc3ccccc3)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C29H32N4O4/c1-36-17-16-33-26-18-23(29(34)35)10-11-25(26)30-27(33)19-32-14-12-22(13-15-32)24-8-5-9-28(31-24)37-20-21-6-3-2-4-7-21/h2-11,18,22H,12-17,19-20H2,1H3,(H,34,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349664 (2-[(4-{6-[(4-cyanobenzyl)oxy]pyridin-2-yl}piperazi...) Show SMILES COCCn1c(CN2CCN(CC2)c2cccc(OCc3ccc(cc3)C#N)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C29H30N6O4/c1-38-16-15-35-25-17-23(29(36)37)9-10-24(25)31-27(35)19-33-11-13-34(14-12-33)26-3-2-4-28(32-26)39-20-22-7-5-21(18-30)6-8-22/h2-10,17H,11-16,19-20H2,1H3,(H,36,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349664 (2-[(4-{6-[(4-cyanobenzyl)oxy]pyridin-2-yl}piperazi...) Show SMILES COCCn1c(CN2CCN(CC2)c2cccc(OCc3ccc(cc3)C#N)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C29H30N6O4/c1-38-16-15-35-25-17-23(29(36)37)9-10-24(25)31-27(35)19-33-11-13-34(14-12-33)26-3-2-4-28(32-26)39-20-22-7-5-21(18-30)6-8-22/h2-10,17H,11-16,19-20H2,1H3,(H,36,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	530	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349665 (2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-y...) Show SMILES COCCn1c(CN2CCN(c3cccc(OCc4ccc(Cl)cc4F)n3)C(C)(C)C2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C30H33ClFN5O4/c1-30(2)19-35(17-27-33-24-10-8-20(29(38)39)15-25(24)36(27)13-14-40-3)11-12-37(30)26-5-4-6-28(34-26)41-18-21-7-9-22(31)16-23(21)32/h4-10,15-16H,11-14,17-19H2,1-3H3,(H,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349666 (2-{[(3S)-4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridi...) Show SMILES COCCn1c(CN2CCN([C@@H](C)C2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C29H31ClFN5O4/c1-19-16-34(17-27-32-24-9-7-20(29(37)38)14-25(24)36(27)12-13-39-2)10-11-35(19)26-4-3-5-28(33-26)40-18-21-6-8-22(30)15-23(21)31/h3-9,14-15,19H,10-13,16-18H2,1-2H3,(H,37,38)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	210	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349667 (2-{[(3R)-4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridi...) Show SMILES COCCn1c(CN2CCN([C@H](C)C2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C29H31ClFN5O4/c1-19-16-34(17-27-32-24-9-7-20(29(37)38)14-25(24)36(27)12-13-39-2)10-11-35(19)26-4-3-5-28(33-26)40-18-21-6-8-22(30)15-23(21)31/h3-9,14-15,19H,10-13,16-18H2,1-2H3,(H,37,38)/t19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	47	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349667 (2-{[(3R)-4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridi...) Show SMILES COCCn1c(CN2CCN([C@H](C)C2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C29H31ClFN5O4/c1-19-16-34(17-27-32-24-9-7-20(29(37)38)14-25(24)36(27)12-13-39-2)10-11-35(19)26-4-3-5-28(33-26)40-18-21-6-8-22(30)15-23(21)31/h3-9,14-15,19H,10-13,16-18H2,1-2H3,(H,37,38)/t19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349668 (2-{[(3R)-4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridi...) Show SMILES COCCn1c(CN2CCN([C@@H](CO)C2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C29H31ClFN5O5/c1-40-12-11-36-25-13-19(29(38)39)6-8-24(25)32-27(36)16-34-9-10-35(22(15-34)17-37)26-3-2-4-28(33-26)41-18-20-5-7-21(30)14-23(20)31/h2-8,13-14,22,37H,9-12,15-18H2,1H3,(H,38,39)/t22-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349669 (2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl...) Show SMILES Cn1cncc1Cn1c(CN2CCC(CC2)c2cccc(OCc3ccc(cc3F)C#N)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C32H30FN7O3/c1-38-20-35-16-25(38)17-40-29-14-23(32(41)42)7-8-28(29)36-30(40)18-39-11-9-22(10-12-39)27-3-2-4-31(37-27)43-19-24-6-5-21(15-34)13-26(24)33/h2-8,13-14,16,20,22H,9-12,17-19H2,1H3,(H,41,42)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.5	