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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM1081 ((4R,5R,6R)-Tetrahydro-1,3-bis[(3-benzamide oxime)m...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet  | PC cid PC sid UniChem Similars | Article PubMed | 0.0180 | -63.8 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | J Med Chem 40: 1707-9 (1997) Article DOI: 10.1021/jm970081i BindingDB Entry DOI: 10.7270/Q2CR5RHB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM1080 ((4R,5R,6R)-Tetrahydro-1,3-bis[(3-benzamido)methyl]...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0880 | -59.7 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | J Med Chem 40: 1707-9 (1997) Article DOI: 10.1021/jm970081i BindingDB Entry DOI: 10.7270/Q2CR5RHB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM1090 ((4R,5R,6R)-1,3-bis[(3-amino-4-fluorophenyl)methyl]...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.25 | -57.0 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | J Med Chem 40: 1707-9 (1997) Article DOI: 10.1021/jm970081i BindingDB Entry DOI: 10.7270/Q2CR5RHB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM1089 ((4R,5R,6R)-4-benzyl-5-hydroxy-1,3-bis[(3-hydroxyph...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.300 | -56.5 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | J Med Chem 40: 1707-9 (1997) Article DOI: 10.1021/jm970081i BindingDB Entry DOI: 10.7270/Q2CR5RHB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM1079 ((4R,5R,6R)-4-benzyl-5-hydroxy-1,3-bis({[3-(hydroxy...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.490 | -55.3 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | J Med Chem 40: 1707-9 (1997) Article DOI: 10.1021/jm970081i BindingDB Entry DOI: 10.7270/Q2CR5RHB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM1093 ((4R,5R,6R)-Tetrahydro-1,3-bis[(4-fluoro-3-benzamid...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.40 | -52.6 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | J Med Chem 40: 1707-9 (1997) Article DOI: 10.1021/jm970081i BindingDB Entry DOI: 10.7270/Q2CR5RHB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM1078 ((4R,5R,6R)-Tetrahydro-1,3-bis[(3-carbomethoxypheny...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.5 | -52.4 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | J Med Chem 40: 1707-9 (1997) Article DOI: 10.1021/jm970081i BindingDB Entry DOI: 10.7270/Q2CR5RHB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM1091 ((4R,5R,6R)-1,3-bis[(3-aminophenyl)methyl]-4-benzyl...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.70 | -52.1 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | J Med Chem 40: 1707-9 (1997) Article DOI: 10.1021/jm970081i BindingDB Entry DOI: 10.7270/Q2CR5RHB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM1095 ((4R,5R,6R)-4-benzyl-5-hydroxy-1,3-bis({[4-(hydroxy...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 2.5 | -51.1 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | J Med Chem 40: 1707-9 (1997) Article DOI: 10.1021/jm970081i BindingDB Entry DOI: 10.7270/Q2CR5RHB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM1087 ((4R,5R,6R)-4-benzyl-1,3-bis(cyclopropylmethyl)-5-h...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 3.80 | -50.0 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | J Med Chem 40: 1707-9 (1997) Article DOI: 10.1021/jm970081i BindingDB Entry DOI: 10.7270/Q2CR5RHB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM1092 ((4R,5R,6R)-4-benzyl-5-hydroxy-1,3-bis({[3-(methyla...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 4.90 | -49.3 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | J Med Chem 40: 1707-9 (1997) Article DOI: 10.1021/jm970081i BindingDB Entry DOI: 10.7270/Q2CR5RHB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM1094 ((4R,5R,6R)-1,3-bis[(4-amino-3-fluorophenyl)methyl]...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 8 | -48.1 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | J Med Chem 40: 1707-9 (1997) Article DOI: 10.1021/jm970081i BindingDB Entry DOI: 10.7270/Q2CR5RHB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM1076 ((4R,5R,6R)-Tetrahydro-1,3-bis[(3-cyanophenyl)methy...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 11 | -47.3 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | J Med Chem 40: 1707-9 (1997) Article DOI: 10.1021/jm970081i BindingDB Entry DOI: 10.7270/Q2CR5RHB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM1088 ((4R,5R,6R)-1,3,4-tribenzyl-5-hydroxy-6-(2-phenylet...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 15 | -46.5 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | J Med Chem 40: 1707-9 (1997) Article DOI: 10.1021/jm970081i BindingDB Entry DOI: 10.7270/Q2CR5RHB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM1077 ((4S,5S,6S)-4-benzyl-5-hydroxy-1,3-bis({[3-(hydroxy...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 550 | -37.2 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | J Med Chem 40: 1707-9 (1997) Article DOI: 10.1021/jm970081i BindingDB Entry DOI: 10.7270/Q2CR5RHB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM1085 ((4S,5S,6S)-Tetrahydro-1,3-bis[(3-benzamide oxime)m...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 780 | -36.3 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | J Med Chem 40: 1707-9 (1997) Article DOI: 10.1021/jm970081i BindingDB Entry DOI: 10.7270/Q2CR5RHB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM1086 ((4R,5R,6R)-4-benzyl-5-hydroxy-6-(2-phenylethyl)-1,...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 970 | -35.7 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | J Med Chem 40: 1707-9 (1997) Article DOI: 10.1021/jm970081i BindingDB Entry DOI: 10.7270/Q2CR5RHB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM1096 ((4R,5R,6R)-Tetrahydro-1,3-bis[(4-carbomethoxypheny...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.97E+3 | -33.9 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | J Med Chem 40: 1707-9 (1997) Article DOI: 10.1021/jm970081i BindingDB Entry DOI: 10.7270/Q2CR5RHB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM1083 ((4S,5S,6S)-Tetrahydro-1,3-bis[(3-carbomethoxypheny...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 3.30E+3 | -32.5 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | J Med Chem 40: 1707-9 (1997) Article DOI: 10.1021/jm970081i BindingDB Entry DOI: 10.7270/Q2CR5RHB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM1084 ((4S,5S,6S)-Tetrahydro-1,3-bis[(3-benzamido)methyl]...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 4.80E+3 | -31.6 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | J Med Chem 40: 1707-9 (1997) Article DOI: 10.1021/jm970081i BindingDB Entry DOI: 10.7270/Q2CR5RHB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dimer of Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1) | BDBM1082 ((4S,5S,6S)-Tetrahydro-1,3-bis[(3-cyanophenyl)methy...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 8.00E+3 | -30.3 | n/a | n/a | n/a | n/a | n/a | 5.5 | 37 |
DuPont Merck Pharmaceutical Company | Assay Description Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-... | J Med Chem 40: 1707-9 (1997) Article DOI: 10.1021/jm970081i BindingDB Entry DOI: 10.7270/Q2CR5RHB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
