Compile Data Set for Download or QSAR

Found 82 hits Enz. Inhib. hit(s) with all data for entry = 43   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102160 (US9695165, 9) Show SMILES CCn1c2cc(ncc2cc(-c2cc(ccc2Cl)C(=O)NOC)c1=O)-c1ccccc1NC(=O)C=C Show InChI InChI=1S/C27H23ClN4O4/c1-4-25(33)30-22-9-7-6-8-18(22)23-14-24-17(15-29-23)13-20(27(35)32(24)5-2)19-12-16(10-11-21(19)28)26(34)31-36-3/h4,6-15H,1,5H2,2-3H3,(H,30,33)(H,31,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103873 (US9695165, 56) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1nc2cnc(cc2n(C2CCCC2)c1=O)-c1ccc2OCCN(C(=O)C=C)c2c1 |(3.85,9.24,;3.85,7.7,;2.52,6.93,;1.18,7.7,;-.15,6.93,;-1.48,7.7,;-2.82,6.93,;-.15,5.39,;-1.48,4.62,;1.18,4.62,;2.52,5.39,;3.85,4.62,;1.18,3.08,;2.52,2.31,;2.52,.77,;3.85,,;3.85,-1.54,;2.52,-2.31,;1.18,-1.54,;1.18,,;-.15,.77,;-1.48,,;-2.95,.48,;-3.85,-.77,;-2.95,-2.02,;-1.48,-1.54,;-.15,2.31,;-1.48,3.08,;2.52,-3.85,;3.85,-4.62,;3.85,-6.16,;2.52,-6.93,;2.52,-8.47,;1.18,-9.24,;-.15,-8.47,;-.15,-6.93,;-1.48,-6.16,;-1.48,-4.62,;-2.82,-6.93,;-2.82,-8.47,;1.18,-6.16,;1.18,-4.62,)| Show InChI InChI=1S/C31H28Cl2N4O5/c1-4-26(38)36-11-12-42-23-10-9-17(13-22(23)36)19-14-21-20(16-34-19)35-30(31(39)37(21)18-7-5-6-8-18)27-28(32)24(40-2)15-25(41-3)29(27)33/h4,9-10,13-16,18H,1,5-8,11-12H2,2-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102180 (US9695165, 12) Show SMILES CCn1c2cc(ncc2cc(-c2cc(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1F Show InChI InChI=1S/C27H23ClFN3O4/c1-5-25(33)31-16-7-8-21(29)20(10-16)22-13-23-15(14-30-22)9-19(27(34)32(23)6-2)18-11-17(35-3)12-24(36-4)26(18)28/h5,7-14H,1,6H2,2-4H3,(H,31,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM102180 (US9695165, 12) Show SMILES CCn1c2cc(ncc2cc(-c2cc(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1F Show InChI InChI=1S/C27H23ClFN3O4/c1-5-25(33)31-16-7-8-21(29)20(10-16)22-13-23-15(14-30-22)9-19(27(34)32(23)6-2)18-11-17(35-3)12-24(36-4)26(18)28/h5,7-14H,1,6H2,2-4H3,(H,31,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102207 (US9695165, 17) Show SMILES COc1cc(OC)c(F)c(c1F)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F |(-2,10.01,;-2,8.47,;-.67,7.7,;.67,8.47,;2,7.7,;3.33,8.47,;4.67,7.7,;2,6.16,;3.33,5.39,;.67,5.39,;-.67,6.16,;-2,5.39,;.67,3.85,;-.67,3.08,;-.67,1.54,;-2,.77,;-2,-.77,;-.67,-1.54,;.67,-.77,;.67,.77,;2,1.54,;3.33,.77,;3.33,-.77,;4.67,1.54,;2,3.08,;3.33,3.85,;-.67,-3.08,;-2,-3.85,;-2,-5.39,;-3.33,-6.16,;-3.33,-7.7,;-2,-8.47,;-4.67,-8.47,;-4.67,-10.01,;-.67,-6.16,;.67,-5.39,;.67,-3.85,;2,-3.08,)| Show InChI InChI=1S/C28H24F3N3O4/c1-6-24(35)33-16-7-8-19(29)17(10-16)20-11-21-15(13-32-20)9-18(28(36)34(21)14(2)3)25-26(30)22(37-4)12-23(38-5)27(25)31/h6-14H,1H2,2-5H3,(H,33,35)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM102207 (US9695165, 17) Show SMILES COc1cc(OC)c(F)c(c1F)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F |(-2,10.01,;-2,8.47,;-.67,7.7,;.67,8.47,;2,7.7,;3.33,8.47,;4.67,7.7,;2,6.16,;3.33,5.39,;.67,5.39,;-.67,6.16,;-2,5.39,;.67,3.85,;-.67,3.08,;-.67,1.54,;-2,.77,;-2,-.77,;-.67,-1.54,;.67,-.77,;.67,.77,;2,1.54,;3.33,.77,;3.33,-.77,;4.67,1.54,;2,3.08,;3.33,3.85,;-.67,-3.08,;-2,-3.85,;-2,-5.39,;-3.33,-6.16,;-3.33,-7.7,;-2,-8.47,;-4.67,-8.47,;-4.67,-10.01,;-.67,-6.16,;.67,-5.39,;.67,-3.85,;2,-3.08,)| Show InChI InChI=1S/C28H24F3N3O4/c1-6-24(35)33-16-7-8-19(29)17(10-16)20-11-21-15(13-32-20)9-18(28(36)34(21)14(2)3)25-26(30)22(37-4)12-23(38-5)27(25)31/h6-14H,1H2,2-5H3,(H,33,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102213 (US9695165, 18) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1cc2N(CCc2cc1F)C(=O)C=C Show InChI