Compile Data Set for Download or QSAR

Found 438 hits Enz. Inhib. hit(s) with all data for entry = 3306   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397008 (US10442810, Example 70 | US10844069, Example 70 | ...) Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)N(C)C)n3ncnc(N)c23)c(=O)n(-c2cccc(F)c2)c1=O Show InChI InChI=1S/C34H36FN9O4/c1-20(2)42-18-27(32(46)43(34(42)48)25-7-5-6-23(35)16-25)31(45)39-24-10-8-21(9-11-24)26-17-28(44-29(26)30(36)37-19-38-44)22-12-14-41(15-13-22)33(47)40(3)4/h5-11,16-20,22H,12-15H2,1-4H3,(H,39,45)(H2,36,37,38)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397008 (US10442810, Example 70 | US10844069, Example 70 | ...) Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)N(C)C)n3ncnc(N)c23)c(=O)n(-c2cccc(F)c2)c1=O Show InChI InChI=1S/C34H36FN9O4/c1-20(2)42-18-27(32(46)43(34(42)48)25-7-5-6-23(35)16-25)31(45)39-24-10-8-21(9-11-24)26-17-28(44-29(26)30(36)37-19-38-44)22-12-14-41(15-13-22)33(47)40(3)4/h5-11,16-20,22H,12-15H2,1-4H3,(H,39,45)(H2,36,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397009 (US10442810, Example 71 | US10844069, Example 71 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4cccc(F)c4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C35H37FN8O4/c1-20(2)33(46)41-14-12-23(13-15-41)29-17-27(30-31(37)38-19-39-44(29)30)22-8-10-25(11-9-22)40-32(45)28-18-42(21(3)4)35(48)43(34(28)47)26-7-5-6-24(36)16-26/h5-11,16-21,23H,12-15H2,1-4H3,(H,40,45)(H2,37,38,39)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397010 (US10442810, Example 72 | US10844069, Example 72 | ...) Show SMILES CCn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)N(C)C)n3ncnc(N)c23)c(=O)n(-c2cccc(F)c2)c1=O Show InChI InChI=1S/C33H34FN9O4/c1-4-40-18-26(31(45)42(33(40)47)24-7-5-6-22(34)16-24)30(44)38-23-10-8-20(9-11-23)25-17-27(43-28(25)29(35)36-19-37-43)21-12-14-41(15-13-21)32(46)39(2)3/h5-11,16-19,21H,4,12-15H2,1-3H3,(H,38,44)(H2,35,36,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397011 (US10442810, Example 73 | US10844069, Example 73 | ...) Show SMILES CCn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C(C)C)n3ncnc(N)c23)c(=O)n(-c2cccc(F)c2)c1=O Show InChI InChI=1S/C34H35FN8O4/c1-4-40-18-27(33(46)42(34(40)47)25-7-5-6-23(35)16-25)31(44)39-24-10-8-21(9-11-24)26-17-28(43-29(26)30(36)37-19-38-43)22-12-14-41(15-13-22)32(45)20(2)3/h5-11,16-20,22H,4,12-15H2,1-3H3,(H,39,44)(H2,36,37,38)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397012 (US10442810, Example 74 | US10844069, Example 74 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc4C(=O)CCCc4n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C37H37N7O4/c1-22(2)36(47)42-17-15-24(16-18-42)31-20-27(33-34(38)39-21-40-44(31)33)23-11-13-25(14-12-23)41-35(46)29-19-28-30(9-6-10-32(28)45)43(37(29)48)26-7-4-3-5-8-26/h3-5,7-8,11-14,19-22,24H,6,9-10,15-18H2,1-2H3,(H,41,46)(H2,38,39,40)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397012 (US10442810, Example 74 | US10844069, Example 74 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc4C(=O)CCCc4n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C37H37N7O4/c1-22(2)36(47)42-17-15-24(16-18-42)31-20-27(33-34(38)39-21-40-44(31)33)23-11-13-25(14-12-23)41-35(46)29-19-28-30(9-6-10-32(28)45)43(37(29)48)26-7-4-3-5-8-26/h3-5,7-8,11-14,19-22,24H,6,9-10,15-18H2,1-2H3,(H,41,46)(H2,38,39,40)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397013 (US10442810, Example 75 | US10844069, Example 75 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C35H37FN8O4/c1-20(2)33(46)41-14-12-22(13-15-41)29-17-26(30-31(37)38-19-39-44(29)30)25-11-10-23(16-28(25)36)40-32(45)27-18-42(21(3)4)35(48)43(34(27)47)24-8-6-5-7-9-24/h5-11,16-22H,12-15H2,1-4H3,(H,40,45)(H2,37,38,39)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397013 (US10442810, Example 75 | US10844069, Example 75 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C35H37FN8O4/c1-20(2)33(46)41-14-12-22(13-15-41)29-17-26(30-31(37)38-19-39-44(29)30)25-11-10-23(16-28(25)36)40-32(45)27-18-42(21(3)4)35(48)43(34(27)47)24-8-6-5-7-9-24/h5-11,16-22H,12-15H2,1-4H3,(H,40,45)(H2,37,38,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397014 (US10442810, Example 76 | US10844069, Example 76 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4cc(F)ccc4F)c3=O)cc2)c2c(N)ncnn12 |(2.27,-10.37,;1.18,-11.46,;1.57,-12.95,;-.31,-11.06,;-1.4,-12.15,;-.71,-9.57,;-2.2,-9.17,;-2.6,-7.69,;-1.51,-6.6,;-.02,-7,;.38,-8.48,;-1.91,-5.11,;-1,-3.86,;-1.91,-2.62,;-1.51,-1.13,;-.02,-.73,;.38,.75,;-.71,1.84,;-.31,3.33,;1.18,3.73,;2.27,2.64,;1.57,5.22,;3.06,5.62,;3.46,7.1,;4.95,7.5,;5.35,8.99,;6.04,6.41,;2.37,8.19,;2.77,9.68,;.88,7.79,;-.2,8.88,;.19,10.37,;-.89,11.46,;-.5,12.95,;-2.38,11.06,;-2.78,9.57,;-1.69,8.48,;-2.09,7,;.49,6.31,;-1,5.91,;-2.2,1.45,;-2.6,-.04,;-3.37,-3.09,;-4.7,-2.32,;-4.7,-.78,;-6.04,-3.09,;-6.04,-4.63,;-4.7,-5.4,;-3.37,-4.63,)| Show InChI InChI=1S/C35H36F2N8O4/c1-19(2)33(47)42-13-11-22(12-14-42)28-16-25(30-31(38)39-18-40-45(28)30)21-5-8-24(9-6-21)41-32(46)26-17-43(20(3)4)35(49)44(34(26)48)29-15-23(36)7-10-27(29)37/h5-10,15-20,22H,11-14H2,1-4H3,(H,41,46)(H2,38,39,40)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397015 (US10442810, Example 77 | US10844069, Example 77 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2C)c2c(N)ncnn12 Show InChI InChI=1S/C36H40N8O4/c1-21(2)34(46)41-15-13-24(14-16-41)30-18-28(31-32(37)38-20-39-44(30)31)27-12-11-25(17-23(27)5)40-33(45)29-19-42(22(3)4)36(48)43(35(29)47)26-9-7-6-8-10-26/h6-12,17-22,24H,13-16H2,1-5H3,(H,40,45)(H2,37,38,39)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397016 (US10442810, Example 78 | US10844069, Example 78 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4cccnc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C34H37N9O4/c1-20(2)32(45)40-14-11-23(12-15-40)28-16-26(29-30(35)37-19-38-43(28)29)22-7-9-24(10-8-22)39-31(44)27-18-41(21(3)4)34(47)42(33(27)46)25-6-5-13-36-17-25/h5-10,13,16-21,23H,11-12,14-15H2,1-4H3,(H,39,44)(H2,35,37,38)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397016 (US10442810, Example 78 | US10844069, Example 78 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4cccnc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C34H37N9O4/c1-20(2)32(45)40-14-11-23(12-15-40)28-16-26(29-30(35)37-19-38-43(28)29)22-7-9-24(10-8-22)39-31(44)27-18-41(21(3)4)34(47)42(33(27)46)25-6-5-13-36-17-25/h5-10,13,16-21,23H,11-12,14-15H2,1-4H3,(H,39,44)(H2,35,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397017 (US10442810, Example 79 | US10844069, Example 79 | ...) Show SMILES