Compile Data Set for Download or QSAR

Found 34 hits Enz. Inhib. hit(s) with all data for entry = 2109   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM17003 (Indolinone based compound, 7l | [(3Z)-3-({4-[3-(am...) Show SMILES NCc1cccc(c1)-c1c[nH]c(\C=C2/C(=O)Nc3ccc(NC(N)=O)cc23)c1 Show InChI InChI=1S/C21H19N5O2/c22-10-12-2-1-3-13(6-12)14-7-16(24-11-14)9-18-17-8-15(25-21(23)28)4-5-19(17)26-20(18)27/h1-9,11,24H,10,22H2,(H,26,27)(H3,23,25,28)/b18-9-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM17014 (Indolinone based compound, 22 | N-[(5-{1-[(3Z)-5-(...) Show SMILES C\C(=C1\C(=O)Nc2ccc(NC(N)=O)cc12)c1cc(CNC(=O)CCN2CCCCC2)c[nH]1 Show InChI InChI=1S/C24H30N6O3/c1-15(22-18-12-17(28-24(25)33)5-6-19(18)29-23(22)32)20-11-16(13-26-20)14-27-21(31)7-10-30-8-3-2-4-9-30/h5-6,11-13,26H,2-4,7-10,14H2,1H3,(H,27,31)(H,29,32)(H3,25,28,33)/b22-15-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM17010 (Indolinone based compound, 18 | N-[(5-{1-[(3Z)-5-(...) Show SMILES CN1CCC(CC1)C(=O)NCc1c[nH]c(c1)C(\C)=C1/C(=O)Nc2ccc(NC(N)=O)cc12 Show InChI InChI=1S/C23H28N6O3/c1-13(20-17-10-16(27-23(24)32)3-4-18(17)28-22(20)31)19-9-14(11-25-19)12-26-21(30)15-5-7-29(2)8-6-15/h3-4,9-11,15,25H,5-8,12H2,1-2H3,(H,26,30)(H,28,31)(H3,24,27,32)/b20-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM16995 (3-(5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1...) Show SMILES CN(C)CCNC(=O)c1cccc(c1)-c1c[nH]c(\C=C2/C(=O)Nc3ccc(NC(N)=O)cc23)c1 Show InChI InChI=1S/C25H26N6O3/c1-31(2)9-8-27-23(32)16-5-3-4-15(10-16)17-11-19(28-14-17)13-21-20-12-18(29-25(26)34)6-7-22(20)30-24(21)33/h3-7,10-14,28H,8-9H2,1-2H3,(H,27,32)(H,30,33)(H3,26,29,34)/b21-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	7.2	22
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM16996 (3-(5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1...) Show SMILES NC(=O)Nc1ccc2NC(=O)\C(=C/c3cc(c[nH]3)-c3cccc(c3)C(=O)NCCN3CCCCC3)c2c1 Show InChI InChI=1S/C28H30N6O3/c29-28(37)32-21-7-8-25-23(15-21)24(27(36)33-25)16-22-14-20(17-31-22)18-5-4-6-19(13-18)26(35)30-9-12-34-10-2-1-3-11-34/h4-8,13-17,31H,1-3,9-12H2,(H,30,35)(H,33,36)(H3,29,32,37)/b24-16-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	7.2	22
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair				3D Structure (crystal)
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM17004 (BX-517 | Indolinone based inhibitor, 4i | [(3Z)-2-...) Show SMILES C\C(=C1\C(=O)Nc2ccc(NC(N)=O)cc12)c1ccc[nH]1 Show InChI InChI=1S/C15H14N4O2/c1-8(11-3-2-6-17-11)13-10-7-9(18-15(16)21)4-5-12(10)19-14(13)20/h2-7,17H,1H3,(H,19,20)(H3,16,18,21)/b13-8-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair				3D Structure (crystal)