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349669 (2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl...) Show SMILES Cn1cncc1Cn1c(CN2CCC(CC2)c2cccc(OCc3ccc(cc3F)C#N)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C32H30FN7O3/c1-38-20-35-16-25(38)17-40-29-14-23(32(41)42)7-8-28(29)36-30(40)18-39-11-9-22(10-12-39)27-3-2-4-31(37-27)43-19-24-6-5-21(15-34)13-26(24)33/h2-8,13-14,16,20,22H,9-12,17-19H2,1H3,(H,41,42)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349670 (2-[(4-{6-[(2,4-difluorobenzyl)oxy]pyridin-2-yl}pip...) Show SMILES Cn1cncc1Cn1c(CN2CCC(CC2)c2cccc(OCc3ccc(F)cc3F)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C31H30F2N6O3/c1-37-19-34-15-24(37)16-39-28-13-21(31(40)41)6-8-27(28)35-29(39)17-38-11-9-20(10-12-38)26-3-2-4-30(36-26)42-18-22-5-7-23(32)14-25(22)33/h2-8,13-15,19-20H,9-12,16-18H2,1H3,(H,40,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.40	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349670 (2-[(4-{6-[(2,4-difluorobenzyl)oxy]pyridin-2-yl}pip...) Show SMILES Cn1cncc1Cn1c(CN2CCC(CC2)c2cccc(OCc3ccc(F)cc3F)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C31H30F2N6O3/c1-37-19-34-15-24(37)16-39-28-13-21(31(40)41)6-8-27(28)35-29(39)17-38-11-9-20(10-12-38)26-3-2-4-30(36-26)42-18-22-5-7-23(32)14-25(22)33/h2-8,13-15,19-20H,9-12,16-18H2,1H3,(H,40,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	45	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349671 (2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-y...) Show SMILES CCCn1cnnc1Cn1c(CN2CCC(CC2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C32H33ClFN7O3/c1-2-12-40-20-35-38-30(40)18-41-28-15-22(32(42)43)7-9-27(28)36-29(41)17-39-13-10-21(11-14-39)26-4-3-5-31(37-26)44-19-23-6-8-24(33)16-25(23)34/h3-9,15-16,20-21H,2,10-14,17-19H2,1H3,(H,42,43)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.40	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349671 (2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-y...) Show SMILES CCCn1cnnc1Cn1c(CN2CCC(CC2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C32H33ClFN7O3/c1-2-12-40-20-35-38-30(40)18-41-28-15-22(32(42)43)7-9-27(28)36-29(41)17-39-13-10-21(11-14-39)26-4-3-5-31(37-26)44-19-23-6-8-24(33)16-25(23)34/h3-9,15-16,20-21H,2,10-14,17-19H2,1H3,(H,42,43)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	110	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349672 (2-{[(2S)-4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridi...) Show SMILES C[C@H]1CN(CCN1Cc1nc2ccc(cc2n1C[C@@H]1CCO1)C(O)=O)c1cccc(OCc2ccc(Cl)cc2F)n1 Show InChI InChI=1S/C30H31ClFN5O4/c1-19-15-36(27-3-2-4-29(34-27)41-18-21-5-7-22(31)14-24(21)32)11-10-35(19)17-28-33-25-8-6-20(30(38)39)13-26(25)37(28)16-23-9-12-40-23/h2-8,13-14,19,23H,9-12,15-18H2,1H3,(H,38,39)/t19-,23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.280	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349672 (2-{[(2S)-4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridi...) Show SMILES C[C@H]1CN(CCN1Cc1nc2ccc(cc2n1C[C@@H]1CCO1)C(O)=O)c1cccc(OCc2ccc(Cl)cc2F)n1 Show InChI InChI=1S/C30H31ClFN5O4/c1-19-15-36(27-3-2-4-29(34-27)41-18-21-5-7-22(31)14-24(21)32)11-10-35(19)17-28-33-25-8-6-20(30(38)39)13-26(25)37(28)16-23-9-12-40-23/h2-8,13-14,19,23H,9-12,15-18H2,1H3,(H,38,39)/t19-,23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.20	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349673 (2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl...) Show SMILES Cn1cnnc1Cn1c(CN2CCC(CC2)c2cccc(OCc3ccc(cc3F)C#N)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C31H29FN8O3/c1-38-19-34-37-29(38)17-40-27-14-22(31(41)42)7-8-26(27)35-28(40)16-39-11-9-21(10-12-39)25-3-2-4-30(36-25)43-18-23-6-5-20(15-33)13-24(23)32/h2-8,13-14,19,21H,9-12,16-18H2,1H3,(H,41,42)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	44	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349673 (2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl...) Show SMILES Cn1cnnc1Cn1c(CN2CCC(CC2)c2cccc(OCc3ccc(cc3F)C#N)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C31H29FN8O3/c1-38-19-34-37-29(38)17-40-27-14-22(31(41)42)7-8-26(27)35-28(40)16-39-11-9-21(10-12-39)25-3-2-4-30(36-25)43-18-23-6-5-20(15-33)13-24(23)32/h2-8,13-14,19,21H,9-12,16-18H2,1H3,(H,41,42)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	880	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349674 (2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl...) Show SMILES OC(=O)c1ccc2nc(CN3CCC(CC3)c3cccc(OCc4ccc(cc4F)C#N)n3)n(C[C@@H]3CCCO3)c2c1 Show InChI InChI=1S/C32H32FN5O4/c33-26-15-21(17-34)6-7-24(26)20-42-31-5-1-4-27(36-31)22-10-12-37(13-11-22)19-30-35-28-9-8-23(32(39)40)16-29(28)38(30)18-25-3-2-14-41-25/h1,4-9,15-16,22,25H,2-3,10-14,18-20H2,(H,39,40)/t25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4.90	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349674 (2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl...) Show SMILES OC(=O)c1ccc2nc(CN3CCC(CC3)c3cccc(OCc4ccc(cc4F)C#N)n3)n(C[C@@H]3CCCO3)c2c1 Show InChI InChI=1S/C32H32FN5O4/c33-26-15-21(17-34)6-7-24(26)20-42-31-5-1-4-27(36-31)22-10-12-37(13-11-22)19-30-35-28-9-8-23(32(39)40)16-29(28)38(30)18-25-3-2-14-41-25/h1,4-9,15-16,22,25H,2-3,10-14,18-20H2,(H,39,40)/t25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	75	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349675 (US10208019, Example 1A-22 | rac 2-{[(3S,4S)-4-{6-[...) Show SMILES COCCn1c(CN2CC[C@H]([C@H](F)C2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O |r| Show InChI InChI=1S/C29H29ClF2N4O4/c1-39-12-11-36-26-13-18(29(37)38)6-8-25(26)33-27(36)16-35-10-9-21(23(32)15-35)24-3-2-4-28(34-24)40-17-19-5-7-20(30)14-22(19)31/h2-8,13-14,21,23H,9-12,15-17H2,1H3,(H,37,38)/t21-,23-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	36	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349675 (US10208019, Example 1A-22 | rac 2-{[(3S,4S)-4-{6-[...) Show SMILES COCCn1c(CN2CC[C@H]([C@H](F)C2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O |r| Show InChI InChI=1S/C29H29ClF2N4O4/c1-39-12-11-36-26-13-18(29(37)38)6-8-25(26)33-27(36)16-35-10-9-21(23(32)15-35)24-3-2-4-28(34-24)40-17-19-5-7-20(30)14-22(19)31/h2-8,13-14,21,23H,9-12,15-17H2,1H3,(H,37,38)/t21-,23-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349676 (US10208019, Example 1A-23 | rac-2-{[(3S,4S)-4-{6-[...) Show SMILES COCCn1c(CN2CC[C@H]([C@H](O)C2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O |r| Show InChI InChI=1S/C29H30ClFN4O5/c1-39-12-11-35-25-13-18(29(37)38)6-8-24(25)32-27(35)16-34-10-9-21(26(36)15-34)23-3-2-4-28(33-23)40-17-19-5-7-20(30)14-22(19)31/h2-8,13-14,21,26,36H,9-12,15-17H2,1H3,(H,37,38)/t21-,26+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349676 (US10208019, Example 1A-23 | rac-2-{[(3S,4S)-4-{6-[...) Show SMILES COCCn1c(CN2CC[C@H]([C@H](O)C2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O |r| Show InChI InChI=1S/C29H30ClFN4O5/c1-39-12-11-35-25-13-18(29(37)38)6-8-24(25)32-27(35)16-34-10-9-21(26(36)15-34)23-3-2-4-28(33-23)40-17-19-5-7-20(30)14-22(19)31/h2-8,13-14,21,26,36H,9-12,15-17H2,1H3,(H,37,38)/t21-,26+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349677 (US10208019, Example 1A-24 | rac-2-{[(3R,4S)-4-{6-[...) Show SMILES COCCn1c(CN2CC[C@H]([C@@H](O)C2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O |r| Show InChI InChI=1S/C29H30ClFN4O5/c1-39-12-11-35-25-13-18(29(37)38)6-8-24(25)32-27(35)16-34-10-9-21(26(36)15-34)23-3-2-4-28(33-23)40-17-19-5-7-20(30)14-22(19)31/h2-8,13-14,21,26,36H,9-12,15-17H2,1H3,(H,37,38)/t21-,26-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.10E+4	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349678 (US10208019, Example 1A-25 | rac-2-{[(3R,4R)-4-{6-[...) Show SMILES COCCn1c(CN2CC[C@H]([C@@H](C)C2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O |r| Show InChI InChI=1S/C30H32ClFN4O4/c1-19-16-35(17-28-33-26-9-7-20(30(37)38)14-27(26)36(28)12-13-39-2)11-10-23(19)25-4-3-5-29(34-25)40-18-21-6-8-22(31)15-24(21)32/h3-9,14-15,19,23H,10-13,16-18H2,1-2H3,(H,37,38)/t19-,23+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	45	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349678 (US10208019, Example 1A-25 | rac-2-{[(3R,4R)-4-{6-[...) Show SMILES COCCn1c(CN2CC[C@H]([C@@H](C)C2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O |r| Show InChI InChI=1S/C30H32ClFN4O4/c1-19-16-35(17-28-33-26-9-7-20(30(37)38)14-27(26)36(28)12-13-39-2)11-10-23(19)25-4-3-5-29(34-25)40-18-21-6-8-22(31)15-24(21)32/h3-9,14-15,19,23H,10-13,16-18H2,1-2H3,(H,37,38)/t19-,23+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349679 (US10208019, Example 1A-26 | rac-2-{[(3S,4R)-4-{6-[...) Show SMILES COCCn1c(CN2CC[C@H]([C@H](C)C2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O |r| Show InChI InChI=1S/C30H32ClFN4O4/c1-19-16-35(17-28-33-26-9-7-20(30(37)38)14-27(26)36(28)12-13-39-2)11-10-23(19)25-4-3-5-29(34-25)40-18-21-6-8-22(31)15-24(21)32/h3-9,14-15,19,23H,10-13,16-18H2,1-2H3,(H,37,38)/t19-,23-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349679 (US10208019, Example 1A-26 | rac-2-{[(3S,4R)-4-{6-[...) Show SMILES COCCn1c(CN2CC[C@H]([C@H](C)C2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O |r| Show InChI InChI=1S/C30H32ClFN4O4/c1-19-16-35(17-28-33-26-9-7-20(30(37)38)14-27(26)36(28)12-13-39-2)11-10-23(19)25-4-3-5-29(34-25)40-18-21-6-8-22(31)15-24(21)32/h3-9,14-15,19,23H,10-13,16-18H2,1-2H3,(H,37,38)/t19-,23-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349680 (2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-y...) Show SMILES CO[C@@H]1CCC[C@H]1n1c(CN2CCC(CC2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C32H34ClFN4O4/c1-41-29-6-3-5-27(29)38-28-16-21(32(39)40)9-11-26(28)35-30(38)18-37-14-12-20(13-15-37)25-4-2-7-31(36-25)42-19-22-8-10-23(33)17-24(22)34/h2,4,7-11,16-17,20,27,29H,3,5-6,12-15,18-19H2,1H3,(H,39,40)/t27-,29-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	190	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair
Glucagon-like peptide 1 receptor (Homo sapiens (Human))	BDBM349680 (2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-y...) Show SMILES CO[C@@H]1CCC[C@H]1n1c(CN2CCC(CC2)c2cccc(OCc3ccc(Cl)cc3F)n2)nc2ccc(cc12)C(O)=O Show InChI InChI=1S/C32H34ClFN4O4/c1-41-29-6-3-5-27(29)38-28-16-21(32(39)40)9-11-26(28)35-30(38)18-37-14-12-20(13-15-37)25-4-2-7-31(36-25)42-19-22-8-10-23(33)17-24(22)34/h2,4,7-11,16-17,20,27,29H,3,5-6,12-15,18-19H2,1H3,(H,39,40)/t27-,29-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...				US Patent US10208019 (2019) BindingDB Entry DOI: 10.7270/Q2WH2S4X
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 434 total )  |  Next  |  Last  >>

Jump to: