Found 772 hits Enz. Inhib. hit(s) with all data for entry = 2366 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Apelin receptor
(Homo sapiens (Human)) | BDBM360377
((1R,2S)-1-(5-chloro-2-pyridinyl)-N-(4-(2,4-dimetho...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)ccnc1OC)c1ccc(Cl)cn1 |r,wU:3.3,2.1,(3.85,-10.07,;2.76,-8.98,;3.16,-7.49,;2.07,-6.41,;2.47,-4.92,;.58,-6.8,;-.19,-8.14,;1.35,-8.14,;-.51,-5.72,;-2,-6.11,;-2.47,-7.58,;-4.01,-7.58,;-4.49,-6.11,;-6.03,-6.11,;-6.8,-7.45,;-8.34,-7.45,;-9.11,-6.11,;-8.34,-4.78,;-6.8,-4.78,;-3.24,-5.21,;-3.24,-3.67,;-1.91,-2.9,;-.57,-3.67,;.76,-2.9,;-1.91,-1.36,;-3.24,-.59,;-4.58,-1.36,;-4.58,-2.9,;-5.91,-3.67,;-7.24,-2.9,;4.64,-7.1,;5.04,-5.61,;6.53,-5.21,;7.62,-6.3,;9.11,-5.9,;7.22,-7.79,;5.73,-8.18,)| Show InChI InChI=1S/C23H24ClN7O5S/c1-14(20(35-3)17-8-7-16(24)13-27-17)37(32,33)30-23-29-28-21(15-6-5-10-25-12-15)31(23)19-18(34-2)9-11-26-22(19)36-4/h5-14,20H,1-4H3,(H,29,30)/t14-,20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.310 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360379
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(3-pyridinyl)...)Show SMILES COc1cnc(cn1)[C@@H](C)[C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC |r,wU:10.11,8.9,(9.64,2.67,;8.55,3.76,;7.06,3.36,;5.97,4.45,;4.49,4.05,;4.09,2.56,;5.18,1.47,;6.66,1.87,;2.6,2.16,;2.2,.68,;1.51,3.25,;1.91,4.74,;.02,2.85,;-.75,1.52,;.79,1.52,;-1.06,3.94,;-2.55,3.54,;-3.03,2.08,;-4.57,2.08,;-5.04,3.54,;-6.58,3.54,;-7.35,2.21,;-8.89,2.21,;-9.66,3.54,;-8.89,4.88,;-7.35,4.88,;-3.8,4.45,;-3.8,5.99,;-5.13,6.76,;-6.47,5.99,;-7.8,6.76,;-5.13,8.3,;-3.8,9.07,;-2.46,8.3,;-2.46,6.76,;-1.13,5.99,;.2,6.76,)| Show InChI InChI=1S/C24H27N7O5S/c1-15(18-13-27-21(36-5)14-26-18)16(2)37(32,33)30-24-29-28-23(17-8-7-11-25-12-17)31(24)22-19(34-3)9-6-10-20(22)35-4/h6-16H,1-5H3,(H,29,30)/t15-,16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.320 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270146
((2R,3S)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,4-dimet...)Show SMILES COc1ccnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1cccnc1 |r,wU:16.17,18.19,(.22,1.89,;-1.12,1.12,;-2.45,1.89,;-2.45,3.43,;-3.79,4.2,;-5.12,3.43,;-5.12,1.89,;-6.45,1.12,;-7.79,1.89,;-3.79,1.12,;-3.79,-.42,;-2.54,-1.33,;-1.05,-.93,;.04,-2.02,;-1.05,-3.11,;.43,-3.51,;1.52,-1.62,;1.92,-.13,;2.61,-2.71,;2.21,-4.2,;4.1,-2.31,;5.19,-3.4,;6.68,-3,;7.08,-1.51,;8.56,-1.11,;5.99,-.42,;4.5,-.82,;-3.02,-2.79,;-4.56,-2.79,;-5.03,-1.33,;-6.57,-1.33,;-7.34,-2.66,;-8.88,-2.66,;-9.65,-1.33,;-8.88,.01,;-7.34,.01,)| Show InChI InChI=1S/C22H23ClN8O4S/c1-13(19-26-11-16(23)12-27-19)14(2)36(32,33)30-22-29-28-20(15-6-5-8-24-10-15)31(22)18-17(34-3)7-9-25-21(18)35-4/h5-14H,1-4H3,(H,29,30)/t13-,14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.950 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270146
((2R,3S)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,4-dimet...)Show SMILES COc1ccnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1cccnc1 |r,wU:16.17,18.19,(.22,1.89,;-1.12,1.12,;-2.45,1.89,;-2.45,3.43,;-3.79,4.2,;-5.12,3.43,;-5.12,1.89,;-6.45,1.12,;-7.79,1.89,;-3.79,1.12,;-3.79,-.42,;-2.54,-1.33,;-1.05,-.93,;.04,-2.02,;-1.05,-3.11,;.43,-3.51,;1.52,-1.62,;1.92,-.13,;2.61,-2.71,;2.21,-4.2,;4.1,-2.31,;5.19,-3.4,;6.68,-3,;7.08,-1.51,;8.56,-1.11,;5.99,-.42,;4.5,-.82,;-3.02,-2.79,;-4.56,-2.79,;-5.03,-1.33,;-6.57,-1.33,;-7.34,-2.66,;-8.88,-2.66,;-9.65,-1.33,;-8.88,.01,;-7.34,.01,)| Show InChI InChI=1S/C22H23ClN8O4S/c1-13(19-26-11-16(23)12-27-19)14(2)36(32,33)30-22-29-28-20(15-6-5-8-24-10-15)31(22)18-17(34-3)7-9-25-21(18)35-4/h5-14H,1-4H3,(H,29,30)/t13-,14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.340 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM363562
((1R,2S)-1-cyclobutyl-N-(4-(2,6-dimethoxyphenyl)-5-...)Show SMILES CO[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)C1CCC1 |r,wU:2.1,wD:3.3,(14.72,-10.66,;13.38,-9.89,;13.38,-8.35,;12.05,-7.58,;12.05,-6.04,;10.72,-8.35,;9.95,-9.69,;11.49,-9.69,;9.38,-7.58,;8.05,-8.35,;7.57,-9.82,;6.03,-9.82,;5.56,-8.35,;4.22,-7.58,;3.14,-8.67,;1.65,-8.27,;1.25,-6.78,;2.34,-5.7,;1.94,-4.21,;3.83,-6.09,;6.8,-7.45,;6.8,-5.55,;5.47,-4.78,;4.14,-5.55,;2.8,-4.78,;5.47,-3.24,;6.8,-2.47,;8.14,-3.24,;8.14,-4.78,;9.47,-5.55,;10.81,-4.78,;14.72,-7.58,;16.21,-7.98,;16.6,-6.49,;15.12,-6.09,)| Show InChI InChI=1S/C24H31N5O5S/c1-15-12-18(14-25-13-15)23-26-27-24(29(23)21-19(32-3)10-7-11-20(21)33-4)28-35(30,31)16(2)22(34-5)17-8-6-9-17/h7,10-14,16-17,22H,6,8-9H2,1-5H3,(H,27,28)/t16-,22+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 44 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM363739
(US9845310, Example 720.0)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@@H](O)C2CC(F)(F)C2)n1-c1c(OC)cccc1OC |wU:16.17,18.19,(4.91,1.83,;4.01,.58,;4.63,-.82,;6.17,-.99,;6.79,-2.39,;5.89,-3.64,;4.36,-3.48,;3.73,-2.07,;3.45,-4.72,;1.91,-4.72,;1.43,-6.19,;2.68,-7.09,;2.68,-8.63,;1.35,-9.4,;2.12,-10.74,;.58,-8.07,;.01,-10.17,;.01,-11.71,;-1.32,-9.4,;-2.65,-10.17,;-1.32,-7.86,;-.23,-6.77,;-1.32,-5.68,;-2.41,-4.6,;-.23,-4.6,;-2.41,-6.77,;3.93,-6.19,;5.39,-6.66,;5.71,-8.17,;4.57,-9.2,;4.89,-10.71,;7.18,-8.65,;8.32,-7.61,;8,-6.11,;6.54,-5.63,;6.22,-4.13,;7.36,-3.1,)| Show InChI InChI=1S/C23H27F2N5O6S/c1-13(20(31)14-11-23(24,25)12-14)37(32,33)29-22-28-27-21(15-7-5-10-18(26-15)36-4)30(22)19-16(34-2)8-6-9-17(19)35-3/h5-10,13-14,20,31H,11-12H2,1-4H3,(H,28,29)/t13-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 35 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270153