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM17007 (Indolinone based compound, 15 | N-[(5-{1-[(3Z)-5-(...) Show SMILES C\C(=C1\C(=O)Nc2ccc(NC(N)=O)cc12)c1cc(CNC(=O)c2ccncc2)c[nH]1 Show InChI InChI=1S/C22H20N6O3/c1-12(19-16-9-15(27-22(23)31)2-3-17(16)28-21(19)30)18-8-13(10-25-18)11-26-20(29)14-4-6-24-7-5-14/h2-10,25H,11H2,1H3,(H,26,29)(H,28,30)(H3,23,27,31)/b19-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM17001 (3-(5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1...) Show SMILES NC(=O)Nc1ccc2NC(=O)\C(=C/c3cc(c[nH]3)-c3cccc(c3)C(N)=O)c2c1 Show InChI InChI=1S/C21H17N5O3/c22-19(27)12-3-1-2-11(6-12)13-7-15(24-10-13)9-17-16-8-14(25-21(23)29)4-5-18(16)26-20(17)28/h1-10,24H,(H2,22,27)(H,26,28)(H3,23,25,29)/b17-9-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM17011 (Indolinone based compound, 19 | N-[(5-{1-[(3Z)-5-(...) Show SMILES C\C(=C1\C(=O)Nc2ccc(NC(N)=O)cc12)c1cc(CNC(=O)C2CNCCN2)c[nH]1 Show InChI InChI=1S/C21H25N7O3/c1-11(18-14-7-13(27-21(22)31)2-3-15(14)28-20(18)30)16-6-12(8-25-16)9-26-19(29)17-10-23-4-5-24-17/h2-3,6-8,17,23-25H,4-5,9-10H2,1H3,(H,26,29)(H,28,30)(H3,22,27,31)/b18-11-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM17012 (2-amino-N-[(5-{1-[(3Z)-5-(carbamoylamino)-2-oxo-2,...) Show SMILES C\C(=C1\C(=O)Nc2ccc(NC(N)=O)cc12)c1cc(CNC(=O)CN)c[nH]1 Show InChI InChI=1S/C18H20N6O3/c1-9(14-4-10(7-21-14)8-22-15(25)6-19)16-12-5-11(23-18(20)27)2-3-13(12)24-17(16)26/h2-5,7,21H,6,8,19H2,1H3,(H,22,25)(H,24,26)(H3,20,23,27)/b16-9-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM17009 (Indolinone based compound, 17 | N-[(5-{1-[(3Z)-5-(...) Show SMILES C\C(=C1\C(=O)Nc2ccc(NC(N)=O)cc12)c1cc(CNC(=O)C2CCNCC2)c[nH]1 Show InChI InChI=1S/C22H26N6O3/c1-12(19-16-9-15(27-22(23)31)2-3-17(16)28-21(19)30)18-8-13(10-25-18)11-26-20(29)14-4-6-24-7-5-14/h2-3,8-10,14,24-25H,4-7,11H2,1H3,(H,26,29)(H,28,30)(H3,23,27,31)/b19-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM16997 (Indolinone based compound, 7f | [(3Z)-3-{[4-(3-hyd...) Show SMILES NC(=O)Nc1ccc2NC(=O)\C(=C/c3cc(c[nH]3)-c3cccc(O)c3)c2c1 Show InChI InChI=1S/C20H16N4O3/c21-20(27)23-13-4-5-18-16(8-13)17(19(26)24-18)9-14-6-12(10-22-14)11-2-1-3-15(25)7-11/h1-10,22,25H,(H,24,26)(H3,21,23,27)/b17-9-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.2	22
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM16993 (Indolinone based compound, 7b | [(3Z)-2-oxo-3-{[4-...) Show SMILES NC(=O)Nc1ccc2NC(=O)\C(=C/c3cc(c[nH]3)-c3cccnc3)c2c1 Show InChI InChI=1S/C19H15N5O2/c20-19(26)23-13-3-4-17-15(7-13)16(18(25)24-17)8-14-6-12(10-22-14)11-2-1-5-21-9-11/h1-10,22H,(H,24,25)(H3,20,23,26)/b16-8-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.2	22
