Compile Data Set for Download or QSAR

Found 130 hits Enz. Inhib. hit(s) with all data for entry = 425   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268528 (N-(6-cyclopropyl-7-((3,5-dichlorophenoxy)methyl)-[...) Show SMILES Clc1cc(Cl)cc(OCc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)c1 Show InChI InChI=1S/C19H18Cl2N4O3S/c20-13-6-14(21)8-15(7-13)28-10-12-5-18-22-23-19(24-29(26,27)16-3-4-16)25(18)9-17(12)11-1-2-11/h5-9,11,16H,1-4,10H2,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268599 (N-(6-cyclopropyl-7-((3,5,7-trimethyladamantan-1-yl...) Show SMILES CC12CC3(C)CC(C)(C1)CC(COc1cc4nnc(NS(C)(=O)=O)n4cc1C1CC1)(C2)C3 |TLB:11:10:5:2.1.8,7:6:2:10.30.31,THB:30:10:5:2.1.8,30:1:5:10.9.31,9:10:2:5.6.8,9:6:2:10.30.31| Show InChI InChI=1S/C24H34N4O3S/c1-21-9-22(2)11-23(3,10-21)14-24(12-21,13-22)15-31-18-7-19-25-26-20(27-32(4,29)30)28(19)8-17(18)16-5-6-16/h7-8,16H,5-6,9-15H2,1-4H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268528 (N-(6-cyclopropyl-7-((3,5-dichlorophenoxy)methyl)-[...) Show SMILES Clc1cc(Cl)cc(OCc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)c1 Show InChI InChI=1S/C19H18Cl2N4O3S/c20-13-6-14(21)8-15(7-13)28-10-12-5-18-22-23-19(24-29(26,27)16-3-4-16)25(18)9-17(12)11-1-2-11/h5-9,11,16H,1-4,10H2,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.05	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268519 (N-(7-((3-chloro-5-(trifluoromethoxy)phenoxy)methyl...) Show SMILES CS(=O)(=O)Nc1nnc2cc(COc3cc(Cl)cc(OC(F)(F)F)c3)c(cn12)C1CC1 Show InChI InChI=1S/C18H16ClF3N4O4S/c1-31(27,28)25-17-24-23-16-4-11(15(8-26(16)17)10-2-3-10)9-29-13-5-12(19)6-14(7-13)30-18(20,21)22/h4-8,10H,2-3,9H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268503 (N-(6-cyclopropyl-7-(((1S,2S,5S)-6,6-dimethylbicycl...) Show SMILES CC1(C)[C@@H]2C[C@H]1[C@@H](COc1cc3nnc(NS(C)(=O)=O)n3cc1C1CC1)CC2 |r| Show InChI InChI=1S/C20H28N4O3S/c1-20(2)14-7-6-13(16(20)8-14)11-27-17-9-18-21-22-19(23-28(3,25)26)24(18)10-15(17)12-4-5-12/h9-10,12-14,16H,4-8,11H2,1-3H3,(H,22,23)/t13-,14+,16+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268531 (N-(6-bromo-7-((3,4-dichlorophenoxy)methyl)-[1,2,4]...) Show SMILES CS(=O)(=O)Nc1nnc2cc(COc3ccc(Cl)c(Cl)c3)c(Br)cn12 Show InChI InChI=1S/C14H11BrCl2N4O3S/c1-25(22,23)20-14-19-18-13-4-8(10(15)6-21(13)14)7-24-9-2-3-11(16)12(17)5-9/h2-6H,7H2,1H3,(H,19,20)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268518 (N-(7-((3-chloro-5-(trifluoromethoxy)phenoxy)methyl...) Show SMILES FC(F)(F)Oc1cc(Cl)cc(OCc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)c1 Show InChI InChI=1S/C20H18ClF3N4O4S/c21-13-6-14(8-15(7-13)32-20(22,23)24)31-10-12-5-18-25-26-19(27-33(29,30)16-3-4-16)28(18)9-17(12)11-1-2-11/h5-9,11,16H,1-4,10H2,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.81	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268418 (N-(7-(adamantan-1-ylmethoxy)-6-ethyl-[1,2,4]triazo...) Show SMILES O=S(=O)(Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1)C1CC1 |TLB:21:12:19:15.17.16,11:12:19:15.17.16,THB:17:18:13:15.16.21,17:16:13:19.18.20,21:16:19:12.13.20| Show InChI InChI=1S/C23H30N4O3S/c28-31(29,18-3-4-18)26-22-25-24-21-8-20(19(12-27(21)22)17-1-2-17)30-13-23-9-14-5-15(10-23)7-16(6-14)11-23/h8,12,14-18H,1-7,9-11,13H2,(H,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	2.92	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268532 (N-(7-((1s,3s)-adamantan-1-ylmethoxy)-6-cyclopropyl...) Show SMILES O=S(=O)(Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1)C1CC1 |TLB:21:12:19:15.16.17,THB:21:16:19:12.20.13,20:12:15:19.18.17,20:18:15:12.21.13,11:12:19:15.16.17| Show InChI InChI=1S/C23H30N4O3S/c28-31(29,18-3-4-18)26-22-25-24-21-8-20(19(12-27(21)22)17-1-2-17)30-13-23-9-14-5-15(10-23)7-16(6-14)11-23/h8,12,14-18H,1-7,9-11,13H2,(H,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268527 (N-(6-cyclopropyl-7-((3,5-dichlorophenoxy)methyl)-[...) Show SMILES CS(=O)(=O)Nc1nnc2cc(COc3cc(Cl)cc(Cl)c3)c(cn12)C1CC1 Show InChI InChI=1S/C17H16Cl2N4O3S/c1-27(24,25)22-17-21-20-16-4-11(15(8-23(16)17)10-2-3-10)9-26-14-6-12(18)5-13(19)7-14/h4-8,10H,2-3,9H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268519 (N-(7-((3-chloro-5-(trifluoromethoxy)phenoxy)methyl...) Show SMILES CS(=O)(=O)Nc1nnc2cc(COc3cc(Cl)cc(OC(F)(F)F)c3)c(cn12)C1CC1 Show InChI InChI=1S/C18H16ClF3N4O4S/c1-31(27,28)25-17-24-23-16-4-11(15(8-26(16)17)10-2-3-10)9-29-13-5-12(19)6-14(7-13)30-18(20,21)22/h4-8,10H,2-3,9H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268518 (N-(7-((3-chloro-5-(trifluoromethoxy)phenoxy)methyl...) Show SMILES FC(F)(F)Oc1cc(Cl)cc(OCc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)c1 Show InChI InChI=1S/C20H18ClF3N4O4S/c21-13-6-14(8-15(7-13)32-20(22,23)24)31-10-12-5-18-25-26-19(27-33(29,30)16-3-4-16)28(18)9-17(12)11-1-2-11/h5-9,11,16H,1-4,10H2,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268504 (N-(6-cyclopropyl-7-(((1S,2S,5S)-6,6-dimethylbicycl...) Show SMILES CC1(C)[C@@H]2C[C@H]1[C@@H](COc1cc3nnc(NS(=O)(=O)C4CC4)n3cc1C1CC1)CC2 |r| Show InChI InChI=1S/C22H30N4O3S/c1-22(2)15-6-5-14(18(22)9-15)12-29-19-10-20-23-24-21(25-30(27,28)16-7-8-16)26(20)11-17(19)13-3-4-13/h10-11,13-16,18H,3-9,12H2,1-2H3,(H,24,25)/t14-,15+,18+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268551 (N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...) Show SMILES O=S(=O)(Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1)C1CCC1 |TLB:21:12:19:15.16.17,THB:21:16:19:20.13.12,20:18:15:21.13.12,20:12:15:19.18.17,11:12:19:15.16.17| Show InChI InChI=1S/C24H32N4O3S/c29-32(30,19-2-1-3-19)27-23-26-25-22-9-21(20(13-28(22)23)18-4-5-18)31-14-24-10-15-6-16(11-24)8-17(7-15)12-24/h9,13,15-19H,1-8,10-12,14H2,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268503 (N-(6-cyclopropyl-7-(((1S,2S,5S)-6,6-dimethylbicycl...) Show SMILES CC1(C)[C@@H]2C[C@H]1[C@@H](COc1cc3nnc(NS(C)(=O)=O)n3cc1C1CC1)CC2 |r| Show InChI InChI=1S/C20H28N4O3S/c1-20(2)14-7-6-13(16(20)8-14)11-27-17-9-18-21-22-19(23-28(3,25)26)24(18)10-15(17)12-4-5-12/h9-10,12-14,16H,4-8,11H2,1-3H3,(H,22,23)/t13-,14+,16+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268527 (N-(6-cyclopropyl-7-((3,5-dichlorophenoxy)methyl)-[...) Show SMILES CS(=O)(=O)Nc1nnc2cc(COc3cc(Cl)cc(Cl)c3)c(cn12)C1CC1 Show InChI InChI=1S/C17H16Cl2N4O3S/c1-27(24,25)22-17-21-20-16-4-11(15(8-23(16)17)10-2-3-10)9-26-14-6-12(18)5-13(19)7-14/h4-8,10H,2-3,9H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.15	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268504 (N-(6-cyclopropyl-7-(((1S,2S,5S)-6,6-dimethylbicycl...) Show SMILES CC1(C)[C@@H]2C[C@H]1[C@@H](COc1cc3nnc(NS(=O)(=O)C4CC4)n3cc1C1CC1)CC2 |r| Show InChI InChI=1S/C22H30N4O3S/c1-22(2)15-6-5-14(18(22)9-15)12-29-19-10-20-23-24-21(25-30(27,28)16-7-8-16)26(20)11-17(19)13-3-4-13/h10-11,13-16,18H,3-9,12H2,1-2H3,(H,24,25)/t14-,15+,18+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.39	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268423 (N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...) Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1 |TLB:22:13:20:16.18.17,16:17:21:15.20.14,THB:22:17:20:21.13.14,16:15:21:22.18.17,12:13:20:16.18.17| Show InChI InChI=1S/C21H28N4O3S/c1-29(26,27)24-20-23-22-19-7-18(17(11-25(19)20)16-2-3-16)28-12-21-8-13-4-14(9-21)6-15(5-13)10-21/h7,11,13-16H,2-6,8-10,12H2,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.69	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268501 (N-(6-cyclopropyl-7-(octahydro-1H-4,7-methanoinden-...) Show SMILES O=S(=O)(Nc1nnc2cc(OCC3CC4C5CCC(C5)C4C3)c(cn12)C1CC1)C1CC1 |TLB:13:14:16.17:19| Show InChI InChI=1S/C23H30N4O3S/c28-31(29,17-5-6-17)26-23-25-24-22-10-21(20(11-27(22)23)14-1-2-14)30-12-13-7-18-15-3-4-16(9-15)19(18)8-13/h10-11,13-19H,1-9,12H2,(H,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.71	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268525 (N-(7-((3-chloro-5-(trifluoromethoxy)phenoxy)methyl...) Show SMILES CC1(CC1)S(=O)(=O)Nc1nnc2cc(COc3cc(Cl)cc(OC(F)(F)F)c3)c(cn12)C1CC1 Show InChI InChI=1S/C21H20ClF3N4O4S/c1-20(4-5-20)34(30,31)28-19-27-26-18-6-13(17(10-29(18)19)12-2-3-12)11-32-15-7-14(22)8-16(9-15)33-21(23,24)25/h6-10,12H,2-5,11H2,1H3,(H,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.94	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268534 (N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...) Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1 |TLB:12:13:15.16.20:18,THB:21:19:16:22.13.14,21:13:16:20.18.19,14:15:18:22.21.13,14:13:15.16.20:18| Show InChI InChI=1S/C21H28N4O3S/c1-29(26,27)24-20-23-22-19-7-18(17(11-25(19)20)16-2-3-16)28-12-21-8-13-4-14(9-21)6-15(5-13)10-21/h7,11,13-16H,2-6,8-10,12H2,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268548 (N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...) Show SMILES CCS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1 |TLB:23:14:21:17.18.19,THB:23:18:21:22.15.14,22:20:17:23.15.14,22:14:17:21.20.19,13:14:21:17.18.19| Show InChI