(US10058550, Example 720.0 721.0 | US9845310, Examp...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](O)C2CC(F)(F)C2)n1-c1c(OC)cccc1OC |r,wU:16.17,18.19,(-10.52,-7.61,;-9.03,-8.01,;-7.94,-6.92,;-8.34,-5.44,;-7.25,-4.35,;-5.77,-4.75,;-5.37,-6.23,;-6.46,-7.32,;-3.88,-6.63,;-3.4,-8.1,;-1.86,-8.1,;-1.39,-6.63,;-.05,-5.86,;1.28,-6.63,;.51,-7.97,;2.05,-7.97,;2.61,-5.86,;2.61,-4.32,;3.95,-6.63,;3.95,-8.17,;5.28,-5.86,;6.77,-6.26,;7.17,-4.77,;8.5,-4,;8.39,-5.71,;5.68,-4.37,;-2.63,-5.73,;-2.63,-4.16,;-3.97,-3.39,;-5.3,-4.16,;-6.63,-3.39,;-3.97,-1.85,;-2.63,-1.08,;-1.3,-1.85,;-1.3,-3.39,;.03,-4.16,;1.37,-3.39,)| Show InChI InChI=1S/C23H27F2N5O6S/c1-13(20(31)14-11-23(24,25)12-14)37(32,33)29-22-28-27-21(15-7-5-10-18(26-15)36-4)30(22)19-16(34-2)8-6-9-17(19)35-3/h5-10,13-14,20,31H,11-12H2,1-4H3,(H,28,29)/t13-,20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270153
(US10058550, Example 720.0 721.0 | US9845310, Examp...)Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](O)C2CC(F)(F)C2)n1-c1c(OC)cccc1OC |r,wU:16.17,18.19,(-10.52,-7.61,;-9.03,-8.01,;-7.94,-6.92,;-8.34,-5.44,;-7.25,-4.35,;-5.77,-4.75,;-5.37,-6.23,;-6.46,-7.32,;-3.88,-6.63,;-3.4,-8.1,;-1.86,-8.1,;-1.39,-6.63,;-.05,-5.86,;1.28,-6.63,;.51,-7.97,;2.05,-7.97,;2.61,-5.86,;2.61,-4.32,;3.95,-6.63,;3.95,-8.17,;5.28,-5.86,;6.77,-6.26,;7.17,-4.77,;8.5,-4,;8.39,-5.71,;5.68,-4.37,;-2.63,-5.73,;-2.63,-4.16,;-3.97,-3.39,;-5.3,-4.16,;-6.63,-3.39,;-3.97,-1.85,;-2.63,-1.08,;-1.3,-1.85,;-1.3,-3.39,;.03,-4.16,;1.37,-3.39,)| Show InChI InChI=1S/C23H27F2N5O6S/c1-13(20(31)14-11-23(24,25)12-14)37(32,33)29-22-28-27-21(15-7-5-10-18(26-15)36-4)30(22)19-16(34-2)8-6-9-17(19)35-3/h5-10,13-14,20,31H,11-12H2,1-4H3,(H,28,29)/t13-,20-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM363740
(US9845310, Example 724.0 | US9845310, Example 726....)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)C1CC(C)(C)C1 |wU:2.1,3.3,(3.74,-15.02,;2.41,-15.79,;1.08,-15.02,;-.26,-15.79,;-1.59,-15.02,;-.26,-17.33,;-1.8,-17.33,;1.28,-17.33,;-.26,-18.87,;-1.59,-19.64,;-3,-19.01,;-4.03,-20.15,;-3.26,-21.49,;-3.89,-22.89,;-2.98,-24.14,;-3.61,-25.55,;-5.14,-25.71,;-6.04,-24.46,;-7.58,-24.62,;-5.42,-23.06,;-1.75,-21.17,;-.61,-22.2,;-.93,-23.7,;-2.39,-24.18,;-2.71,-25.69,;.22,-24.73,;1.68,-24.26,;2,-22.75,;.86,-21.72,;1.18,-20.22,;2.64,-19.74,;1.08,-13.48,;-.01,-12.39,;1.08,-11.3,;.27,-9.98,;1.88,-9.98,;2.16,-12.39,)| Show InChI InChI=1S/C26H35N5O5S/c1-16-11-18(15-27-14-16)24-28-29-25(31(24)22-20(34-5)9-8-10-21(22)35-6)30-37(32,33)17(2)23(36-7)19-12-26(3,4)13-19/h8-11,14-15,17,19,23H,12-13H2,1-7H3,(H,29,30)/t17-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 220 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270158
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)C1CC(C)(C)C1 |r,wU:3.3,2.1,(-4.52,.88,;-5.86,1.65,;-5.86,3.19,;-7.19,3.96,;-7.19,5.5,;-8.52,3.19,;-9.29,1.86,;-7.75,1.86,;-9.86,3.96,;-11.19,3.19,;-11.67,1.73,;-13.21,1.73,;-13.68,3.19,;-15.17,3.59,;-16.26,2.5,;-17.75,2.9,;-18.15,4.39,;-17.06,5.48,;-17.46,6.97,;-15.57,5.08,;-12.44,4.1,;-12.44,5.64,;-11.1,6.41,;-9.77,5.64,;-8.44,6.41,;-11.1,7.95,;-12.44,8.72,;-13.77,7.95,;-13.77,6.41,;-15.1,5.64,;-16.44,6.41,;-4.52,3.96,;-3.04,3.57,;-2.64,5.05,;-1.1,5.05,;-1.87,6.39,;-4.12,5.45,)| Show InChI InChI=1S/C26H35N5O5S/c1-16-11-18(15-27-14-16)24-28-29-25(31(24)22-20(34-5)9-8-10-21(22)35-6)30-37(32,33)17(2)23(36-7)19-12-26(3,4)13-19/h8-11,14-15,17,19,23H,12-13H2,1-7H3,(H,29,30)/t17-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 36 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM363740
(US9845310, Example 724.0 | US9845310, Example 726....)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)C1CC(C)(C)C1 |wU:2.1,3.3,(3.74,-15.02,;2.41,-15.79,;1.08,-15.02,;-.26,-15.79,;-1.59,-15.02,;-.26,-17.33,;-1.8,-17.33,;1.28,-17.33,;-.26,-18.87,;-1.59,-19.64,;-3,-19.01,;-4.03,-20.15,;-3.26,-21.49,;-3.89,-22.89,;-2.98,-24.14,;-3.61,-25.55,;-5.14,-25.71,;-6.04,-24.46,;-7.58,-24.62,;-5.42,-23.06,;-1.75,-21.17,;-.61,-22.2,;-.93,-23.7,;-2.39,-24.18,;-2.71,-25.69,;.22,-24.73,;1.68,-24.26,;2,-22.75,;.86,-21.72,;1.18,-20.22,;2.64,-19.74,;1.08,-13.48,;-.01,-12.39,;1.08,-11.3,;.27,-9.98,;1.88,-9.98,;2.16,-12.39,)| Show InChI InChI=1S/C26H35N5O5S/c1-16-11-18(15-27-14-16)24-28-29-25(31(24)22-20(34-5)9-8-10-21(22)35-6)30-37(32,33)17(2)23(36-7)19-12-26(3,4)13-19/h8-11,14-15,17,19,23H,12-13H2,1-7H3,(H,29,30)/t17-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 7.5 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270158
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)C1CC(C)(C)C1 |r,wU:3.3,2.1,(-4.52,.88,;-5.86,1.65,;-5.86,3.19,;-7.19,3.96,;-7.19,5.5,;-8.52,3.19,;-9.29,1.86,;-7.75,1.86,;-9.86,3.96,;-11.19,3.19,;-11.67,1.73,;-13.21,1.73,;-13.68,3.19,;-15.17,3.59,;-16.26,2.5,;-17.75,2.9,;-18.15,4.39,;-17.06,5.48,;-17.46,6.97,;-15.57,5.08,;-12.44,4.1,;-12.44,5.64,;-11.1,6.41,;-9.77,5.64,;-8.44,6.41,;-11.1,7.95,;-12.44,8.72,;-13.77,7.95,;-13.77,6.41,;-15.1,5.64,;-16.44,6.41,;-4.52,3.96,;-3.04,3.57,;-2.64,5.05,;-1.1,5.05,;-1.87,6.39,;-4.12,5.45,)| Show InChI InChI=1S/C26H35N5O5S/c1-16-11-18(15-27-14-16)24-28-29-25(31(24)22-20(34-5)9-8-10-21(22)35-6)30-37(32,33)17(2)23(36-7)19-12-26(3,4)13-19/h8-11,14-15,17,19,23H,12-13H2,1-7H3,(H,29,30)/t17-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM363570