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM17006 (Indolinone based compound, 14 | N-[(5-{1-[(3Z)-5-(...) Show SMILES CC(=O)NCc1c[nH]c(c1)C(\C)=C1/C(=O)Nc2ccc(NC(N)=O)cc12 Show InChI InChI=1S/C18H19N5O3/c1-9(15-5-11(8-21-15)7-20-10(2)24)16-13-6-12(22-18(19)26)3-4-14(13)23-17(16)25/h3-6,8,21H,7H2,1-2H3,(H,20,24)(H,23,25)(H3,19,22,26)/b16-9-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM17002 (Indolinone based compound, 7k | N-[3-(5-{[(3Z)-5-(...) Show SMILES CC(=O)Nc1cccc(c1)-c1c[nH]c(\C=C2/C(=O)Nc3ccc(NC(N)=O)cc23)c1 Show InChI InChI=1S/C22H19N5O3/c1-12(28)25-15-4-2-3-13(7-15)14-8-17(24-11-14)10-19-18-9-16(26-22(23)30)5-6-20(18)27-21(19)29/h2-11,24H,1H3,(H,25,28)(H,27,29)(H3,23,26,30)/b19-10-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM16983 (5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1H-i...) Show SMILES Cc1c(\C=C2/C(=O)Nc3ccc(NC(N)=O)cc23)[nH]cc1C(O)=O Show InChI InChI=1S/C16H14N4O4/c1-7-11(15(22)23)6-18-13(7)5-10-9-4-8(19-16(17)24)2-3-12(9)20-14(10)21/h2-6,18H,1H3,(H,20,21)(H,22,23)(H3,17,19,24)/b10-5-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	7.2	22
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM16982 (5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1H-i...) Show SMILES NC(=O)Nc1ccc2NC(=O)\C(=C/c3cc(c[nH]3)C(O)=O)c2c1 Show InChI InChI=1S/C15H12N4O4/c16-15(23)18-8-1-2-12-10(4-8)11(13(20)19-12)5-9-3-7(6-17-9)14(21)22/h1-6,17H,(H,19,20)(H,21,22)(H3,16,18,23)/b11-5-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	7.2	22
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM17008 (Indolinone based compound, 16 | N-[(5-{1-[(3Z)-5-(...) Show SMILES C\C(=C1\C(=O)Nc2ccc(NC(N)=O)cc12)c1cc(CNC(=O)c2cccnc2)c[nH]1 Show InChI InChI=1S/C22H20N6O3/c1-12(19-16-8-15(27-22(23)31)4-5-17(16)28-21(19)30)18-7-13(9-25-18)10-26-20(29)14-3-2-6-24-11-14/h2-9,11,25H,10H2,1H3,(H,26,29)(H,28,30)(H3,23,27,31)/b19-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM17013 (Indolinone based compound, 21 | N-[(5-{1-[(3Z)-5-(...) Show SMILES C\C(=C1\C(=O)Nc2ccc(NC(N)=O)cc12)c1cc(CNC(=O)CO)c[nH]1 Show InChI InChI=1S/C18H19N5O4/c1-9(14-4-10(6-20-14)7-21-15(25)8-24)16-12-5-11(22-18(19)27)2-3-13(12)23-17(16)26/h2-6,20,24H,7-8H2,1H3,(H,21,25)(H,23,26)(H3,19,22,27)/b16-9-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM17005 (Indolinone based compound, 13 | [(3Z)-3-{1-[4-(ami...) Show SMILES C\C(=C1\C(=O)Nc2ccc(NC(N)=O)cc12)c1cc(CN)c[nH]1 Show InChI InChI=1S/C16H17N5O2/c1-8(13-4-9(6-17)7-19-13)14-11-5-10(20-16(18)23)2-3-12(11)21-15(14)22/h2-5,7,19H,6,17H2,1H3,(H,21,22)(H3,18,20,23)/b14-8-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM16987 (5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1H-i...) Show SMILES NC(=O)Nc1ccc2NC(=O)\C(=C/c3cc(c[nH]3)C(=O)NCCN3CCCCC3)c2c1 Show InChI InChI=1S/C22H26N6O3/c23-22(31)26-15-4-5-19-17(11-15)18(21(30)27-19)12-16-10-14(13-25-16)20(29)24-6-9-28-7-2-1-3-8-28/h4-5,10-13,25H,1-3,6-9H2,(H,24,29)(H,27,30)(H3,23,26,31)/b18-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.2	22
