BindingDB PrimarySearch

Found 21 hits Enz. Inhib. hit(s) with all data for entry = 50000246
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM23926 ((E)-resveratrol \| 5-[(E)-2-(4-hydroxyphenyl)etheny...) Show SMILES Oc1ccc(\C=C\c2cc(O)cc(O)c2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
Hyogo University of Health Sciences Curated by ChEMBL					Assay Description Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced current response by whole cell patch clamp method				Bioorg Med Chem Lett 27: 3167-3172 (2017) Article DOI: 10.1016/j.bmcl.2017.05.025 BindingDB Entry DOI: 10.7270/Q2TH8Q4R
Hyogo University of Health Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50140144 (CHEMBL2387060) Show SMILES Oc1ccccc1\C=C\c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hyogo University of Health Sciences Curated by ChEMBL					Assay Description Inhibition of TRPA1 (unknown origin)				Bioorg Med Chem Lett 27: 3167-3172 (2017) Article DOI: 10.1016/j.bmcl.2017.05.025 BindingDB Entry DOI: 10.7270/Q2TH8Q4R
Hyogo University of Health Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50140156 (CHEMBL2387062) Show SMILES COc1ccccc1\C=C\c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hyogo University of Health Sciences Curated by ChEMBL					Assay Description Inhibition of TRPA1 (unknown origin)				Bioorg Med Chem Lett 27: 3167-3172 (2017) Article DOI: 10.1016/j.bmcl.2017.05.025 BindingDB Entry DOI: 10.7270/Q2TH8Q4R
Hyogo University of Health Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50243347 (CHEMBL4064244) Show SMILES Oc1ccc(\C=C\c2cc(Br)c(O)c(Br)c2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.61E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hyogo University of Health Sciences Curated by ChEMBL					Assay Description Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...				Bioorg Med Chem Lett 27: 3167-3172 (2017) Article DOI: 10.1016/j.bmcl.2017.05.025 BindingDB Entry DOI: 10.7270/Q2TH8Q4R
Hyogo University of Health Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50243348 (CHEMBL3827411) Show SMILES Oc1cc(O)cc(\C=C\c2ccc(Cl)cc2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hyogo University of Health Sciences Curated by ChEMBL					Assay Description Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...				Bioorg Med Chem Lett 27: 3167-3172 (2017) Article DOI: 10.1016/j.bmcl.2017.05.025 BindingDB Entry DOI: 10.7270/Q2TH8Q4R
Hyogo University of Health Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50085531 (3,4',5-trihydroxybibenzyl \| 5-(4-hydroxyphenethyl)...) Show SMILES Oc1ccc(CCc2cc(O)cc(O)c2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hyogo University of Health Sciences Curated by ChEMBL					Assay Description Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...				Bioorg Med Chem Lett 27: 3167-3172 (2017) Article DOI: 10.1016/j.bmcl.2017.05.025 BindingDB Entry DOI: 10.7270/Q2TH8Q4R
Hyogo University of Health Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM23926 ((E)-resveratrol \| 5-[(E)-2-(4-hydroxyphenyl)etheny...) Show SMILES Oc1ccc(\C=C\c2cc(O)cc(O)c2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hyogo University of Health Sciences Curated by ChEMBL					Assay Description Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...				Bioorg Med Chem Lett 27: 3167-3172 (2017) Article DOI: 10.1016/j.bmcl.2017.05.025 BindingDB Entry DOI: 10.7270/Q2TH8Q4R
Hyogo University of Health Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50243349 (CHEMBL4090371) Show SMILES COc1ccc(NC(=O)c2cc(O)cc(O)c2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hyogo University of Health Sciences Curated by ChEMBL					Assay Description Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...				Bioorg Med Chem Lett 27: 3167-3172 (2017) Article DOI: 10.1016/j.bmcl.2017.05.025 BindingDB Entry DOI: 10.7270/Q2TH8Q4R
Hyogo University of Health Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50243350 (CHEMBL4088443) Show SMILES Clc1cc(Cl)cc(\C=C\c2ccccc2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hyogo University of Health Sciences Curated by ChEMBL					Assay Description Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...				Bioorg Med Chem Lett 27: 3167-3172 (2017) Article DOI: 10.1016/j.bmcl.2017.05.025 BindingDB Entry DOI: 10.7270/Q2TH8Q4R
Hyogo University of Health Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50140144 (CHEMBL2387060) Show SMILES Oc1ccccc1\C=C\c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hyogo University of Health Sciences Curated by ChEMBL					Assay Description Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.				Bioorg Med Chem Lett 27: 3167-3172 (2017) Article DOI: 10.1016/j.bmcl.2017.05.025 BindingDB Entry DOI: 10.7270/Q2TH8Q4R
Hyogo University of Health Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50045922 (5-[2-(3-Hydroxy-phenyl)-vinyl]-benzene-1,3-diol \| ...) Show SMILES Oc1cccc(\C=C\c2cc(O)cc(O)c2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hyogo University of Health Sciences Curated by ChEMBL					Assay Description Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...				Bioorg Med Chem Lett 27: 3167-3172 (2017) Article DOI: 10.1016/j.bmcl.2017.05.025 BindingDB Entry DOI: 10.7270/Q2TH8Q4R