((R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CC(O)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |(-6.71,-4.85,;-5.38,-5.62,;-4.05,-4.85,;-4.05,-3.31,;-2.71,-2.54,;-1.38,-3.31,;-1.38,-4.85,;-.04,-5.62,;1.29,-4.85,;-2.71,-5.62,;-2.71,-7.25,;-1.47,-8.16,;-.13,-7.39,;1.2,-8.16,;.43,-9.49,;1.97,-9.49,;2.53,-7.39,;3.87,-8.16,;3.87,-9.7,;5.2,-7.39,;6.54,-8.16,;7.87,-7.39,;7.87,-5.85,;9.2,-5.08,;6.54,-5.08,;5.2,-5.85,;-1.94,-9.62,;-3.48,-9.62,;-3.96,-8.16,;-5.45,-7.76,;-6.53,-8.85,;-8.02,-8.45,;-8.42,-6.96,;-7.33,-5.87,;-7.73,-4.38,;-5.84,-6.27,)| Show InChI InChI=1S/C23H25N7O5S/c1-14-8-16(12-24-9-14)22-27-28-23(30(22)20-18(34-3)6-5-7-19(20)35-4)29-36(32,33)13-17(31)21-25-10-15(2)11-26-21/h5-12,17,31H,13H2,1-4H3,(H,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.880 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270161
((R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyr...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)C[C@@H](O)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wD:17.18,(.86,-3.29,;-.47,-4.06,;-1.81,-3.29,;-1.81,-1.75,;-3.14,-.98,;-4.48,-1.75,;-4.48,-3.29,;-5.81,-4.06,;-7.14,-3.29,;-3.14,-4.06,;-3.14,-5.6,;-1.9,-6.5,;-.56,-5.73,;.77,-6.5,;0,-7.84,;1.54,-7.84,;2.11,-5.73,;3.44,-6.5,;3.44,-8.04,;4.77,-5.73,;6.11,-6.5,;7.44,-5.73,;7.44,-4.19,;8.77,-3.42,;6.11,-3.42,;4.77,-4.19,;-2.37,-7.97,;-3.91,-7.97,;-4.39,-6.5,;-5.87,-6.11,;-6.96,-7.19,;-8.45,-6.8,;-8.85,-5.31,;-7.76,-4.22,;-8.16,-2.73,;-6.27,-4.62,)| Show InChI InChI=1S/C23H25N7O5S/c1-14-8-16(12-24-9-14)22-27-28-23(30(22)20-18(34-3)6-5-7-19(20)35-4)29-36(32,33)13-17(31)21-25-10-15(2)11-26-21/h5-12,17,31H,13H2,1-4H3,(H,28,29)/t17-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270162
((1R,2S)—N-(4-(4,6-dimethoxypyrimidin-5-yl)-5-...)Show SMILES CO[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)ncnc1OC)C1CC(C)(C)C1 |r,wU:2.1,wD:3.3,(17.04,-8.7,;15.7,-7.93,;15.7,-6.39,;14.37,-5.62,;14.37,-4.08,;13.03,-6.39,;12.26,-7.72,;13.8,-7.72,;11.7,-5.62,;10.37,-6.39,;9.89,-7.85,;8.35,-7.85,;7.88,-6.39,;6.39,-5.99,;5.99,-4.5,;4.5,-4.1,;3.41,-5.19,;3.81,-6.68,;2.72,-7.77,;1.23,-7.37,;5.3,-7.08,;9.12,-5.48,;9.12,-3.94,;10.46,-3.17,;11.79,-3.94,;13.12,-3.17,;10.46,-1.63,;9.12,-.86,;7.79,-1.63,;7.79,-3.17,;6.45,-3.94,;5.12,-3.17,;17.04,-5.62,;18.52,-6.02,;18.92,-4.53,;20.46,-4.53,;19.69,-3.2,;17.43,-4.13,)| Show InChI InChI=1S/C24H33N7O6S/c1-14(19(35-5)15-11-24(2,3)12-15)38(32,33)30-23-29-28-20(16-9-8-10-17(27-16)34-4)31(23)18-21(36-6)25-13-26-22(18)37-7/h8-10,13-15,19H,11-12H2,1-7H3,(H,29,30)/t14-,19+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 4.10 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360392
((1R,2S)-N-(4-(4,6-dimethoxy-5-pyrimidinyl)-5-(6-me...)Show SMILES CO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)ncnc1OC)C1CC(C)(C)C1 |r,wU:3.3,wD:2.1,(-4.64,-11.19,;-5.97,-10.42,;-5.97,-8.88,;-7.3,-8.11,;-7.3,-6.57,;-8.64,-8.88,;-9.41,-10.21,;-7.87,-10.21,;-9.97,-8.11,;-11.43,-8.58,;-11.91,-10.05,;-13.45,-10.05,;-13.93,-8.58,;-15.39,-8.11,;-15.71,-6.6,;-17.18,-6.12,;-18.32,-7.16,;-18,-8.66,;-19.14,-9.69,;-20.61,-9.22,;-16.54,-9.14,;-12.68,-7.68,;-12.68,-6.14,;-14.01,-5.37,;-15.35,-6.14,;-16.68,-5.37,;-14.01,-3.83,;-12.68,-3.06,;-11.35,-3.83,;-11.35,-5.37,;-10.01,-6.14,;-8.68,-5.37,;-4.64,-8.11,;-3.15,-8.51,;-2.75,-7.02,;-1.21,-7.02,;-1.98,-5.68,;-4.24,-6.62,)| Show InChI InChI=1S/C24H33N7O6S/c1-14(19(35-5)15-11-24(2,3)12-15)38(32,33)30-23-29-28-20(16-9-8-10-17(27-16)34-4)31(23)18-21(36-6)25-13-26-22(18)37-7/h8-10,13-15,19H,11-12H2,1-7H3,(H,29,30)/t14-,19+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 38 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270164
((2S,3R)—N-(4-(3,5-dibromo-2,6-dimethoxyphenyl...)Show SMILES COc1c(Br)cc(Br)c(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:20.21,18.19,(2.4,-5.29,;1.07,-6.06,;-.27,-5.29,;-.27,-3.75,;1.07,-2.98,;-1.6,-2.98,;-2.94,-3.75,;-4.27,-2.98,;-2.94,-5.29,;-4.27,-6.06,;-5.6,-5.29,;-1.6,-6.06,;-1.6,-7.6,;-.36,-8.51,;.98,-7.74,;2.31,-8.51,;1.54,-9.84,;3.08,-9.84,;3.64,-7.74,;3.64,-6.2,;4.98,-8.51,;4.98,-10.05,;6.31,-7.74,;7.65,-8.51,;8.98,-7.74,;8.98,-6.2,;10.31,-5.43,;7.65,-5.43,;6.31,-6.2,;-.83,-9.97,;-2.37,-9.97,;-2.85,-8.51,;-4.34,-8.11,;-5.42,-9.2,;-6.91,-8.8,;-7.31,-7.31,;-6.22,-6.22,;-6.62,-4.74,;-4.73,-6.62,)| Show InChI InChI=1S/C25H27Br2N7O4S/c1-13-7-17(12-28-9-13)24-31-32-25(34(24)20-21(37-5)18(26)8-19(27)22(20)38-6)33-39(35,36)16(4)15(3)23-29-10-14(2)11-30-23/h7-12,15-16H,1-6H3,(H,32,33)/t15-,16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 37 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270165
((2S,3R)—N-(5-(5-bromopyridin-3-yl)-4-(2,6-dim...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1-c1cncc(Br)c1 |r,wU:18.19,16.17,(-7.1,1.22,;-5.77,.45,;-4.44,1.22,;-4.44,2.76,;-3.1,3.53,;-1.77,2.76,;-1.77,1.22,;-.44,.45,;.9,1.22,;-3.1,.45,;-3.1,-1.09,;-1.86,-1.99,;-.52,-1.22,;.81,-1.99,;.04,-3.33,;1.58,-3.33,;2.14,-1.22,;2.14,.32,;3.48,-1.99,;3.48,-3.53,;4.81,-1.22,;6.14,-1.99,;7.48,-1.22,;7.48,.32,;8.81,1.09,;6.14,1.09,;4.81,.32,;-2.33,-3.46,;-3.87,-3.46,;-4.35,-1.99,;-5.84,-1.59,;-6.93,-2.68,;-8.41,-2.28,;-8.81,-.8,;-7.72,.29,;-8.12,1.78,;-6.24,-.11,)| Show InChI InChI=1S/C24H26BrN7O4S/c1-14-10-27-22(28-11-14)15(2)16(3)37(33,34)31-24-30-29-23(17-9-18(25)13-26-12-17)32(24)21-19(35-4)7-6-8-20(21)36-5/h6-13,15-16H,1-5H3,(H,30,31)/t15-,16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.420 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270165
((2S,3R)—N-(5-(5-bromopyridin-3-yl)-4-(2,6-dim...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1-c1cncc(Br)c1 |r,wU:18.19,16.17,(-7.1,1.22,;-5.77,.45,;-4.44,1.22,;-4.44,2.76,;-3.1,3.53,;-1.77,2.76,;-1.77,1.22,;-.44,.45,;.9,1.22,;-3.1,.45,;-3.1,-1.09,;-1.86,-1.99,;-.52,-1.22,;.81,-1.99,;.04,-3.33,;1.58,-3.33,;2.14,-1.22,;2.14,.32,;3.48,-1.99,;3.48,-3.53,;4.81,-1.22,;6.14,-1.99,;7.48,-1.22,;7.48,.32,;8.81,1.09,;6.14,1.09,;4.81,.32,;-2.33,-3.46,;-3.87,-3.46,;-4.35,-1.99,;-5.84,-1.59,;-6.93,-2.68,;-8.41,-2.28,;-8.81,-.8,;-7.72,.29,;-8.12,1.78,;-6.24,-.11,)| Show InChI InChI=1S/C24H26BrN7O4S/c1-14-10-27-22(28-11-14)15(2)16(3)37(33,34)31-24-30-29-23(17-9-18(25)13-26-12-17)32(24)21-19(35-4)7-6-8-20(21)36-5/h6-13,15-16H,1-5H3,(H,30,31)/t15-,16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270167