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM16990 (5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1H-i...) Show SMILES NC(=O)Nc1ccc2NC(=O)C(=Cc3cc(c[nH]3)C(=O)NCCc3cnc[nH]3)c2c1 |w:12.12| Show InChI InChI=1S/C20H19N7O3/c21-20(30)26-12-1-2-17-15(6-12)16(19(29)27-17)7-14-5-11(8-24-14)18(28)23-4-3-13-9-22-10-25-13/h1-2,5-10,24H,3-4H2,(H,22,25)(H,23,28)(H,27,29)(H3,21,26,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.2	22
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM16991 (5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1H-i...) Show SMILES NC(=O)Nc1ccc2NC(=O)\C(=C/c3cc(c[nH]3)C(=O)NCCc3ccncc3)c2c1 Show InChI InChI=1S/C22H20N6O3/c23-22(31)27-15-1-2-19-17(10-15)18(21(30)28-19)11-16-9-14(12-26-16)20(29)25-8-5-13-3-6-24-7-4-13/h1-4,6-7,9-12,26H,5,8H2,(H,25,29)(H,28,30)(H3,23,27,31)/b18-11-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	7.2	22
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM16998 (Indolinone based compound, 7g | [(3Z)-3-{[4-(3-met...) Show SMILES COc1cccc(c1)-c1c[nH]c(\C=C2/C(=O)Nc3ccc(NC(N)=O)cc23)c1 Show InChI InChI=1S/C21H18N4O3/c1-28-16-4-2-3-12(8-16)13-7-15(23-11-13)10-18-17-9-14(24-21(22)27)5-6-19(17)25-20(18)26/h2-11,23H,1H3,(H,25,26)(H3,22,24,27)/b18-10-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	7.2	22
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM16981 (BX-201 | [(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)...) Show SMILES NC(=O)Nc1ccc2NC(=O)\C(=C/c3ccc[nH]3)c2c1 Show InChI InChI=1S/C14H12N4O2/c15-14(20)17-9-3-4-12-10(7-9)11(13(19)18-12)6-8-2-1-5-16-8/h1-7,16H,(H,18,19)(H3,15,17,20)/b11-6-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	7.2	22
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM16992 (Indolinone based compound, 7a | [(3Z)-2-oxo-3-[(4-...) Show SMILES NC(=O)Nc1ccc2NC(=O)\C(=C/c3cc(c[nH]3)-c3ccccc3)c2c1 Show InChI InChI=1S/C20H16N4O2/c21-20(26)23-14-6-7-18-16(9-14)17(19(25)24-18)10-15-8-13(11-22-15)12-4-2-1-3-5-12/h1-11,22H,(H,24,25)(H3,21,23,26)/b17-10-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	7.2	22
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM16986 (5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1H-i...) Show SMILES CN(C)CCNC(=O)c1c[nH]c(\C=C2/C(=O)Nc3ccc(NC(N)=O)cc23)c1 Show InChI InChI=1S/C19H22N6O3/c1-25(2)6-5-21-17(26)11-7-13(22-10-11)9-15-14-8-12(23-19(20)28)3-4-16(14)24-18(15)27/h3-4,7-10,22H,5-6H2,1-2H3,(H,21,26)(H,24,27)(H3,20,23,28)/b15-9-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	7.2	22
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM16988 (5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1H-i...) Show SMILES NC(=O)Nc1ccc2NC(=O)\C(=C/c3cc(c[nH]3)C(=O)NCCN3CCOCC3)c2c1 Show InChI InChI=1S/C21H24N6O4/c22-21(30)25-14-1-2-18-16(10-14)17(20(29)26-18)11-15-9-13(12-24-15)19(28)23-3-4-27-5-7-31-8-6-27/h1-2,9-12,24H,3-8H2,(H,23,28)(H,26,29)(H3,22,25,30)/b17-11-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	7.2	22