InChI=1S/C22H30N4O3S/c1-2-30(27,28)25-21-24-23-20-8-19(18(12-26(20)21)17-3-4-17)29-13-22-9-14-5-15(10-22)7-16(6-14)11-22/h8,12,14-17H,2-7,9-11,13H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268501 (N-(6-cyclopropyl-7-(octahydro-1H-4,7-methanoinden-...) Show SMILES O=S(=O)(Nc1nnc2cc(OCC3CC4C5CCC(C5)C4C3)c(cn12)C1CC1)C1CC1 |TLB:13:14:16.17:19| Show InChI InChI=1S/C23H30N4O3S/c28-31(29,17-5-6-17)26-23-25-24-22-10-21(20(11-27(22)23)14-1-2-14)30-12-13-7-18-15-3-4-16(9-15)19(18)8-13/h10-11,13-19H,1-9,12H2,(H,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268525 (N-(7-((3-chloro-5-(trifluoromethoxy)phenoxy)methyl...) Show SMILES CC1(CC1)S(=O)(=O)Nc1nnc2cc(COc3cc(Cl)cc(OC(F)(F)F)c3)c(cn12)C1CC1 Show InChI InChI=1S/C21H20ClF3N4O4S/c1-20(4-5-20)34(30,31)28-19-27-26-18-6-13(17(10-29(18)19)12-2-3-12)11-32-15-7-14(22)8-16(9-15)33-21(23,24)25/h6-10,12H,2-5,11H2,1H3,(H,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268490 (N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...) Show SMILES CCS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1 |TLB:23:14:21:17.18.19,THB:23:18:21:14.22.15,22:14:17:21.20.19,22:20:17:14.23.15,13:14:21:17.18.19| Show InChI InChI=1S/C22H30N4O3S/c1-2-30(27,28)25-21-24-23-20-8-19(18(12-26(20)21)17-3-4-17)29-13-22-9-14-5-15(10-22)7-16(6-14)11-22/h8,12,14-17H,2-7,9-11,13H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.26	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268526 (N-(6-cyclopropyl-7-((3,5-dichlorophenoxy)methyl)-[...) Show SMILES CC1(CC1)S(=O)(=O)Nc1nnc2cc(COc3cc(Cl)cc(Cl)c3)c(cn12)C1CC1 Show InChI InChI=1S/C20H20Cl2N4O3S/c1-20(4-5-20)30(27,28)25-19-24-23-18-6-13(17(10-26(18)19)12-2-3-12)11-29-16-8-14(21)7-15(22)9-16/h6-10,12H,2-5,11H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.87	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268526 (N-(6-cyclopropyl-7-((3,5-dichlorophenoxy)methyl)-[...) Show SMILES CC1(CC1)S(=O)(=O)Nc1nnc2cc(COc3cc(Cl)cc(Cl)c3)c(cn12)C1CC1 Show InChI InChI=1S/C20H20Cl2N4O3S/c1-20(4-5-20)30(27,28)25-19-24-23-18-6-13(17(10-26(18)19)12-2-3-12)11-29-16-8-14(21)7-15(22)9-16/h6-10,12H,2-5,11H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268500 (N-(6-cyclopropyl-7-(octahydro-1H-4,7-methanoinden-...) Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC3CC4C5CCC(C5)C4C3)c(cn12)C1CC1 |TLB:14:15:17.18:20| Show InChI InChI=1S/C21H28N4O3S/c1-29(26,27)24-21-23-22-20-9-19(18(10-25(20)21)13-2-3-13)28-11-12-6-16-14-4-5-15(8-14)17(16)7-12/h9-10,12-17H,2-8,11H2,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268500 (N-(6-cyclopropyl-7-(octahydro-1H-4,7-methanoinden-...) Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC3CC4C5CCC(C5)C4C3)c(cn12)C1CC1 |TLB:14:15:17.18:20| Show InChI InChI=1S/C21H28N4O3S/c1-29(26,27)24-21-23-22-20-9-19(18(10-25(20)21)13-2-3-13)28-11-12-6-16-14-4-5-15(8-14)17(16)7-12/h9-10,12-17H,2-8,11H2,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.24	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268514 (US9550775, 38 second compound) Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CCC1 |TLB:12:13:16:20.19.18,12:13:20:16.17.18,22:13:20:16.17.18,THB:22:17:20:13.21.14,21:13:16:20.19.18,21:19:16:13.22.14| Show InChI InChI=1S/C22H30N4O3S/c1-30(27,28)25-21-24-23-20-8-19(18(12-26(20)21)17-3-2-4-17)29-13-22-9-14-5-15(10-22)7-16(6-14)11-22/h8,12,14-17H,2-7,9-11,13H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.59	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268570 (US9550775, 93 - Second) Show SMILES CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CCC1 |TLB:22:13:20:16.17.18,12:13:16:20.19.18,12:13:20:16.17.18,THB:22:17:20:13.21.14,21:13:16:20.19.18,21:19:16:13.22.14| Show InChI InChI=1S/C22H30N4O3S/c1-30(27,28)25-21-24-23-20-8-19(18(12-26(20)21)17-3-2-4-17)29-13-22-9-14-5-15(10-22)7-16(6-14)11-22/h8,12,14-17H,2-7,9-11,13H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268524 (N-(7-((3-chloro-5-methylphenoxy)methyl)-6-cyclopro...) Show SMILES Cc1cc(Cl)cc(OCc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)c1 Show InChI InChI=1S/C20H21ClN4O3S/c1-12-6-15(21)9-16(7-12)28-11-14-8-19-22-23-20(24-29(26,27)17-4-5-17)25(19)10-18(14)13-2-3-13/h6-10,13,17H,2-5,11H2,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268524 (N-(7-((3-chloro-5-methylphenoxy)methyl)-6-cyclopro...) Show SMILES Cc1cc(Cl)cc(OCc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)c1 Show InChI InChI=1S/C20H21ClN4O3S/c1-12-6-15(21)9-16(7-12)28-11-14-8-19-22-23-20(24-29(26,27)17-4-5-17)25(19)10-18(14)13-2-3-13/h6-10,13,17H,2-5,11H2,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.33	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268505 (N-(6-cyclopropyl-7-(01S,2S,5S)-6,6-dimethylbicyclo...) Show SMILES CC1(C)[C@@H]2C[C@H]1[C@@H](COc1cc3nnc(NS(=O)(=O)N4CCC4)n3cc1C1CC1)CC2 |r| Show InChI InChI=1S/C22H31N5O3S/c1-22(2)16-7-6-15(18(22)10-16)13-30-19-11-20-23-24-21(25-31(28,29)26-8-3-9-26)27(20)12-17(19)14-4-5-14/h11-12,14-16,18H,3-10,13H2,1-2H3,(H,24,25)/t15-,16+,18+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.75	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268515 (N-(6-cyclopropyl-7-((3,4-dichlorophenoxy)methyl)-[...) Show SMILES Clc1ccc(OCc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)cc1Cl Show InChI InChI=1S/C19H18Cl2N4O3S/c20-16-6-3-13(8-17(16)21)28-10-12-7-18-22-23-19(24-29(26,27)14-4-5-14)25(18)9-15(12)11-1-2-11/h3,6-9,11,14H,1-2,4-5,10H2,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.83	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268523 (N-(7-((3-chloro-5-methylphenoxy)methyl)-6-cyclopro...) Show SMILES Cc1cc(Cl)cc(OCc2cc3nnc(NS(C)(=O)=O)n3cc2C2CC2)c1 Show InChI InChI=1S/C18H19ClN4O3S/c1-11-5-14(19)8-15(6-11)26-10-13-7-17-20-21-18(22-27(2,24)25)23(17)9-16(13)12-3-4-12/h5-9,12H,3-4,10H2,1-2H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268521 (N-(7-((4-chloro-3-(trifluoromethyl)phenoxy)methyl)...) Show SMILES CS(=O)(=O)Nc1nnc2cc(COc3ccc(Cl)c(c3)C(F)(F)F)c(cn12)C1CC1 Show InChI