InChI=1S/C27H20Cl2FN3O3/c1-4-23(34)33-8-7-14-10-18(30)17(11-20(14)33)27-31-13-16-9-15(5-6-19(16)32-27)24-25(28)21(35-2)12-22(36-3)26(24)29/h4-6,9-13H,1,7-8H2,2-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102217 (US9695165, 19) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccccc1NC(=O)C=C |(-6,-.38,;-4.67,-1.15,;-3.33,-.38,;-2,-1.15,;-2,-2.69,;-.67,-3.47,;.67,-2.69,;.67,-1.15,;-.67,-.38,;-.67,1.15,;-2,1.93,;-2,3.47,;-.67,4.23,;.67,3.47,;-.67,5.78,;.67,6.54,;2,5.78,;-2,6.54,;-3.33,5.78,;-4.67,6.54,;-4.67,8.08,;-3.33,4.23,;-4.67,3.47,;-3.33,1.15,;-4.67,1.93,;-.67,-5,;-2,-5.78,;-2,-7.31,;-.67,-8.08,;.67,-7.31,;.67,-5.78,;2,-5,;3.33,-5.77,;3.33,-7.31,;4.67,-5,;6,-5.77,)| Show InChI InChI=1S/C27H23Cl2N3O4/c1-5-23(33)31-18-10-8-7-9-16(18)19-12-20-15(14-30-19)11-17(27(34)32(20)6-2)24-25(28)21(35-3)13-22(36-4)26(24)29/h5,7-14H,1,6H2,2-4H3,(H,31,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102218 (US9695165, 20) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cccc(NC(=O)C=C)c1 |(6,-.39,;4.67,-1.16,;3.33,-.39,;2,-1.16,;2,-2.7,;.67,-3.47,;-.67,-2.7,;-.67,-1.16,;.67,-.39,;.67,1.15,;2,1.92,;2,3.46,;.67,4.23,;-.67,3.46,;.67,5.77,;-.67,6.54,;-2,5.77,;2,6.54,;3.33,5.77,;4.67,6.55,;4.67,8.09,;3.33,4.23,;4.67,3.47,;3.33,1.15,;4.67,1.92,;.67,-5.01,;2,-5.78,;2,-7.32,;.67,-8.09,;-.67,-7.32,;-2,-8.09,;-3.33,-7.32,;-3.33,-5.78,;-4.67,-8.09,;-6,-7.32,;-.67,-5.78,)| Show InChI InChI=1S/C27H23Cl2N3O4/c1-5-23(33)31-17-9-7-8-15(10-17)19-12-20-16(14-30-19)11-18(27(34)32(20)6-2)24-25(28)21(35-3)13-22(36-4)26(24)29/h5,7-14H,1,6H2,2-4H3,(H,31,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM102218 (US9695165, 20) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cccc(NC(=O)C=C)c1 |(6,-.39,;4.67,-1.16,;3.33,-.39,;2,-1.16,;2,-2.7,;.67,-3.47,;-.67,-2.7,;-.67,-1.16,;.67,-.39,;.67,1.15,;2,1.92,;2,3.46,;.67,4.23,;-.67,3.46,;.67,5.77,;-.67,6.54,;-2,5.77,;2,6.54,;3.33,5.77,;4.67,6.55,;4.67,8.09,;3.33,4.23,;4.67,3.47,;3.33,1.15,;4.67,1.92,;.67,-5.01,;2,-5.78,;2,-7.32,;.67,-8.09,;-.67,-7.32,;-2,-8.09,;-3.33,-7.32,;-3.33,-5.78,;-4.67,-8.09,;-6,-7.32,;-.67,-5.78,)| Show InChI InChI=1S/C27H23Cl2N3O4/c1-5-23(33)31-17-9-7-8-15(10-17)19-12-20-16(14-30-19)11-18(27(34)32(20)6-2)24-25(28)21(35-3)13-22(36-4)26(24)29/h5,7-14H,1,6H2,2-4H3,(H,31,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102219 (US9695165, 21) Show SMILES CCn1c2cc(ncc2cc(-c2c(F)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1F |(4,1.54,;2.67,.77,;1.33,1.54,;,.77,;,-.77,;-1.33,-1.54,;-2.67,-.77,;-2.67,.77,;-1.33,1.54,;-1.33,3.08,;,3.85,;,5.39,;-1.33,6.16,;-2.67,5.39,;-1.33,7.7,;-2.67,8.47,;-4,7.7,;,8.47,;1.33,7.7,;2.67,8.47,;2.67,10.01,;1.33,6.16,;2.67,5.39,;1.33,3.08,;2.67,3.85,;-1.33,-3.08,;,-3.85,;,-5.39,;1.33,-6.16,;1.33,-7.7,;,-8.47,;2.67,-8.47,;2.67,-10.01,;-1.33,-6.16,;-2.67,-5.39,;-2.67,-3.85,;-4,-3.08,)| Show InChI InChI=1S/C27H22ClF2N3O4/c1-5-23(34)32-15-7-8-18(29)16(10-15)19-11-20-14(13-31-19)9-17(27(35)33(20)6-2)24-25(28)21(36-3)12-22(37-4)26(24)30/h5,7-13H,1,6H2,2-4H3,(H,32,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM102219 (US9695165, 21) Show SMILES CCn1c2cc(ncc2cc(-c2c(F)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1F |(4,1.54,;2.67,.77,;1.33,1.54,;,.77,;,-.77,;-1.33,-1.54,;-2.67,-.77,;-2.67,.77,;-1.33,1.54,;-1.33,3.08,;,3.85,;,5.39,;-1.33,6.16,;-2.67,5.39,;-1.33,7.7,;-2.67,8.47,;-4,7.7,;,8.47,;1.33,7.7,;2.67,8.47,;2.67,10.01,;1.33,6.16,;2.67,5.39,;1.33,3.08,;2.67,3.85,;-1.33,-3.08,;,-3.85,;,-5.39,;1.33,-6.16,;1.33,-7.7,;,-8.47,;2.67,-8.47,;2.67,-10.01,;-1.33,-6.16,;-2.67,-5.39,;-2.67,-3.85,;-4,-3.08,)| Show InChI InChI=1S/C27H22ClF2N3O4/c1-5-23(34)32-15-7-8-18(29)16(10-15)19-11-20-14(13-31-19)9-17(27(35)33(20)6-2)24-25(28)21(36-3)12-22(37-4)26(24)30/h5,7-13H,1,6H2,2-4H3,(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102229 (US9695165, 23) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C)c1=O)-c1cc(NC(=O)C=C)ccc1F |(-2,10.01,;-2,8.47,;-.67,7.7,;.67,8.47,;2,7.7,;3.33,8.47,;4.67,7.7,;2,6.16,;3.33,5.39,;.67,5.39,;-.67,6.16,;-2,5.39,;.67,3.85,;-.67,3.08,;-.67,1.54,;-2,.77,;-2,-.77,;-.67,-1.54,;.67,-.77,;.67,.77,;2,1.54,;3.33,.77,;2,3.08,;3.33,3.85,;-.67,-3.08,;-2,-3.85,;-2,-5.39,;-3.33,-6.16,;-3.33,-7.7,;-2,-8.47,;-4.67,-8.47,;-4.67,-10.01,;-.67,-6.16,;.67,-5.39,;.67,-3.85,;2,-3.08,)| Show InChI InChI=1S/C26H20Cl2FN3O4/c1-5-22(33)31-14-6-7-17(29)15(9-14)18-10-19-13(12-30-18)8-16(26(34)32(19)2)23-24(27)20(35-3)11-21(36-4)25(23)28/h5-12H,1H2,2-4H3,(H,31,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102277 (US9695165, 25) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1ccccc1NC(=O)C=C |(-4,8.09,;-4,6.54,;-2.67,5.77,;-1.33,6.54,;,5.77,;1.33,6.55,;2.67,5.78,;,4.23,;1.33,3.47,;-1.33,3.46,;-2.67,4.23,;-4,3.46,;-1.33,1.92,;-2.67,1.15,;-2.67,-.39,;-4,-1.16,;-4,-2.7,;-2.67,-3.47,;-1.33,-2.7,;-1.33,-1.16,;,-.39,;1.33,-1.16,;2.67,-.38,;1.33,-2.69,;,1.15,;1.33,1.92,;-2.67,-5.01,;-4,-5.78,;-4,-7.32,;-2.67,-8.09,;-1.33,-7.32,;-1.33,-5.78,;,-5,;1.33,-5.77,;1.33,-7.31,;2.67,-5,;4,-5.77,)| Show InChI InChI=1S/C28H25Cl2N3O4/c1-6-24(34)32-19-10-8-7-9-17(19)20-12-21-16(14-31-20)11-18(28(35)33(21)15(2)3)25-26(29)22(36-4)13-23(37-5)27(25)30/h6-15H,1H2,2-5H3,(H,32,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103607 (US9695165, 28) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1cc2N(CCOc2cc1F)C(=O)C=C Show InChI InChI=1S/C27H20Cl2FN3O4/c1-4-23(34)33-7-8-37-20-11-17(30)16(10-19(20)33)27-31-13-15-9-14(5-6-18(15)32-27)24-25(28)21(35-2)12-22(36-3)26(24)29/h4-6,9-13H,1,7-8H2,2-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103847 (US9695165, 30 | US9695165, 31) Show SMILES CCn1c2nc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1F |(4,1.54,;2.67,.77,;1.33,1.54,;,.77,;,-.77,;-1.33,-1.54,;-2.67,-.77,;-2.67,.77,;-1.33,1.54,;-1.33,3.08,;,3.85,;,5.39,;-1.33,6.16,;-2.67,5.39,;-1.33,7.7,;-2.67,8.47,;-4,7.7,;,8.47,;1.33,7.7,;2.67,8.47,;2.67,10.01,;1.33,6.16,;2.67,5.39,;1.33,3.08,;2.67,3.85,;-1.33,-3.08,;,-3.85,;,-5.39,;1.33,-6.16,;1.33,-7.7,;,-8.47,;2.67,-8.47,;2.67,-10.01,;-1.33,-6.16,;-2.67,-5.39,;-2.67,-3.85,;-4,-3.08,)| Show InChI InChI=1S/C26H21Cl2FN4O4/c1-5-20(34)31-14-7-8-17(29)15(10-14)24-30-12-13-9-16(26(35)33(6-2)25(13)32-24)21-22(27)18(36-3)11-19(37-4)23(21)28/h5,7-12H,1,6H2,2-4H3,(H,31,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM103847 (US9695165, 30 | US9695165, 31) Show SMILES CCn1c2nc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1F |(4,1.54,;2.67,.77,;1.33,1.54,;,.77,;,-.77,;-1.33,-1.54,;-2.67,-.77,;-2.67,.77,;-1.33,1.54,;-1.33,3.08,;,3.85,;,5.39,;-1.33,6.16,;-2.67,5.39,;-1.33,7.7,;-2.67,8.47,;-4,7.7,;,8.47,;1.33,7.7,;2.67,8.47,;2.67,10.01,;1.33,6.16,;2.67,5.39,;1.33,3.08,;2.67,3.85,;-1.33,-3.08,;,-3.85,;,-5.39,;1.33,-6.16,;1.33,-7.7,;,-8.47,;2.67,-8.47,;2.67,-10.01,;-1.33,-6.16,;-2.67,-5.39,;-2.67,-3.85,;-4,-3.08,)| Show InChI InChI=1S/C26H21Cl2FN4O4/c1-5-20(34)31-14-7-8-17(29)15(10-14)24-30-12-13-9-16(26(35)33(6-2)25(13)32-24)21-22(27)18(36-3)11-19(37-4)23(21)28/h5,7-12H,1,6H2,2-4H3,(H,31,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103849 (US9695165, 32) Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cc(NC(=O)C=C)ccc1F)c1c(Cl)c(OC)cc(OC)c1Cl Show InChI InChI=1S/C26H23Cl2FN4O4/c1-5-22(34)31-15-7-8-17(29)16(9-15)18-10-19-14(12-30-18)13-33(26(35)32(19)6-2)25-23(27)20(36-3)11-21(37-4)24(25)28/h5,7-12H,1,6,13H2,2-4H3,(H,31,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103852 (US9695165, 35) Show SMILES CCn1c2nc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccc2CCN(C(=O)C=C)c2c1 |(5.19,.45,;3.86,-.32,;2.53,.45,;1.19,-.32,;1.19,-1.86,;-.14,-2.63,;-1.47,-1.86,;-1.47,-.32,;-.14,.45,;-.14,1.99,;1.19,2.76,;1.19,4.3,;-.14,5.07,;-1.47,4.3,;-.14,6.61,;-1.47,7.38,;-2.81,6.61,;1.19,7.38,;2.53,6.61,;3.86,7.38,;3.86,8.92,;2.53,5.07,;3.86,4.3,;2.53,1.99,;3.86,2.76,;-.14,-4.17,;1.19,-4.94,;1.19,-6.48,;-.14,-7.25,;-.46,-8.76,;-1.99,-8.92,;-2.62,-7.51,;-4.11,-7.11,;-5.19,-8.2,;-4.5,-5.63,;-3.42,-4.54,;-1.47,-6.48,;-1.47,-4.94,)| Show InChI InChI=1S/C28H24Cl2N4O4/c1-5-22(35)34-10-9-15-7-8-16(12-19(15)34)26-31-14-17-11-18(28(36)33(6-2)27(17)32-26)23-24(29)20(37-3)13-21(38-4)25(23)30/h5,7-8,11-14H,1,6,9-10H2,2-4H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103854 (US9695165, 37) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C)c1=O)-c1ccc2OCCN(C(=O)C=C)c2c1 |(-3.33,9.24,;-3.33,7.7,;-2,6.93,;-.67,7.7,;.67,6.93,;2,7.7,;3.33,6.93,;.67,5.39,;2,4.62,;-.67,4.62,;-2,5.39,;-3.33,4.62,;-.67,3.08,;-2,2.31,;-2,.77,;-3.33,,;-3.33,-1.54,;-2,-2.31,;-.67,-1.54,;-.67,,;.67,.77,;2,,;.67,2.31,;2,3.08,;-2,-3.85,;-3.33,-4.62,;-3.33,-6.16,;-2,-6.93,;-2,-8.47,;-.67,-9.24,;.67,-8.47,;.67,-6.93,;2,-6.16,;2,-4.62,;3.33,-6.93,;3.33,-8.47,;-.67,-6.16,;-.67,-4.62,)| Show InChI InChI=1S/C28H23Cl2N3O5/c1-5-24(34)33-8-9-38-21-7-6-15(11-20(21)33)18-12-19-16(14-31-18)10-17(28(35)32(19)2)25-26(29)22(36-3)13-23(37-4)27(25)30/h5-7,10-14H,1,8-9H2,2-4H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103856 (US9695165, 39) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1OC |(4.67,1.54,;3.33,.77,;2,1.54,;.67,.77,;.67,-.77,;-.67,-1.54,;-2,-.77,;-2,.77,;-.67,1.54,;-.67,3.08,;.67,3.85,;.67,5.39,;-.67,6.16,;-2,5.39,;-.67,7.7,;-2,8.47,;-3.33,7.7,;.67,8.47,;2,7.7,;3.33,8.47,;3.33,10.01,;2,6.16,;3.33,5.39,;2,3.08,;3.33,3.85,;-.67,-3.08,;.67,-3.85,;.67,-5.39,;2,-6.16,;2,-7.7,;.67,-8.47,;3.33,-8.47,;3.33,-10.01,;-.67,-6.16,;-2,-5.39,;-2,-3.85,;-3.33,-3.08,;-4.67,-3.85,)| Show InChI InChI=1S/C28H25Cl2N3O5/c1-6-24(34)32-16-8-9-21(36-3)17(11-16)19-12-20-15(14-31-19)10-18(28(35)33(20)7-2)25-26(29)22(37-4)13-23(38-5)27(25)30/h6,8-14H,1,7H2,2-5H3,(H,32,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM103856 (US9695165, 39) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1OC |(4.67,1.54,;3.33,.77,;2,1.54,;.67,.77,;.67,-.77,;-.67,-1.54,;-2,-.77,;-2,.77,;-.67,1.54,;-.67,3.08,;.67,3.85,;.67,5.39,;-.67,6.16,;-2,5.39,;-.67,7.7,;-2,8.47,;-3.33,7.7,;.67,8.47,;2,7.7,;3.33,8.47,;3.33,10.01,;2,6.16,;3.33,5.39,;2,3.08,;3.33,3.85,;-.67,-3.08,;.67,-3.85,;.67,-5.39,;2,-6.16,;2,-7.7,;.67,-8.47,;3.33,-8.47,;3.33,-10.01,;-.67,-6.16,;-2,-5.39,;-2,-3.85,;-3.33,-3.08,;-4.67,-3.85,)| Show InChI InChI=1S/C28H25Cl2N3O5/c1-6-24(34)32-16-8-9-21(36-3)17(11-16)19-12-20-15(14-31-19)10-18(28(35)33(20)7-2)25-26(29)22(37-4)13-23(38-5)27(25)30/h6,8-14H,1,7H2,2-5H3,(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103857 (US9695165, 40) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F |(-2,10.01,;-2,8.47,;-.67,7.7,;.67,8.47,;2,7.7,;3.33,8.47,;4.67,7.7,;2,6.16,;3.33,5.39,;.67,5.39,;-.67,6.16,;-2,5.39,;.67,3.85,;-.67,3.08,;-.67,1.54,;-2,.77,;-2,-.77,;-.67,-1.54,;.67,-.77,;.67,.77,;2,1.54,;3.33,.77,;4.67,1.54,;3.33,-.77,;2,3.08,;3.33,3.85,;-.67,-3.08,;-2,-3.85,;-2,-5.39,;-3.33,-6.16,;-3.33,-7.7,;-2,-8.47,;-4.67,-8.47,;-4.67,-10.01,;-.67,-6.16,;.67,-5.39,;.67,-3.85,;2,-3.08,)| Show InChI InChI=1S/C28H24Cl2FN3O4/c1-6-24(35)33-16-7-8-19(31)17(10-16)20-11-21-15(13-32-20)9-18(28(36)34(21)14(2)3)25-26(29)22(37-4)12-23(38-5)27(25)30/h6-14H,1H2,2-5H3,(H,33,35)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM103857 (US9695165, 40) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F |(-2,10.01,;-2,8.47,;-.67,7.7,;.67,8.47,;2,7.7,;3.33,8.47,;4.67,7.7,;2,6.16,;3.33,5.39,;.67,5.39,;-.67,6.16,;-2,5.39,;.67,3.85,;-.67,3.08,;-.67,1.54,;-2,.77,;-2,-.77,;-.67,-1.54,;.67,-.77,;.67,.77,;2,1.54,;3.33,.77,;4.67,1.54,;3.33,-.77,;2,3.08,;3.33,3.85,;-.67,-3.08,;-2,-3.85,;-2,-5.39,;-3.33,-6.16,;-3.33,-7.7,;-2,-8.47,;-4.67,-8.47,;-4.67,-10.01,;-.67,-6.16,;.67,-5.39,;.67,-3.85,;2,-3.08,)| Show InChI InChI=1S/C28H24Cl2FN3O4/c1-6-24(35)33-16-7-8-19(31)17(10-16)20-11-21-15(13-32-20)9-18(28(36)34(21)14(2)3)25-26(29)22(37-4)12-23(38-5)27(25)30/h6-14H,1H2,2-5H3,(H,33,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103858 (US9695165, 41) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)cc(F)c1F |(4,1.54,;2.67,.77,;1.33,1.54,;,.77,;,-.77,;-1.33,-1.54,;-2.67,-.77,;-2.67,.77,;-1.33,1.54,;-1.33,3.08,;,3.85,;,5.39,;-1.33,6.16,;-2.67,5.39,;-1.33,7.7,;-2.67,8.47,;-4,7.7,;,8.47,;1.33,7.7,;2.67,8.47,;2.67,10.01,;1.33,6.16,;2.67,5.39,;1.33,3.08,;2.67,3.85,;-1.33,-3.08,;,-3.85,;,-5.39,;1.33,-6.16,;1.33,-7.7,;,-8.47,;2.67,-8.47,;2.67,-10.01,;-1.33,-6.16,;-2.67,-5.39,;-4,-6.16,;-2.67,-3.85,;-4,-3.08,)| Show InChI InChI=1S/C27H21Cl2F2N3O4/c1-5-22(35)33-14-8-15(26(31)17(30)9-14)18-10-19-13(12-32-18)7-16(27(36)34(19)6-2)23-24(28)20(37-3)11-21(38-4)25(23)29/h5,7-12H,1,6H2,2-4H3,(H,33,35)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103859 (US9695165, 42) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C2CCCC2)c1=O)-c1ccccc1NC(=O)C=C |(4,8.08,;4,6.54,;2.67,5.78,;1.33,6.54,;,5.78,;-1.33,6.54,;-2.67,5.78,;,4.23,;-1.33,3.47,;1.33,3.47,;2.67,4.23,;4,3.47,;1.33,1.93,;2.67,1.15,;2.67,-.38,;4,-1.15,;4,-2.69,;2.67,-3.47,;1.33,-2.69,;1.33,-1.15,;,-.38,;-1.33,-1.15,;-2.8,-.68,;-3.7,-1.93,;-2.8,-3.17,;-1.33,-2.69,;,1.15,;-1.33,1.93,;2.67,-5,;4,-5.78,;4,-7.31,;2.67,-8.08,;1.33,-7.31,;1.33,-5.78,;,-5,;-1.33,-5.78,;-1.33,-7.31,;-2.67,-5,;-4,-5.78,)| Show InChI InChI=1S/C30H27Cl2N3O4/c1-4-26(36)34-21-12-8-7-11-19(21)22-14-23-17(16-33-22)13-20(30(37)35(23)18-9-5-6-10-18)27-28(31)24(38-2)15-25(39-3)29(27)32/h4,7-8,11-16,18H,1,5-6,9-10H2,2-3H3,(H,34,36)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103860 (US9695165, 43) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C2CCCC2)c1=O)-c1cccc(NC(=O)C=C)c1 |(4,8.08,;4,6.54,;2.67,5.78,;1.33,6.54,;,5.78,;-1.33,6.54,;-2.67,5.78,;,4.23,;-1.33,3.47,;1.33,3.47,;2.67,4.23,;4,3.47,;1.33,1.93,;2.67,1.15,;2.67,-.38,;4,-1.15,;4,-2.69,;2.67,-3.47,;1.33,-2.69,;1.33,-1.15,;,-.38,;-1.33,-1.15,;-2.8,-.68,;-3.7,-1.93,;-2.8,-3.17,;-1.33,-2.69,;,1.15,;-1.33,1.93,;2.67,-5,;4,-5.78,;4,-7.31,;2.67,-8.08,;1.33,-7.31,;,-8.08,;-1.33,-7.31,;-1.33,-5.77,;-2.67,-8.08,;-4,-7.31,;1.33,-5.78,)| Show InChI InChI=1S/C30H27Cl2N3O4/c1-4-26(36)34-19-9-7-8-17(12-19)22-14-23-18(16-33-22)13-21(30(37)35(23)20-10-5-6-11-20)27-28(31)24(38-2)15-25(39-3)29(27)32/h4,7-9,12-16,20H,1,5-6,10-11H2,2-3H3,(H,34,36)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103862 (US9695165, 45) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccc2CCCN(C(=O)C=C)c2c1 |(5.33,.77,;4,,;2.67,.77,;1.33,,;1.33,-1.54,;,-2.31,;-1.33,-1.54,;-1.33,,;,.77,;,2.31,;1.33,3.08,;1.33,4.62,;,5.39,;-1.33,4.62,;,6.93,;-1.33,7.7,;-2.67,6.93,;1.33,7.7,;2.67,6.93,;4,7.7,;4,9.24,;2.67,5.39,;4,4.62,;2.67,2.31,;4,3.08,;,-3.85,;1.33,-4.62,;1.33,-6.16,;,-6.93,;,-8.47,;-1.33,-9.24,;-2.67,-8.47,;-2.67,-6.93,;-4,-6.16,;-4,-4.62,;-5.33,-6.93,;-5.33,-8.47,;-1.33,-6.16,;-1.33,-4.62,)| Show InChI InChI=1S/C30H27Cl2N3O4/c1-5-26(36)35-11-7-8-17-9-10-18(13-22(17)35)21-14-23-19(16-33-21)12-20(30(37)34(23)6-2)27-28(31)24(38-3)15-25(39-4)29(27)32/h5,9-10,12-16H,1,6-8,11H2,2-4H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103864 (US9695165, 47) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccc2OCCN(C(=O)C=C)c2c1 |(5.33,.77,;4,,;2.67,.77,;1.33,,;1.33,-1.54,;,-2.31,;-1.33,-1.54,;-1.33,,;,.77,;,2.31,;1.33,3.08,;1.33,4.62,;,5.39,;-1.33,4.62,;,6.93,;-1.33,7.7,;-2.67,6.93,;1.33,7.7,;2.67,6.93,;4,7.7,;4,9.24,;2.67,5.39,;4,4.62,;2.67,2.31,;4,3.08,;,-3.85,;1.33,-4.62,;1.33,-6.16,;,-6.93,;,-8.47,;-1.33,-9.24,;-2.67,-8.47,;-2.67,-6.93,;-4,-6.16,;-4,-4.62,;-5.33,-6.93,;-5.33,-8.47,;-1.33,-6.16,;-1.33,-4.62,)| Show InChI InChI=1S/C29H25Cl2N3O5/c1-5-25(35)34-9-10-39-22-8-7-16(12-21(22)34)19-13-20-17(15-32-19)11-18(29(36)33(20)6-2)26-27(30)23(37-3)14-24(38-4)28(26)31/h5,7-8,11-15H,1,6,9-10H2,2-4H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103867 (US9695165, 50) Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1ccc2OCCN(C(=O)C=C)c2c1)c1c(Cl)c(OC)cc(OC)c1Cl Show InChI InChI=1S/C28H26Cl2N4O5/c1-5-24(35)33-9-10-39-21-8-7-16(11-20(21)33)18-12-19-17(14-31-18)15-34(28(36)32(19)6-2)27-25(29)22(37-3)13-23(38-4)26(27)30/h5,7-8,11-14H,1,6,9-10,15H2,2-4H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103869 (US9695165, 52) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccc2OC(C)(C)CN(C(=O)C=C)c2c1 |(5.33,1.44,;4,.67,;2.67,1.44,;1.33,.67,;1.33,-.87,;,-1.64,;-1.33,-.87,;-1.33,.67,;,1.44,;,2.98,;1.33,3.75,;1.33,5.29,;,6.06,;-1.33,5.29,;,7.6,;-1.33,8.37,;-2.67,7.6,;1.33,8.37,;2.67,7.6,;4,8.37,;4,9.91,;2.67,6.06,;4,5.29,;2.67,2.98,;4,3.75,;,-3.18,;1.33,-3.95,;1.33,-5.49,;,-6.26,;,-7.8,;-1.33,-8.57,;-2.1,-9.91,;-.56,-9.91,;-2.67,-7.8,;-2.67,-6.26,;-4,-5.49,;-4,-3.95,;-5.33,-6.26,;-5.33,-7.8,;-1.33,-5.49,;-1.33,-3.95,)| Show InChI InChI=1S/C31H29Cl2N3O5/c1-7-26(37)36-16-31(3,4)41-23-10-9-17(12-22(23)36)20-13-21-18(15-34-20)11-19(30(38)35(21)8-2)27-28(32)24(39-5)14-25(40-6)29(27)33/h7,9-15H,1,8,16H2,2-6H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103870 (US9695165, 53) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc2N(C(C)COc2cc1F)C(=O)C=C |(3.33,.77,;2,,;.67,.77,;-.67,,;-.67,-1.54,;-2,-2.31,;-3.33,-1.54,;-3.33,,;-2,.77,;-2,2.31,;-.67,3.08,;-.67,4.62,;-2,5.39,;-3.33,4.62,;-2,6.93,;-3.33,7.7,;-4.67,6.93,;-.67,7.7,;.67,6.93,;2,7.7,;2,9.24,;.67,5.39,;2,4.62,;.67,2.31,;2,3.08,;-2,-3.85,;-.67,-4.62,;-.67,-6.16,;.67,-6.93,;.67,-8.47,;2,-9.24,;-.67,-9.24,;-2,-8.47,;-2,-6.93,;-3.33,-6.16,;-3.33,-4.62,;-4.67,-3.85,;2,-6.16,;2,-4.62,;3.33,-6.93,;4.67,-6.16,)| Show InChI InChI=1S/C30H26Cl2FN3O5/c1-6-26(37)36-15(3)14-41-23-10-19(33)17(9-22(23)36)20-11-21-16(13-34-20)8-18(30(38)35(21)7-2)27-28(31)24(39-4)12-25(40-5)29(27)32/h6,8-13,15H,1,7,14H2,2-5H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102167 (US9695165, 10) Show SMILES COc1cc(OC)c(F)c(c1)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F Show InChI InChI=1S/C28H25F2N3O4/c1-6-26(34)32-17-7-8-22(29)21(10-17)23-13-24-16(14-31-23)9-20(28(35)33(24)15(2)3)19-11-18(36-4)12-25(37-5)27(19)30/h6-15H,1H2,2-5H3,(H,32,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102058 (US9695165, 4) Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F Show InChI InChI=1S/C28H26FN3O4/c1-6-27(33)31-19-7-8-24(29)23(12-19)25-14-26-18(15-30-25)11-22(28(34)32(26)16(2)3)17-9-20(35-4)13-21(10-17)36-5/h6-16H,1H2,2-5H3,(H,31,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102119 (US9695165, 7) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1c(F)cccc1NC(=O)C=C Show InChI InChI=1S/C25H18Cl2FN3O3/c1-4-20(32)30-17-7-5-6-15(28)22(17)25-29-12-14-10-13(8-9-16(14)31-25)21-23(26)18(33-2)11-19(34-3)24(21)27/h4-12H,1H2,2-3H3,(H,30,32)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM102160 (US9695165, 9) Show SMILES CCn1c2cc(ncc2cc(-c2cc(ccc2Cl)C(=O)NOC)c1=O)-c1ccccc1NC(=O)C=C Show InChI InChI=1S/C27H23ClN4O4/c1-4-25(33)30-22-9-7-6-8-18(22)23-14-24-17(15-29-23)13-20(27(35)32(24)5-2)19-12-16(10-11-21(19)28)26(34)31-36-3/h4,6-15H,1,5H2,2-3H3,(H,30,33)(H,31,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM102167 (US9695165, 10) Show SMILES COc1cc(OC)c(F)c(c1)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1cc(NC(=O)C=C)ccc1F Show InChI InChI=1S/C28H25F2N3O4/c1-6-26(34)32-17-7-8-22(29)21(10-17)23-13-24-16(14-31-23)9-20(28(35)33(24)15(2)3)19-11-18(36-4)12-25(37-5)27(19)30/h6-15H,1H2,2-5H3,(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102175 (US9695165, 11) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1ccc2CCN(C(=O)C=C)c2c1 Show InChI InChI=1S/C27H21Cl2N3O3/c1-4-23(33)32-10-9-15-5-6-17(12-20(15)32)27-30-14-18-11-16(7-8-19(18)31-27)24-25(28)21(34-2)13-22(35-3)26(24)29/h4-8,11-14H,1,9-10H2,2-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102204 (US9695165, 16) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1ccc2OCCN(C(=O)C=C)c2c1 Show InChI InChI=1S/C27H21Cl2N3O4/c1-4-23(33)32-9-10-36-20-8-6-16(12-19(20)32)27-30-14-17-11-15(5-7-18(17)31-27)24-25(28)21(34-2)13-22(35-3)26(24)29/h4-8,11-14H,1,9-10H2,2-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM102213 (US9695165, 18) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1cc2N(CCc2cc1F)C(=O)C=C Show InChI InChI=1S/C27H20Cl2FN3O3/c1-4-23(34)33-8-7-14-10-18(30)17(11-20(14)33)27-31-13-16-9-15(5-6-19(16)32-27)24-25(28)21(35-2)12-22(36-3)26(24)29/h4-6,9-13H,1,7-8H2,2-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM102217 (US9695165, 19) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccccc1NC(=O)C=C |(-6,-.38,;-4.67,-1.15,;-3.33,-.38,;-2,-1.15,;-2,-2.69,;-.67,-3.47,;.67,-2.69,;.67,-1.15,;-.67,-.38,;-.67,1.15,;-2,1.93,;-2,3.47,;-.67,4.23,;.67,3.47,;-.67,5.78,;.67,6.54,;2,5.78,;-2,6.54,;-3.33,5.78,;-4.67,6.54,;-4.67,8.08,;-3.33,4.23,;-4.67,3.47,;-3.33,1.15,;-4.67,1.93,;-.67,-5,;-2,-5.78,;-2,-7.31,;-.67,-8.08,;.67,-7.31,;.67,-5.78,;2,-5,;3.33,-5.77,;3.33,-7.31,;4.67,-5,;6,-5.77,)| Show InChI InChI=1S/C27H23Cl2N3O4/c1-5-23(33)31-18-10-8-7-9-16(18)19-12-20-15(14-30-19)11-17(27(34)32(20)6-2)24-25(28)21(35-3)13-22(36-4)26(24)29/h5,7-14H,1,6H2,2-4H3,(H,31,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102226 (US9695165, 22) Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cccc(NC(=O)C=C)c1)c1c(Cl)c(OC)cc(OC)c1Cl Show InChI InChI=1S/C26H24Cl2N4O4/c1-5-22(33)30-17-9-7-8-15(10-17)18-11-19-16(13-29-18)14-32(26(34)31(19)6-2)25-23(27)20(35-3)12-21(36-4)24(25)28/h5,7-13H,1,6,14H2,2-4H3,(H,30,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM102226 (US9695165, 22) Show SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cccc(NC(=O)C=C)c1)c1c(Cl)c(OC)cc(OC)c1Cl Show InChI InChI=1S/C26H24Cl2N4O4/c1-5-22(33)30-17-9-7-8-15(10-17)18-11-19-16(13-29-18)14-32(26(34)31(19)6-2)25-23(27)20(35-3)12-21(36-4)24(25)28/h5,7-13H,1,6,14H2,2-4H3,(H,30,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM102229 (US9695165, 23) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C)c1=O)-c1cc(NC(=O)C=C)ccc1F |(-2,10.01,;-2,8.47,;-.67,7.7,;.67,8.47,;2,7.7,;3.33,8.47,;4.67,7.7,;2,6.16,;3.33,5.39,;.67,5.39,;-.67,6.16,;-2,5.39,;.67,3.85,;-.67,3.08,;-.67,1.54,;-2,.77,;-2,-.77,;-.67,-1.54,;.67,-.77,;.67,.77,;2,1.54,;3.33,.77,;2,3.08,;3.33,3.85,;-.67,-3.08,;-2,-3.85,;-2,-5.39,;-3.33,-6.16,;-3.33,-7.7,;-2,-8.47,;-4.67,-8.47,;-4.67,-10.01,;-.67,-6.16,;.67,-5.39,;.67,-3.85,;2,-3.08,)| Show InChI InChI=1S/C26H20Cl2FN3O4/c1-5-22(33)31-14-6-7-17(29)15(9-14)18-10-19-13(12-30-18)8-16(26(34)32(19)2)23-24(27)20(35-3)11-21(36-4)25(23)28/h5-12H,1H2,2-4H3,(H,31,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM102252 (US9695165, 24) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1cc2N(CCOc2cc1C)C(=O)C=C Show InChI