Compile Data Set for Download or QSAR

Found 373 hits Enz. Inhib. hit(s) with all data for entry = 3146   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318045 (US10301317, Example 1 | US9624228, Example 1) Show SMILES O=C1Nc2cc3[nH]nc(-c4ccncc4)c3cc2CN1Cc1ccccc1 Show InChI InChI=1S/C21H17N5O/c27-21-23-18-11-19-17(20(25-24-19)15-6-8-22-9-7-15)10-16(18)13-26(21)12-14-4-2-1-3-5-14/h1-11H,12-13H2,(H,23,27)(H,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM272554 (US10065967, Example 20 | US10301317, Example 2 | U...) Show SMILES C[C@@H](N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1)c1ccccc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318047 (US10301317, Example 3 | US9624228, Example 3) Show SMILES Clc1cccc(CN2Cc3cc4c(n[nH]c4cc3NC2=O)-c2ccncc2)c1 Show InChI InChI=1S/C21H16ClN5O/c22-16-3-1-2-13(8-16)11-27-12-15-9-17-19(10-18(15)24-21(27)28)25-26-20(17)14-4-6-23-7-5-14/h1-10H,11-12H2,(H,24,28)(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318048 (US10301317, Example 4 | US9624228, Example 4) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc4cccc(Cl)c4)Cc3cc12 Show InChI InChI=1S/C22H18ClN5O/c1-13-7-15(5-6-24-13)21-18-9-16-12-28(11-14-3-2-4-17(23)8-14)22(29)25-19(16)10-20(18)26-27-21/h2-10H,11-12H2,1H3,(H,25,29)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318051 (US10301317, Example 7 | US9624228, Example 7) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc4cc(F)cc(F)c4)Cc3cc12 Show InChI InChI=1S/C22H17F2N5O/c1-12-4-14(2-3-25-12)21-18-7-15-11-29(10-13-5-16(23)8-17(24)6-13)22(30)26-19(15)9-20(18)27-28-21/h2-9H,10-11H2,1H3,(H,26,30)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318052 (US10301317, Example 8 | US9624228, Example 8) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc4ccc(F)c(Cl)c4)Cc3cc12 Show InChI InChI=1S/C22H17ClFN5O/c1-12-6-14(4-5-25-12)21-16-8-15-11-29(10-13-2-3-18(24)17(23)7-13)22(30)26-19(15)9-20(16)27-28-21/h2-9H,10-11H2,1H3,(H,26,30)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318053 (US10301317, Example 9 | US9624228, Example 9) Show SMILES COc1ncccc1CN1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1 Show InChI InChI=1S/C22H20N6O2/c1-13-8-14(5-7-23-13)20-17-9-16-12-28(11-15-4-3-6-24-21(15)30-2)22(29)25-18(16)10-19(17)26-27-20/h3-10H,11-12H2,1-2H3,(H,25,29)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318054 (US10301317, Example 10 | US9624228, Example 10) Show SMILES COc1ccc(CN2Cc3cc4c(n[nH]c4cc3NC2=O)-c2ccnc(C)c2)cc1 Show InChI InChI=1S/C23H21N5O2/c1-14-9-16(7-8-24-14)22-19-10-17-13-28(12-15-3-5-18(30-2)6-4-15)23(29)25-20(17)11-21(19)26-27-22/h3-11H,12-13H2,1-2H3,(H,25,29)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318055 (US10301317, Example 11 | US9624228, Example 11) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc4ccc(F)cc4F)Cc3cc12 Show InChI InChI=1S/C22H17F2N5O/c1-12-6-13(4-5-25-12)21-17-7-15-11-29(10-14-2-3-16(23)8-18(14)24)22(30)26-19(15)9-20(17)27-28-21/h2-9H,10-11H2,1H3,(H,26,30)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318057 (US10301317, Example 13 | US9624228, Example 13) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc4ccc(F)c(F)c4)Cc3cc12 Show InChI InChI=1S/C22H17F2N5O/c1-12-6-14(4-5-25-12)21-16-8-15-11-29(10-13-2-3-17(23)18(24)7-13)22(30)26-19(15)9-20(16)27-28-21/h2-9H,10-11H2,1H3,(H,26,30)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318058 (US10301317, Example 14 | US9624228, Example 14) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc4ccc(Cl)cc4)Cc3cc12 Show InChI