InChI=1S/C18H16ClF3N4O3S/c1-30(27,28)25-17-24-23-16-6-11(13(8-26(16)17)10-2-3-10)9-29-12-4-5-15(19)14(7-12)18(20,21)22/h4-8,10H,2-3,9H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268520 (N-(7-((3-chloro-5-(trifluoromethoxy)phenoxy)methyl...) Show SMILES FC(F)(F)Oc1cc(Cl)cc(OCc2cc3nnc(NS(=O)(=O)N4CCC4)n3cc2C2CC2)c1 Show InChI InChI=1S/C20H19ClF3N5O4S/c21-14-7-15(9-16(8-14)33-20(22,23)24)32-11-13-6-18-25-26-19(27-34(30,31)28-4-1-5-28)29(18)10-17(13)12-2-3-12/h6-10,12H,1-5,11H2,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268571 (N-(6-cyclopropyl-7-((3,4-dichlorophenoxy)methyl)-[...) Show SMILES Clc1ccc(COc2cc3nnc(NS(=O)(=O)C4CC4)n3cc2C2CC2)cc1Cl Show InChI InChI=1S/C19H18Cl2N4O3S/c20-15-6-1-11(7-16(15)21)10-28-17-8-18-22-23-19(24-29(26,27)13-4-5-13)25(18)9-14(17)12-2-3-12/h1,6-9,12-13H,2-5,10H2,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268505 (N-(6-cyclopropyl-7-(01S,2S,5S)-6,6-dimethylbicyclo...) Show SMILES CC1(C)[C@@H]2C[C@H]1[C@@H](COc1cc3nnc(NS(=O)(=O)N4CCC4)n3cc1C1CC1)CC2 |r| Show InChI InChI=1S/C22H31N5O3S/c1-22(2)16-7-6-15(18(22)10-16)13-30-19-11-20-23-24-21(25-31(28,29)26-8-3-9-26)27(20)12-17(19)14-4-5-14/h11-12,14-16,18H,3-10,13H2,1-2H3,(H,24,25)/t15-,16+,18+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268553 (N-(7-(2-((3r,5r,7r)-adamantan-1-yl)ethoxy)-6-cyclo...) Show SMILES O=S(=O)(Nc1nnc2cc(OCCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1)C1CC1 |TLB:22:13:20:16.17.18,12:13:16:20.19.18,THB:22:17:20:21.14.13,21:19:16:22.14.13,21:13:16:20.19.18| Show InChI InChI=1S/C24H32N4O3S/c29-32(30,19-3-4-19)27-23-26-25-22-10-21(20(14-28(22)23)18-1-2-18)31-6-5-24-11-15-7-16(12-24)9-17(8-15)13-24/h10,14-19H,1-9,11-13H2,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268550 (N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...) Show SMILES CC1(CC1)S(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1 |TLB:25:16:23:19.20.21,THB:25:20:23:24.17.16,24:22:19:25.17.16,24:16:19:23.22.21,15:16:23:19.20.21| Show InChI InChI=1S/C24H32N4O3S/c1-23(4-5-23)32(29,30)27-22-26-25-21-9-20(19(13-28(21)22)18-2-3-18)31-14-24-10-15-6-16(11-24)8-17(7-15)12-24/h9,13,15-18H,2-8,10-12,14H2,1H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268521 (N-(7-((4-chloro-3-(trifluoromethyl)phenoxy)methyl)...) Show SMILES CS(=O)(=O)Nc1nnc2cc(COc3ccc(Cl)c(c3)C(F)(F)F)c(cn12)C1CC1 Show InChI InChI=1S/C18H16ClF3N4O3S/c1-30(27,28)25-17-24-23-16-6-11(13(8-26(16)17)10-2-3-10)9-29-12-4-5-15(19)14(7-12)18(20,21)22/h4-8,10H,2-3,9H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.15	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268493 (N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...) Show SMILES CC1(CC1)S(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1 |TLB:25:16:23:19.20.21,THB:25:20:23:16.24.17,24:16:19:23.22.21,24:22:19:16.25.17,15:16:23:19.20.21| Show InChI InChI=1S/C24H32N4O3S/c1-23(4-5-23)32(29,30)27-22-26-25-21-9-20(19(13-28(21)22)18-2-3-18)31-14-24-10-15-6-16(11-24)8-17(7-15)12-24/h9,13,15-18H,2-8,10-12,14H2,1H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.19	