InChI=1S/C28H23Cl2N3O4/c1-5-24(34)33-8-9-37-21-10-15(2)18(12-20(21)33)28-31-14-17-11-16(6-7-19(17)32-28)25-26(29)22(35-3)13-23(36-4)27(25)30/h5-7,10-14H,1,8-9H2,2-4H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM102252 (US9695165, 24) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(ncc2c1)-c1cc2N(CCOc2cc1C)C(=O)C=C Show InChI InChI=1S/C28H23Cl2N3O4/c1-5-24(34)33-8-9-37-21-10-15(2)18(12-20(21)33)28-31-14-17-11-16(6-7-19(17)32-28)25-26(29)22(35-3)13-23(36-4)27(25)30/h5-7,10-14H,1,8-9H2,2-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM102277 (US9695165, 25) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(cc2n(C(C)C)c1=O)-c1ccccc1NC(=O)C=C |(-4,8.09,;-4,6.54,;-2.67,5.77,;-1.33,6.54,;,5.77,;1.33,6.55,;2.67,5.78,;,4.23,;1.33,3.47,;-1.33,3.46,;-2.67,4.23,;-4,3.46,;-1.33,1.92,;-2.67,1.15,;-2.67,-.39,;-4,-1.16,;-4,-2.7,;-2.67,-3.47,;-1.33,-2.7,;-1.33,-1.16,;,-.39,;1.33,-1.16,;2.67,-.38,;1.33,-2.69,;,1.15,;1.33,1.92,;-2.67,-5.01,;-4,-5.78,;-4,-7.32,;-2.67,-8.09,;-1.33,-7.32,;-1.33,-5.78,;,-5,;1.33,-5.77,;1.33,-7.31,;2.67,-5,;4,-5.77,)| Show InChI InChI=1S/C28H25Cl2N3O4/c1-6-24(34)32-19-10-8-7-9-17(19)20-12-21-16(14-31-20)11-18(28(35)33(21)15(2)3)25-26(29)22(36-4)13-23(37-5)27(25)30/h6-15H,1H2,2-5H3,(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103502 (US9695165, 26) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1ccccc1N(C)C(=O)C=C |(5.33,-.38,;4,-1.16,;2.67,-.39,;1.33,-1.16,;1.33,-2.7,;,-3.47,;-1.33,-2.7,;-1.33,-1.16,;,-.39,;,1.15,;1.33,1.92,;1.33,3.46,;,4.23,;-1.33,3.46,;,5.77,;-1.33,6.54,;-2.67,5.77,;1.33,6.54,;2.67,5.77,;4,6.55,;4,8.09,;2.67,4.23,;4,3.47,;2.67,1.15,;4,1.92,;,-5.01,;1.33,-5.78,;1.33,-7.32,;,-8.09,;-1.33,-7.32,;-1.33,-5.78,;-2.67,-5.01,;-2.67,-3.47,;-4,-5.78,;-5.33,-5.01,;-4,-7.32,;-5.33,-8.09,)| Show InChI InChI=1S/C28H25Cl2N3O4/c1-6-24(34)32(3)20-11-9-8-10-17(20)19-13-21-16(15-31-19)12-18(28(35)33(21)7-2)25-26(29)22(36-4)14-23(37-5)27(25)30/h6,8-15H,1,7H2,2-5H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM103503 (US9695165, 27) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1C |(4,1.54,;2.67,.77,;1.33,1.54,;,.77,;,-.77,;-1.33,-1.54,;-2.67,-.77,;-2.67,.77,;-1.33,1.54,;-1.33,3.08,;,3.85,;,5.39,;-1.33,6.16,;-2.67,5.39,;-1.33,7.7,;-2.67,8.47,;-4,7.7,;,8.47,;1.33,7.7,;2.67,8.47,;2.67,10.01,;1.33,6.16,;2.67,5.39,;1.33,3.08,;2.67,3.85,;-1.33,-3.08,;,-3.85,;,-5.39,;1.33,-6.16,;1.33,-7.7,;,-8.47,;2.67,-8.47,;2.67,-10.01,;-1.33,-6.16,;-2.67,-5.39,;-2.67,-3.85,;-4,-3.08,)| Show InChI InChI=1S/C28H25Cl2N3O4/c1-6-24(34)32-17-9-8-15(3)18(11-17)20-12-21-16(14-31-20)10-19(28(35)33(21)7-2)25-26(29)22(36-4)13-23(37-5)27(25)30/h6,8-14H,1,7H2,2-5H3,(H,32,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	7.5	25
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 (Homo sapiens (Human))	BDBM103503 (US9695165, 27) Show SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1C |(4,1.54,;2.67,.77,;1.33,1.54,;,.77,;,-.77,;-1.33,-1.54,;-2.67,-.77,;-2.67,.77,;-1.33,1.54,;-1.33,3.08,;,3.85,;,5.39,;-1.33,6.16,;-2.67,5.39,;-1.33,7.7,;-2.67,8.47,;-4,7.7,;,8.47,;1.33,7.7,;2.67,8.47,;2.67,10.01,;1.33,6.16,;2.67,5.39,;1.33,3.08,;2.67,3.85,;-1.33,-3.08,;,-3.85,;,-5.39,;1.33,-6.16,;1.33,-7.7,;,-8.47,;2.67,-8.47,;2.67,-10.01,;-1.33,-6.16,;-2.67,-5.39,;-2.67,-3.85,;-4,-3.08,)| Show InChI InChI=1S/C28H25Cl2N3O4/c1-6-24(34)32-17-9-8-15(3)18(11-17)20-12-21-16(14-31-20)10-19(28(35)33(21)7-2)25-26(29)22(36-4)13-23(37-5)27(25)30/h6,8-14H,1,7H2,2-5H3,(H,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
BLUEPRINT MEDICINES CORPORATION US Patent					Assay Description MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...				US Patent US9695165 (2017) BindingDB Entry DOI: 10.7270/Q25M67QZ
					More data for this Ligand-Target Pair

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