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(pyridin...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](O)c2cn3ccccc3n2)nnc1-c1cccnc1 |r,wU:16.17,18.19,(2.4,-5.29,;1.07,-6.06,;-.27,-5.29,;-.27,-3.75,;-1.6,-2.98,;-2.94,-3.75,;-2.94,-5.29,;-4.27,-6.06,;-5.6,-5.29,;-1.6,-6.06,;-1.6,-7.6,;-.36,-8.51,;.98,-7.74,;2.31,-8.51,;1.54,-9.84,;3.08,-9.84,;3.64,-7.74,;3.64,-6.2,;4.98,-8.51,;4.98,-10.05,;6.31,-7.74,;6.47,-6.21,;7.98,-5.89,;8.75,-4.55,;10.29,-4.55,;11.06,-5.89,;10.29,-7.22,;8.75,-7.22,;7.72,-8.37,;-.83,-9.97,;-2.37,-9.97,;-2.85,-8.51,;-4.34,-8.11,;-4.73,-6.62,;-6.22,-6.22,;-7.31,-7.31,;-6.91,-8.8,;-5.42,-9.2,)| Show InChI InChI=1S/C25H25N7O5S/c1-16(23(33)18-15-31-13-5-4-11-21(31)27-18)38(34,35)30-25-29-28-24(17-8-7-12-26-14-17)32(25)22-19(36-2)9-6-10-20(22)37-3/h4-16,23,33H,1-3H3,(H,29,30)/t16-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.480 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270167
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(pyridin...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](O)c2cn3ccccc3n2)nnc1-c1cccnc1 |r,wU:16.17,18.19,(2.4,-5.29,;1.07,-6.06,;-.27,-5.29,;-.27,-3.75,;-1.6,-2.98,;-2.94,-3.75,;-2.94,-5.29,;-4.27,-6.06,;-5.6,-5.29,;-1.6,-6.06,;-1.6,-7.6,;-.36,-8.51,;.98,-7.74,;2.31,-8.51,;1.54,-9.84,;3.08,-9.84,;3.64,-7.74,;3.64,-6.2,;4.98,-8.51,;4.98,-10.05,;6.31,-7.74,;6.47,-6.21,;7.98,-5.89,;8.75,-4.55,;10.29,-4.55,;11.06,-5.89,;10.29,-7.22,;8.75,-7.22,;7.72,-8.37,;-.83,-9.97,;-2.37,-9.97,;-2.85,-8.51,;-4.34,-8.11,;-4.73,-6.62,;-6.22,-6.22,;-7.31,-7.31,;-6.91,-8.8,;-5.42,-9.2,)| Show InChI InChI=1S/C25H25N7O5S/c1-16(23(33)18-15-31-13-5-4-11-21(31)27-18)38(34,35)30-25-29-28-24(17-8-7-12-26-14-17)32(25)22-19(36-2)9-6-10-20(22)37-3/h4-16,23,33H,1-3H3,(H,29,30)/t16-,23-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM363742
(US9845310, Example 737.0)Show SMILES CCO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(F)cccc1F)c1ncc(C)cn1 |wU:3.2,4.4,(-11.04,-4.8,;-10.72,-6.31,;-9.25,-6.78,;-8.93,-8.29,;-7.47,-8.77,;-7.15,-10.27,;-6.32,-7.73,;-7.35,-6.59,;-5.29,-8.88,;-5.18,-6.7,;-3.71,-7.18,;-3.24,-8.64,;-1.7,-8.64,;-1.22,-7.18,;.24,-6.7,;.56,-5.2,;2.03,-4.72,;3.17,-5.75,;2.85,-7.26,;4,-8.29,;1.39,-7.73,;-2.47,-6.27,;-2.47,-4.73,;-1.13,-3.96,;.2,-4.73,;-1.13,-2.42,;-2.47,-1.65,;-3.8,-2.42,;-3.8,-3.96,;-5.14,-4.73,;-10.08,-9.32,;-9.76,-10.83,;-10.9,-11.86,;-12.37,-11.38,;-13.51,-12.41,;-12.69,-9.87,;-11.54,-8.84,)| Show InChI InChI=1S/C24H25F2N7O3S/c1-5-36-21(22-28-11-15(3)12-29-22)16(4)37(34,35)32-24-31-30-23(17-9-14(2)10-27-13-17)33(24)20-18(25)7-6-8-19(20)26/h6-13,16,21H,5H2,1-4H3,(H,31,32)/t16-,21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270170
((1S,2S)-1-isopropoxy-1-(5-methylpyrimidin-2-yl)pro...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1-c1cccc(C)n1 |r,wU:16.17,wD:18.19,(-6.76,2.38,;-5.43,1.61,;-4.09,2.38,;-4.09,3.92,;-2.76,4.69,;-1.42,3.92,;-1.42,2.38,;-.09,1.61,;1.24,2.38,;-2.76,1.61,;-2.76,.07,;-1.51,-.84,;-.18,-.07,;1.15,-.84,;.38,-2.17,;1.92,-2.17,;2.49,-.07,;2.49,1.47,;3.82,-.84,;3.82,-2.38,;5.16,-3.15,;5.16,-4.69,;6.49,-2.38,;5.16,-.07,;6.49,-.84,;7.82,-.07,;7.82,1.47,;9.16,2.24,;6.49,2.24,;5.16,1.47,;-1.99,-2.3,;-3.53,-2.3,;-4,-.84,;-5.49,-.44,;-5.89,1.05,;-7.38,1.45,;-8.47,.36,;-8.07,-1.13,;-9.16,-2.22,;-6.58,-1.53,)| Show InChI InChI=1S/C27H33N7O5S/c1-16(2)39-24(25-28-14-17(3)15-29-25)19(5)40(35,36)33-27-32-31-26(20-11-8-10-18(4)30-20)34(27)23-21(37-6)12-9-13-22(23)38-7/h8-16,19,24H,1-7H3,(H,32,33)/t19-,24+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270171
((1R,2S)-1-methoxy-N-(4-(4-methoxy-6-oxo-1,6-dihydr...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(O)ncnc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(5.16,-3.15,;3.82,-2.38,;3.82,-.84,;2.49,-.07,;2.49,1.47,;1.15,-.84,;.38,-2.17,;1.92,-2.17,;-.18,-.07,;-1.51,-.84,;-1.99,-2.3,;-3.53,-2.3,;-4,-.84,;-5.49,-.44,;-5.89,1.05,;-7.38,1.45,;-8.47,.36,;-8.07,-1.13,;-9.16,-2.22,;-10.64,-1.82,;-6.58,-1.53,;-2.76,.07,;-2.76,1.61,;-4.09,2.38,;-5.43,1.61,;-4.09,3.92,;-2.76,4.69,;-1.42,3.92,;-1.42,2.38,;-.09,1.61,;1.24,2.38,;5.16,-.07,;6.49,-.84,;7.82,-.07,;7.82,1.47,;9.16,2.24,;6.49,2.24,;5.16,1.47,)| Show InChI InChI=1S/C22H25N9O6S/c1-12-9-23-18(24-10-12)17(36-4)13(2)38(33,34)30-22-29-28-19(14-7-6-8-15(27-14)35-3)31(22)16-20(32)25-11-26-21(16)37-5/h6-11,13,17H,1-5H3,(H,29,30)(H,25,26,32)/t13-,17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270171
((1R,2S)-1-methoxy-N-(4-(4-methoxy-6-oxo-1,6-dihydr...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(O)ncnc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(5.16,-3.15,;3.82,-2.38,;3.82,-.84,;2.49,-.07,;2.49,1.47,;1.15,-.84,;.38,-2.17,;1.92,-2.17,;-.18,-.07,;-1.51,-.84,;-1.99,-2.3,;-3.53,-2.3,;-4,-.84,;-5.49,-.44,;-5.89,1.05,;-7.38,1.45,;-8.47,.36,;-8.07,-1.13,;-9.16,-2.22,;-10.64,-1.82,;-6.58,-1.53,;-2.76,.07,;-2.76,1.61,;-4.09,2.38,;-5.43,1.61,;-4.09,3.92,;-2.76,4.69,;-1.42,3.92,;-1.42,2.38,;-.09,1.61,;1.24,2.38,;5.16,-.07,;6.49,-.84,;7.82,-.07,;7.82,1.47,;9.16,2.24,;6.49,2.24,;5.16,1.47,)| Show InChI InChI=1S/C22H25N9O6S/c1-12-9-23-18(24-10-12)17(36-4)13(2)38(33,34)30-22-29-28-19(14-7-6-8-15(27-14)35-3)31(22)16-20(32)25-11-26-21(16)37-5/h6-11,13,17H,1-5H3,(H,29,30)(H,25,26,32)/t13-,17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 56 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM363743