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268523 (N-(7-((3-chloro-5-methylphenoxy)methyl)-6-cyclopro...) Show SMILES Cc1cc(Cl)cc(OCc2cc3nnc(NS(C)(=O)=O)n3cc2C2CC2)c1 Show InChI InChI=1S/C18H19ClN4O3S/c1-11-5-14(19)8-15(6-11)26-10-13-7-17-20-21-18(22-27(2,24)25)23(17)9-16(13)12-3-4-12/h5-9,12H,3-4,10H2,1-2H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.29	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268520 (N-(7-((3-chloro-5-(trifluoromethoxy)phenoxy)methyl...) Show SMILES FC(F)(F)Oc1cc(Cl)cc(OCc2cc3nnc(NS(=O)(=O)N4CCC4)n3cc2C2CC2)c1 Show InChI InChI=1S/C20H19ClF3N5O4S/c21-14-7-15(9-16(8-14)33-20(22,23)24)32-11-13-6-18-25-26-19(27-34(30,31)28-4-1-5-28)29(18)10-17(13)12-2-3-12/h6-10,12H,1-5,11H2,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.33	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268497 (N-(7-(2-adamantan-1-yl)ethoxy)-6-cyclopropyl-[1,2,...) Show SMILES O=S(=O)(Nc1nnc2cc(OCCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1)C1CC1 |TLB:22:13:20:16.17.18,12:13:16:20.19.18,THB:22:17:20:13.21.14,21:13:16:20.19.18,21:19:16:13.22.14| Show InChI InChI=1S/C24H32N4O3S/c29-32(30,19-3-4-19)27-23-26-25-22-10-21(20(14-28(22)23)18-1-2-18)31-6-5-24-11-15-7-16(12-24)9-17(8-15)13-24/h10,14-19H,1-9,11-13H2,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.35	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268495 (N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...) Show SMILES O=S(=O)(Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1)C1CCC1 |TLB:21:12:19:15.16.17,THB:21:16:19:12.20.13,20:12:15:19.18.17,20:18:15:12.21.13,11:12:19:15.16.17| Show InChI InChI=1S/C24H32N4O3S/c29-32(30,19-2-1-3-19)27-23-26-25-22-9-21(20(13-28(22)23)18-4-5-18)31-14-24-10-15-6-16(11-24)8-17(7-15)12-24/h9,13,15-19H,1-8,10-12,14H2,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.54	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268516 (N-(6-cyclopropyl-7-((3,4-dichlorophenoxy)methyl)-[...) Show SMILES CS(=O)(=O)Nc1nnc2cc(COc3ccc(Cl)c(Cl)c3)c(cn12)C1CC1 Show InChI InChI=1S/C17H16Cl2N4O3S/c1-27(24,25)22-17-21-20-16-6-11(13(8-23(16)17)10-2-3-10)9-26-12-4-5-14(18)15(19)7-12/h4-8,10H,2-3,9H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.54	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM268492 (N-[6-cyclopropyl-7-(tricyclo[3.3.1.13,7]dec-1-ylme...) Show SMILES CNS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(cn12)C1CC1 |TLB:23:14:21:17.18.19,THB:23:18:21:14.22.15,22:14:17:21.20.19,22:20:17:14.23.15,13:14:21:17.18.19| Show InChI InChI=1S/C21H29N5O3S/c1-22-30(27,28)25-20-24-23-19-7-18(17(11-26(19)20)16-2-3-16)29-12-21-8-13-4-14(9-21)6-15(5-13)10-21/h7,11,13-16,22H,2-6,8-10,12H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.78	n/a	n/a	n/a	n/a	7.2	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9550775 (2017) BindingDB Entry DOI: 10.7270/Q20C4XRZ
					More data for this Ligand-Target Pair

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