CCn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)[C@@H](C)O)n3ncnc(N)c23)c(=O)n(-c2ccc(F)cc2)c1=O |r| Show InChI InChI=1S/C33H33FN8O5/c1-3-39-17-26(32(46)41(33(39)47)24-10-6-22(34)7-11-24)30(44)38-23-8-4-20(5-9-23)25-16-27(42-28(25)29(35)36-18-37-42)21-12-14-40(15-13-21)31(45)19(2)43/h4-11,16-19,21,43H,3,12-15H2,1-2H3,(H,38,44)(H2,35,36,37)/t19-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397017 (US10442810, Example 79 | US10844069, Example 79 | ...) Show SMILES CCn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)[C@@H](C)O)n3ncnc(N)c23)c(=O)n(-c2ccc(F)cc2)c1=O |r| Show InChI InChI=1S/C33H33FN8O5/c1-3-39-17-26(32(46)41(33(39)47)24-10-6-22(34)7-11-24)30(44)38-23-8-4-20(5-9-23)25-16-27(42-28(25)29(35)36-18-37-42)21-12-14-40(15-13-21)31(45)19(2)43/h4-11,16-19,21,43H,3,12-15H2,1-2H3,(H,38,44)(H2,35,36,37)/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397018 (US10442810, Example 80 | US10844069, Example 80 | ...) Show SMILES CC(O)Cn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)C3CC3)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C35H36N8O5/c1-21(44)18-41-19-28(34(47)42(35(41)48)26-5-3-2-4-6-26)32(45)39-25-11-9-22(10-12-25)27-17-29(43-30(27)31(36)37-20-38-43)23-13-15-40(16-14-23)33(46)24-7-8-24/h2-6,9-12,17,19-21,23-24,44H,7-8,13-16,18H2,1H3,(H,39,45)(H2,36,37,38)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397019 (US10442810, Example 81 | US10844069, Example 81 | ...) Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC(=O)N(C)C)CC3)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C35H39N9O4/c1-22(2)42-19-28(34(47)43(35(42)48)26-8-6-5-7-9-26)33(46)39-25-12-10-23(11-13-25)27-18-29(44-31(27)32(36)37-21-38-44)24-14-16-41(17-15-24)20-30(45)40(3)4/h5-13,18-19,21-22,24H,14-17,20H2,1-4H3,(H,39,46)(H2,36,37,38)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397019 (US10442810, Example 81 | US10844069, Example 81 | ...) Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC(=O)N(C)C)CC3)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C35H39N9O4/c1-22(2)42-19-28(34(47)43(35(42)48)26-8-6-5-7-9-26)33(46)39-25-12-10-23(11-13-25)27-18-29(44-31(27)32(36)37-21-38-44)24-14-16-41(17-15-24)20-30(45)40(3)4/h5-13,18-19,21-22,24H,14-17,20H2,1-4H3,(H,39,46)(H2,36,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397020 (US10442810, Example 82 | US10844069, Example 82 | ...) Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C3CCN(C)C3=O)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C36H39N9O4/c1-22(2)43-20-28(34(47)44(36(43)49)26-7-5-4-6-8-26)33(46)40-25-11-9-23(10-12-25)27-19-30(45-31(27)32(37)38-21-39-45)24-13-17-42(18-14-24)29-15-16-41(3)35(29)48/h4-12,19-22,24,29H,13-18H2,1-3H3,(H,40,46)(H2,37,38,39)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397020 (US10442810, Example 82 | US10844069, Example 82 | ...) Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C3CCN(C)C3=O)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C36H39N9O4/c1-22(2)43-20-28(34(47)44(36(43)49)26-7-5-4-6-8-26)33(46)40-25-11-9-23(10-12-25)27-19-30(45-31(27)32(37)38-21-39-45)24-13-17-42(18-14-24)29-15-16-41(3)35(29)48/h4-12,19-22,24,29H,13-18H2,1-3H3,(H,40,46)(H2,37,38,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397021 (US10442810, Example 83 | US10844069, Example 83 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccn4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C34H37N9O4/c1-20(2)32(45)40-15-12-23(13-16-40)27-17-25(29-30(35)37-19-38-43(27)29)22-8-10-24(11-9-22)39-31(44)26-18-41(21(3)4)34(47)42(33(26)46)28-7-5-6-14-36-28/h5-11,14,17-21,23H,12-13,15-16H2,1-4H3,(H,39,44)(H2,35,37,38)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397021 (US10442810, Example 83 | US10844069, Example 83 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccn4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C34H37N9O4/c1-20(2)32(45)40-15-12-23(13-16-40)27-17-25(29-30(35)37-19-38-43(27)29)22-8-10-24(11-9-22)39-31(44)26-18-41(21(3)4)34(47)42(33(26)46)28-7-5-6-14-36-28/h5-11,14,17-21,23H,12-13,15-16H2,1-4H3,(H,39,44)(H2,35,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396968 (N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:33.37,36.44,(-5.98,13.38,;-6.45,11.92,;-7.96,11.6,;-8.44,10.13,;-7.41,8.99,;-5.9,9.31,;-4.65,8.4,;-3.41,9.31,;-3.88,10.77,;-3.11,12.11,;-3.88,13.44,;-3.11,14.78,;-1.57,14.78,;-.8,16.11,;.74,16.11,;1.51,14.78,;1.51,17.44,;.74,18.78,;1.51,20.11,;3.05,20.11,;3.82,18.78,;5.36,18.78,;6.13,17.44,;7.67,17.44,;8.44,18.78,;7.67,20.11,;6.13,20.11,;3.05,17.44,;3.82,16.11,;-.8,13.44,;-1.57,12.11,;-.8,10.77,;-5.42,10.77,;-4.65,6.86,;-5.99,6.09,;-5.99,4.55,;-4.65,3.78,;-3.32,4.55,;-3.32,6.09,;-4.65,2.24,;-4.65,.7,)| Show InChI InChI=1S/C31H26FN7O2/c32-26-15-21(37-30(40)24-7-4-14-38(31(24)41)22-5-2-1-3-6-22)12-13-23(26)25-16-27(20-10-8-19(17-33)9-11-20)39-28(25)29(34)35-18-36-39/h1-7,12-16,18-20H,8-11H2,(H,37,40)(H2,34,35,36)/t19-,20+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396969 (N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:34.38,37.45,(-6.75,13.38,;-7.22,11.92,;-8.73,11.6,;-9.21,10.13,;-8.18,8.99,;-6.67,9.31,;-5.42,8.4,;-4.18,9.31,;-4.65,10.77,;-3.88,12.11,;-4.65,13.44,;-3.88,14.78,;-2.34,14.78,;-1.57,16.11,;-.03,16.11,;.74,14.78,;.74,17.44,;-.03,18.78,;.74,20.11,;2.28,20.11,;3.05,18.78,;4.59,18.78,;5.36,17.44,;6.9,17.44,;7.67,18.78,;9.21,18.78,;6.9,20.11,;5.36,20.11,;2.28,17.44,;3.05,16.11,;-1.57,13.44,;-2.34,12.11,;-1.57,10.77,;-6.19,10.77,;-5.42,6.86,;-6.76,6.09,;-6.76,4.55,;-5.42,3.78,;-4.09,4.55,;-4.09,6.09,;-5.42,2.24,;-5.42,.7,)| Show InChI InChI=1S/C31H25F2N7O2/c32-20-7-10-22(11-8-20)39-13-1-2-24(31(39)42)30(41)38-21-9-12-23(26(33)14-21)25-15-27(19-5-3-18(16-34)4-6-19)40-28(25)29(35)36-17-37-40/h1-2,7-15,17-19H,3-6H2,(H,38,41)(H2,35,36,37)/t18-,19+	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396969 (N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:34.38,37.45,(-6.75,13.38,;-7.22,11.92,;-8.73,11.6,;-9.21,10.13,;-8.18,8.99,;-6.67,9.31,;-5.42,8.4,;-4.18,9.31,;-4.65,10.77,;-3.88,12.11,;-4.65,13.44,;-3.88,14.78,;-2.34,14.78,;-1.57,16.11,;-.03,16.11,;.74,14.78,;.74,17.44,;-.03,18.78,;.74,20.11,;2.28,20.11,;3.05,18.78,;4.59,18.78,;5.36,17.44,;6.9,17.44,;7.67,18.78,;9.21,18.78,;6.9,20.11,;5.36,20.11,;2.28,17.44,;3.05,16.11,;-1.57,13.44,;-2.34,12.11,;-1.57,10.77,;-6.19,10.77,;-5.42,6.86,;-6.76,6.09,;-6.76,4.55,;-5.42,3.78,;-4.09,4.55,;-4.09,6.09,;-5.42,2.24,;-5.42,.7,)| Show InChI