(US9845310, Example 741.0)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1cccnc1OC)c1ncc(C)cn1 |wD:2.1,3.3,(6.47,.66,;6.47,-.88,;7.8,-1.65,;7.8,-3.19,;9.14,-3.96,;6.47,-3.96,;7.24,-5.3,;5.7,-2.63,;5.14,-4.73,;5.14,-6.27,;6.38,-7.18,;5.91,-8.64,;4.37,-8.64,;3.46,-9.89,;4.09,-11.3,;3.18,-12.54,;1.65,-12.38,;1.02,-10.98,;-.51,-10.81,;-1.41,-12.06,;1.93,-9.73,;3.89,-7.18,;2.42,-6.7,;1.28,-7.73,;-.18,-7.26,;-.5,-5.75,;.64,-4.72,;2.1,-5.2,;3.25,-4.17,;2.93,-2.66,;9.14,-.88,;9.14,.66,;10.47,1.43,;11.8,.66,;13.14,1.43,;11.8,-.88,;10.47,-1.65,)| Show InChI InChI=1S/C23H26N8O5S/c1-14-12-25-20(26-13-14)19(35-4)15(2)37(32,33)30-23-29-28-21(16-8-6-10-18(27-16)34-3)31(23)17-9-7-11-24-22(17)36-5/h6-13,15,19H,1-5H3,(H,29,30)/t15-,19-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360404
((1R,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)Show SMILES COc1cnc(cn1)[C@@H](OC(C)C)[C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC |r,wU:8.9,wD:13.14,(9.51,6.9,;8.18,7.67,;6.84,6.9,;6.84,5.36,;5.51,4.59,;4.18,5.36,;4.18,6.9,;5.51,7.67,;2.84,4.59,;2.84,3.05,;4.18,2.28,;4.18,.74,;5.51,3.05,;1.51,5.36,;1.51,6.9,;.17,4.59,;-1.16,3.82,;1.51,3.82,;-1.16,5.36,;-2.62,4.88,;-3.1,3.42,;-4.64,3.42,;-5.12,4.88,;-6.58,5.36,;-7.73,4.33,;-9.19,4.8,;-9.51,6.31,;-8.37,7.34,;-8.69,8.84,;-6.9,6.86,;-3.87,5.79,;-3.87,7.33,;-5.2,8.1,;-6.54,7.33,;-7.87,8.1,;-5.2,9.64,;-3.87,10.41,;-2.54,9.64,;-2.54,8.1,;-1.2,7.33,;.13,8.1,)| Show InChI InChI=1S/C27H33N7O6S/c1-16(2)40-25(20-14-30-23(39-7)15-29-20)18(4)41(35,36)33-27-32-31-26(19-11-17(3)12-28-13-19)34(27)24-21(37-5)9-8-10-22(24)38-6/h8-16,18,25H,1-7H3,(H,32,33)/t18-,25+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 35 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360404
((1R,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)Show SMILES COc1cnc(cn1)[C@@H](OC(C)C)[C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC |r,wU:8.9,wD:13.14,(9.51,6.9,;8.18,7.67,;6.84,6.9,;6.84,5.36,;5.51,4.59,;4.18,5.36,;4.18,6.9,;5.51,7.67,;2.84,4.59,;2.84,3.05,;4.18,2.28,;4.18,.74,;5.51,3.05,;1.51,5.36,;1.51,6.9,;.17,4.59,;-1.16,3.82,;1.51,3.82,;-1.16,5.36,;-2.62,4.88,;-3.1,3.42,;-4.64,3.42,;-5.12,4.88,;-6.58,5.36,;-7.73,4.33,;-9.19,4.8,;-9.51,6.31,;-8.37,7.34,;-8.69,8.84,;-6.9,6.86,;-3.87,5.79,;-3.87,7.33,;-5.2,8.1,;-6.54,7.33,;-7.87,8.1,;-5.2,9.64,;-3.87,10.41,;-2.54,9.64,;-2.54,8.1,;-1.2,7.33,;.13,8.1,)| Show InChI InChI=1S/C27H33N7O6S/c1-16(2)40-25(20-14-30-23(39-7)15-29-20)18(4)41(35,36)33-27-32-31-26(19-11-17(3)12-28-13-19)34(27)24-21(37-5)9-8-10-22(24)38-6/h8-16,18,25H,1-7H3,(H,32,33)/t18-,25+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270177
((1R,2R)-1-(5-chloro-2-pyridinyl)-N-(4-(2,6-dimetho...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](OC(C)C)c2ccc(Cl)cn2)nnc1-c1cncc(C)c1 |r,wU:18.19,wD:16.17,(1.24,2.38,;-.09,1.61,;-1.42,2.38,;-1.42,3.92,;-2.76,4.69,;-4.09,3.92,;-4.09,2.38,;-5.43,1.61,;-6.76,2.38,;-2.76,1.61,;-2.76,.07,;-1.51,-.84,;-.18,-.07,;1.15,-.84,;.38,-2.17,;1.92,-2.17,;2.49,-.07,;2.49,1.47,;3.82,-.84,;3.82,-2.38,;5.16,-3.15,;5.16,-4.69,;6.49,-2.38,;5.16,-.07,;5.16,1.47,;6.49,2.24,;7.82,1.47,;9.16,2.24,;7.82,-.07,;6.49,-.84,;-1.99,-2.3,;-3.53,-2.3,;-4,-.84,;-5.49,-.44,;-5.89,1.05,;-7.38,1.45,;-8.47,.36,;-8.07,-1.13,;-9.16,-2.22,;-6.58,-1.53,)| Show InChI InChI=1S/C27H31ClN6O5S/c1-16(2)39-25(21-11-10-20(28)15-30-21)18(4)40(35,36)33-27-32-31-26(19-12-17(3)13-29-14-19)34(27)24-22(37-5)8-7-9-23(24)38-6/h7-16,18,25H,1-6H3,(H,32,33)/t18-,25+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 26 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270177
((1R,2R)-1-(5-chloro-2-pyridinyl)-N-(4-(2,6-dimetho...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](OC(C)C)c2ccc(Cl)cn2)nnc1-c1cncc(C)c1 |r,wU:18.19,wD:16.17,(1.24,2.38,;-.09,1.61,;-1.42,2.38,;-1.42,3.92,;-2.76,4.69,;-4.09,3.92,;-4.09,2.38,;-5.43,1.61,;-6.76,2.38,;-2.76,1.61,;-2.76,.07,;-1.51,-.84,;-.18,-.07,;1.15,-.84,;.38,-2.17,;1.92,-2.17,;2.49,-.07,;2.49,1.47,;3.82,-.84,;3.82,-2.38,;5.16,-3.15,;5.16,-4.69,;6.49,-2.38,;5.16,-.07,;5.16,1.47,;6.49,2.24,;7.82,1.47,;9.16,2.24,;7.82,-.07,;6.49,-.84,;-1.99,-2.3,;-3.53,-2.3,;-4,-.84,;-5.49,-.44,;-5.89,1.05,;-7.38,1.45,;-8.47,.36,;-8.07,-1.13,;-9.16,-2.22,;-6.58,-1.53,)| Show InChI InChI=1S/C27H31ClN6O5S/c1-16(2)39-25(21-11-10-20(28)15-30-21)18(4)40(35,36)33-27-32-31-26(19-12-17(3)13-29-14-19)34(27)24-22(37-5)8-7-9-23(24)38-6/h7-16,18,25H,1-6H3,(H,32,33)/t18-,25+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270178
((1R,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](OC(C)C)c2cnc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:18.19,wD:16.17,(-7.1,2.38,;-5.77,1.61,;-4.44,2.38,;-4.44,3.92,;-3.1,4.69,;-1.77,3.92,;-1.77,2.38,;-.44,1.61,;.9,2.38,;-3.1,1.61,;-3.1,.07,;-1.86,-.84,;-.52,-.07,;.81,-.84,;1.58,-2.17,;.04,-2.17,;2.14,-.07,;2.14,1.47,;3.48,-.84,;3.48,-2.38,;4.81,-3.15,;6.14,-2.38,;4.81,-4.69,;4.81,-.07,;4.81,1.47,;6.14,2.24,;7.48,1.47,;8.81,2.24,;7.48,-.07,;6.14,-.84,;-2.33,-2.3,;-3.87,-2.3,;-4.35,-.84,;-5.84,-.44,;-6.93,-1.53,;-8.41,-1.13,;-8.81,.36,;-7.72,1.45,;-8.12,2.93,;-6.24,1.05,)| Show InChI InChI=1S/C27H33N7O5S/c1-16(2)39-25(21-15-29-18(4)13-30-21)19(5)40(35,36)33-27-32-31-26(20-11-17(3)12-28-14-20)34(27)24-22(37-6)9-8-10-23(24)38-7/h8-16,19,25H,1-7H3,(H,32,33)/t19-,25+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 80 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270178
