Compile Data Set for Download or QSAR

Found 271 hits Enz. Inhib. hit(s) with all data for entry = 3012   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388347 (US10294246, Compound No. 44) Show SMILES CN(C)c1ccc(CC(=O)N[C@@H](Cc2ccc(C)cc2C)B(O)O)cc1 |r| Show InChI InChI=1S/C20H27BN2O3/c1-14-5-8-17(15(2)11-14)13-19(21(25)26)22-20(24)12-16-6-9-18(10-7-16)23(3)4/h5-11,19,25-26H,12-13H2,1-4H3,(H,22,24)/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388348 (US10294246, Compound No. 45) Show SMILES C[C@@H](C(=O)N[C@@H](Cc1coc2ccccc12)B(O)O)c1ccccc1 |r| Show InChI InChI=1S/C19H20BNO4/c1-13(14-7-3-2-4-8-14)19(22)21-18(20(23)24)11-15-12-25-17-10-6-5-9-16(15)17/h2-10,12-13,18,23-24H,11H2,1H3,(H,21,22)/t13-,18+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388351 (US10294246, Compound No. 48) Show SMILES COCc1ccccc1CC(=O)N[C@@H](Cc1coc2ccccc12)B(O)O |r| Show InChI InChI=1S/C20H22BNO5/c1-26-12-15-7-3-2-6-14(15)11-20(23)22-19(21(24)25)10-16-13-27-18-9-5-4-8-17(16)18/h2-9,13,19,24-25H,10-12H2,1H3,(H,22,23)/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388352 (US10294246, Compound No. 49) Show SMILES COCc1cccc(CC(=O)N[C@@H](Cc2coc3ccccc23)B(O)O)c1 |r| Show InChI InChI=1S/C20H22BNO5/c1-26-12-15-6-4-5-14(9-15)10-20(23)22-19(21(24)25)11-16-13-27-18-8-3-2-7-17(16)18/h2-9,13,19,24-25H,10-12H2,1H3,(H,22,23)/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388353 (US10294246, Compound No. 50) Show SMILES OCCOc1ccccc1CC(=O)N[C@@H](Cc1coc2ccccc12)B(O)O |r| Show InChI InChI=1S/C20H22BNO6/c23-9-10-27-17-7-3-1-5-14(17)12-20(24)22-19(21(25)26)11-15-13-28-18-8-4-2-6-16(15)18/h1-8,13,19,23,25-26H,9-12H2,(H,22,24)/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388354 (US10294246, Compound No. 51 | [(1R)-2-(benzofuran-...) Show SMILES COc1ccc(cc1)C(F)(F)C(=O)N[C@@H](Cc1coc2ccccc12)B(O)O Show InChI InChI=1S/C19H18BF2NO5/c1-27-14-8-6-13(7-9-14)19(21,22)18(24)23-17(20(25)26)10-12-11-28-16-5-3-2-4-15(12)16/h2-9,11,17,25-26H,10H2,1H3,(H,23,24)/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388355 (US10294246, Compound No. 52) Show SMILES COc1cc(CC(=O)N[C@@H](Cc2coc3ccccc23)B(O)O)cc(OC)c1OC |r| Show InChI InChI=1S/C21H24BNO7/c1-27-17-8-13(9-18(28-2)21(17)29-3)10-20(24)23-19(22(25)26)11-14-12-30-16-7-5-4-6-15(14)16/h4-9,12,19,25-26H,10-11H2,1-3H3,(H,23,24)/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388356 (US10294246, Compound No. 53) Show SMILES Cc1ccc(C[C@H](NC(=O)Cc2ccc(NC(=O)C(F)(F)F)cc2)B(O)O)c(C)c1 |r| Show InChI InChI=1S/C20H22BF3N2O4/c1-12-3-6-15(13(2)9-12)11-17(21(29)30)26-18(27)10-14-4-7-16(8-5-14)25-19(28)20(22,23)24/h3-9,17,29-30H,10-11H2,1-2H3,(H,25,28)(H,26,27)/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388357 (US10294246, Compound No. 54) Show SMILES OB(O)[C@H](Cc1coc2ccccc12)NC(=O)Cc1ccccc1OC1CCOCC1 |r| Show InChI InChI=1S/C23H26BNO6/c26-23(14-16-5-1-3-7-20(16)31-18-9-11-29-12-10-18)25-22(24(27)28)13-17-15-30-21-8-4-2-6-19(17)21/h1-8,15,18,22,27-28H,9-14H2,(H,25,26)/t22-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388358 (US10294246, Compound No. 55) Show SMILES OCCCOc1ccccc1CC(=O)N[C@@H](Cc1coc2ccccc12)B(O)O |r| Show InChI InChI=1S/C21H24BNO6/c24-10-5-11-28-18-8-3-1-6-15(18)13-21(25)23-20(22(26)27)12-16-14-29-19-9-4-2-7-17(16)19/h1-4,6-9,14,20,24,26-27H,5,10-13H2,(H,23,25)/t20-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388360 (US10294246, Compound No. 57) Show SMILES OC[C@@H](C(=O)N[C@@H](Cc1coc2ccccc12)B(O)O)c1ccccc1 |r| Show InChI InChI=1S/C19H20BNO5/c22-11-16(13-6-2-1-3-7-13)19(23)21-18(20(24)25)10-14-12-26-17-9-5-4-8-15(14)17/h1-9,12,16,18,22,24-25H,10-11H2,(H,21,23)/t16-,18+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388361 (US10294246, Compound No. 58) Show SMILES COc1ccc(OC)c(CC(=O)N[C@@H](Cc2coc3ccccc23)B(O)O)c1 |r| Show InChI InChI=1S/C20H22BNO6/c1-26-15-7-8-17(27-2)13(9-15)11-20(23)22-19(21(24)25)10-14-12-28-18-6-4-3-5-16(14)18/h3-9,12,19,24-25H,10-11H2,1-2H3,(H,22,23)/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388362 (US10294246, Compound No. 59) Show SMILES OC[C@H](C(=O)N[C@@H](Cc1coc2ccccc12)B(O)O)c1ccccc1 |r| Show InChI InChI=1S/C19H20BNO5/c22-11-16(13-6-2-1-3-7-13)19(23)21-18(20(24)25)10-14-12-26-17-9-5-4-8-15(14)17/h1-9,12,16,18,22,24-25H,10-11H2,(H,21,23)/t16-,18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388363 (US10294246, Compound No. 60) Show SMILES COc1ccc(CC(=O)N[C@@H](Cc2coc3ccccc23)B(O)O)c(OC)c1OC |r| Show InChI InChI=1S/C21H24BNO7/c1-27-17-9-8-13(20(28-2)21(17)29-3)11-19(24)23-18(22(25)26)10-14-12-30-16-7-5-4-6-15(14)16/h4-9,12,18,25-26H,10-11H2,1-3H3,(H,23,24)/t18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388365 (US10294246, Compound No. 62) Show SMILES OC[C@H](C(=O)N[C@H](Cc1coc2ccccc12)B(O)O)c1ccccc1 |r| Show InChI InChI=1S/C19H20BNO5/c22-11-16(13-6-2-1-3-7-13)19(23)21-18(20(24)25)10-14-12-26-17-9-5-4-8-15(14)17/h1-9,12,16,18,22,24-25H,10-11H2,(H,21,23)/t16-,18+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388366 (US10294246, Compound No. 63) Show SMILES OB(O)[C@H](Cc1coc2ccccc12)NC(=O)Cc1ccccc1C(=O)N1CCOCC1 |r| Show InChI InChI=1S/C23H25BN2O6/c27-22(14-16-5-1-2-7-19(16)23(28)26-9-11-31-12-10-26)25-21(24(29)30)13-17-15-32-20-8-4-3-6-18(17)20/h1-8,15,21,29-30H,9-14H2,(H,25,27)/t21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388367 (US10294246, Compound No. 64) Show SMILES OB(O)[C@H](Cc1coc2ccccc12)NC(=O)Cc1ccc(cc1)N1CCCC1=O |r| Show InChI InChI=1S/C22H23BN2O5/c26-21(12-15-7-9-17(10-8-15)25-11-3-6-22(25)27)24-20(23(28)29)13-16-14-30-19-5-2-1-4-18(16)19/h1-2,4-5,7-10,14,20,28-29H,3,6,11-13H2,(H,24,26)/t20-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388368 (US10294246, Compound No. 65) Show SMILES CCNC(=O)c1ccccc1CC(=O)N[C@@H](Cc1coc2ccccc12)B(O)O |r| Show InChI InChI=1S/C21H23BN2O5/c1-2-23-21(26)17-9-4-3-7-14(17)12-20(25)24-19(22(27)28)11-15-13-29-18-10-6-5-8-16(15)18/h3-10,13,19,27-28H,2,11-12H2,1H3,(H,23,26)(H,24,25)/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388369 (US10294246, Compound No. 66) Show SMILES CN(C)C(=O)c1ccccc1CC(=O)N[C@@H](Cc1coc2ccccc12)B(O)O |r| Show InChI InChI=1S/C21H23BN2O5/c1-24(2)21(26)17-9-4-3-7-14(17)12-20(25)23-19(22(27)28)11-15-13-29-18-10-6-5-8-16(15)18/h3-10,13,19,27-28H,11-12H2,1-2H3,(H,23,25)/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388370 (US10294246, Compound No. 67) Show SMILES OB(O)[C@H](Cc1coc2ccccc12)NC(=O)Cc1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C24H22BNO4/c27-24(14-17-10-12-19(13-11-17)18-6-2-1-3-7-18)26-23(25(28)29)15-20-16-30-22-9-5-4-8-21(20)22/h1-13,16,23,28-29H,14-15H2,(H,26,27)/t23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388371 (US10294246, Compound No. 68) Show SMILES OB(O)[C@H](Cc1coc2ccccc12)NC(=O)C(c1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C24H22BNO4/c27-24(23(17-9-3-1-4-10-17)18-11-5-2-6-12-18)26-22(25(28)29)15-19-16-30-21-14-8-7-13-20(19)21/h1-14,16,22-23,28-29H,15H2,(H,26,27)/t22-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388373 (US10294246, Compound No. 70 | [(1R)-2-(benzofuran-...) Show SMILES CCO[C@@H](C(=O)N[C@@H](Cc1coc2ccccc12)B(O)O)c1ccccc1 Show InChI InChI=1S/C20H22BNO5/c1-2-26-19(14-8-4-3-5-9-14)20(23)22-18(21(24)25)12-15-13-27-17-11-7-6-10-16(15)17/h3-11,13,18-19,24-25H,2,12H2,1H3,(H,22,23)/t18-,19+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388374 (US10294246, Compound No. 71) Show SMILES COc1ccc(CC(C(=O)N[C@@H](Cc2coc3ccccc23)B(O)O)c2ccccc2)cc1 |r| Show InChI InChI=1S/C26H26BNO5/c1-32-21-13-11-18(12-14-21)15-23(19-7-3-2-4-8-19)26(29)28-25(27(30)31)16-20-17-33-24-10-6-5-9-22(20)24/h2-14,17,23,25,30-31H,15-16H2,1H3,(H,28,29)/t23?,25-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388375 (US10294246, Compound No. 72) Show SMILES CCOC(=O)Nc1cccc(CC(=O)N[C@@H](Cc2coc3ccccc23)B(O)O)c1 |r| Show InChI InChI=1S/C21H23BN2O6/c1-2-29-21(26)23-16-7-5-6-14(10-16)11-20(25)24-19(22(27)28)12-15-13-30-18-9-4-3-8-17(15)18/h3-10,13,19,27-28H,2,11-12H2,1H3,(H,23,26)(H,24,25)/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388377 (US10294246, Compound No. 74 | [(1R)-2-(2,3-dihydro...) Show SMILES OB(O)[C@H](CC1COc2ccccc12)NC(=O)Cc1ccccc1 |r| Show InChI InChI=1S/C18H20BNO4/c21-18(10-13-6-2-1-3-7-13)20-17(19(22)23)11-14-12-24-16-9-5-4-8-15(14)16/h1-9,14,17,22-23H,10-12H2,(H,20,21)/t14?,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388378 (US10294246, Compound No. 75) Show