InChI=1S/C22H18ClN5O/c1-13-8-15(6-7-24-13)21-18-9-16-12-28(11-14-2-4-17(23)5-3-14)22(29)25-19(16)10-20(18)26-27-21/h2-10H,11-12H2,1H3,(H,25,29)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318062 (US10301317, Example 18 | US9624228, Example 18) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(CCc4ccc(F)cc4)Cc3cc12 Show InChI InChI=1S/C23H20FN5O/c1-14-10-16(6-8-25-14)22-19-11-17-13-29(9-7-15-2-4-18(24)5-3-15)23(30)26-20(17)12-21(19)27-28-22/h2-6,8,10-12H,7,9,13H2,1H3,(H,26,30)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318063 (US10301317, Example 19 | US9624228, Example 19) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3[nH]c(=O)n(Cc4ccccc4)c3cc12 Show InChI InChI=1S/C21H17N5O/c1-13-9-15(7-8-22-13)20-16-10-19-18(11-17(16)24-25-20)23-21(27)26(19)12-14-5-3-2-4-6-14/h2-11H,12H2,1H3,(H,23,27)(H,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318066 (US10301317, Example 22 | US9624228, Example 22) Show SMILES CC(c1ccccc1)c1cc2cc3c(n[nH]c3cc2[nH]c1=O)-c1ccnc(C)c1 Show InChI InChI=1S/C24H18N4O/c1-14-10-17(8-9-25-14)23-20-12-18-11-19(15(2)16-6-4-3-5-7-16)24(29)26-21(18)13-22(20)27-28-23/h3-13,15H,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318067 (US10301317, Example 23 | US9624228, Example 23) Show SMILES C[C@@H](N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1)c1ccc(cc1)C#N |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318070 (US10301317, Example 26 | US9624228, Example 26) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@H](CO)c1cccc(Cl)c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318071 (US10301317, Example 27 | US9624228, Example 27) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3[nH]c(=O)n(Cc4ccccc4)c(=O)c3cc12 Show InChI InChI=1S/C22H17N5O2/c1-13-9-15(7-8-23-13)20-16-10-17-18(11-19(16)25-26-20)24-22(29)27(21(17)28)12-14-5-3-2-4-6-14/h2-11H,12H2,1H3,(H,24,29)(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318074 (US10301317, Example 30 | US9624228, Example 30) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc4ccc(F)cc4)Cc3cc12 Show InChI InChI=1S/C22H18FN5O/c1-13-8-15(6-7-24-13)21-18-9-16-12-28(11-14-2-4-17(23)5-3-14)22(29)25-19(16)10-20(18)26-27-21/h2-10H,11-12H2,1H3,(H,25,29)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318075 (US10301317, Example 31 | US9624228, Example 31) Show SMILES Cn1cc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc4ccc(F)c(Cl)c4)Cc3cc12 Show InChI InChI=1S/C20H16ClFN6O/c1-27-9-13(7-23-27)19-14-5-12-10-28(8-11-2-3-16(22)15(21)4-11)20(29)24-17(12)6-18(14)25-26-19/h2-7,9H,8,10H2,1H3,(H,24,29)(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318077 (US10301317, Example 33 | US9624228, Example 33) Show SMILES CN1CCC[C@H](C1)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318079 (US10301317, Example 35 | US9624228, Example 35) Show SMILES C[C@@H](N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1)c1cccc(Cl)c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318080 (US10301317, Example 36 | US9624228, Example 36) Show SMILES COc1ccc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc4ccc(F)c(Cl)c4)Cc3cc12 Show InChI InChI=1S/C22H17ClFN5O2/c1-31-20-5-3-13(9-25-20)21-15-7-14-11-29(10-12-2-4-17(24)16(23)6-12)22(30)26-18(14)8-19(15)27-28-21/h2-9H,10-11H2,1H3,(H,26,30)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318081 (US10301317, Example 37 | US9624228, Example 37) Show SMILES COc1ncc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc4ccc(F)c(Cl)c4)Cc3cc12 Show InChI