((1R,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](OC(C)C)c2cnc(C)cn2)nnc1-c1cncc(C)c1 |r,wU:18.19,wD:16.17,(-7.1,2.38,;-5.77,1.61,;-4.44,2.38,;-4.44,3.92,;-3.1,4.69,;-1.77,3.92,;-1.77,2.38,;-.44,1.61,;.9,2.38,;-3.1,1.61,;-3.1,.07,;-1.86,-.84,;-.52,-.07,;.81,-.84,;1.58,-2.17,;.04,-2.17,;2.14,-.07,;2.14,1.47,;3.48,-.84,;3.48,-2.38,;4.81,-3.15,;6.14,-2.38,;4.81,-4.69,;4.81,-.07,;4.81,1.47,;6.14,2.24,;7.48,1.47,;8.81,2.24,;7.48,-.07,;6.14,-.84,;-2.33,-2.3,;-3.87,-2.3,;-4.35,-.84,;-5.84,-.44,;-6.93,-1.53,;-8.41,-1.13,;-8.81,.36,;-7.72,1.45,;-8.12,2.93,;-6.24,1.05,)| Show InChI InChI=1S/C27H33N7O5S/c1-16(2)39-25(21-15-29-18(4)13-30-21)19(5)40(35,36)33-27-32-31-26(20-11-17(3)12-28-14-20)34(27)24-22(37-6)9-8-10-23(24)38-7/h8-16,19,25H,1-7H3,(H,32,33)/t19-,25+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 7.60 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360410
((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)Show SMILES COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)[C@H](C)[C@H](O)c2ncc(C)cn2)cc1 |r| Show InChI InChI=1S/C24H29N3O5S/c1-17-13-25-24(26-14-17)23(28)18(2)33(29,30)27(15-19-5-9-21(31-3)10-6-19)16-20-7-11-22(32-4)12-8-20/h5-14,18,23,28H,15-16H2,1-4H3/t18-,23+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270181
((1R,2S)-1-(5-(3,6-dihydro-2H-pyran-4-yl)pyrimidin-...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(cn1)C1=CCOCC1 |r,wU:2.1,3.3,t:41,(3.42,-3.85,;2.08,-3.08,;2.08,-1.54,;.75,-.77,;.75,.77,;-.58,-1.54,;-1.35,-2.87,;.19,-2.87,;-1.92,-.77,;-3.25,-1.54,;-3.25,-3.08,;-4.72,-3.56,;-5.62,-2.31,;-7.11,-1.91,;-8.2,-3,;-9.69,-2.6,;-10.08,-1.11,;-9,-.03,;-9.39,1.46,;-7.51,-.42,;-4.72,-1.06,;-5.12,.42,;-4.03,1.51,;-2.54,1.11,;-1.45,2.2,;-4.43,3,;-5.91,3.4,;-7,2.31,;-6.6,.82,;-8.09,.42,;-8.49,1.91,;3.42,-.77,;4.75,-1.54,;6.08,-.77,;6.08,.77,;4.75,1.54,;3.42,.77,;7.42,1.54,;7.42,3.08,;8.75,3.85,;10.08,3.08,;10.08,1.54,;8.75,.77,)| Show InChI InChI=1S/C29H33N7O6S/c1-18-13-21(15-30-14-18)28-33-34-29(36(28)25-23(39-3)7-6-8-24(25)40-4)35-43(37,38)19(2)26(41-5)27-31-16-22(17-32-27)20-9-11-42-12-10-20/h6-9,13-17,19,26H,10-12H2,1-5H3,(H,34,35)/t19-,26-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 15 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360421
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)Show SMILES COC1CN(C1)[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:6.6,7.8,(2.97,2.93,;4.3,3.7,;4.3,5.24,;3.21,6.33,;4.3,7.42,;5.39,6.33,;4.3,8.96,;2.97,9.73,;2.97,11.27,;1.63,8.96,;.86,7.62,;2.4,7.62,;.3,9.73,;-1.04,8.96,;-1.2,7.43,;-2.7,7.1,;-3.47,8.44,;-5.01,8.44,;-5.78,9.77,;-7.32,9.77,;-8.09,8.44,;-7.32,7.1,;-8.09,5.77,;-9.63,5.77,;-5.78,7.1,;-2.44,9.58,;-2.76,11.09,;-1.62,12.12,;-.15,11.64,;1.33,12.04,;-1.94,13.63,;-3.4,14.1,;-4.55,13.07,;-4.23,11.57,;-5.72,11.17,;-6.49,12.5,;5.63,9.73,;6.97,8.96,;8.3,9.73,;8.3,11.27,;9.63,12.04,;6.97,12.04,;5.63,11.27,)| Show InChI InChI=1S/C28H34N8O6S/c1-17-13-29-26(30-14-17)24(35-15-19(16-35)39-3)18(2)43(37,38)34-28-33-32-27(20-9-7-12-23(31-20)42-6)36(28)25-21(40-4)10-8-11-22(25)41-5/h7-14,18-19,24H,15-16H2,1-6H3,(H,33,34)/t18-,24-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.360 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM363593
((1R,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxypyr...)Show SMILES COC1CN(C1)[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:7.8,wD:6.6,(4.94,1.77,;3.6,2.54,;3.6,4.08,;2.51,5.17,;3.6,6.26,;4.69,5.17,;3.6,7.8,;2.27,8.57,;2.27,10.11,;.93,7.8,;1.7,6.46,;.16,6.46,;-.4,8.57,;-1.73,7.8,;-1.73,6.26,;-3.2,5.78,;-4.1,7.03,;-5.64,7.03,;-6.41,8.36,;-7.95,8.36,;-8.72,7.03,;-7.95,5.69,;-8.72,4.36,;-10.26,4.36,;-6.41,5.69,;-3.2,8.27,;-3.6,9.76,;-2.51,10.85,;-1.02,10.45,;.07,11.54,;-2.91,12.34,;-4.39,12.74,;-5.48,11.65,;-5.08,10.16,;-6.57,9.76,;-7.34,11.09,;4.94,8.57,;6.27,7.8,;7.6,8.57,;7.6,10.11,;8.94,10.88,;6.27,10.88,;4.94,10.11,)| Show InChI InChI=1S/C28H34N8O6S/c1-17-13-29-26(30-14-17)24(35-15-19(16-35)39-3)18(2)43(37,38)34-28-33-32-27(20-9-7-12-23(31-20)42-6)36(28)25-21(40-4)10-8-11-22(25)41-5/h7-14,18-19,24H,15-16H2,1-6H3,(H,33,34)/t18-,24+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270184
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(cn1)-c1cccnc1 |r,wU:2.1,3.3,(3.43,-3.85,;2.08,-3.08,;2.08,-1.54,;.75,-.77,;.75,.77,;-.58,-1.54,;-1.35,-2.87,;.19,-2.87,;-1.92,-.77,;-3.25,-1.54,;-3.25,-3.08,;-4.72,-3.56,;-5.62,-2.31,;-7.11,-1.91,;-8.2,-3,;-9.69,-2.6,;-10.08,-1.11,;-9,-.03,;-9.39,1.46,;-7.51,-.42,;-4.72,-1.06,;-5.12,.42,;-4.03,1.51,;-2.54,1.11,;-1.45,2.2,;-4.43,3,;-5.91,3.4,;-7,2.31,;-6.6,.82,;-8.09,.42,;-8.49,1.91,;3.42,-.77,;4.75,-1.54,;6.08,-.77,;6.08,.77,;4.75,1.54,;3.42,.77,;7.42,1.54,;7.42,3.08,;8.75,3.85,;10.08,3.08,;10.08,1.54,;8.75,.77,)| Show InChI InChI=1S/C29H30N8O5S/c1-18-12-21(15-31-13-18)28-34-35-29(37(28)25-23(40-3)9-6-10-24(25)41-4)36-43(38,39)19(2)26(42-5)27-32-16-22(17-33-27)20-8-7-11-30-14-20/h6-17,19,26H,1-5H3,(H,35,36)/t19-,26-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270187
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES CN[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wD:2.1,3.3,(4.79,-8.7,;3.46,-7.93,;3.46,-6.39,;2.12,-5.62,;2.12,-4.08,;.79,-6.39,;.02,-7.72,;1.56,-7.72,;-.54,-5.62,;-1.88,-6.39,;-1.88,-7.93,;-3.34,-8.4,;-4.25,-7.16,;-5.79,-7.16,;-6.56,-8.49,;-8.1,-8.49,;-8.87,-7.16,;-8.1,-5.82,;-8.87,-4.49,;-6.56,-5.82,;-3.34,-5.91,;-3.74,-4.42,;-2.65,-3.33,;-1.16,-3.73,;-.08,-2.64,;-3.05,-1.85,;-4.54,-1.45,;-5.63,-2.54,;-5.23,-4.02,;-6.72,-4.42,;-7.11,-2.94,;4.79,-5.62,;6.12,-6.39,;7.46,-5.62,;7.46,-4.08,;8.79,-3.31,;6.12,-3.31,;4.79,-4.08,)| Show InChI InChI=1S/C25H30N8O4S/c1-15-10-18(14-27-11-15)24-30-31-25(33(24)22-19(36-5)8-7-9-20(22)37-6)32-38(34,35)17(3)21(26-4)23-28-12-16(2)13-29-23/h7-14,17,21,26H,1-6H3,(H,31,32)/t17-,21-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 5.90 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360416