SMILES Cc1cccc2c(C[C@H](NC(=O)Cc3ccccc3)B(O)O)coc12 |r| Show InChI InChI=1S/C19H20BNO4/c1-13-6-5-9-16-15(12-25-19(13)16)11-17(20(23)24)21-18(22)10-14-7-3-2-4-8-14/h2-9,12,17,23-24H,10-11H2,1H3,(H,21,22)/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388379 (US10294246, Compound No. 76) Show SMILES CO[C@@H](C(=O)N[C@@H](Cc1coc2c(C)cccc12)B(O)O)c1ccccc1 |r| Show InChI InChI=1S/C20H22BNO5/c1-13-7-6-10-16-15(12-27-18(13)16)11-17(21(24)25)22-20(23)19(26-2)14-8-4-3-5-9-14/h3-10,12,17,19,24-25H,11H2,1-2H3,(H,22,23)/t17-,19+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388380 (US10294246, Compound No. 77) Show SMILES Cc1cccc2C(C[C@H](NC(=O)Cc3ccccc3)B(O)O)COc12 |r| Show InChI InChI=1S/C19H22BNO4/c1-13-6-5-9-16-15(12-25-19(13)16)11-17(20(23)24)21-18(22)10-14-7-3-2-4-8-14/h2-9,15,17,23-24H,10-12H2,1H3,(H,21,22)/t15?,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388381 (US10294246, Compound No. 78) Show SMILES COc1ccc(OC)c(CC(=O)N[C@@H](Cc2coc3c(C)cccc23)B(O)O)c1 |r| Show InChI InChI=1S/C21H24BNO6/c1-13-5-4-6-17-15(12-29-21(13)17)10-19(22(25)26)23-20(24)11-14-9-16(27-2)7-8-18(14)28-3/h4-9,12,19,25-26H,10-11H2,1-3H3,(H,23,24)/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388382 (US10294246, Compound No. 79) Show SMILES Cc1cccc2c(C[C@H](NC(=O)[C@H](CO)c3ccccc3)B(O)O)coc12 |r| Show InChI InChI=1S/C20H22BNO5/c1-13-6-5-9-16-15(12-27-19(13)16)10-18(21(25)26)22-20(24)17(11-23)14-7-3-2-4-8-14/h2-9,12,17-18,23,25-26H,10-11H2,1H3,(H,22,24)/t17-,18+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388385 (US10294246, Compound No. 82) Show SMILES COc1ccc(CC(=O)N[C@@H](Cc2coc3c(C)cccc23)B(O)O)cc1 |r| Show InChI InChI=1S/C20H22BNO5/c1-13-4-3-5-17-15(12-27-20(13)17)11-18(21(24)25)22-19(23)10-14-6-8-16(26-2)9-7-14/h3-9,12,18,24-25H,10-11H2,1-2H3,(H,22,23)/t18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388386 (US10294246, Compound No. 83) Show SMILES Cc1cccc2c(C[C@H](NC(=O)[C@@H](CO)c3ccccc3)B(O)O)coc12 |r| Show InChI InChI=1S/C20H22BNO5/c1-13-6-5-9-16-15(12-27-19(13)16)10-18(21(25)26)22-20(24)17(11-23)14-7-3-2-4-8-14/h2-9,12,17-18,23,25-26H,10-11H2,1H3,(H,22,24)/t17-,18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388388 (US10294246, Compound No. 85) Show SMILES OB(O)[C@H](Cc1coc2c(Cl)cccc12)NC(=O)Cc1ccccc1 |r| Show InChI InChI=1S/C18H17BClNO4/c20-15-8-4-7-14-13(11-25-18(14)15)10-16(19(23)24)21-17(22)9-12-5-2-1-3-6-12/h1-8,11,16,23-24H,9-10H2,(H,21,22)/t16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388389 (US10294246, Compound No. 86) Show SMILES COc1ccc(CCC(=O)N[C@@H](CC2COc3c2cccc3C)B(O)O)nc1 |r| Show InChI InChI=1S/C20H25BN2O5/c1-13-4-3-5-17-14(12-28-20(13)17)10-18(21(25)26)23-19(24)9-7-15-6-8-16(27-2)11-22-15/h3-6,8,11,14,18,25-26H,7,9-10,12H2,1-2H3,(H,23,24)/t14?,18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388392 (US10294246, Compound No. 89) Show SMILES COc1ccc(CC(=O)N[C@@H](C[C@@H]2COc3c2cccc3C)B(O)O)cc1 |r| Show InChI InChI=1S/C20H24BNO5/c1-13-4-3-5-17-15(12-27-20(13)17)11-18(21(24)25)22-19(23)10-14-6-8-16(26-2)9-7-14/h3-9,15,18,24-25H,10-12H2,1-2H3,(H,22,23)/t15-,18+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388393 (US10294246, Compound No. 90) Show SMILES OB(O)[C@H](Cc1coc2ccccc12)NC(=O)Cc1ccccc1C#N |r| Show InChI InChI=1S/C19H17BN2O4/c21-11-14-6-2-1-5-13(14)10-19(23)22-18(20(24)25)9-15-12-26-17-8-4-3-7-16(15)17/h1-8,12,18,24-25H,9-10H2,(H,22,23)/t18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388394 (US10294246, Compound No. 91) Show SMILES CC(C)(O)c1ccc(CC(=O)N[C@@H](Cc2coc3ccccc23)B(O)O)cc1 |r| Show InChI InChI=1S/C21H24BNO5/c1-21(2,25)16-9-7-14(8-10-16)11-20(24)23-19(22(26)27)12-15-13-28-18-6-4-3-5-17(15)18/h3-10,13,19,25-27H,11-12H2,1-2H3,(H,23,24)/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388395 (US10294246, Compound No. 92) Show SMILES COc1cccc2c(C[C@H](NC(=O)Cc3ccccc3)B(O)O)coc12 |r| Show InChI InChI=1S/C19H20BNO5/c1-25-16-9-5-8-15-14(12-26-19(15)16)11-17(20(23)24)21-18(22)10-13-6-3-2-4-7-13/h2-9,12,17,23-24H,10-11H2,1H3,(H,21,22)/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388396 (US10294246, Compound No. 93) Show SMILES CO[C@@H](C(=O)N[C@@H](CC1COc2c1cccc2C)B(O)O)c1ccccc1 |r| Show InChI InChI=1S/C20H24BNO5/c1-13-7-6-10-16-15(12-27-18(13)16)11-17(21(24)25)22-20(23)19(26-2)14-8-4-3-5-9-14/h3-10,15,17,19,24-25H,11-12H2,1-2H3,(H,22,23)/t15?,17-,19+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388397 (US10294246, Compound No. 94) Show SMILES Cc1ccc2c(C[C@H](NC(=O)Cc3ccccc3)B(O)O)coc2c1C |r| Show InChI InChI=1S/C20H22BNO4/c1-13-8-9-17-16(12-26-20(17)14(13)2)11-18(21(24)25)22-19(23)10-15-6-4-3-5-7-15/h3-9,12,18,24-25H,10-11H2,1-2H3,(H,22,23)/t18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388398 (US10294246, Compound No. 95) Show SMILES COc1ccc(CCC(=O)N[C@@H](Cc2coc3c(C)c(C)ccc23)B(O)O)nc1 |r| Show InChI InChI=1S/C21H25BN2O5/c1-13-4-8-18-15(12-29-21(18)14(13)2)10-19(22(26)27)24-20(25)9-6-16-5-7-17(28-3)11-23-16/h4-5,7-8,11-12,19,26-27H,6,9-10H2,1-3H3,(H,24,25)/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388401 (US10294246, Compound No. 98) Show SMILES OB(O)[C@H](Cc1coc2ccccc12)NC(=O)Cc1ccccc1-c1ccccc1 |r| Show InChI InChI=1S/C24H22BNO4/c27-24(15-18-10-4-5-11-20(18)17-8-2-1-3-9-17)26-23(25(28)29)14-19-16-30-22-13-7-6-12-21(19)22/h1-13,16,23,28-29H,14-15H2,(H,26,27)/t23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388404 (US10294246, Compound No. 101) Show SMILES Cc1ccc2C(C[C@H](NC(=O)Cc3ccccc3)B(O)O)COc2c1C |r| Show InChI InChI=1S/C20H24BNO4/c1-13-8-9-17-16(12-26-20(17)14(13)2)11-18(21(24)25)22-19(23)10-15-6-4-3-5-7-15/h3-9,16,18,24-25H,10-12H2,1-2H3,(H,22,23)/t16?,18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388407 (US10294246, Compound No. 104) Show SMILES Cc1cccc2c(C[C@H](NC(=O)Cc3ccccc3C#N)B(O)O)coc12 |r| Show InChI InChI=1S/C20H19BN2O4/c1-13-5-4-8-17-16(12-27-20(13)17)9-18(21(25)26)23-19(24)10-14-6-2-3-7-15(14)11-22/h2-8,12,18,25-26H,9-10H2,1H3,(H,23,24)/t18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388408 (US10294246, Compound No. 105) Show SMILES OB(O)[C@H](C[C@@H]1COc2ccccc12)NC(=O)Cc1ccccc1C#N |r| Show InChI InChI=1S/C19H19BN2O4/c21-11-14-6-2-1-5-13(14)10-19(23)22-18(20(24)25)9-15-12-26-17-8-4-3-7-16(15)17/h1-8,15,18,24-25H,9-10,12H2,(H,22,23)/t15-,18+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388409 (US10294246, Compound No. 106) Show SMILES C[C@H](C(=O)N[C@@H](C[C@H]1COc2ccccc12)B(O)O)c1ccccc1C(=O)N(C)C |r| Show InChI InChI=1S/C22H27BN2O5/c1-14(16-8-4-5-10-18(16)22(27)25(2)3)21(26)24-20(23(28)29)12-15-13-30-19-11-7-6-9-17(15)19/h4-11,14-15,20,28-29H,12-13H2,1-3H3,(H,24,26)/t14-,15-,20-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388411 (US10294246, Compound No. 108) Show SMILES COc1ccc(CC(=O)N[C@@H](Cc2cc3ccccc3o2)B(O)O)cc1 |r| Show InChI InChI=1S/C19H20BNO5/c1-25-15-8-6-13(7-9-15)10-19(22)21-18(20(23)24)12-16-11-14-4-2-3-5-17(14)26-16/h2-9,11,18,23-24H,10,12H2,1H3,(H,21,22)/t18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388412 (US10294246, Compound No. 109) Show SMILES CCO[C@@H](C(=O)N[C@@H](CC1COc2c1cccc2C)B(O)O)c1ccccc1 |r| Show InChI InChI=1S/C21H26BNO5/c1-3-27-20(15-9-5-4-6-10-15)21(24)23-18(22(25)26)12-16-13-28-19-14(2)8-7-11-17(16)19/h4-11,16,18,20,25-26H,3,12-13H2,1-2H3,(H,23,24)/t16?,18-,20+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388414 (US10294246, Compound No. 111) Show SMILES CCO[C@@H](C(=O)N[C@@H](CC1COc2ccccc12)B(O)O)c1ccccc1 |r| Show InChI InChI=1S/C20H24BNO5/c1-2-26-19(14-8-4-3-5-9-14)20(23)22-18(21(24)25)12-15-13-27-17-11-7-6-10-16(15)17/h3-11,15,18-19,24-25H,2,12-13H2,1H3,(H,22,23)/t15?,18-,19+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair
Proteasome subunit beta type-8 (Homo sapiens (Human))	BDBM388415 (US10294246, Compound No. 112 | [2-(benzofuran-3-yl...) Show SMILES OB(O)C(Cc1coc2ccccc12)NC(=O)Cc1ccccn1 Show InChI InChI=1S/C17H17BN2O4/c21-17(10-13-5-3-4-8-19-13)20-16(18(22)23)9-12-11-24-15-7-2-1-6-14(12)15/h1-8,11,16,22-23H,9-10H2,(H,20,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute					Assay Description Measurement of LMP7 inhibition is performed in 384 well format based on fluorescence intensity assay.Purified human immunoproteasome (0.25 nM) and se...				Bioorg Med Chem Lett 19: 1164-7 (2009) BindingDB Entry DOI: 10.7270/Q2V40XHN
					More data for this Ligand-Target Pair

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