InChI=1S/C21H16ClFN6O2/c1-31-20-24-7-13(8-25-20)19-14-5-12-10-29(9-11-2-3-16(23)15(22)4-11)21(30)26-17(12)6-18(14)27-28-19/h2-8H,9-10H2,1H3,(H,26,30)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318082 (US10301317, Example 38 | US9624228, Example 38) Show SMILES COc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc4ccc(F)c(Cl)c4)Cc3cc12 Show InChI InChI=1S/C22H17ClFN5O2/c1-31-20-8-13(4-5-25-20)21-15-7-14-11-29(10-12-2-3-17(24)16(23)6-12)22(30)26-18(14)9-19(15)27-28-21/h2-9H,10-11H2,1H3,(H,26,30)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318083 (US10301317, Example 39 | US9624228, Example 39) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc4ccc(cc4)C#N)Cc3cc12 Show InChI InChI=1S/C23H18N6O/c1-14-8-17(6-7-25-14)22-19-9-18-13-29(12-16-4-2-15(11-24)3-5-16)23(30)26-20(18)10-21(19)27-28-22/h2-10H,12-13H2,1H3,(H,26,30)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318085 (US10301317, Example 41 | US9624228, Example 41) Show SMILES Cn1cc(ccc1=O)-c1n[nH]c2cc3NC(=O)N(Cc4ccc(F)c(Cl)c4)Cc3cc12 Show InChI InChI=1S/C22H17ClFN5O2/c1-28-10-13(3-5-20(28)30)21-15-7-14-11-29(9-12-2-4-17(24)16(23)6-12)22(31)25-18(14)8-19(15)26-27-21/h2-8,10H,9,11H2,1H3,(H,25,31)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318087 (US10301317, Example 43 | US9624228, Example 43) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(CCO)Cc3cc12 Show InChI InChI=1S/C17H17N5O2/c1-10-6-11(2-3-18-10)16-13-7-12-9-22(4-5-23)17(24)19-14(12)8-15(13)20-21-16/h2-3,6-8,23H,4-5,9H2,1H3,(H,19,24)(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318088 (US10301317, Example 44 | US9624228, Example 44) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)C1CCOCC1 Show InChI InChI=1S/C20H21N5O2/c1-12-8-13(2-5-21-12)19-16-9-14-11-25(15-3-6-27-7-4-15)20(26)22-17(14)10-18(16)23-24-19/h2,5,8-10,15H,3-4,6-7,11H2,1H3,(H,22,26)(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318089 (US10301317, Example 45 | US9624228, Example 45) Show SMILES COCCOCCN1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1 Show InChI InChI=1S/C20H23N5O3/c1-13-9-14(3-4-21-13)19-16-10-15-12-25(5-6-28-8-7-27-2)20(26)22-17(15)11-18(16)23-24-19/h3-4,9-11H,5-8,12H2,1-2H3,(H,22,26)(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318166 (US10301317, Example 122 | US9624228, Example 122) Show SMILES Fc1cccc(F)c1CN1CCC[C@H](C1)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnnc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318167 (US10301317, Example 123 | US9624228, Example 123) Show SMILES Clc1cccc(CN2Cc3cc4c(n[nH]c4cc3NC2=O)-c2cncnc2)c1 Show InChI InChI=1S/C20H15ClN6O/c21-15-3-1-2-12(4-15)9-27-10-13-5-16-18(6-17(13)24-20(27)28)25-26-19(16)14-7-22-11-23-8-14/h1-8,11H,9-10H2,(H,24,28)(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318168 (US10301317, Example 124 | US9624228, Example 124) Show SMILES FC(F)(F)c1cccc(CN2Cc3cc4c(n[nH]c4cc3NC2=O)-c2ccnnc2)c1 Show InChI InChI=1S/C21H15F3N6O/c22-21(23,24)15-3-1-2-12(6-15)10-30-11-14-7-16-18(8-17(14)27-20(30)31)28-29-19(16)13-4-5-25-26-9-13/h1-9H,10-11H2,(H,27,31)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318169 (US10301317, Example 125 | US9624228, Example 125) Show SMILES COc1ncc(cn1)-c1n[nH]c2cc3NC(=O)N(Cc4cccc(c4)C#N)Cc3cc12 Show InChI InChI=1S/C22H17N7O2/c1-31-21-24-9-16(10-25-21)20-17-6-15-12-29(11-14-4-2-3-13(5-14)8-23)22(30)26-18(15)7-19(17)27-28-20/h2-7,9-10H,11-12H2,1H3,(H,26,30)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318170 (US10301317, Example 126 | US9624228, Example 126) Show SMILES