((1R,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-p...)Show SMILES CN[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:2.1,wD:3.3,(5.35,-8.25,;4.01,-7.48,;4.01,-5.94,;2.68,-5.17,;2.68,-3.63,;1.35,-5.94,;.58,-7.28,;2.12,-7.28,;.01,-5.17,;-1.32,-5.94,;-1.48,-7.47,;-2.99,-7.79,;-3.76,-6.46,;-5.3,-6.46,;-6.07,-7.79,;-7.61,-7.79,;-8.38,-6.46,;-7.61,-5.13,;-8.38,-3.79,;-6.07,-5.13,;-2.73,-5.32,;-3.05,-3.81,;-1.9,-2.78,;-.44,-3.25,;1.05,-2.86,;-2.22,-1.27,;-3.69,-.8,;-4.83,-1.83,;-4.51,-3.33,;-6,-3.73,;-6.77,-2.4,;5.35,-5.17,;6.68,-5.94,;8.01,-5.17,;8.01,-3.63,;9.35,-2.86,;6.68,-2.86,;5.35,-3.63,)| Show InChI InChI=1S/C25H30N8O4S/c1-15-10-18(14-27-11-15)24-30-31-25(33(24)22-19(36-5)8-7-9-20(22)37-6)32-38(34,35)17(3)21(26-4)23-28-12-16(2)13-29-23/h7-14,17,21,26H,1-6H3,(H,31,32)/t17-,21+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 9.60 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270187
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES CN[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wD:2.1,3.3,(4.79,-8.7,;3.46,-7.93,;3.46,-6.39,;2.12,-5.62,;2.12,-4.08,;.79,-6.39,;.02,-7.72,;1.56,-7.72,;-.54,-5.62,;-1.88,-6.39,;-1.88,-7.93,;-3.34,-8.4,;-4.25,-7.16,;-5.79,-7.16,;-6.56,-8.49,;-8.1,-8.49,;-8.87,-7.16,;-8.1,-5.82,;-8.87,-4.49,;-6.56,-5.82,;-3.34,-5.91,;-3.74,-4.42,;-2.65,-3.33,;-1.16,-3.73,;-.08,-2.64,;-3.05,-1.85,;-4.54,-1.45,;-5.63,-2.54,;-5.23,-4.02,;-6.72,-4.42,;-7.11,-2.94,;4.79,-5.62,;6.12,-6.39,;7.46,-5.62,;7.46,-4.08,;8.79,-3.31,;6.12,-3.31,;4.79,-4.08,)| Show InChI InChI=1S/C25H30N8O4S/c1-15-10-18(14-27-11-15)24-30-31-25(33(24)22-19(36-5)8-7-9-20(22)37-6)32-38(34,35)17(3)21(26-4)23-28-12-16(2)13-29-23/h7-14,17,21,26H,1-6H3,(H,31,32)/t17-,21-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270187
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES CN[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wD:2.1,3.3,(4.79,-8.7,;3.46,-7.93,;3.46,-6.39,;2.12,-5.62,;2.12,-4.08,;.79,-6.39,;.02,-7.72,;1.56,-7.72,;-.54,-5.62,;-1.88,-6.39,;-1.88,-7.93,;-3.34,-8.4,;-4.25,-7.16,;-5.79,-7.16,;-6.56,-8.49,;-8.1,-8.49,;-8.87,-7.16,;-8.1,-5.82,;-8.87,-4.49,;-6.56,-5.82,;-3.34,-5.91,;-3.74,-4.42,;-2.65,-3.33,;-1.16,-3.73,;-.08,-2.64,;-3.05,-1.85,;-4.54,-1.45,;-5.63,-2.54,;-5.23,-4.02,;-6.72,-4.42,;-7.11,-2.94,;4.79,-5.62,;6.12,-6.39,;7.46,-5.62,;7.46,-4.08,;8.79,-3.31,;6.12,-3.31,;4.79,-4.08,)| Show InChI InChI=1S/C25H30N8O4S/c1-15-10-18(14-27-11-15)24-30-31-25(33(24)22-19(36-5)8-7-9-20(22)37-6)32-38(34,35)17(3)21(26-4)23-28-12-16(2)13-29-23/h7-14,17,21,26H,1-6H3,(H,31,32)/t17-,21-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270186
((1R,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES CN[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:3.3,wD:2.1,(4.34,4.79,;3,5.56,;3,7.1,;1.67,7.87,;1.67,9.41,;.33,7.1,;-.44,5.76,;1.1,5.76,;-1,7.87,;-2.33,7.1,;-2.81,5.63,;-4.35,5.63,;-4.82,7.1,;-6.36,7.1,;-7.13,5.76,;-8.67,5.76,;-9.44,7.1,;-8.67,8.43,;-9.44,9.76,;-7.13,8.43,;-3.58,8,;-3.98,9.49,;-5.47,9.89,;-6.95,9.49,;-7.72,10.82,;-5.86,11.38,;-4.77,12.47,;-3.29,12.07,;-2.89,10.58,;-1.4,10.18,;-.07,10.95,;4.34,7.87,;5.67,7.1,;7,7.87,;7,9.41,;8.34,10.18,;5.67,10.18,;4.34,9.41,)| Show InChI InChI=1S/C25H30N8O4S/c1-15-10-18(14-27-11-15)24-30-31-25(33(24)22-19(36-5)8-7-9-20(22)37-6)32-38(34,35)17(3)21(26-4)23-28-12-16(2)13-29-23/h7-14,17,21,26H,1-6H3,(H,31,32)/t17-,21+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 61 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270186
((1R,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)Show SMILES CN[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:3.3,wD:2.1,(4.34,4.79,;3,5.56,;3,7.1,;1.67,7.87,;1.67,9.41,;.33,7.1,;-.44,5.76,;1.1,5.76,;-1,7.87,;-2.33,7.1,;-2.81,5.63,;-4.35,5.63,;-4.82,7.1,;-6.36,7.1,;-7.13,5.76,;-8.67,5.76,;-9.44,7.1,;-8.67,8.43,;-9.44,9.76,;-7.13,8.43,;-3.58,8,;-3.98,9.49,;-5.47,9.89,;-6.95,9.49,;-7.72,10.82,;-5.86,11.38,;-4.77,12.47,;-3.29,12.07,;-2.89,10.58,;-1.4,10.18,;-.07,10.95,;4.34,7.87,;5.67,7.1,;7,7.87,;7,9.41,;8.34,10.18,;5.67,10.18,;4.34,9.41,)| Show InChI InChI=1S/C25H30N8O4S/c1-15-10-18(14-27-11-15)24-30-31-25(33(24)22-19(36-5)8-7-9-20(22)37-6)32-38(34,35)17(3)21(26-4)23-28-12-16(2)13-29-23/h7-14,17,21,26H,1-6H3,(H,31,32)/t17-,21+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360421
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)Show SMILES COC1CN(C1)[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:6.6,7.8,(2.97,2.93,;4.3,3.7,;4.3,5.24,;3.21,6.33,;4.3,7.42,;5.39,6.33,;4.3,8.96,;2.97,9.73,;2.97,11.27,;1.63,8.96,;.86,7.62,;2.4,7.62,;.3,9.73,;-1.04,8.96,;-1.2,7.43,;-2.7,7.1,;-3.47,8.44,;-5.01,8.44,;-5.78,9.77,;-7.32,9.77,;-8.09,8.44,;-7.32,7.1,;-8.09,5.77,;-9.63,5.77,;-5.78,7.1,;-2.44,9.58,;-2.76,11.09,;-1.62,12.12,;-.15,11.64,;1.33,12.04,;-1.94,13.63,;-3.4,14.1,;-4.55,13.07,;-4.23,11.57,;-5.72,11.17,;-6.49,12.5,;5.63,9.73,;6.97,8.96,;8.3,9.73,;8.3,11.27,;9.63,12.04,;6.97,12.04,;5.63,11.27,)| Show InChI InChI=1S/C28H34N8O6S/c1-17-13-29-26(30-14-17)24(35-15-19(16-35)39-3)18(2)43(37,38)34-28-33-32-27(20-9-7-12-23(31-20)42-6)36(28)25-21(40-4)10-8-11-22(25)41-5/h7-14,18-19,24H,15-16H2,1-6H3,(H,33,34)/t18-,24-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 6.80 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM360421