InChI=1S/C31H25F2N7O2/c32-20-7-10-22(11-8-20)39-13-1-2-24(31(39)42)30(41)38-21-9-12-23(26(33)14-21)25-15-27(19-5-3-18(16-34)4-6-19)40-28(25)29(35)36-17-37-40/h1-2,7-15,17-19H,3-6H2,(H,38,41)(H2,35,36,37)/t18-,19+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396970 (US10442810, Example 32 | US10844069, Example 32 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)C1CCNCC1 Show InChI InChI=1S/C29H27N7O2/c30-27-26-24(17-25(36(26)33-18-32-27)20-12-14-31-15-13-20)19-8-10-21(11-9-19)34-28(37)23-7-4-16-35(29(23)38)22-5-2-1-3-6-22/h1-11,16-18,20,31H,12-15H2,(H,34,37)(H2,30,32,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396970 (US10442810, Example 32 | US10844069, Example 32 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)C1CCNCC1 Show InChI InChI=1S/C29H27N7O2/c30-27-26-24(17-25(36(26)33-18-32-27)20-12-14-31-15-13-20)19-8-10-21(11-9-19)34-28(37)23-7-4-16-35(29(23)38)22-5-2-1-3-6-22/h1-11,16-18,20,31H,12-15H2,(H,34,37)(H2,30,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396971 (US10442810, Example 33 | US10844069, Example 33 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCNCC1 Show InChI InChI=1S/C29H26FN7O2/c30-20-5-9-22(10-6-20)36-15-1-2-23(29(36)39)28(38)35-21-7-3-18(4-8-21)24-16-25(19-11-13-32-14-12-19)37-26(24)27(31)33-17-34-37/h1-10,15-17,19,32H,11-14H2,(H,35,38)(H2,31,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396971 (US10442810, Example 33 | US10844069, Example 33 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCNCC1 Show InChI InChI=1S/C29H26FN7O2/c30-20-5-9-22(10-6-20)36-15-1-2-23(29(36)39)28(38)35-21-7-3-18(4-8-21)24-16-25(19-11-13-32-14-12-19)37-26(24)27(31)33-17-34-37/h1-10,15-17,19,32H,11-14H2,(H,35,38)(H2,31,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396972 (US10442810, Example 34 | US10844069, Example 34 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)C1CCNCC1 Show InChI InChI=1S/C29H26FN7O2/c30-24-15-19(35-28(38)22-7-4-14-36(29(22)39)20-5-2-1-3-6-20)8-9-21(24)23-16-25(18-10-12-32-13-11-18)37-26(23)27(31)33-17-34-37/h1-9,14-18,32H,10-13H2,(H,35,38)(H2,31,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396972 (US10442810, Example 34 | US10844069, Example 34 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)C1CCNCC1 Show InChI InChI=1S/C29H26FN7O2/c30-24-15-19(35-28(38)22-7-4-14-36(29(22)39)20-5-2-1-3-6-20)8-9-21(24)23-16-25(18-10-12-32-13-11-18)37-26(23)27(31)33-17-34-37/h1-9,14-18,32H,10-13H2,(H,35,38)(H2,31,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396973 (US10442810, Example 35 | US10844069, Example 35 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCNCC1 Show InChI InChI=1S/C29H25F2N7O2/c30-18-3-6-20(7-4-18)37-13-1-2-22(29(37)40)28(39)36-19-5-8-21(24(31)14-19)23-15-25(17-9-11-33-12-10-17)38-26(23)27(32)34-16-35-38/h1-8,13-17,33H,9-12H2,(H,36,39)(H2,32,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396973 (US10442810, Example 35 | US10844069, Example 35 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCNCC1 Show InChI InChI=1S/C29H25F2N7O2/c30-18-3-6-20(7-4-18)37-13-1-2-22(29(37)40)28(39)36-19-5-8-21(24(31)14-19)23-15-25(17-9-11-33-12-10-17)38-26(23)27(32)34-16-35-38/h1-8,13-17,33H,9-12H2,(H,36,39)(H2,32,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396975 (US10442810, Example 37 | US10844069, Example 37 | ...) Show SMILES