COc1cccc(F)c1CN1CCC[C@H](C1)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnnc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318171 (US10301317, Example 127 | US9624228, Example 127) Show SMILES Fc1cc(F)cc(CN2Cc3cc4c(n[nH]c4cc3NC2=O)-c2ccnnc2)c1 Show InChI InChI=1S/C20H14F2N6O/c21-14-3-11(4-15(22)6-14)9-28-10-13-5-16-18(7-17(13)25-20(28)29)26-27-19(16)12-1-2-23-24-8-12/h1-8H,9-10H2,(H,25,29)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318172 (US10301317, Example 128 | US9624228, Example 128) Show SMILES O=C1Nc2cc3[nH]nc(-c4ccnnc4)c3cc2CN1Cc1cccc(c1)C#N Show InChI InChI=1S/C21H15N7O/c22-9-13-2-1-3-14(6-13)11-28-12-16-7-17-19(8-18(16)25-21(28)29)26-27-20(17)15-4-5-23-24-10-15/h1-8,10H,11-12H2,(H,25,29)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318176 (US10301317, Example 132 | US9624228, Example 132) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2ccc(F)cn2)C1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318177 (US10301317, Example 133 | US9624228, Example 133) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2cnn(C)c2)C1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318178 (US10301317, Example 134 | US9624228, Example 134) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2ccc(F)c(Cl)c2)C1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318183 (US10301317, Example 139 | US9624228, Example 139) Show SMILES Cc1cc(CN2CCC[C@H](C2)N2Cc3cc4c(n[nH]c4cc3NC2=O)-c2ccnc(C)c2)on1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318184 (US10301317, Example 140 | US9624228, Example 140) Show SMILES Cc1nc(CN2CCC[C@H](C2)N2Cc3cc4c(n[nH]c4cc3NC2=O)-c2ccnc(C)c2)cs1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318186 (US10301317, Example 142 | US9624228, Example 142) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(CC2CC3CCC2C3)C1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318187 (US10301317, Example 143 | US9624228, Example 143) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2c(F)cccc2F)C1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318188 (US10301317, Example 144 | US9624228, Example 144) Show SMILES COc1cccc(F)c1CN1CCC[C@H](C1)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318189 (US10301317, Example 145 | US9624228, Example 145) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(CCc2ccccc2)C1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318190 (US10301317, Example 146 | US9624228, Example 146) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCN(Cc2ccccc2)C1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318107 (US10301317, Example 165 | US9624228, Example 148 |...) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2ccccc2)C1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318193 (US10301317, Example 149 | US9624228, Example 149) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(CCNCc4ccccc4)Cc3cc12 Show InChI InChI=1S/C24H24N6O/c1-16-11-18(7-8-26-16)23-20-12-19-15-30(10-9-25-14-17-5-3-2-4-6-17)24(31)27-21(19)13-22(20)28-29-23/h2-8,11-13,25H,9-10,14-15H2,1H3,(H,27,31)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318194 (US10301317, Example 150 | US9624228, Example 150) Show SMILES COc1ncccc1CN1CCC[C@H](C1)N1Cc2cc3c(n[nH]c3cc2NC1=O)-c1ccnc(C)c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318195 (US10301317, Example 151 | US9624228, Example 151) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@@H]1CCCN(Cc2ccc(F)cc2)C1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair

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