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)Show SMILES COC1CN(C1)[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:6.6,7.8,(2.97,2.93,;4.3,3.7,;4.3,5.24,;3.21,6.33,;4.3,7.42,;5.39,6.33,;4.3,8.96,;2.97,9.73,;2.97,11.27,;1.63,8.96,;.86,7.62,;2.4,7.62,;.3,9.73,;-1.04,8.96,;-1.2,7.43,;-2.7,7.1,;-3.47,8.44,;-5.01,8.44,;-5.78,9.77,;-7.32,9.77,;-8.09,8.44,;-7.32,7.1,;-8.09,5.77,;-9.63,5.77,;-5.78,7.1,;-2.44,9.58,;-2.76,11.09,;-1.62,12.12,;-.15,11.64,;1.33,12.04,;-1.94,13.63,;-3.4,14.1,;-4.55,13.07,;-4.23,11.57,;-5.72,11.17,;-6.49,12.5,;5.63,9.73,;6.97,8.96,;8.3,9.73,;8.3,11.27,;9.63,12.04,;6.97,12.04,;5.63,11.27,)| Show InChI InChI=1S/C28H34N8O6S/c1-17-13-29-26(30-14-17)24(35-15-19(16-35)39-3)18(2)43(37,38)34-28-33-32-27(20-9-7-12-23(31-20)42-6)36(28)25-21(40-4)10-8-11-22(25)41-5/h7-14,18-19,24H,15-16H2,1-6H3,(H,33,34)/t18-,24-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.0950 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM363603
((1R,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxypyr...)Show SMILES COC1CN(C1)[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:7.8,wD:6.6,(2.19,1.01,;3.52,1.78,;3.52,3.32,;2.43,4.41,;3.5,5.5,;4.61,4.41,;3.5,7.04,;2.17,7.81,;2.17,9.35,;.84,7.04,;1.61,5.71,;.07,5.71,;-.5,7.81,;-1.83,7.04,;-2.31,5.58,;-3.85,5.58,;-4.32,7.04,;-5.86,7.04,;-6.63,8.37,;-8.17,8.37,;-8.94,7.04,;-8.17,5.71,;-8.94,4.37,;-10.48,4.37,;-6.63,5.71,;-3.08,7.95,;-3.08,9.49,;-4.41,10.26,;-5.75,9.49,;-7.08,10.26,;-4.41,11.8,;-3.08,12.57,;-1.74,11.8,;-1.74,10.26,;-.41,9.49,;.92,10.26,;4.84,7.81,;6.17,7.04,;7.5,7.81,;7.5,9.35,;8.84,10.12,;6.17,10.12,;4.84,9.35,)| Show InChI InChI=1S/C28H34N8O6S/c1-17-13-29-26(30-14-17)24(35-15-19(16-35)39-3)18(2)43(37,38)34-28-33-32-27(20-9-7-12-23(31-20)42-6)36(28)25-21(40-4)10-8-11-22(25)41-5/h7-14,18-19,24H,15-16H2,1-6H3,(H,33,34)/t18-,24+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 15 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM363603
((1R,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxypyr...)Show SMILES COC1CN(C1)[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:7.8,wD:6.6,(2.19,1.01,;3.52,1.78,;3.52,3.32,;2.43,4.41,;3.5,5.5,;4.61,4.41,;3.5,7.04,;2.17,7.81,;2.17,9.35,;.84,7.04,;1.61,5.71,;.07,5.71,;-.5,7.81,;-1.83,7.04,;-2.31,5.58,;-3.85,5.58,;-4.32,7.04,;-5.86,7.04,;-6.63,8.37,;-8.17,8.37,;-8.94,7.04,;-8.17,5.71,;-8.94,4.37,;-10.48,4.37,;-6.63,5.71,;-3.08,7.95,;-3.08,9.49,;-4.41,10.26,;-5.75,9.49,;-7.08,10.26,;-4.41,11.8,;-3.08,12.57,;-1.74,11.8,;-1.74,10.26,;-.41,9.49,;.92,10.26,;4.84,7.81,;6.17,7.04,;7.5,7.81,;7.5,9.35,;8.84,10.12,;6.17,10.12,;4.84,9.35,)| Show InChI InChI=1S/C28H34N8O6S/c1-17-13-29-26(30-14-17)24(35-15-19(16-35)39-3)18(2)43(37,38)34-28-33-32-27(20-9-7-12-23(31-20)42-6)36(28)25-21(40-4)10-8-11-22(25)41-5/h7-14,18-19,24H,15-16H2,1-6H3,(H,33,34)/t18-,24+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.160 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270195
((2S,3R)—N-(4-(2,6-bis(difluoromethoxy)phenyl)...)Show SMILES C[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC(F)F)cccc1OC(F)F)c1ncc(C)cn1 |r,wU:1.0,2.2,(3.56,-3.34,;3.56,-1.8,;2.22,-1.03,;2.22,.51,;.89,-1.8,;.12,-3.14,;1.66,-3.14,;-.45,-1.03,;-1.78,-1.8,;-2.25,-3.27,;-3.79,-3.27,;-4.27,-1.8,;-5.81,-1.8,;-6.58,-.47,;-8.12,-.47,;-8.89,-1.8,;-8.12,-3.14,;-8.89,-4.47,;-6.58,-3.14,;-3.02,-.9,;-3.02,1.39,;-1.69,2.16,;-.36,1.39,;.98,2.16,;2.31,1.39,;.98,3.7,;-1.69,3.7,;-3.02,4.47,;-4.36,3.7,;-4.36,2.16,;-5.69,1.39,;-7.03,2.16,;-8.36,1.39,;-7.03,3.7,;4.89,-1.03,;6.22,-1.8,;7.56,-1.03,;7.56,.51,;8.89,1.28,;6.22,1.28,;4.89,.51,)| Show InChI InChI=1S/C25H25F4N7O4S/c1-13-8-17(12-30-9-13)22-33-34-25(35-41(37,38)16(4)15(3)21-31-10-14(2)11-32-21)36(22)20-18(39-23(26)27)6-5-7-19(20)40-24(28)29/h5-12,15-16,23-24H,1-4H3,(H,34,35)/t15-,16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 0.710 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM363744
(US9845310, Example 764.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@@H](O)C#CC)nnc1-c1cncc(C)c1 |wU:16.17,18.19,(5.33,,;4,-.77,;2.67,,;2.67,1.54,;1.33,2.31,;,1.54,;;-1.33,-.77,;-2.67,,;1.33,-.77,;1.33,-2.31,;.09,-3.22,;-1.38,-2.74,;-2.52,-3.77,;-1.49,-4.91,;-3.55,-2.63,;-3.67,-4.8,;-5.13,-4.32,;-3.35,-6.31,;-1.88,-6.78,;-4.49,-7.34,;-5.63,-8.37,;-6.78,-9.4,;.56,-4.68,;2.1,-4.68,;2.58,-3.22,;4.04,-2.74,;4.36,-1.23,;5.83,-.76,;6.97,-1.79,;6.65,-3.29,;7.8,-4.32,;5.19,-3.77,)| Show InChI InChI=1S/C22H25N5O5S/c1-6-8-17(28)15(3)33(29,30)26-22-25-24-21(16-11-14(2)12-23-13-16)27(22)20-18(31-4)9-7-10-19(20)32-5/h7,9-13,15,17,28H,1-5H3,(H,25,26)/t15-,17+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 27 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM363745
(US9845310, Example 765.0)Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](O)c2ccc(C)nn2)nnc1-c1cncc(C)c1 |wU:18.19,16.17,(1.53,-3.96,;.2,-4.73,;-1.13,-3.96,;-1.13,-2.42,;-2.47,-1.65,;-3.8,-2.42,;-3.8,-3.96,;-5.14,-4.73,;-6.47,-3.96,;-2.47,-4.73,;-2.47,-6.27,;-3.71,-7.18,;-5.18,-6.7,;-6.32,-7.73,;-7.35,-6.59,;-5.29,-8.88,;-7.47,-8.77,;-7.15,-10.27,;-8.93,-8.29,;-9.25,-6.78,;-10.08,-9.32,;-11.54,-8.84,;-12.69,-9.87,;-12.37,-11.38,;-13.51,-12.41,;-10.9,-11.86,;-9.76,-10.83,;-3.24,-8.64,;-1.7,-8.64,;-1.22,-7.18,;.24,-6.7,;.56,-5.2,;2.03,-4.72,;3.17,-5.75,;2.85,-7.26,;4,-8.29,;1.39,-7.73,)| Show InChI InChI=1S/C24H27N7O5S/c1-14-11-17(13-25-12-14)23-28-29-24(31(23)21-19(35-4)7-6-8-20(21)36-5)30-37(33,34)16(3)22(32)18-10-9-15(2)26-27-18/h6-13,16,22,32H,1-5H3,(H,29,30)/t16-,22-/m0/s1 | PDB
Reactome pathway
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UniProtKB/SwissProt
B.MOAD
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AffyNet
| PC cid
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UniChem
| US Patent
| n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
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Ligand-Target Pair | |
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