Hyogo University of Health Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM23929 (1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benz...) Show SMILES Clc1ccc(\C=C\c2cc(Cl)cc(Cl)c2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hyogo University of Health Sciences Curated by ChEMBL					Assay Description Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...				Bioorg Med Chem Lett 27: 3167-3172 (2017) Article DOI: 10.1016/j.bmcl.2017.05.025 BindingDB Entry DOI: 10.7270/Q2TH8Q4R
Hyogo University of Health Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50243347 (CHEMBL4064244) Show SMILES Oc1ccc(\C=C\c2cc(Br)c(O)c(Br)c2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Hyogo University of Health Sciences Curated by ChEMBL					Assay Description Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.				Bioorg Med Chem Lett 27: 3167-3172 (2017) Article DOI: 10.1016/j.bmcl.2017.05.025 BindingDB Entry DOI: 10.7270/Q2TH8Q4R
Hyogo University of Health Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM23926 ((E)-resveratrol \| 5-[(E)-2-(4-hydroxyphenyl)etheny...) Show SMILES Oc1ccc(\C=C\c2cc(O)cc(O)c2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Hyogo University of Health Sciences Curated by ChEMBL					Assay Description Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assay				Bioorg Med Chem Lett 27: 3167-3172 (2017) Article DOI: 10.1016/j.bmcl.2017.05.025 BindingDB Entry DOI: 10.7270/Q2TH8Q4R
Hyogo University of Health Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50140144 (CHEMBL2387060) Show SMILES Oc1ccccc1\C=C\c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Hyogo University of Health Sciences Curated by ChEMBL					Assay Description Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assay				Bioorg Med Chem Lett 27: 3167-3172 (2017) Article DOI: 10.1016/j.bmcl.2017.05.025 BindingDB Entry DOI: 10.7270/Q2TH8Q4R
Hyogo University of Health Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50045922 (5-[2-(3-Hydroxy-phenyl)-vinyl]-benzene-1,3-diol \| ...) Show SMILES Oc1cccc(\C=C\c2cc(O)cc(O)c2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Hyogo University of Health Sciences Curated by ChEMBL					Assay Description Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assay				Bioorg Med Chem Lett 27: 3167-3172 (2017) Article DOI: 10.1016/j.bmcl.2017.05.025 BindingDB Entry DOI: 10.7270/Q2TH8Q4R
Hyogo University of Health Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM23929 (1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benz...) Show SMILES Clc1ccc(\C=C\c2cc(Cl)cc(Cl)c2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Hyogo University of Health Sciences Curated by ChEMBL					Assay Description Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assay				Bioorg Med Chem Lett 27: 3167-3172 (2017) Article DOI: 10.1016/j.bmcl.2017.05.025 BindingDB Entry DOI: 10.7270/Q2TH8Q4R
Hyogo University of Health Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50243350 (CHEMBL4088443) Show SMILES Clc1cc(Cl)cc(\C=C\c2ccccc2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Hyogo University of Health Sciences Curated by ChEMBL					Assay Description Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assay				Bioorg Med Chem Lett 27: 3167-3172 (2017) Article DOI: 10.1016/j.bmcl.2017.05.025 BindingDB Entry DOI: 10.7270/Q2TH8Q4R
Hyogo University of Health Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50243348 (CHEMBL3827411) Show SMILES Oc1cc(O)cc(\C=C\c2ccc(Cl)cc2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Hyogo University of Health Sciences Curated by ChEMBL					Assay Description Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.				Bioorg Med Chem Lett 27: 3167-3172 (2017) Article DOI: 10.1016/j.bmcl.2017.05.025 BindingDB Entry DOI: 10.7270/Q2TH8Q4R
Hyogo University of Health Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50243349 (CHEMBL4090371) Show SMILES COc1ccc(NC(=O)c2cc(O)cc(O)c2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Hyogo University of Health Sciences Curated by ChEMBL					Assay Description Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assay				Bioorg Med Chem Lett 27: 3167-3172 (2017) Article DOI: 10.1016/j.bmcl.2017.05.025 BindingDB Entry DOI: 10.7270/Q2TH8Q4R
Hyogo University of Health Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM50085531 (3,4',5-trihydroxybibenzyl \| 5-(4-hydroxyphenethyl)...) Show SMILES Oc1ccc(CCc2cc(O)cc(O)c2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Hyogo University of Health Sciences Curated by ChEMBL					Assay Description Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assay				Bioorg Med Chem Lett 27: 3167-3172 (2017) Article DOI: 10.1016/j.bmcl.2017.05.025 BindingDB Entry DOI: 10.7270/Q2TH8Q4R
Hyogo University of Health Sciences Curated by ChEMBL					More data for this Ligand-Target Pair