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM16989 (Indolinone based compound, 3d | [(3Z)-3-[(4-{[(3S)...) Show SMILES CN(C)[C@H]1CCN(C1)C(=O)c1c[nH]c(\C=C2/C(=O)Nc3ccc(NC(N)=O)cc23)c1 |r| Show InChI InChI=1S/C21H24N6O3/c1-26(2)15-5-6-27(11-15)20(29)12-7-14(23-10-12)9-17-16-8-13(24-21(22)30)3-4-18(16)25-19(17)28/h3-4,7-10,15,23H,5-6,11H2,1-2H3,(H,25,28)(H3,22,24,30)/b17-9-/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	7.2	22
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM17000 (Indolinone based compound, 7i | [(3Z)-3-{[4-(3-met...) Show SMILES Cc1cccc(c1)-c1c[nH]c(\C=C2/C(=O)Nc3ccc(NC(N)=O)cc23)c1 Show InChI InChI=1S/C21H18N4O2/c1-12-3-2-4-13(7-12)14-8-16(23-11-14)10-18-17-9-15(24-21(22)27)5-6-19(17)25-20(18)26/h2-11,23H,1H3,(H,25,26)(H3,22,24,27)/b18-10-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM16984 (3-(5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1...) Show SMILES Cc1c(CCC(O)=O)c[nH]c1\C=C1/C(=O)Nc2ccc(NC(N)=O)cc12 Show InChI InChI=1S/C18H18N4O4/c1-9-10(2-5-16(23)24)8-20-15(9)7-13-12-6-11(21-18(19)26)3-4-14(12)22-17(13)25/h3-4,6-8,20H,2,5H2,1H3,(H,22,25)(H,23,24)(H3,19,21,26)/b13-7-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	7.2	22
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM16994 (3-(5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1...) Show SMILES NC(=O)Nc1ccc2NC(=O)\C(=C/c3cc(c[nH]3)-c3cccc(c3)C(O)=O)c2c1 Show InChI InChI=1S/C21H16N4O4/c22-21(29)24-14-4-5-18-16(8-14)17(19(26)25-18)9-15-7-13(10-23-15)11-2-1-3-12(6-11)20(27)28/h1-10,23H,(H,25,26)(H,27,28)(H3,22,24,29)/b17-9-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	7.2	22
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM16999 (Indolinone based compound, 7h | [(3Z)-3-{[4-(3-flu...) Show SMILES NC(=O)Nc1ccc2NC(=O)\C(=C/c3cc(c[nH]3)-c3cccc(F)c3)c2c1 Show InChI InChI=1S/C20H15FN4O2/c21-13-3-1-2-11(6-13)12-7-15(23-10-12)9-17-16-8-14(24-20(22)27)4-5-18(16)25-19(17)26/h1-10,23H,(H,25,26)(H3,22,24,27)/b17-9-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM16985 (3-(5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1...) Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(NC(N)=O)cc23)c(C)c1CCC(O)=O Show InChI InChI=1S/C19H20N4O4/c1-9-12(4-6-17(24)25)10(2)21-16(9)8-14-13-7-11(22-19(20)27)3-5-15(13)23-18(14)26/h3,5,7-8,21H,4,6H2,1-2H3,(H,23,26)(H,24,25)(H3,20,22,27)/b14-8-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	7.2	22
Berlex Biosciences					Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...				Bioorg Med Chem Lett 17: 3819-25 (2007) Article DOI: 10.1016/j.bmcl.2007.05.060 BindingDB Entry DOI: 10.7270/Q29G5K22
					More data for this Ligand-Target Pair