COC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C31H28FN7O4/c1-43-31(42)37-15-12-20(13-16-37)26-17-25(27-28(33)34-18-35-39(26)27)19-4-8-22(9-5-19)36-29(40)24-3-2-14-38(30(24)41)23-10-6-21(32)7-11-23/h2-11,14,17-18,20H,12-13,15-16H2,1H3,(H,36,40)(H2,33,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396975 (US10442810, Example 37 | US10844069, Example 37 | ...) Show SMILES COC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C31H28FN7O4/c1-43-31(42)37-15-12-20(13-16-37)26-17-25(27-28(33)34-18-35-39(26)27)19-4-8-22(9-5-19)36-29(40)24-3-2-14-38(30(24)41)23-10-6-21(32)7-11-23/h2-11,14,17-18,20H,12-13,15-16H2,1H3,(H,36,40)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396976 (US10442810, Example 38 | US10844069, Example 38 | ...) Show SMILES COC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C31H28FN7O4/c1-43-31(42)37-14-11-19(12-15-37)26-17-24(27-28(33)34-18-35-39(26)27)22-10-9-20(16-25(22)32)36-29(40)23-8-5-13-38(30(23)41)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,36,40)(H2,33,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396976 (US10442810, Example 38 | US10844069, Example 38 | ...) Show SMILES COC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C31H28FN7O4/c1-43-31(42)37-14-11-19(12-15-37)26-17-24(27-28(33)34-18-35-39(26)27)22-10-9-20(16-25(22)32)36-29(40)23-8-5-13-38(30(23)41)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,36,40)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396977 (US10442810, Example 39 | US10844069, Example 39 | ...) Show SMILES COC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C31H27F2N7O4/c1-44-31(43)38-13-10-18(11-14-38)26-16-24(27-28(34)35-17-36-40(26)27)22-9-6-20(15-25(22)33)37-29(41)23-3-2-12-39(30(23)42)21-7-4-19(32)5-8-21/h2-9,12,15-18H,10-11,13-14H2,1H3,(H,37,41)(H2,34,35,36)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396977 (US10442810, Example 39 | US10844069, Example 39 | ...) Show SMILES COC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C31H27F2N7O4/c1-44-31(43)38-13-10-18(11-14-38)26-16-24(27-28(34)35-17-36-40(26)27)22-9-6-20(15-25(22)33)37-29(41)23-3-2-12-39(30(23)42)21-7-4-19(32)5-8-21/h2-9,12,15-18H,10-11,13-14H2,1H3,(H,37,41)(H2,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396979 (US10442810, Example 41 | US10844069, Example 41 | ...) Show SMILES CS(=O)(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C30H28FN7O4S/c1-43(41,42)36-15-12-20(13-16-36)26-17-25(27-28(32)33-18-34-38(26)27)19-4-8-22(9-5-19)35-29(39)24-3-2-14-37(30(24)40)23-10-6-21(31)7-11-23/h2-11,14,17-18,20H,12-13,15-16H2,1H3,(H,35,39)(H2,32,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396979 (US10442810, Example 41 | US10844069, Example 41 | ...) Show SMILES CS(=O)(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C30H28FN7O4S/c1-43(41,42)36-15-12-20(13-16-36)26-17-25(27-28(32)33-18-34-38(26)27)19-4-8-22(9-5-19)35-29(39)24-3-2-14-37(30(24)40)23-10-6-21(31)7-11-23/h2-11,14,17-18,20H,12-13,15-16H2,1H3,(H,35,39)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396980 (US10442810, Example 42 | US10844069, Example 42 | ...) Show SMILES CS(=O)(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C30H28FN7O4S/c1-43(41,42)36-14-11-19(12-15-36)26-17-24(27-28(32)33-18-34-38(26)27)22-10-9-20(16-25(22)31)35-29(39)23-8-5-13-37(30(23)40)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,35,39)(H2,32,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396980 (US10442810, Example 42 | US10844069, Example 42 | ...) Show SMILES CS(=O)(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C30H28FN7O4S/c1-43(41,42)36-14-11-19(12-15-36)26-17-24(27-28(32)33-18-34-38(26)27)22-10-9-20(16-25(22)31)35-29(39)23-8-5-13-37(30(23)40)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,35,39)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396981 (US10442810, Example 43 | US10844069, Example 43 | ...) Show SMILES CS(=O)(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C30H27F2N7O4S/c1-44(42,43)37-13-10-18(11-14-37)26-16-24(27-28(33)34-17-35-39(26)27)22-9-6-20(15-25(22)32)36-29(40)23-3-2-12-38(30(23)41)21-7-4-19(31)5-8-21/h2-9,12,15-18H,10-11,13-14H2,1H3,(H,36,40)(H2,33,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396981 (US10442810, Example 43 | US10844069, Example 43 | ...) Show SMILES CS(=O)(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C30H27F2N7O4S/c1-44(42,43)37-13-10-18(11-14-37)26-16-24(27-28(33)34-17-35-39(26)27)22-9-6-20(15-25(22)32)36-29(40)23-3-2-12-38(30(23)41)21-7-4-19(31)5-8-21/h2-9,12,15-18H,10-11,13-14H2,1H3,(H,36,40)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396982 (US10442810, Example 44 | US10844069, Example 44 | ...) Show SMILES CN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C32H32N8O3/c1-37(2)32(43)38-17-14-22(15-18-38)27-19-26(28-29(33)34-20-35-40(27)28)21-10-12-23(13-11-21)36-30(41)25-9-6-16-39(31(25)42)24-7-4-3-5-8-24/h3-13,16,19-20,22H,14-15,17-18H2,1-2H3,(H,36,41)(H2,33,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396982 (US10442810, Example 44 | US10844069, Example 44 | ...) Show SMILES CN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C32H32N8O3/c1-37(2)32(43)38-17-14-22(15-18-38)27-19-26(28-29(33)34-20-35-40(27)28)21-10-12-23(13-11-21)36-30(41)25-9-6-16-39(31(25)42)24-7-4-3-5-8-24/h3-13,16,19-20,22H,14-15,17-18H2,1-2H3,(H,36,41)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396983 (US10442810, Example 45 | US10844069, Example 45 | ...) Show SMILES CN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C32H31FN8O3/c1-38(2)32(44)39-16-13-21(14-17-39)27-18-26(28-29(34)35-19-36-41(27)28)20-5-9-23(10-6-20)37-30(42)25-4-3-15-40(31(25)43)24-11-7-22(33)8-12-24/h3-12,15,18-19,21H,13-14,16-17H2,1-2H3,(H,37,42)(H2,34,35,36)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396983 (US10442810, Example 45 | US10844069, Example 45 | ...) Show SMILES CN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C32H31FN8O3/c1-38(2)32(44)39-16-13-21(14-17-39)27-18-26(28-29(34)35-19-36-41(27)28)20-5-9-23(10-6-20)37-30(42)25-4-3-15-40(31(25)43)24-11-7-22(33)8-12-24/h3-12,15,18-19,21H,13-14,16-17H2,1-2H3,(H,37,42)(H2,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396984 (US10442810, Example 46 | US10844069, Example 46 | ...) Show SMILES CN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C32H31FN8O3/c1-38(2)32(44)39-15-12-20(13-16-39)27-18-25(28-29(34)35-19-36-41(27)28)23-11-10-21(17-26(23)33)37-30(42)24-9-6-14-40(31(24)43)22-7-4-3-5-8-22/h3-11,14,17-20H,12-13,15-16H2,1-2H3,(H,37,42)(H2,34,35,36)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair

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